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Q6W2J9

- BCOR_HUMAN

UniProt

Q6W2J9 - BCOR_HUMAN

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Protein

BCL-6 corepressor

Gene

BCOR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).5 Publications

GO - Molecular functioni

  1. heat shock protein binding Source: UniProtKB
  2. histone deacetylase binding Source: UniProtKB
  3. transcription corepressor activity Source: UniProtKB
  4. transcription factor binding Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. heart development Source: UniProtKB
  2. histone H2A monoubiquitination Source: UniProtKB
  3. negative regulation of bone mineralization Source: UniProtKB
  4. negative regulation of histone H3-K36 methylation Source: UniProtKB
  5. negative regulation of histone H3-K4 methylation Source: UniProtKB
  6. negative regulation of tooth mineralization Source: UniProtKB
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. odontogenesis Source: UniProtKB
  10. palate development Source: UniProtKB
  11. specification of axis polarity Source: UniProtKB
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BCL-6 corepressor
Short name:
BCoR
Gene namesi
Name:BCOR
Synonyms:KIAA1575
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:20893. BCOR.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Microphthalmia, syndromic, 2 (MCOPS2) [MIM:300166]: A very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851P → L in MCOPS2. 1 Publication
Corresponds to variant rs28935183 [ dbSNP | Ensembl ].
VAR_020921

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi507 – 5071S → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-509 and A-511. 1 Publication
Mutagenesisi508 – 5081S → A: Diminishes interaction with BCL6. 1 Publication
Mutagenesisi509 – 5091W → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-511. 1 Publication
Mutagenesisi511 – 5111V → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-509. 1 Publication
Mutagenesisi1706 – 17061L → D or R: Slightly inhibits interaction with PCGF1. 1 Publication

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

MIMi300166. phenotype.
Orphaneti568. Microphthalmia, Lenz type.
2712. Oculofaciocardiodental syndrome.
PharmGKBiPA134921737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17551755BCL-6 corepressorPRO_0000066978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei336 – 3361Phosphoserine1 Publication
Modified residuei340 – 3401Phosphoserine1 Publication
Modified residuei365 – 3651Phosphoserine1 Publication
Modified residuei367 – 3671Phosphoserine1 Publication
Modified residuei392 – 3921N6-acetyllysine1 Publication
Modified residuei423 – 4231Phosphoserine3 Publications
Modified residuei1139 – 11391Phosphoserine1 Publication
Modified residuei1410 – 14101Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6W2J9.
PaxDbiQ6W2J9.
PRIDEiQ6W2J9.

PTM databases

PhosphoSiteiQ6W2J9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ6W2J9.
ExpressionAtlasiQ6W2J9. baseline and differential.
GenevestigatoriQ6W2J9.

Interactioni

Subunit structurei

Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximative 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1. Isoform 1 may interact with MLLT3/AF9.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM2BQ8NHM52EBI-950027,EBI-3955564
PCGF1Q9BSM16EBI-950027,EBI-749901

Protein-protein interaction databases

BioGridi120228. 32 interactions.
DIPiDIP-50009N.
IntActiQ6W2J9. 8 interactions.
MINTiMINT-2817388.

Structurei

Secondary structure

1
1755
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi500 – 5034
Beta strandi1637 – 16448
Beta strandi1650 – 16534
Turni1656 – 16583
Beta strandi1660 – 16656
Helixi1666 – 16738
Helixi1677 – 16837
Beta strandi1689 – 16935
Helixi1694 – 17029
Helixi1705 – 17073
Helixi1710 – 17123
Turni1713 – 17153
Beta strandi1723 – 17286
Helixi1731 – 17366
Beta strandi1740 – 17445

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3BIMX-ray2.60I/J/K/L/M/N/O/P498-514[»]
4HPLX-ray2.00A1634-1748[»]
ProteinModelPortaliQ6W2J9.
SMRiQ6W2J9. Positions 1463-1579, 1636-1748.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6W2J9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1462 – 149534ANK 1Add
BLAST
Repeati1496 – 152530ANK 2Add
BLAST
Repeati1529 – 155830ANK 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni498 – 51417Interaction with BCL6Add
BLAST
Regioni1634 – 1748115Necessary and sufficient for interaction with PCGF1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi634 – 71178Pro-richAdd
BLAST
Compositional biasi1625 – 16317Poly-Asp

Sequence similaritiesi

Belongs to the BCOR family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000119090.
HOVERGENiHBG050682.
InParanoidiQ6W2J9.
OMAiSSCPRMG.
PhylomeDBiQ6W2J9.
TreeFamiTF333317.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6W2J9) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP
60 70 80 90 100
LNHNVVDAST AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK
110 120 130 140 150
GREAATSTLG GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK
160 170 180 190 200
TPPGIQKSAV ATAEALGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT
210 220 230 240 250
PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN GERFLYLPPP
260 270 280 290 300
HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD
310 320 330 340 350
SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA
360 370 380 390 400
ADTYSEFHKH YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG
410 420 430 440 450
EGAQPVPGHA RKTAVQDRKD GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV
460 470 480 490 500
DASKADHMKK MAPTVLVHSR AGSGLVLSGS EIPKETLSPP GNGCAIYRSE
510 520 530 540 550
IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR SSSCPRMGGT
560 570 580 590 600
DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ
610 620 630 640 650
PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP
660 670 680 690 700
IPYPRSYLPY PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP
710 720 730 740 750
GLPYGLPTGR PEFVTYQDAL GLGMVHPMLI PHTPIEITKE EKPERRSRSH
760 770 780 790 800
ERARYEDPTL RNRFSEILET SSTKLHPDVP TDKNLKPNPN WNQGKTVVKS
810 820 830 840 850
DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP SVEPALQQHR
860 870 880 890 900
DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF
910 920 930 940 950
LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN
960 970 980 990 1000
DGKVLKPKPS KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM
1010 1020 1030 1040 1050
EGLQEDSILC LPAAYCERAM MRFSELEMKE REGGHPATKD SEMCKFSPAD
1060 1070 1080 1090 1100
WERLKGNQDK KPKSVTLEEA IAEQNESERC EYSVGNKHRD PFEAPEDKDL
1110 1120 1130 1140 1150
PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG DSSHTETTAE
1160 1170 1180 1190 1200
EVPEDPLLKA KRRRVSKDDW PEREMTNSSS NHLEDPHYSE LTNLKVCIEL
1210 1220 1230 1240 1250
TGLHPKKQRH LLHLRERWEQ QVSAADGKPG RQSRKEVTQA TQPEAIPQGT
1260 1270 1280 1290 1300
NITEEKPGRK RAEAKGNRSW SEESLKPSDN EQGLPVFSGS PPMKSLSSTS
1310 1320 1330 1340 1350
AGGKKQAQPS CAPASRPPAK QQKIKENQKT DVLCADEEED CQAASLLQKY
1360 1370 1380 1390 1400
TDNSEKPSGK RLCKTKHLIP QESRRGLPLT GEYYVENADG KVTVRRFRKR
1410 1420 1430 1440 1450
PEPSSDYDLS PAKQEPKPFD RLQQLLPASQ STQLPCSSSP QETTQSRPMP
1460 1470 1480 1490 1500
PEARRLIVNK NAGETLLQRA ARLGYEEVVL YCLENKICDV NHRDNAGYCA
1510 1520 1530 1540 1550
LHEACARGWL NIVRHLLEYG ADVNCSAQDG TRPLHDAVEN DHLEIVRLLL
1560 1570 1580 1590 1600
SYGADPTLAT YSGRTIMKMT HSELMEKFLT DYLNDLQGRN DDDASGTWDF
1610 1620 1630 1640 1650
YGSSVCEPDD ESGYDVLANP PGPEDQDDDD DAYSDVFEFE FSETPLLPCY
1660 1670 1680 1690 1700
NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF RCNFPNVEIV TIAEAEFYRQ
1710 1720 1730 1740 1750
VSASLLFSCS KDLEAFNPES KELLDLVEFT NEIQTLLGSS VEWLHPSDLA

SDNYW
Length:1,755
Mass (Da):192,189
Last modified:July 5, 2004 - v1
Checksum:iA80CFCD5618EE717
GO
Isoform 2 (identifier: Q6W2J9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1168-1201: Missing.

Show »
Length:1,721
Mass (Da):188,202
Checksum:iF22343D545DB67AB
GO
Isoform 3 (identifier: Q6W2J9-3) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1004: MEGLQ → VSPPT
     1005-1755: Missing.

Show »
Length:1,004
Mass (Da):107,404
Checksum:i126BD762958CB9F4
GO
Isoform 4 (identifier: Q6W2J9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1017: Missing.
     1168-1201: Missing.

Show »
Length:1,703
Mass (Da):186,235
Checksum:i7433FBCE7238261F
GO

Sequence cautioni

The sequence AAH63536.1 differs from that shown. Reason: Contaminating sequence. Presence of complementary strand sequence in the clone.
The sequence BAA91061.1 differs from that shown. Reason: Intron retention.
The sequence BAB85037.1 differs from that shown. Reason: Frameshift at position 1353.
The sequence BAB13401.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti406 – 4061V → A in BAB85037. (PubMed:14702039)Curated
Sequence conflicti596 – 5961Q → L in BAB85037. (PubMed:14702039)Curated
Sequence conflicti1459 – 14591N → S in BAA91061. (PubMed:14702039)Curated
Sequence conflicti1577 – 15771K → R in BAA91061. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851P → L in MCOPS2. 1 Publication
Corresponds to variant rs28935183 [ dbSNP | Ensembl ].
VAR_020921

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1000 – 101718Missing in isoform 4. 2 PublicationsVSP_012555Add
BLAST
Alternative sequencei1000 – 10045MEGLQ → VSPPT in isoform 3. 2 PublicationsVSP_012554
Alternative sequencei1005 – 1755751Missing in isoform 3. 2 PublicationsVSP_012556Add
BLAST
Alternative sequencei1168 – 120134Missing in isoform 2 and isoform 4. 3 PublicationsVSP_012557Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317391 mRNA. Translation: AAG41429.1.
AF317392 mRNA. Translation: AAG41430.1.
AY316592 mRNA. Translation: AAR08265.1.
AB046795 mRNA. Translation: BAB13401.2. Different initiation.
CH471141 Genomic DNA. Translation: EAW59425.1.
CH471141 Genomic DNA. Translation: EAW59427.1.
CH471141 Genomic DNA. Translation: EAW59428.1.
CH471141 Genomic DNA. Translation: EAW59430.1.
BC009675 mRNA. Translation: AAH09675.2.
BC063536 mRNA. Translation: AAH63536.1. Sequence problems.
BC114220 mRNA. Translation: AAI14221.1.
AK000292 mRNA. Translation: BAA91061.1. Sequence problems.
AK074286 mRNA. Translation: BAB85037.1. Frameshift.
CCDSiCCDS14250.1. [Q6W2J9-2]
CCDS48092.1. [Q6W2J9-4]
CCDS48093.1. [Q6W2J9-1]
RefSeqiNP_001116855.1. NM_001123383.1. [Q6W2J9-2]
NP_001116856.1. NM_001123384.1. [Q6W2J9-4]
NP_001116857.1. NM_001123385.1. [Q6W2J9-1]
NP_060215.4. NM_017745.5. [Q6W2J9-2]
XP_005272673.1. XM_005272616.1. [Q6W2J9-1]
XP_005272674.1. XM_005272617.2. [Q6W2J9-1]
XP_005272675.1. XM_005272618.1. [Q6W2J9-1]
XP_005272677.1. XM_005272620.2. [Q6W2J9-4]
XP_006724599.1. XM_006724536.1. [Q6W2J9-1]
UniGeneiHs.659681.

Genome annotation databases

EnsembliENST00000342274; ENSP00000345923; ENSG00000183337. [Q6W2J9-2]
ENST00000378444; ENSP00000367705; ENSG00000183337. [Q6W2J9-1]
ENST00000378455; ENSP00000367716; ENSG00000183337. [Q6W2J9-4]
ENST00000397354; ENSP00000380512; ENSG00000183337. [Q6W2J9-2]
GeneIDi54880.
KEGGihsa:54880.
UCSCiuc004dem.4. human. [Q6W2J9-2]
uc004den.4. human. [Q6W2J9-1]
uc004deo.4. human. [Q6W2J9-4]
uc004deq.4. human. [Q6W2J9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317391 mRNA. Translation: AAG41429.1 .
AF317392 mRNA. Translation: AAG41430.1 .
AY316592 mRNA. Translation: AAR08265.1 .
AB046795 mRNA. Translation: BAB13401.2 . Different initiation.
CH471141 Genomic DNA. Translation: EAW59425.1 .
CH471141 Genomic DNA. Translation: EAW59427.1 .
CH471141 Genomic DNA. Translation: EAW59428.1 .
CH471141 Genomic DNA. Translation: EAW59430.1 .
BC009675 mRNA. Translation: AAH09675.2 .
BC063536 mRNA. Translation: AAH63536.1 . Sequence problems.
BC114220 mRNA. Translation: AAI14221.1 .
AK000292 mRNA. Translation: BAA91061.1 . Sequence problems.
AK074286 mRNA. Translation: BAB85037.1 . Frameshift.
CCDSi CCDS14250.1. [Q6W2J9-2 ]
CCDS48092.1. [Q6W2J9-4 ]
CCDS48093.1. [Q6W2J9-1 ]
RefSeqi NP_001116855.1. NM_001123383.1. [Q6W2J9-2 ]
NP_001116856.1. NM_001123384.1. [Q6W2J9-4 ]
NP_001116857.1. NM_001123385.1. [Q6W2J9-1 ]
NP_060215.4. NM_017745.5. [Q6W2J9-2 ]
XP_005272673.1. XM_005272616.1. [Q6W2J9-1 ]
XP_005272674.1. XM_005272617.2. [Q6W2J9-1 ]
XP_005272675.1. XM_005272618.1. [Q6W2J9-1 ]
XP_005272677.1. XM_005272620.2. [Q6W2J9-4 ]
XP_006724599.1. XM_006724536.1. [Q6W2J9-1 ]
UniGenei Hs.659681.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3BIM X-ray 2.60 I/J/K/L/M/N/O/P 498-514 [» ]
4HPL X-ray 2.00 A 1634-1748 [» ]
ProteinModelPortali Q6W2J9.
SMRi Q6W2J9. Positions 1463-1579, 1636-1748.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120228. 32 interactions.
DIPi DIP-50009N.
IntActi Q6W2J9. 8 interactions.
MINTi MINT-2817388.

PTM databases

PhosphoSitei Q6W2J9.

Proteomic databases

MaxQBi Q6W2J9.
PaxDbi Q6W2J9.
PRIDEi Q6W2J9.

Protocols and materials databases

DNASUi 54880.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342274 ; ENSP00000345923 ; ENSG00000183337 . [Q6W2J9-2 ]
ENST00000378444 ; ENSP00000367705 ; ENSG00000183337 . [Q6W2J9-1 ]
ENST00000378455 ; ENSP00000367716 ; ENSG00000183337 . [Q6W2J9-4 ]
ENST00000397354 ; ENSP00000380512 ; ENSG00000183337 . [Q6W2J9-2 ]
GeneIDi 54880.
KEGGi hsa:54880.
UCSCi uc004dem.4. human. [Q6W2J9-2 ]
uc004den.4. human. [Q6W2J9-1 ]
uc004deo.4. human. [Q6W2J9-4 ]
uc004deq.4. human. [Q6W2J9-3 ]

Organism-specific databases

CTDi 54880.
GeneCardsi GC0XM039909.
GeneReviewsi BCOR.
HGNCi HGNC:20893. BCOR.
MIMi 300166. phenotype.
300485. gene.
neXtProti NX_Q6W2J9.
Orphaneti 568. Microphthalmia, Lenz type.
2712. Oculofaciocardiodental syndrome.
PharmGKBi PA134921737.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00760000119090.
HOVERGENi HBG050682.
InParanoidi Q6W2J9.
OMAi SSCPRMG.
PhylomeDBi Q6W2J9.
TreeFami TF333317.

Miscellaneous databases

ChiTaRSi BCOR. human.
EvolutionaryTracei Q6W2J9.
GeneWikii BCOR.
GenomeRNAii 54880.
NextBioi 57837.
PROi Q6W2J9.
SOURCEi Search...

Gene expression databases

Bgeei Q6W2J9.
ExpressionAtlasi Q6W2J9. baseline and differential.
Genevestigatori Q6W2J9.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BCoR, a novel corepressor involved in BCL-6 repression."
    Huynh K.D., Fischle W., Verdin E., Bardwell V.J.
    Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, INTERACTION WITH BCL6; HDAC1; HDAC3 AND HDAC5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Frontal cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT MCOPS2 LEU-85.
  3. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1395-1755 (ISOFORM 1).
    Tissue: Liver, Lymph and Uterus.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-1755 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 1328-1755.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets."
    Gearhart M.D., Corcoran C.M., Wamstad J.A., Bardwell V.J.
    Mol. Cell. Biol. 26:6880-6889(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PCGF1 AND KDM2B, IDENTIFICATION IN A COMPLEX WITH RYBP; PCGF1; RING1; RNF2; KDM2B AND SKP1.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-1410, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "BCOR regulates mesenchymal stem cell function by epigenetic mechanisms."
    Fan Z., Yamaza T., Lee J.S., Yu J., Wang S., Fan G., Shi S., Wang C.-Y.
    Nat. Cell Biol. 11:1002-1009(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-392, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; SER-340; SER-365; SER-367 AND SER-423, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: FUNCTION AS COREPRESSOR, INTERACTION WITH BCL6, IDENTIFICATION IN A COMPLEX WITH BCL6 AND SMRT.
  18. "Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs."
    Junco S.E., Wang R., Gaipa J.C., Taylor A.B., Schirf V., Gearhart M.D., Bardwell V.J., Demeler B., Hart P.J., Kim C.A.
    Structure 21:665-671(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1634-1748 IN COMPLEX WITH PCGF1, INTERACTION WITH PCGF1, MUTAGENESIS OF LEU-1706.
  19. "Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer."
    Ghetu A.F., Corcoran C.M., Cerchietti L., Bardwell V.J., Melnick A., Prive G.G.
    Mol. Cell 29:384-391(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 498-514 IN COMPLEX WITH BCL6, FUNCTION, MUTAGENESIS OF SER-507; SER-508; TRP-509 AND VAL-511.

Entry informationi

Entry nameiBCOR_HUMAN
AccessioniPrimary (citable) accession number: Q6W2J9
Secondary accession number(s): D3DWB3
, D3DWB4, Q29RF6, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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