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Protein

BCL-6 corepressor

Gene

BCOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).5 Publications

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • heart development Source: UniProtKB
  • histone H2A monoubiquitination Source: UniProtKB
  • negative regulation of bone mineralization Source: UniProtKB
  • negative regulation of histone H3-K36 methylation Source: UniProtKB
  • negative regulation of histone H3-K4 methylation Source: UniProtKB
  • negative regulation of tooth mineralization Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • odontogenesis Source: UniProtKB
  • palate development Source: UniProtKB
  • specification of axis polarity Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-31219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BCL-6 corepressor
Short name:
BCoR
Gene namesi
Name:BCOR
Synonyms:KIAA1575
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:20893. BCOR.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • mitochondrion Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Microphthalmia, syndromic, 2 (MCOPS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
See also OMIM:300166
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02092185P → L in MCOPS2. 1 PublicationCorresponds to variant rs28935183dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi507S → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-509 and A-511. 1 Publication1
Mutagenesisi508S → A: Diminishes interaction with BCL6. 1 Publication1
Mutagenesisi509W → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-511. 1 Publication1
Mutagenesisi511V → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-509. 1 Publication1
Mutagenesisi1706L → D or R: Slightly inhibits interaction with PCGF1. 1 Publication1

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNETi54880.
MalaCardsiBCOR.
MIMi300166. phenotype.
OpenTargetsiENSG00000183337.
Orphaneti568. Microphthalmia, Lenz type.
2712. Oculofaciocardiodental syndrome.
PharmGKBiPA134921737.

Polymorphism and mutation databases

BioMutaiBCOR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669781 – 1755BCL-6 corepressorAdd BLAST1755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei392N6-acetyllysineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei1127PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1345PhosphoserineBy similarity1
Modified residuei1410PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6W2J9.
MaxQBiQ6W2J9.
PaxDbiQ6W2J9.
PeptideAtlasiQ6W2J9.
PRIDEiQ6W2J9.

PTM databases

iPTMnetiQ6W2J9.
PhosphoSitePlusiQ6W2J9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000183337.
ExpressionAtlasiQ6W2J9. baseline and differential.
GenevisibleiQ6W2J9. HS.

Organism-specific databases

HPAiHPA003381.
HPA065391.

Interactioni

Subunit structurei

Interacts with BCL6; the interaction is direct (PubMed:10898795). Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression (PubMed:23911289, PubMed:18280243). Can interact with HDAC1, HDAC3 and HDAC5 (PubMed:10898795). Interacts with PCGF1; the interaction is direct (PubMed:16943429, PubMed:23523425, PubMed:26687479). Interacts with KDM2B. Component of an approximative 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (PubMed:16943429). Interacts with CPNE4 (via VWFA domain) (By similarity). Isoform 1 may interact with MLLT3/AF9 (By similarity).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM2BQ8NHM53EBI-950027,EBI-3955564
NAA10P412273EBI-10208579,EBI-747693
PCGF1Q9BSM18EBI-950027,EBI-749901
PCGF3Q3KNV83EBI-10208579,EBI-2339807
PCGF5Q86SE93EBI-10208579,EBI-2827999
USP7Q930093EBI-950027,EBI-302474

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120228. 103 interactors.
DIPiDIP-50009N.
IntActiQ6W2J9. 37 interactors.
MINTiMINT-2817388.
STRINGi9606.ENSP00000367705.

Structurei

Secondary structure

11755
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi500 – 503Combined sources4
Beta strandi1637 – 1644Combined sources8
Beta strandi1650 – 1653Combined sources4
Turni1656 – 1658Combined sources3
Beta strandi1660 – 1665Combined sources6
Helixi1666 – 1673Combined sources8
Helixi1677 – 1683Combined sources7
Beta strandi1689 – 1693Combined sources5
Helixi1694 – 1702Combined sources9
Helixi1705 – 1707Combined sources3
Helixi1710 – 1712Combined sources3
Turni1713 – 1715Combined sources3
Beta strandi1723 – 1728Combined sources6
Helixi1731 – 1736Combined sources6
Beta strandi1740 – 1744Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N1LNMR-A1634-1748[»]
3BIMX-ray2.60I/J/K/L/M/N/O/P498-514[»]
4HPLX-ray2.00A1634-1748[»]
ProteinModelPortaliQ6W2J9.
SMRiQ6W2J9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6W2J9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1462 – 1495ANK 1Add BLAST34
Repeati1496 – 1525ANK 2Add BLAST30
Repeati1529 – 1558ANK 3Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 514Interaction with BCL6Add BLAST17
Regioni1634 – 1748Necessary and sufficient for interaction with PCGF1Add BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi634 – 711Pro-richAdd BLAST78
Compositional biasi1625 – 1631Poly-Asp7

Sequence similaritiesi

Belongs to the BCOR family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHDH. Eukaryota.
ENOG410YT00. LUCA.
GeneTreeiENSGT00760000119090.
HOVERGENiHBG050682.
InParanoidiQ6W2J9.
OMAiPGNIVYS.
OrthoDBiEOG091G0R1A.
PhylomeDBiQ6W2J9.
TreeFamiTF333317.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031628. BCOR.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF15808. BCOR. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6W2J9-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP
60 70 80 90 100
LNHNVVDAST AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK
110 120 130 140 150
GREAATSTLG GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK
160 170 180 190 200
TPPGIQKSAV ATAEALGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT
210 220 230 240 250
PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN GERFLYLPPP
260 270 280 290 300
HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD
310 320 330 340 350
SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA
360 370 380 390 400
ADTYSEFHKH YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG
410 420 430 440 450
EGAQPVPGHA RKTAVQDRKD GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV
460 470 480 490 500
DASKADHMKK MAPTVLVHSR AGSGLVLSGS EIPKETLSPP GNGCAIYRSE
510 520 530 540 550
IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR SSSCPRMGGT
560 570 580 590 600
DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ
610 620 630 640 650
PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP
660 670 680 690 700
IPYPRSYLPY PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP
710 720 730 740 750
GLPYGLPTGR PEFVTYQDAL GLGMVHPMLI PHTPIEITKE EKPERRSRSH
760 770 780 790 800
ERARYEDPTL RNRFSEILET SSTKLHPDVP TDKNLKPNPN WNQGKTVVKS
810 820 830 840 850
DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP SVEPALQQHR
860 870 880 890 900
DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF
910 920 930 940 950
LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN
960 970 980 990 1000
DGKVLKPKPS KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM
1010 1020 1030 1040 1050
EGLQEDSILC LPAAYCERAM MRFSELEMKE REGGHPATKD SEMCKFSPAD
1060 1070 1080 1090 1100
WERLKGNQDK KPKSVTLEEA IAEQNESERC EYSVGNKHRD PFEAPEDKDL
1110 1120 1130 1140 1150
PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG DSSHTETTAE
1160 1170 1180 1190 1200
EVPEDPLLKA KRRRVSKDDW PEREMTNSSS NHLEDPHYSE LTNLKVCIEL
1210 1220 1230 1240 1250
TGLHPKKQRH LLHLRERWEQ QVSAADGKPG RQSRKEVTQA TQPEAIPQGT
1260 1270 1280 1290 1300
NITEEKPGRK RAEAKGNRSW SEESLKPSDN EQGLPVFSGS PPMKSLSSTS
1310 1320 1330 1340 1350
AGGKKQAQPS CAPASRPPAK QQKIKENQKT DVLCADEEED CQAASLLQKY
1360 1370 1380 1390 1400
TDNSEKPSGK RLCKTKHLIP QESRRGLPLT GEYYVENADG KVTVRRFRKR
1410 1420 1430 1440 1450
PEPSSDYDLS PAKQEPKPFD RLQQLLPASQ STQLPCSSSP QETTQSRPMP
1460 1470 1480 1490 1500
PEARRLIVNK NAGETLLQRA ARLGYEEVVL YCLENKICDV NHRDNAGYCA
1510 1520 1530 1540 1550
LHEACARGWL NIVRHLLEYG ADVNCSAQDG TRPLHDAVEN DHLEIVRLLL
1560 1570 1580 1590 1600
SYGADPTLAT YSGRTIMKMT HSELMEKFLT DYLNDLQGRN DDDASGTWDF
1610 1620 1630 1640 1650
YGSSVCEPDD ESGYDVLANP PGPEDQDDDD DAYSDVFEFE FSETPLLPCY
1660 1670 1680 1690 1700
NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF RCNFPNVEIV TIAEAEFYRQ
1710 1720 1730 1740 1750
VSASLLFSCS KDLEAFNPES KELLDLVEFT NEIQTLLGSS VEWLHPSDLA

SDNYW
Length:1,755
Mass (Da):192,189
Last modified:July 5, 2004 - v1
Checksum:iA80CFCD5618EE717
GO
Isoform 2 (identifier: Q6W2J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1168-1201: Missing.

Show »
Length:1,721
Mass (Da):188,202
Checksum:iF22343D545DB67AB
GO
Isoform 3 (identifier: Q6W2J9-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1004: MEGLQ → VSPPT
     1005-1755: Missing.

Show »
Length:1,004
Mass (Da):107,404
Checksum:i126BD762958CB9F4
GO
Isoform 4 (identifier: Q6W2J9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1017: Missing.
     1168-1201: Missing.

Show »
Length:1,703
Mass (Da):186,235
Checksum:i7433FBCE7238261F
GO

Sequence cautioni

The sequence AAH63536 differs from that shown. Contaminating sequence. Presence of complementary strand sequence in the clone.Curated
The sequence BAA91061 differs from that shown. Intron retention.Curated
The sequence BAB13401 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB85037 differs from that shown. Reason: Frameshift at position 1353.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406V → A in BAB85037 (PubMed:14702039).Curated1
Sequence conflicti596Q → L in BAB85037 (PubMed:14702039).Curated1
Sequence conflicti1459N → S in BAA91061 (PubMed:14702039).Curated1
Sequence conflicti1577K → R in BAA91061 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02092185P → L in MCOPS2. 1 PublicationCorresponds to variant rs28935183dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0125551000 – 1017Missing in isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0125541000 – 1004MEGLQ → VSPPT in isoform 3. 2 Publications5
Alternative sequenceiVSP_0125561005 – 1755Missing in isoform 3. 2 PublicationsAdd BLAST751
Alternative sequenceiVSP_0125571168 – 1201Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317391 mRNA. Translation: AAG41429.1.
AF317392 mRNA. Translation: AAG41430.1.
AY316592 mRNA. Translation: AAR08265.1.
AB046795 mRNA. Translation: BAB13401.2. Different initiation.
CH471141 Genomic DNA. Translation: EAW59425.1.
CH471141 Genomic DNA. Translation: EAW59427.1.
CH471141 Genomic DNA. Translation: EAW59428.1.
CH471141 Genomic DNA. Translation: EAW59430.1.
BC009675 mRNA. Translation: AAH09675.2.
BC063536 mRNA. Translation: AAH63536.1. Sequence problems.
BC114220 mRNA. Translation: AAI14221.1.
AK000292 mRNA. Translation: BAA91061.1. Sequence problems.
AK074286 mRNA. Translation: BAB85037.1. Frameshift.
CCDSiCCDS14250.1. [Q6W2J9-2]
CCDS48092.1. [Q6W2J9-4]
CCDS48093.1. [Q6W2J9-1]
RefSeqiNP_001116855.1. NM_001123383.1. [Q6W2J9-2]
NP_001116856.1. NM_001123384.1. [Q6W2J9-4]
NP_001116857.1. NM_001123385.1. [Q6W2J9-1]
NP_060215.4. NM_017745.5. [Q6W2J9-2]
XP_005272673.1. XM_005272616.1. [Q6W2J9-1]
XP_005272675.1. XM_005272618.3. [Q6W2J9-1]
XP_005272677.1. XM_005272620.3. [Q6W2J9-4]
XP_006724599.1. XM_006724536.3. [Q6W2J9-1]
XP_011542231.1. XM_011543929.2. [Q6W2J9-1]
XP_011542232.1. XM_011543930.1. [Q6W2J9-1]
XP_011542233.1. XM_011543931.2. [Q6W2J9-1]
XP_016885104.1. XM_017029615.1. [Q6W2J9-2]
UniGeneiHs.659681.

Genome annotation databases

EnsembliENST00000342274; ENSP00000345923; ENSG00000183337. [Q6W2J9-2]
ENST00000378444; ENSP00000367705; ENSG00000183337. [Q6W2J9-1]
ENST00000378455; ENSP00000367716; ENSG00000183337. [Q6W2J9-4]
ENST00000397354; ENSP00000380512; ENSG00000183337. [Q6W2J9-2]
GeneIDi54880.
KEGGihsa:54880.
UCSCiuc004dem.5. human. [Q6W2J9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317391 mRNA. Translation: AAG41429.1.
AF317392 mRNA. Translation: AAG41430.1.
AY316592 mRNA. Translation: AAR08265.1.
AB046795 mRNA. Translation: BAB13401.2. Different initiation.
CH471141 Genomic DNA. Translation: EAW59425.1.
CH471141 Genomic DNA. Translation: EAW59427.1.
CH471141 Genomic DNA. Translation: EAW59428.1.
CH471141 Genomic DNA. Translation: EAW59430.1.
BC009675 mRNA. Translation: AAH09675.2.
BC063536 mRNA. Translation: AAH63536.1. Sequence problems.
BC114220 mRNA. Translation: AAI14221.1.
AK000292 mRNA. Translation: BAA91061.1. Sequence problems.
AK074286 mRNA. Translation: BAB85037.1. Frameshift.
CCDSiCCDS14250.1. [Q6W2J9-2]
CCDS48092.1. [Q6W2J9-4]
CCDS48093.1. [Q6W2J9-1]
RefSeqiNP_001116855.1. NM_001123383.1. [Q6W2J9-2]
NP_001116856.1. NM_001123384.1. [Q6W2J9-4]
NP_001116857.1. NM_001123385.1. [Q6W2J9-1]
NP_060215.4. NM_017745.5. [Q6W2J9-2]
XP_005272673.1. XM_005272616.1. [Q6W2J9-1]
XP_005272675.1. XM_005272618.3. [Q6W2J9-1]
XP_005272677.1. XM_005272620.3. [Q6W2J9-4]
XP_006724599.1. XM_006724536.3. [Q6W2J9-1]
XP_011542231.1. XM_011543929.2. [Q6W2J9-1]
XP_011542232.1. XM_011543930.1. [Q6W2J9-1]
XP_011542233.1. XM_011543931.2. [Q6W2J9-1]
XP_016885104.1. XM_017029615.1. [Q6W2J9-2]
UniGeneiHs.659681.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N1LNMR-A1634-1748[»]
3BIMX-ray2.60I/J/K/L/M/N/O/P498-514[»]
4HPLX-ray2.00A1634-1748[»]
ProteinModelPortaliQ6W2J9.
SMRiQ6W2J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120228. 103 interactors.
DIPiDIP-50009N.
IntActiQ6W2J9. 37 interactors.
MINTiMINT-2817388.
STRINGi9606.ENSP00000367705.

PTM databases

iPTMnetiQ6W2J9.
PhosphoSitePlusiQ6W2J9.

Polymorphism and mutation databases

BioMutaiBCOR.

Proteomic databases

EPDiQ6W2J9.
MaxQBiQ6W2J9.
PaxDbiQ6W2J9.
PeptideAtlasiQ6W2J9.
PRIDEiQ6W2J9.

Protocols and materials databases

DNASUi54880.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342274; ENSP00000345923; ENSG00000183337. [Q6W2J9-2]
ENST00000378444; ENSP00000367705; ENSG00000183337. [Q6W2J9-1]
ENST00000378455; ENSP00000367716; ENSG00000183337. [Q6W2J9-4]
ENST00000397354; ENSP00000380512; ENSG00000183337. [Q6W2J9-2]
GeneIDi54880.
KEGGihsa:54880.
UCSCiuc004dem.5. human. [Q6W2J9-1]

Organism-specific databases

CTDi54880.
DisGeNETi54880.
GeneCardsiBCOR.
GeneReviewsiBCOR.
HGNCiHGNC:20893. BCOR.
HPAiHPA003381.
HPA065391.
MalaCardsiBCOR.
MIMi300166. phenotype.
300485. gene.
neXtProtiNX_Q6W2J9.
OpenTargetsiENSG00000183337.
Orphaneti568. Microphthalmia, Lenz type.
2712. Oculofaciocardiodental syndrome.
PharmGKBiPA134921737.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDH. Eukaryota.
ENOG410YT00. LUCA.
GeneTreeiENSGT00760000119090.
HOVERGENiHBG050682.
InParanoidiQ6W2J9.
OMAiPGNIVYS.
OrthoDBiEOG091G0R1A.
PhylomeDBiQ6W2J9.
TreeFamiTF333317.

Enzyme and pathway databases

BioCyciZFISH:G66-31219-MONOMER.

Miscellaneous databases

ChiTaRSiBCOR. human.
EvolutionaryTraceiQ6W2J9.
GeneWikiiBCOR.
GenomeRNAii54880.
PROiQ6W2J9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183337.
ExpressionAtlasiQ6W2J9. baseline and differential.
GenevisibleiQ6W2J9. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031628. BCOR.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF15808. BCOR. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCOR_HUMAN
AccessioniPrimary (citable) accession number: Q6W2J9
Secondary accession number(s): D3DWB3
, D3DWB4, Q29RF6, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.