Q6W2J9 (BCOR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BCL-6 corepressor
Short name=BCoR

Gene names

Name:	BCOR
Synonyms:	KIAA1575

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1755 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). Ref.1 Ref.2 Ref.10 Ref.16
Subunit structure	Isoform 1 may interact with MLLT3/AF9 By similarity. Interacts with BCL6; the interaction is direct. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximative 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1. Ref.1 Ref.8
Subcellular location	Nucleus Ref.1.
Tissue specificity	Ubiquitously expressed. Ref.1
Involvement in disease	Microphthalmia, syndromic, 2 (MCOPS2) [MIM:300166]: A very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2
Sequence similarities	Belongs to the BCOR family. Contains 3 ANK repeats.
Sequence caution	The sequence AAH63536.1 differs from that shown. Reason: Contaminating sequence. Presence of complementary strand sequence in the clone. The sequence BAA91061.1 differs from that shown. Reason: Intron retention. The sequence BAB13401.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB85037.1 differs from that shown. Reason: Frameshift at position 1353.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Disease	Disease mutation Microphthalmia
Domain	ANK repeat Repeat
Molecular function	Chromatin regulator Repressor
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	heart development Inferred from mutant phenotype PubMed 17517692. Source: UniProtKB histone H2A monoubiquitination Inferred from direct assay Ref.8. Source: UniProtKB negative regulation of bone mineralization Inferred from mutant phenotype Ref.10. Source: UniProtKB negative regulation of histone H3-K36 methylation Inferred from mutant phenotype Ref.10. Source: UniProtKB negative regulation of histone H3-K4 methylation Inferred from mutant phenotype Ref.10. Source: UniProtKB negative regulation of tooth mineralization Inferred from mutant phenotype Ref.10. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype Ref.10. Source: UniProtKB odontogenesis Inferred from mutant phenotype PubMed 17517692. Source: UniProtKB palate development Inferred from mutant phenotype PubMed 17517692. Source: UniProtKB specification of axis polarity Inferred from mutant phenotype PubMed 17517692. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	heat shock protein binding Inferred from direct assay Ref.8. Source: UniProtKB transcription corepressor activity Inferred from direct assay Ref.1. Source: UniProtKB transcription regulatory region DNA binding Inferred from mutant phenotype Ref.10. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
KDM2B	Q8NHM5	2	EBI-950027,EBI-3955564
PCGF1	Q9BSM1	6	EBI-950027,EBI-749901

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6W2J9-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6W2J9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1168-1201: Missing.

Isoform 3 (identifier: Q6W2J9-3)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1004: MEGLQ → VSPPT
     1005-1755: Missing.

Isoform 4 (identifier: Q6W2J9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1017: Missing.
     1168-1201: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1755

1755

BCL-6 corepressor

PRO_0000066978

Regions

Repeat

1462 – 1495

34

ANK 1

Repeat

1496 – 1525

30

ANK 2

Repeat

1529 – 1558

30

ANK 3

Region

498 – 514

17

Interaction with BCL6

Compositional bias

634 – 711

78

Pro-rich

Compositional bias

1625 – 1631

7

Poly-Asp

Amino acid modifications

Modified residue

336

1

Phosphoserine Ref.13

Modified residue

340

1

Phosphoserine Ref.13

Modified residue

365

1

Phosphoserine Ref.13

Modified residue

367

1

Phosphoserine Ref.13

Modified residue

392

1

N6-acetyllysine Ref.12

Modified residue

423

1

Phosphoserine Ref.9 Ref.13 Ref.15

Modified residue

1139

1

Phosphoserine Ref.11

Modified residue

1142

1

Phosphoserine By similarity

Modified residue

1410

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

1000 – 1017

18

Missing in isoform 4.

VSP_012555

Alternative sequence

1000 – 1004

5

MEGLQ → VSPPT in isoform 3.

VSP_012554

Alternative sequence

1005 – 1755

751

Missing in isoform 3.

VSP_012556

Alternative sequence

1168 – 1201

34

Missing in isoform 2 and isoform 4.

VSP_012557

Natural variant

85

1

P → L in MCOPS2. Ref.2
Corresponds to variant rs28935183 [ dbSNP | Ensembl ].

VAR_020921

Experimental info

Mutagenesis

507

1

S → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-509 and A-511. Ref.16

Mutagenesis

508

1

S → A: Diminishes interaction with BCL6. Ref.16

Mutagenesis

509

1

W → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-511. Ref.16

Mutagenesis

511

1

V → A: Abolishes interaction with BCL6 and inhibits BCL6 corepression activity; when associated with A-507 and A-509. Ref.16

Sequence conflict

406

1

V → A in BAB85037. Ref.6

Sequence conflict

596

1

Q → L in BAB85037. Ref.6

Sequence conflict

1459

1

N → S in BAA91061. Ref.6

Sequence conflict

1577

1

K → R in BAA91061. Ref.6

Secondary structure

1

.

.

.

1755

Helix Strand Turn

Details...

Beta strand

500 – 503

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A80CFCD5618EE717	FASTA	1,755	192,189
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 1010 1020 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM EGLQEDSILC LPAAYCERAM 1030 1040 1050 1060 1070 1080 MRFSELEMKE REGGHPATKD SEMCKFSPAD WERLKGNQDK KPKSVTLEEA IAEQNESERC 1090 1100 1110 1120 1130 1140 EYSVGNKHRD PFEAPEDKDL PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG 1150 1160 1170 1180 1190 1200 DSSHTETTAE EVPEDPLLKA KRRRVSKDDW PEREMTNSSS NHLEDPHYSE LTNLKVCIEL 1210 1220 1230 1240 1250 1260 TGLHPKKQRH LLHLRERWEQ QVSAADGKPG RQSRKEVTQA TQPEAIPQGT NITEEKPGRK 1270 1280 1290 1300 1310 1320 RAEAKGNRSW SEESLKPSDN EQGLPVFSGS PPMKSLSSTS AGGKKQAQPS CAPASRPPAK 1330 1340 1350 1360 1370 1380 QQKIKENQKT DVLCADEEED CQAASLLQKY TDNSEKPSGK RLCKTKHLIP QESRRGLPLT 1390 1400 1410 1420 1430 1440 GEYYVENADG KVTVRRFRKR PEPSSDYDLS PAKQEPKPFD RLQQLLPASQ STQLPCSSSP 1450 1460 1470 1480 1490 1500 QETTQSRPMP PEARRLIVNK NAGETLLQRA ARLGYEEVVL YCLENKICDV NHRDNAGYCA 1510 1520 1530 1540 1550 1560 LHEACARGWL NIVRHLLEYG ADVNCSAQDG TRPLHDAVEN DHLEIVRLLL SYGADPTLAT 1570 1580 1590 1600 1610 1620 YSGRTIMKMT HSELMEKFLT DYLNDLQGRN DDDASGTWDF YGSSVCEPDD ESGYDVLANP 1630 1640 1650 1660 1670 1680 PGPEDQDDDD DAYSDVFEFE FSETPLLPCY NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF 1690 1700 1710 1720 1730 1740 RCNFPNVEIV TIAEAEFYRQ VSASLLFSCS KDLEAFNPES KELLDLVEFT NEIQTLLGSS 1750 VEWLHPSDLA SDNYW
	Isoform 2 [UniParc]. Checksum: F22343D545DB67AB	FASTA	1,721	188,202
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 1010 1020 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM EGLQEDSILC LPAAYCERAM 1030 1040 1050 1060 1070 1080 MRFSELEMKE REGGHPATKD SEMCKFSPAD WERLKGNQDK KPKSVTLEEA IAEQNESERC 1090 1100 1110 1120 1130 1140 EYSVGNKHRD PFEAPEDKDL PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG 1150 1160 1170 1180 1190 1200 DSSHTETTAE EVPEDPLLKA KRRRVSKGLH PKKQRHLLHL RERWEQQVSA ADGKPGRQSR 1210 1220 1230 1240 1250 1260 KEVTQATQPE AIPQGTNITE EKPGRKRAEA KGNRSWSEES LKPSDNEQGL PVFSGSPPMK 1270 1280 1290 1300 1310 1320 SLSSTSAGGK KQAQPSCAPA SRPPAKQQKI KENQKTDVLC ADEEEDCQAA SLLQKYTDNS 1330 1340 1350 1360 1370 1380 EKPSGKRLCK TKHLIPQESR RGLPLTGEYY VENADGKVTV RRFRKRPEPS SDYDLSPAKQ 1390 1400 1410 1420 1430 1440 EPKPFDRLQQ LLPASQSTQL PCSSSPQETT QSRPMPPEAR RLIVNKNAGE TLLQRAARLG 1450 1460 1470 1480 1490 1500 YEEVVLYCLE NKICDVNHRD NAGYCALHEA CARGWLNIVR HLLEYGADVN CSAQDGTRPL 1510 1520 1530 1540 1550 1560 HDAVENDHLE IVRLLLSYGA DPTLATYSGR TIMKMTHSEL MEKFLTDYLN DLQGRNDDDA 1570 1580 1590 1600 1610 1620 SGTWDFYGSS VCEPDDESGY DVLANPPGPE DQDDDDDAYS DVFEFEFSET PLLPCYNIQV 1630 1640 1650 1660 1670 1680 SVAQGPRNWL LLSDVLKKLK MSSRIFRCNF PNVEIVTIAE AEFYRQVSAS LLFSCSKDLE 1690 1700 1710 1720 AFNPESKELL DLVEFTNEIQ TLLGSSVEWL HPSDLASDNY W
	Isoform 3 (Short) [UniParc]. Checksum: 126BD762958CB9F4	FASTA	1,004	107,404
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQV SPPT
	Isoform 4 [UniParc]. Checksum: 7433FBCE7238261F	FASTA	1,703	186,235
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 1010 1020 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQR AMMRFSELEM KEREGGHPAT 1030 1040 1050 1060 1070 1080 KDSEMCKFSP ADWERLKGNQ DKKPKSVTLE EAIAEQNESE RCEYSVGNKH RDPFEAPEDK 1090 1100 1110 1120 1130 1140 DLPVEKYFVE RQPVSEPPAD QVASDMPHSP TLRVDRKRKV SGDSSHTETT AEEVPEDPLL 1150 1160 1170 1180 1190 1200 KAKRRRVSKG LHPKKQRHLL HLRERWEQQV SAADGKPGRQ SRKEVTQATQ PEAIPQGTNI 1210 1220 1230 1240 1250 1260 TEEKPGRKRA EAKGNRSWSE ESLKPSDNEQ GLPVFSGSPP MKSLSSTSAG GKKQAQPSCA 1270 1280 1290 1300 1310 1320 PASRPPAKQQ KIKENQKTDV LCADEEEDCQ AASLLQKYTD NSEKPSGKRL CKTKHLIPQE 1330 1340 1350 1360 1370 1380 SRRGLPLTGE YYVENADGKV TVRRFRKRPE PSSDYDLSPA KQEPKPFDRL QQLLPASQST 1390 1400 1410 1420 1430 1440 QLPCSSSPQE TTQSRPMPPE ARRLIVNKNA GETLLQRAAR LGYEEVVLYC LENKICDVNH 1450 1460 1470 1480 1490 1500 RDNAGYCALH EACARGWLNI VRHLLEYGAD VNCSAQDGTR PLHDAVENDH LEIVRLLLSY 1510 1520 1530 1540 1550 1560 GADPTLATYS GRTIMKMTHS ELMEKFLTDY LNDLQGRNDD DASGTWDFYG SSVCEPDDES 1570 1580 1590 1600 1610 1620 GYDVLANPPG PEDQDDDDDA YSDVFEFEFS ETPLLPCYNI QVSVAQGPRN WLLLSDVLKK 1630 1640 1650 1660 1670 1680 LKMSSRIFRC NFPNVEIVTI AEAEFYRQVS ASLLFSCSKD LEAFNPESKE LLDLVEFTNE 1690 1700 IQTLLGSSVE WLHPSDLASD NYW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BCoR, a novel corepressor involved in BCL-6 repression." Huynh K.D., Fischle W., Verdin E., Bardwell V.J. Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, INTERACTION WITH BCL6; HDAC1; HDAC3 AND HDAC5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Frontal cortex.
[2]	"Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR." Ng D., Thakker N., Corcoran C.M., Donnai D., Perveen R., Schneider A., Hadley D.W., Tifft C., Zhang L., Wilkie A.O., van der Smagt J.J., Gorlin R.J., Burgess S.M., Bardwell V.J., Black G.C.M., Biesecker L.G. Nat. Genet. 36:411-416(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT MCOPS2 LEU-85.
[3]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1395-1755 (ISOFORM 1). Tissue: Liver, Lymph and Uterus.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-1755 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 1328-1755.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets." Gearhart M.D., Corcoran C.M., Wamstad J.A., Bardwell V.J. Mol. Cell. Biol. 26:6880-6889(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PCGF1 AND KDM2B, IDENTIFICATION IN A COMPLEX WITH RYBP; PCGF1; RING1; RNF2; KDM2B AND SKP1.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-1410, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"BCOR regulates mesenchymal stem cell function by epigenetic mechanisms." Fan Z., Yamaza T., Lee J.S., Yu J., Wang S., Fan G., Shi S., Wang C.-Y. Nat. Cell Biol. 11:1002-1009(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1139, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-392, MASS SPECTROMETRY.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; SER-340; SER-365; SER-367 AND SER-423, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, MASS SPECTROMETRY.
[16]	"Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer." Ghetu A.F., Corcoran C.M., Cerchietti L., Bardwell V.J., Melnick A., Prive G.G. Mol. Cell 29:384-391(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 498-514 IN COMPLEX WITH BCL6, FUNCTION, MUTAGENESIS OF SER-507; SER-508; TRP-509 AND VAL-511.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF317391 mRNA. Translation: AAG41429.1.
AF317392 mRNA. Translation: AAG41430.1.
AY316592 mRNA. Translation: AAR08265.1.
AB046795 mRNA. Translation: BAB13401.2. Different initiation.
CH471141 Genomic DNA. Translation: EAW59425.1.
CH471141 Genomic DNA. Translation: EAW59427.1.
CH471141 Genomic DNA. Translation: EAW59428.1.
CH471141 Genomic DNA. Translation: EAW59430.1.
BC009675 mRNA. Translation: AAH09675.2.
BC063536 mRNA. Translation: AAH63536.1. Sequence problems.
BC114220 mRNA. Translation: AAI14221.1.
AK000292 mRNA. Translation: BAA91061.1. Sequence problems.
AK074286 mRNA. Translation: BAB85037.1. Frameshift.

IPI

IPI00100291.
IPI00143877.
IPI00439548.
IPI00514505.

RefSeq

NP_001116855.1. NM_001123383.1.
NP_001116856.1. NM_001123384.1.
NP_001116857.1. NM_001123385.1.
NP_060215.4. NM_017745.5.

UniGene

Hs.659681.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BIM	X-ray	2.60	I/J/K/L/M/N/O/P	498-514	[»]

ProteinModelPortal

Q6W2J9.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q6W2J9. 8 interactions.

MINT

MINT-2817388.

PTM databases

PhosphoSite

Q6W2J9.

Polymorphism databases

DMDM

57012588.

Proteomic databases

PaxDb

Q6W2J9.

PRIDE

Q6W2J9.

Protocols and materials databases

DNASU

54880.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000342274; ENSP00000345923; ENSG00000183337.
ENST00000378444; ENSP00000367705; ENSG00000183337.
ENST00000378455; ENSP00000367716; ENSG00000183337.
ENST00000397354; ENSP00000380512; ENSG00000183337.

GeneID

54880.

KEGG

hsa:54880.

UCSC

uc004dem.4. human.
uc004den.4. human.
uc004deo.4. human.
uc004deq.4. human.

Organism-specific databases

CTD

54880.

GeneCards

GC0XM039909.

HGNC

HGNC:20893. BCOR.

MIM

300166. phenotype.
300485. gene.

neXtProt

NX_Q6W2J9.

Orphanet

568. Microphthalmia, Lenz type.
2712. Oculofaciocardiodental syndrome.

PharmGKB

PA134921737.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0666.

HOVERGEN

HBG050682.

InParanoid

Q6W2J9.

OMA

SSCPRMG.

Enzyme and pathway databases

Pathway_Interaction_DB

hdac_classii_pathway. Signaling events mediated by HDAC Class II.

Gene expression databases

ArrayExpress

Q6W2J9.

Bgee

Q6W2J9.

Genevestigator

Q6W2J9.

GermOnline

ENSG00000183337. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.20. 1 hit.

InterPro

IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]

Pfam

PF12796. Ank_2. 1 hit.
[Graphical view]

SMART

SM00248. ANK. 3 hits.
[Graphical view]

SUPFAM

SSF48403. ANK. 1 hit.

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

BCOR. human.

EvolutionaryTrace

Q6W2J9.

GenomeRNAi

54880.

NextBio

57837.

SOURCE

Search...

Entry information

Entry name

BCOR_HUMAN

Accession

Primary (citable) accession number: Q6W2J9
Secondary accession number(s): D3DWB3 , D3DWB4, Q29RF6, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.