Reviewed, UniProtKB/Swiss-Prot Q6W2J9 (BCOR_HUMAN)

Names and origin

Protein names

Recommended name:
    BCL-6 corepressor
      Short name=BCoR

Gene names

Name:	BCOR
Synonyms:	KIAA1575

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1755 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Ref.1 Ref.2
Subunit structure	Isoform 1 may interact with MLLT3/AF9 By similarity. Interacts with BCL6. Can interact with HDAC1, HDAC3 and HDAC5. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, RING1 and RNF2/RING2.
Subcellular location	Nucleus. Ref.1
Tissue specificity	Ubiquitously expressed. Ref.1
Involvement in disease	Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Ref.2
Sequence similarities	Belongs to the BCOR family. Contains 3 ANK repeats.
Sequence caution	The sequence AAH63536.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Presence of complementary strand sequence in the clone. The sequence BAA91061.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. The sequence BAB85037.1 differs from that shown. Reason: Frameshift at position 1353.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Disease	Disease mutation Microphthalmia
Domain	ANK repeat Repeat
Molecular function	Chromatin regulator Repressor
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW heart development Inferred from mutant phenotype. Source: UniProtKB negative regulation of transcription, DNA-dependent Ref.1 Inferred from direct assay. Source: UniProtKB odontogenesis Inferred from mutant phenotype. Source: UniProtKB palate development Inferred from mutant phenotype. Source: UniProtKB specification of axis polarity Inferred from mutant phenotype. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	heat shock protein binding Ref.7 Inferred from direct assay. Source: UniProtKB histone deacetylase binding Ref.1 Inferred from physical interaction. Source: UniProtKB transcription corepressor activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6W2J9-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6W2J9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1168-1201: Missing.

Isoform 3 (identifier: Q6W2J9-3)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1004: MEGLQ → VSPPT
     1005-1755: Missing.

Isoform 4 (identifier: Q6W2J9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1000-1017: Missing.
     1168-1201: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1755	1755	BCL-6 corepressor		PRO_0000066978
Regions
	Repeat	1462 – 1495	34	ANK 1
	Repeat	1496 – 1525	30	ANK 2
	Repeat	1529 – 1558	30	ANK 3
	Compositional bias	634 – 711	78	Pro-rich
	Compositional bias	1625 – 1631	7	Poly-Asp
Amino acid modifications
	Modified residue	423	1	Phosphoserine Ref.6 Ref.9
	Modified residue	469	1	Phosphoserine Ref.8
	Modified residue	473	1	Phosphoserine Ref.8
	Modified residue	480	1	Phosphoserine Ref.8
	Modified residue	1142	1	Phosphoserine By similarity
	Modified residue	1410	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1000 – 1017	18	Missing in isoform 4.		VSP_012555
	Alternative sequence	1000 – 1004	5	MEGLQ → VSPPT in isoform 3.		VSP_012554
	Alternative sequence	1005 – 1755	751	Missing in isoform 3.		VSP_012556
	Alternative sequence	1168 – 1201	34	Missing in isoform 2 and isoform 4.		VSP_012557
	Natural variant	85	1	P → L in MCOPS2. Ref.2		VAR_020921
Experimental info
	Sequence conflict	406	1	V → A in BAB85037. Ref.5
	Sequence conflict	596	1	Q → L in BAB85037. Ref.5
	Sequence conflict	1459	1	N → S in BAA91061. Ref.5
	Sequence conflict	1577	1	K → R in BAA91061. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A80CFCD5618EE717	FASTA	1,755	192,189
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 1010 1020 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM EGLQEDSILC LPAAYCERAM 1030 1040 1050 1060 1070 1080 MRFSELEMKE REGGHPATKD SEMCKFSPAD WERLKGNQDK KPKSVTLEEA IAEQNESERC 1090 1100 1110 1120 1130 1140 EYSVGNKHRD PFEAPEDKDL PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG 1150 1160 1170 1180 1190 1200 DSSHTETTAE EVPEDPLLKA KRRRVSKDDW PEREMTNSSS NHLEDPHYSE LTNLKVCIEL 1210 1220 1230 1240 1250 1260 TGLHPKKQRH LLHLRERWEQ QVSAADGKPG RQSRKEVTQA TQPEAIPQGT NITEEKPGRK 1270 1280 1290 1300 1310 1320 RAEAKGNRSW SEESLKPSDN EQGLPVFSGS PPMKSLSSTS AGGKKQAQPS CAPASRPPAK 1330 1340 1350 1360 1370 1380 QQKIKENQKT DVLCADEEED CQAASLLQKY TDNSEKPSGK RLCKTKHLIP QESRRGLPLT 1390 1400 1410 1420 1430 1440 GEYYVENADG KVTVRRFRKR PEPSSDYDLS PAKQEPKPFD RLQQLLPASQ STQLPCSSSP 1450 1460 1470 1480 1490 1500 QETTQSRPMP PEARRLIVNK NAGETLLQRA ARLGYEEVVL YCLENKICDV NHRDNAGYCA 1510 1520 1530 1540 1550 1560 LHEACARGWL NIVRHLLEYG ADVNCSAQDG TRPLHDAVEN DHLEIVRLLL SYGADPTLAT 1570 1580 1590 1600 1610 1620 YSGRTIMKMT HSELMEKFLT DYLNDLQGRN DDDASGTWDF YGSSVCEPDD ESGYDVLANP 1630 1640 1650 1660 1670 1680 PGPEDQDDDD DAYSDVFEFE FSETPLLPCY NIQVSVAQGP RNWLLLSDVL KKLKMSSRIF 1690 1700 1710 1720 1730 1740 RCNFPNVEIV TIAEAEFYRQ VSASLLFSCS KDLEAFNPES KELLDLVEFT NEIQTLLGSS 1750 VEWLHPSDLA SDNYW
	Isoform 2. Checksum: F22343D545DB67AB	FASTA	1,721	188,202
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 1010 1020 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQM EGLQEDSILC LPAAYCERAM 1030 1040 1050 1060 1070 1080 MRFSELEMKE REGGHPATKD SEMCKFSPAD WERLKGNQDK KPKSVTLEEA IAEQNESERC 1090 1100 1110 1120 1130 1140 EYSVGNKHRD PFEAPEDKDL PVEKYFVERQ PVSEPPADQV ASDMPHSPTL RVDRKRKVSG 1150 1160 1170 1180 1190 1200 DSSHTETTAE EVPEDPLLKA KRRRVSKGLH PKKQRHLLHL RERWEQQVSA ADGKPGRQSR 1210 1220 1230 1240 1250 1260 KEVTQATQPE AIPQGTNITE EKPGRKRAEA KGNRSWSEES LKPSDNEQGL PVFSGSPPMK 1270 1280 1290 1300 1310 1320 SLSSTSAGGK KQAQPSCAPA SRPPAKQQKI KENQKTDVLC ADEEEDCQAA SLLQKYTDNS 1330 1340 1350 1360 1370 1380 EKPSGKRLCK TKHLIPQESR RGLPLTGEYY VENADGKVTV RRFRKRPEPS SDYDLSPAKQ 1390 1400 1410 1420 1430 1440 EPKPFDRLQQ LLPASQSTQL PCSSSPQETT QSRPMPPEAR RLIVNKNAGE TLLQRAARLG 1450 1460 1470 1480 1490 1500 YEEVVLYCLE NKICDVNHRD NAGYCALHEA CARGWLNIVR HLLEYGADVN CSAQDGTRPL 1510 1520 1530 1540 1550 1560 HDAVENDHLE IVRLLLSYGA DPTLATYSGR TIMKMTHSEL MEKFLTDYLN DLQGRNDDDA 1570 1580 1590 1600 1610 1620 SGTWDFYGSS VCEPDDESGY DVLANPPGPE DQDDDDDAYS DVFEFEFSET PLLPCYNIQV 1630 1640 1650 1660 1670 1680 SVAQGPRNWL LLSDVLKKLK MSSRIFRCNF PNVEIVTIAE AEFYRQVSAS LLFSCSKDLE 1690 1700 1710 1720 AFNPESKELL DLVEFTNEIQ TLLGSSVEWL HPSDLASDNY W
	Isoform 3 (Short). Checksum: 126BD762958CB9F4	FASTA	1,004	107,404
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQV SPPT
	Isoform 4. Checksum: 7433FBCE7238261F	FASTA	1,703	186,235
	10 20 30 40 50 60 MLSATPLYGN VHSWMNSERV RMCGASEDRK ILVNDGDASK ARLELREENP LNHNVVDAST 70 80 90 100 110 120 AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SSLCGLGSEK GREAATSTLG GLGFSSERNP 130 140 150 160 170 180 EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAEALGLDR PASDKQSPLN 190 200 210 220 230 240 INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYSLA QPLYSPVCTN 250 260 270 280 290 300 GERFLYLPPP HYVGPHIPSS LASPMRLSTP SASPAIPPLV HCADKSLPWK MGVSPGNPVD 310 320 330 340 350 360 SHAYPHIQNS KQPRVPSAKA VTSGLPGDTA LLLPPSPRPS PRVHLPTQPA ADTYSEFHKH 370 380 390 400 410 420 YARISTSPSV ALSKPYMTVS SEFPAARLSN GKYPKAPEGG EGAQPVPGHA RKTAVQDRKD 430 440 450 460 470 480 GSSPPLLEKQ TVTKDVTDKP LDLSSKVVDV DASKADHMKK MAPTVLVHSR AGSGLVLSGS 490 500 510 520 530 540 EIPKETLSPP GNGCAIYRSE IISTAPSSWV VPGPSPNEEN NGKSMSLKNK ALDWAIPQQR 550 560 570 580 590 600 SSSCPRMGGT DAVITNVSGS VSSAGRPASA SPAPNANADG TKTSRSSVET TPSVIQHVGQ 610 620 630 640 650 660 PPATPAKHSS STSSKGAKAS NPEPSFKANE NGLPPSSIFL SPNEAFRSPP IPYPRSYLPY 670 680 690 700 710 720 PAPEGIAVSP LSLHGKGPVY PHPVLLPNGS LFPGHLAPKP GLPYGLPTGR PEFVTYQDAL 730 740 750 760 770 780 GLGMVHPMLI PHTPIEITKE EKPERRSRSH ERARYEDPTL RNRFSEILET SSTKLHPDVP 790 800 810 820 830 840 TDKNLKPNPN WNQGKTVVKS DKLVYVDLLR EEPDAKTDTN VSKPSFAAES VGQSAEPPKP 850 860 870 880 890 900 SVEPALQQHR DFIALREELG RISDFHETYT FKQPVFTVSK DSVLAGTNKE NLGLPVSTPF 910 920 930 940 950 960 LEPPLGSDGP AVTFGKTQED PKPFCVGSAP PSVDVTPTYT KDGADEAESN DGKVLKPKPS 970 980 990 1000 1010 1020 KLAKRIANSA GYVGDRFKCV TTELYADSSQ LSREQRALQR AMMRFSELEM KEREGGHPAT 1030 1040 1050 1060 1070 1080 KDSEMCKFSP ADWERLKGNQ DKKPKSVTLE EAIAEQNESE RCEYSVGNKH RDPFEAPEDK 1090 1100 1110 1120 1130 1140 DLPVEKYFVE RQPVSEPPAD QVASDMPHSP TLRVDRKRKV SGDSSHTETT AEEVPEDPLL 1150 1160 1170 1180 1190 1200 KAKRRRVSKG LHPKKQRHLL HLRERWEQQV SAADGKPGRQ SRKEVTQATQ PEAIPQGTNI 1210 1220 1230 1240 1250 1260 TEEKPGRKRA EAKGNRSWSE ESLKPSDNEQ GLPVFSGSPP MKSLSSTSAG GKKQAQPSCA 1270 1280 1290 1300 1310 1320 PASRPPAKQQ KIKENQKTDV LCADEEEDCQ AASLLQKYTD NSEKPSGKRL CKTKHLIPQE 1330 1340 1350 1360 1370 1380 SRRGLPLTGE YYVENADGKV TVRRFRKRPE PSSDYDLSPA KQEPKPFDRL QQLLPASQST 1390 1400 1410 1420 1430 1440 QLPCSSSPQE TTQSRPMPPE ARRLIVNKNA GETLLQRAAR LGYEEVVLYC LENKICDVNH 1450 1460 1470 1480 1490 1500 RDNAGYCALH EACARGWLNI VRHLLEYGAD VNCSAQDGTR PLHDAVENDH LEIVRLLLSY 1510 1520 1530 1540 1550 1560 GADPTLATYS GRTIMKMTHS ELMEKFLTDY LNDLQGRNDD DASGTWDFYG SSVCEPDDES 1570 1580 1590 1600 1610 1620 GYDVLANPPG PEDQDDDDDA YSDVFEFEFS ETPLLPCYNI QVSVAQGPRN WLLLSDVLKK 1630 1640 1650 1660 1670 1680 LKMSSRIFRC NFPNVEIVTI AEAEFYRQVS ASLLFSCSKD LEAFNPESKE LLDLVEFTNE 1690 1700 IQTLLGSSVE WLHPSDLASD NYW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BCoR, a novel corepressor involved in BCL-6 repression." Huynh K.D., Fischle W., Verdin E., Bardwell V.J. Genes Dev. 14:1810-1823(2000) [PubMed: 10898795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, INTERACTION WITH BCL6; HDAC1; HDAC3 AND HDAC5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Frontal cortex.
[2]	"Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR." Ng D., Thakker N., Corcoran C.M., Donnai D., Perveen R., Schneider A., Hadley D.W., Tifft C., Zhang L., Wilkie A.O., van der Smagt J.J., Gorlin R.J., Burgess S.M., Bardwell V.J., Black G.C.M., Biesecker L.G. Nat. Genet. 36:411-416(2004) [PubMed: 15004558] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT MCOPS2 LEU-85.
[3]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1395-1755 (ISOFORM 1). Tissue: Liver, Lymph and Uterus.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-1755 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 1328-1755.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets." Gearhart M.D., Corcoran C.M., Wamstad J.A., Bardwell V.J. Mol. Cell. Biol. 26:6880-6889(2006) [PubMed: 16943429] [Abstract] Cited for: INTERACTION WITH RYBP, PCGF1, RING1, RNF2.
[8]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469; SER-473 AND SER-480, MASS SPECTROMETRY.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-1410, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF317391 mRNA. Translation: AAG41429.1.
AF317392 mRNA. Translation: AAG41430.1.
AY316592 mRNA. Translation: AAR08265.1.
AB046795 mRNA. Translation: BAB13401.2. Different initiation.
BC009675 mRNA. Translation: AAH09675.2.
BC063536 mRNA. Translation: AAH63536.1. Sequence problems.
BC114220 mRNA. Translation: AAI14221.1.
AK000292 mRNA. Translation: BAA91061.1. Sequence problems.
AK074286 mRNA. Translation: BAB85037.1. Frameshift.

IPI

IPI00100291.
IPI00143877.
IPI00439548.
IPI00514505.

RefSeq

NP_001116855.1.
NP_001116856.1.
NP_001116857.1.
NP_060215.4.

UniGene

Hs.659681

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BIM	X-ray	2.60	I/J/K/L/M/N/O/P	498-514	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q6W2J9. 1 interaction.

PTM databases

PhosphoSite

Q6W2J9.

Proteomic databases

PRIDE

Q6W2J9.

Genome annotation databases

Ensembl

ENSG00000183337. Homo sapiens. [Contig view]

GeneID

54880.

Organism-specific databases

GeneCards

GC0XM039794.

H-InvDB

HIX0016732.

HGNC

HGNC:20893. BCOR.

MIM

300166. phenotype.
300485. gene.

Orphanet

1379. Cataract - microphthalmia - septal defect.
2712. Oculofaciocardiodental syndrome.

PharmGKB

PA134921737.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q6W2J9.

OMA

Q6W2J9. SSSCPRM.

Enzyme and pathway databases

Pathway_Interaction_DB

hdac_classii_pathway. Signaling events mediated by HDAC Class II.

Gene expression databases

ArrayExpress

Q6W2J9.

Bgee

Q6W2J9.

GermOnline

ENSG00000183337. Homo sapiens.

Family and domain databases

InterPro

IPR002110. ANK.
[Graphical view]

Gene3D

G3DSA:1.25.40.20. ANK. 1 hit.

Pfam

PF00023. Ank. 3 hits.
[Graphical view]

SMART

SM00248. ANK. 3 hits.
[Graphical view]

PROSITE

PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

57837.

SOURCE

Search...

Entry information

Entry name

BCOR_HUMAN

Accession

Primary (citable) accession number: Q6W2J9
Secondary accession number(s): Q29RF6 , Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)