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Protein

Catalase-peroxidase

Gene

katG

Organism
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi258 – 2581Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSFRE394:GBYN-4335-MONOMER.

Protein family/group databases

PeroxiBasei3569. RHspCP01_NGR234.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:NGR_b06410
ORF Names:RNGR00441
Encoded oniPlasmid sym pNGR234b0 Publication
OrganismiSinorhizobium fredii (strain NBRC 101917 / NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001054 Componenti: Plasmid sym pNGR234b

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Catalase-peroxidasePRO_0000354888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)UniRule annotation
Cross-linki217 ↔ 243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiKTTYLGP.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6W102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKSDNAGK CPVAHTVPKG RSNRDWWPDQ LDVQVLHQHS GLSDPMGKAF
60 70 80 90 100
NYAEEFKKLD LEELKKDLHA LMTESQDWWP ADFGHYGGLF IRMAWHSAGT
110 120 130 140 150
YRITDGRGGA GQGQQRFAPL NSWPDNANLD KARRLLWPIK QKYGNRISWA
160 170 180 190 200
DLMILTGNVA LESMGFQTFG FAGGRADVWE PQELFWGPEG TWLGDERYSG
210 220 230 240 250
ERQLDEPLAA VQMGLIYVNP EGPNGNPDPV AAAREIRETF ARMAMNDEET
260 270 280 290 300
VALIAGGHTF GKTHGAGDPS FIGPDPEGGA IEDQGLGWKS TFGTGVGKDA
310 320 330 340 350
ITGGPEVTWS QTPTRWSNYF FENLFNYEWE LTKSPAGAHQ WKAKNADASI
360 370 380 390 400
PDAFDASKKH VPTMLTTDLS LRFDPIYEKI SRRFLENPDQ FADAFARAWF
410 420 430 440 450
KLTHRDMGPK VRYLGPEVPA EDLIWQDVIP AVDHKLVDEN DVADLKGKVL
460 470 480 490 500
ASGLSVQELV STAWASASTF RGSDKRGGAN GARIRLAPQK DWEVNQPAQL
510 520 530 540 550
ARVLSVLEGI QKDFNTAHTG GKKISLADLI VLAGAAGVEK AAKAGGHDIT
560 570 580 590 600
VPFTPGRADA SEAQTDAASF AALEPRADGF RNYVSRRRRQ FMKPEEALVD
610 620 630 640 650
RAQLLTLTAP ELTVLVGGLR VVFTSRPEVL TNDFFVNLLD MGTQWSPMAE
660 670 680 690 700
KEGVYEGRDR KTHEVKWTGT RVDLIFGSHS QLRALAEVYA SSDAKEKFVG
710
DFVAAWTKVM NADRFDLV
Length:718
Mass (Da):79,396
Last modified:July 7, 2009 - v3
Checksum:i7FE0DE1975427F41
GO

Sequence cautioni

The sequence AAQ87566 differs from that shown. Reason: Frameshift at position 622. Curated
The sequence AAQ87566 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ACP22099 differs from that shown. Reason: Frameshift at position 622. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316747 Genomic DNA. Translation: AAQ87566.1. Frameshift.
CP000874 Genomic DNA. Translation: ACP22099.1. Frameshift.
RefSeqiWP_015886763.1. NC_012586.1.
YP_002822852.1. NC_012586.1.

Genome annotation databases

EnsemblBacteriaiACP22099; ACP22099; NGR_b06410.
GeneIDi7788380.
KEGGirhi:NGR_b06410.
PATRICi32302911. VBIRhiSp122450_1090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316747 Genomic DNA. Translation: AAQ87566.1. Frameshift.
CP000874 Genomic DNA. Translation: ACP22099.1. Frameshift.
RefSeqiWP_015886763.1. NC_012586.1.
YP_002822852.1. NC_012586.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3569. RHspCP01_NGR234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP22099; ACP22099; NGR_b06410.
GeneIDi7788380.
KEGGirhi:NGR_b06410.
PATRICi32302911. VBIRhiSp122450_1090.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiKTTYLGP.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciSFRE394:GBYN-4335-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SINFN
AccessioniPrimary (citable) accession number: Q6W102
Secondary accession number(s): C3KPU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 7, 2009
Last modified: September 7, 2016
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.