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Protein

Catalase-peroxidase

Gene

katG

Organism
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Transition state stabilizerUniRule annotation1
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi258Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3569 RHspCP01_NGR234

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:NGR_b06410
ORF Names:RNGR00441
Encoded oniPlasmid sym pNGR234b0 Publication
OrganismiSinorhizobium fredii (strain NBRC 101917 / NGR234)
Taxonomic identifieri394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001054 Componenti: Plasmid sym pNGR234b

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548881 – 718Catalase-peroxidaseAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki95 ↔ 217Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-243)UniRule annotation
Cross-linki217 ↔ 243Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ6W102

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

SMRiQ6W102
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q6W102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKSDNAGK CPVAHTVPKG RSNRDWWPDQ LDVQVLHQHS GLSDPMGKAF
60 70 80 90 100
NYAEEFKKLD LEELKKDLHA LMTESQDWWP ADFGHYGGLF IRMAWHSAGT
110 120 130 140 150
YRITDGRGGA GQGQQRFAPL NSWPDNANLD KARRLLWPIK QKYGNRISWA
160 170 180 190 200
DLMILTGNVA LESMGFQTFG FAGGRADVWE PQELFWGPEG TWLGDERYSG
210 220 230 240 250
ERQLDEPLAA VQMGLIYVNP EGPNGNPDPV AAAREIRETF ARMAMNDEET
260 270 280 290 300
VALIAGGHTF GKTHGAGDPS FIGPDPEGGA IEDQGLGWKS TFGTGVGKDA
310 320 330 340 350
ITGGPEVTWS QTPTRWSNYF FENLFNYEWE LTKSPAGAHQ WKAKNADASI
360 370 380 390 400
PDAFDASKKH VPTMLTTDLS LRFDPIYEKI SRRFLENPDQ FADAFARAWF
410 420 430 440 450
KLTHRDMGPK VRYLGPEVPA EDLIWQDVIP AVDHKLVDEN DVADLKGKVL
460 470 480 490 500
ASGLSVQELV STAWASASTF RGSDKRGGAN GARIRLAPQK DWEVNQPAQL
510 520 530 540 550
ARVLSVLEGI QKDFNTAHTG GKKISLADLI VLAGAAGVEK AAKAGGHDIT
560 570 580 590 600
VPFTPGRADA SEAQTDAASF AALEPRADGF RNYVSRRRRQ FMKPEEALVD
610 620 630 640 650
RAQLLTLTAP ELTVLVGGLR VVFTSRPEVL TNDFFVNLLD MGTQWSPMAE
660 670 680 690 700
KEGVYEGRDR KTHEVKWTGT RVDLIFGSHS QLRALAEVYA SSDAKEKFVG
710
DFVAAWTKVM NADRFDLV
Length:718
Mass (Da):79,396
Last modified:July 7, 2009 - v3
Checksum:i7FE0DE1975427F41
GO

Sequence cautioni

The sequence AAQ87566 differs from that shown. Reason: Frameshift at position 622.Curated
The sequence AAQ87566 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ACP22099 differs from that shown. Reason: Frameshift at position 622.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY316747 Genomic DNA Translation: AAQ87566.1 Frameshift.
CP000874 Genomic DNA Translation: ACP22099.1 Frameshift.
RefSeqiYP_002822852.1, NC_012586.1

Genome annotation databases

EnsemblBacteriaiACP22099; ACP22099; NGR_b06410
GeneIDi7788380
KEGGirhi:NGR_b06410
PATRICifig|394.7.peg.1090

Similar proteinsi

Entry informationi

Entry nameiKATG_SINFN
AccessioniPrimary (citable) accession number: Q6W102
Secondary accession number(s): C3KPU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
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Main funding by: National Institutes of Health