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Protein

Developmental pluripotency-associated protein 3

Gene

DPPA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 3
Alternative name(s):
Stella-related protein
Gene namesi
Name:DPPA3
Synonyms:STELLAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000187569.2
HGNCiHGNC:19199 DPPA3
MIMi608408 gene
neXtProtiNX_Q6W0C5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi359787
OpenTargetsiENSG00000187569
PharmGKBiPA134951641

Polymorphism and mutation databases

BioMutaiDPPA3
DMDMi74749483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392651 – 159Developmental pluripotency-associated protein 3Add BLAST159

Proteomic databases

PaxDbiQ6W0C5
PeptideAtlasiQ6W0C5
PRIDEiQ6W0C5

PTM databases

iPTMnetiQ6W0C5
PhosphoSitePlusiQ6W0C5

Expressioni

Tissue specificityi

Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors.3 Publications

Developmental stagei

Expressed in fetal ovary.1 Publication

Gene expression databases

BgeeiENSG00000187569
CleanExiHS_DPPA3
GenevisibleiQ6W0C5 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFIP11Q9UBB94EBI-12082590,EBI-1105213

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1317629 interactors.
IntActiQ6W0C5 10 interactors.
STRINGi9606.ENSP00000339250

Structurei

3D structure databases

ProteinModelPortaliQ6W0C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.By similarity

Phylogenomic databases

eggNOGiENOG410JJNY Eukaryota
ENOG41115BI LUCA
GeneTreeiENSGT00800000124303
HOGENOMiHOG000293369
HOVERGENiHBG094422
InParanoidiQ6W0C5
OMAiIPESSQM
OrthoDBiEOG091G154N
PhylomeDBiQ6W0C5
TreeFamiTF338511

Family and domain databases

InterProiView protein in InterPro
IPR029096 Dppa3
PANTHERiPTHR31577 PTHR31577, 1 hit
PfamiView protein in Pfam
PF15549 PGC7_Stella, 1 hit

Sequencei

Sequence statusi: Complete.

Q6W0C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSQFNPTY IPGSPQMLTE ENSRDDSGAS QISSETLIKN LSNLTINASS
60 70 80 90 100
ESVSPLSEAL LRRESVGAAV LREIEDEWLY SRRGVRTLLS VQREKMARLR
110 120 130 140 150
YMLLGGVRTH ERRPTNKEPK GVKKESRPFK CPCSFCVSNG WDPSENARIG

NQDTKPLQP
Length:159
Mass (Da):17,851
Last modified:July 5, 2004 - v1
Checksum:i0ADDE3C260BF544A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57S → L in AAO39708 (PubMed:14990856).Curated1
Sequence conflicti57S → L in AAH62480 (PubMed:15489334).Curated1
Sequence conflicti57S → L in AAI25146 (PubMed:15489334).Curated1
Sequence conflicti150G → E in AAO39708 (PubMed:14990856).Curated1
Sequence conflicti150G → E in AAH62480 (PubMed:15489334).Curated1
Sequence conflicti150G → E in AAI25146 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03053351E → Q. Corresponds to variant dbSNP:rs2024320Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY317075 mRNA Translation: AAQ84110.1
AY230136 mRNA Translation: AAO39708.1
BC062480 mRNA Translation: AAH62480.1
BC125145 mRNA Translation: AAI25146.1
CCDSiCCDS8582.1
RefSeqiNP_954980.1, NM_199286.3
UniGeneiHs.131358
Hs.528118

Genome annotation databases

EnsembliENST00000345088; ENSP00000339250; ENSG00000187569
GeneIDi359787
KEGGihsa:359787
UCSCiuc001qtf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDPPA3_HUMAN
AccessioniPrimary (citable) accession number: Q6W0C5
Secondary accession number(s): Q0P5U3, Q6JZS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome