Reviewed, UniProtKB/Swiss-Prot Q6W0C5 (DPPA3_HUMAN)

Names and origin

Protein names

Recommended name:
    Developmental pluripotency-associated protein 3
Alternative name(s):
    Stella-related protein

Gene names

Name:	DPPA3
Synonyms:	STELLAR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in maintaining cell pluripotentiality. Ref.1 Ref.2
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Tissue specificity	Low expression in testis, ovary and thymus. Expressed in embryonic stem and carcinoma cells. Highly expressed in testicular germ cell tumors. Ref.1 Ref.2
Developmental stage	Expressed in fetal ovary. Ref.2

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Developmental pluripotency-associated protein 3		PRO_0000239265
Natural variations
	Natural variant	51	1	E → Q: dbSNP rs2024320.		VAR_030533
Experimental info
	Sequence conflict	57	1	S → L in AAO39708. Ref.2
	Sequence conflict	57	1	S → L in AAH62480. Ref.3
	Sequence conflict	57	1	S → L in AAI25146. Ref.3
	Sequence conflict	150	1	G → E in AAO39708. Ref.2
	Sequence conflict	150	1	G → E in AAH62480. Ref.3
	Sequence conflict	150	1	G → E in AAI25146. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6W0C5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0ADDE3C260BF544A	FASTA	159	17,851
	10 20 30 40 50 60 MDPSQFNPTY IPGSPQMLTE ENSRDDSGAS QISSETLIKN LSNLTINASS ESVSPLSEAL 70 80 90 100 110 120 LRRESVGAAV LREIEDEWLY SRRGVRTLLS VQREKMARLR YMLLGGVRTH ERRPTNKEPK 130 140 150 GVKKESRPFK CPCSFCVSNG WDPSENARIG NQDTKPLQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Stella is a maternal effect gene required for normal early development in mice." Payer B., Saitou M., Barton S.C., Thresher R., Dixon J.P., Zahn D., Colledge W.H., Carlton M.B., Nakano T., Surani M.A. Curr. Biol. 13:2110-2117(2003) [PubMed: 14654002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma." Clark A.T., Rodriguez R.T., Bodnar M.S., Abeyta M.J., Cedars M.I., Turek P.J., Firpo M.T., Reijo Pera R.A. Stem Cells 22:169-179(2004) [PubMed: 14990856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY317075 mRNA. Translation: AAQ84110.1. AY230136 mRNA. Translation: AAO39708.1. BC062480 mRNA. Translation: AAH62480.1. BC125145 mRNA. Translation: AAI25146.1.
IPI	IPI00241801.
RefSeq	NP_954980.1.
UniGene	Hs.131358 Hs.528118
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q6W0C5.
Genome annotation databases
Ensembl	ENSG00000187569. Homo sapiens. [Contig view]
GeneID	359787.
KEGG	hsa:359787.
Organism-specific databases
GeneCards	GC12P007757.
H-InvDB	HIX0036766. HIX0056549.
HGNC	HGNC:19199. DPPA3.
MIM	608408. gene.
PharmGKB	PA134951641.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q6W0C5.
HOVERGEN	Q6W0C5.
OMA	Q6W0C5. DVETQSR.
Gene expression databases
Bgee	Q6W0C5.
CleanEx	HS_DPPA3.
GermOnline	ENSG00000187569. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	99921.
SOURCE	Search...

Entry information

Entry name

DPPA3_HUMAN

Accession

Primary (citable) accession number: Q6W0C5
Secondary accession number(s): Q0P5U3, Q6JZS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)