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Protein

Opsin-5

Gene

Opn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 11-cis retinal binding Source: MGI
  • G-protein coupled photoreceptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological process
LigandChromophore

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Gene namesi
Name:Opn5
Synonyms:Gpr136, Pgr12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2662912 Opn5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 74CytoplasmicSequence analysisAdd BLAST20
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 108ExtracellularSequence analysisAdd BLAST13
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 150CytoplasmicSequence analysisAdd BLAST21
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 197ExtracellularSequence analysisAdd BLAST26
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 252CytoplasmicSequence analysisAdd BLAST34
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 288ExtracellularSequence analysisAdd BLAST15
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 377CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978181 – 377Opsin-5Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei296N6-(retinylidene)lysine1
Lipidationi315S-palmitoyl cysteineSequence analysis1
Lipidationi316S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6VZZ7
PRIDEiQ6VZZ7

PTM databases

PhosphoSitePlusiQ6VZZ7

Expressioni

Tissue specificityi

Detected in the eye, brain and testis.

Gene expression databases

BgeeiENSMUSG00000043972
CleanExiMM_OPN5

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063542

Structurei

3D structure databases

ProteinModelPortaliQ6VZZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000115272
HOVERGENiHBG058348
InParanoidiQ6VZZ7
KOiK08385
OMAiKVAMLIC
OrthoDBiEOG091G0ALC
PhylomeDBiQ6VZZ7
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002962 Peropsin
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01244 PEROPSIN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6VZZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALNHTALPQ DERLPHYLRD EDPFASKLSW EADLVAGFYL TIIGILSTFG
60 70 80 90 100
NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV
110 120 130 140 150
FGWFGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY
160 170 180 190 200
ICLAVIWAYA SFWTTMPLVG LGDYAPEPFG TSCTLDWWLA QASGGGQVFI
210 220 230 240 250
LSILFFCLLL PTAVIVFSYA KIIAKVKSSS KEVAHFDSRI HSSHVLEVKL
260 270 280 290 300
TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM
310 320 330 340 350
YNPIIYQVID YRFACCQAGG LRGTKKKSLE DFRLHTVTAV RKSSAVLEIH
360 370
PESSSRFTSA HVMDGESHSN DGDCGKK
Length:377
Mass (Da):42,018
Last modified:July 5, 2004 - v1
Checksum:i26036DC9248B1596
GO
Isoform 2 (identifier: Q6VZZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: S → V
     354-377: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):39,496
Checksum:i31AA0FC48D7547EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 86Missing in AAP72135 (PubMed:14623098).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014041353S → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_014042354 – 377Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288426 mRNA Translation: AAP72135.1
BC125611 mRNA Translation: AAI25612.1
BC132010 mRNA Translation: AAI32011.1
AY255592 mRNA Translation: AAO85104.1
AK039525 mRNA Translation: BAC30373.1
AY318865 mRNA Translation: AAR08201.1
BK001605 Genomic DNA Translation: DAA01972.1
CCDSiCCDS37619.1 [Q6VZZ7-1]
RefSeqiNP_861418.2, NM_181753.4 [Q6VZZ7-1]
UniGeneiMm.184937

Genome annotation databases

EnsembliENSMUST00000068355; ENSMUSP00000063542; ENSMUSG00000043972 [Q6VZZ7-1]
GeneIDi353344
KEGGimmu:353344
UCSCiuc008coq.1 mouse [Q6VZZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOPN5_MOUSE
AccessioniPrimary (citable) accession number: Q6VZZ7
Secondary accession number(s): Q059L5
, Q7TQP1, Q80T51, Q8BYI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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