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Q6VZZ7 (OPN5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Gene names
Name:Opn5
Synonyms:Gpr136, Pgr12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected in the eye, brain and testis.

Post-translational modification

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6VZZ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6VZZ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: S → V
     354-377: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Opsin-5
PRO_0000197818

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5421Helical; Name=1; Potential
Topological domain55 – 7420Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 10813Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 15021Cytoplasmic Potential
Transmembrane151 – 17121Helical; Name=4; Potential
Topological domain172 – 19726Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 25234Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=6; Potential
Topological domain274 – 28815Extracellular Potential
Transmembrane289 – 30921Helical; Name=7; Potential
Topological domain310 – 37768Cytoplasmic Potential

Amino acid modifications

Modified residue2961N6-(retinylidene)lysine
Lipidation3151S-palmitoyl cysteine Potential
Lipidation3161S-palmitoyl cysteine Potential
Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 183 Potential

Natural variations

Alternative sequence3531S → V in isoform 2.
VSP_014041
Alternative sequence354 – 37724Missing in isoform 2.
VSP_014042

Experimental info

Sequence conflict84 – 863Missing in AAP72135. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 26036DC9248B1596

FASTA37742,018
        10         20         30         40         50         60 
MALNHTALPQ DERLPHYLRD EDPFASKLSW EADLVAGFYL TIIGILSTFG NGYVLYMSSR 

        70         80         90        100        110        120 
RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV FGWFGCRWYG WAGFFFGCGS 

       130        140        150        160        170        180 
LITMTAVSLD RYLKICYLSY GVWLKRKHAY ICLAVIWAYA SFWTTMPLVG LGDYAPEPFG 

       190        200        210        220        230        240 
TSCTLDWWLA QASGGGQVFI LSILFFCLLL PTAVIVFSYA KIIAKVKSSS KEVAHFDSRI 

       250        260        270        280        290        300 
HSSHVLEVKL TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM 

       310        320        330        340        350        360 
YNPIIYQVID YRFACCQAGG LRGTKKKSLE DFRLHTVTAV RKSSAVLEIH PESSSRFTSA 

       370 
HVMDGESHSN DGDCGKK 

« Hide

Isoform 2 [UniParc].

Checksum: 31AA0FC48D7547EE
Show »

FASTA35339,496

References

« Hide 'large scale' references
[1]"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-228.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-377 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Spinal cord.
[5]"Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue."
Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J.
FEBS Lett. 554:410-416(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 1).
Strain: C3H.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY288426 mRNA. Translation: AAP72135.1.
BC125611 mRNA. Translation: AAI25612.1.
BC132010 mRNA. Translation: AAI32011.1.
AY255592 mRNA. Translation: AAO85104.1.
AK039525 mRNA. Translation: BAC30373.1.
AY318865 mRNA. Translation: AAR08201.1.
BK001605 Genomic DNA. Translation: DAA01972.1.
CCDSCCDS37619.1. [Q6VZZ7-1]
RefSeqNP_861418.2. NM_181753.4. [Q6VZZ7-1]
XP_006524515.1. XM_006524452.1. [Q6VZZ7-1]
UniGeneMm.184937.

3D structure databases

ProteinModelPortalQ6VZZ7.
SMRQ6VZZ7. Positions 56-313.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ6VZZ7.

Proteomic databases

PRIDEQ6VZZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068355; ENSMUSP00000063542; ENSMUSG00000043972. [Q6VZZ7-1]
GeneID353344.
KEGGmmu:353344.
UCSCuc008coq.1. mouse. [Q6VZZ7-1]

Organism-specific databases

CTD221391.
MGIMGI:2662912. Opn5.

Phylogenomic databases

eggNOGNOG145389.
GeneTreeENSGT00690000101836.
HOGENOMHOG000115272.
HOVERGENHBG058348.
InParanoidQ059L5.
KOK08385.
OMALAAIWAY.
OrthoDBEOG77M8NX.
PhylomeDBQ6VZZ7.
TreeFamTF324998.

Gene expression databases

BgeeQ6VZZ7.
CleanExMM_OPN5.
GenevestigatorQ6VZZ7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio400417.
PROQ6VZZ7.
SOURCESearch...

Entry information

Entry nameOPN5_MOUSE
AccessionPrimary (citable) accession number: Q6VZZ7
Secondary accession number(s): Q059L5 expand/collapse secondary AC list , Q7TQP1, Q80T51, Q8BYI2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries