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Protein

Opsin-5

Gene

Opn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 11-cis retinal binding Source: MGI
  • G-protein coupled photoreceptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-5
Alternative name(s):
G-protein coupled receptor 136
G-protein coupled receptor PGR12
Neuropsin
Gene namesi
Name:Opn5
Synonyms:Gpr136, Pgr12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2662912. Opn5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 74CytoplasmicSequence analysisAdd BLAST20
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 108ExtracellularSequence analysisAdd BLAST13
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 150CytoplasmicSequence analysisAdd BLAST21
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 197ExtracellularSequence analysisAdd BLAST26
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 252CytoplasmicSequence analysisAdd BLAST34
Transmembranei253 – 273Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini274 – 288ExtracellularSequence analysisAdd BLAST15
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 377CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978181 – 377Opsin-5Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
Modified residuei296N6-(retinylidene)lysine1
Lipidationi315S-palmitoyl cysteineSequence analysis1
Lipidationi316S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6VZZ7.
PRIDEiQ6VZZ7.

PTM databases

PhosphoSitePlusiQ6VZZ7.

Expressioni

Tissue specificityi

Detected in the eye, brain and testis.

Gene expression databases

BgeeiENSMUSG00000043972.
CleanExiMM_OPN5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063542.

Structurei

3D structure databases

ProteinModelPortaliQ6VZZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115272.
HOVERGENiHBG058348.
InParanoidiQ6VZZ7.
KOiK08385.
OMAiLGDYVPE.
OrthoDBiEOG091G0ALC.
PhylomeDBiQ6VZZ7.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6VZZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALNHTALPQ DERLPHYLRD EDPFASKLSW EADLVAGFYL TIIGILSTFG
60 70 80 90 100
NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV
110 120 130 140 150
FGWFGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY
160 170 180 190 200
ICLAVIWAYA SFWTTMPLVG LGDYAPEPFG TSCTLDWWLA QASGGGQVFI
210 220 230 240 250
LSILFFCLLL PTAVIVFSYA KIIAKVKSSS KEVAHFDSRI HSSHVLEVKL
260 270 280 290 300
TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM
310 320 330 340 350
YNPIIYQVID YRFACCQAGG LRGTKKKSLE DFRLHTVTAV RKSSAVLEIH
360 370
PESSSRFTSA HVMDGESHSN DGDCGKK
Length:377
Mass (Da):42,018
Last modified:July 5, 2004 - v1
Checksum:i26036DC9248B1596
GO
Isoform 2 (identifier: Q6VZZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-353: S → V
     354-377: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):39,496
Checksum:i31AA0FC48D7547EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 86Missing in AAP72135 (PubMed:14623098).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014041353S → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_014042354 – 377Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288426 mRNA. Translation: AAP72135.1.
BC125611 mRNA. Translation: AAI25612.1.
BC132010 mRNA. Translation: AAI32011.1.
AY255592 mRNA. Translation: AAO85104.1.
AK039525 mRNA. Translation: BAC30373.1.
AY318865 mRNA. Translation: AAR08201.1.
BK001605 Genomic DNA. Translation: DAA01972.1.
CCDSiCCDS37619.1. [Q6VZZ7-1]
RefSeqiNP_861418.2. NM_181753.4. [Q6VZZ7-1]
UniGeneiMm.184937.

Genome annotation databases

EnsembliENSMUST00000068355; ENSMUSP00000063542; ENSMUSG00000043972. [Q6VZZ7-1]
GeneIDi353344.
KEGGimmu:353344.
UCSCiuc008coq.1. mouse. [Q6VZZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288426 mRNA. Translation: AAP72135.1.
BC125611 mRNA. Translation: AAI25612.1.
BC132010 mRNA. Translation: AAI32011.1.
AY255592 mRNA. Translation: AAO85104.1.
AK039525 mRNA. Translation: BAC30373.1.
AY318865 mRNA. Translation: AAR08201.1.
BK001605 Genomic DNA. Translation: DAA01972.1.
CCDSiCCDS37619.1. [Q6VZZ7-1]
RefSeqiNP_861418.2. NM_181753.4. [Q6VZZ7-1]
UniGeneiMm.184937.

3D structure databases

ProteinModelPortaliQ6VZZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063542.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ6VZZ7.

Proteomic databases

PaxDbiQ6VZZ7.
PRIDEiQ6VZZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068355; ENSMUSP00000063542; ENSMUSG00000043972. [Q6VZZ7-1]
GeneIDi353344.
KEGGimmu:353344.
UCSCiuc008coq.1. mouse. [Q6VZZ7-1]

Organism-specific databases

CTDi221391.
MGIiMGI:2662912. Opn5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115272.
HOVERGENiHBG058348.
InParanoidiQ6VZZ7.
KOiK08385.
OMAiLGDYVPE.
OrthoDBiEOG091G0ALC.
PhylomeDBiQ6VZZ7.
TreeFamiTF324998.

Miscellaneous databases

PROiQ6VZZ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043972.
CleanExiMM_OPN5.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPN5_MOUSE
AccessioniPrimary (citable) accession number: Q6VZZ7
Secondary accession number(s): Q059L5
, Q7TQP1, Q80T51, Q8BYI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.