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Q6VZZ7

- OPN5_MOUSE

UniProt

Q6VZZ7 - OPN5_MOUSE

Protein

Opsin-5

Gene

Opn5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. visual perception Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Keywords - Ligandi

    Chromophore

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Opsin-5
    Alternative name(s):
    G-protein coupled receptor 136
    G-protein coupled receptor PGR12
    Neuropsin
    Gene namesi
    Name:Opn5
    Synonyms:Gpr136, Pgr12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2662912. Opn5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Opsin-5PRO_0000197818Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 183PROSITE-ProRule annotation
    Modified residuei296 – 2961N6-(retinylidene)lysine
    Lipidationi315 – 3151S-palmitoyl cysteineSequence Analysis
    Lipidationi316 – 3161S-palmitoyl cysteineSequence Analysis

    Post-translational modificationi

    It is uncertain whether Cys-315 or Cys-316 is palmitoylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ6VZZ7.

    PTM databases

    PhosphoSiteiQ6VZZ7.

    Expressioni

    Tissue specificityi

    Detected in the eye, brain and testis.

    Gene expression databases

    BgeeiQ6VZZ7.
    CleanExiMM_OPN5.
    GenevestigatoriQ6VZZ7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6VZZ7.
    SMRiQ6VZZ7. Positions 56-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 7420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 10813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 19726ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25234CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 37768CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145389.
    GeneTreeiENSGT00690000101836.
    HOGENOMiHOG000115272.
    HOVERGENiHBG058348.
    InParanoidiQ059L5.
    KOiK08385.
    OMAiLAAIWAY.
    OrthoDBiEOG77M8NX.
    PhylomeDBiQ6VZZ7.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002962. Peropsin.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01244. PEROPSIN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6VZZ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALNHTALPQ DERLPHYLRD EDPFASKLSW EADLVAGFYL TIIGILSTFG    50
    NGYVLYMSSR RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV 100
    FGWFGCRWYG WAGFFFGCGS LITMTAVSLD RYLKICYLSY GVWLKRKHAY 150
    ICLAVIWAYA SFWTTMPLVG LGDYAPEPFG TSCTLDWWLA QASGGGQVFI 200
    LSILFFCLLL PTAVIVFSYA KIIAKVKSSS KEVAHFDSRI HSSHVLEVKL 250
    TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM 300
    YNPIIYQVID YRFACCQAGG LRGTKKKSLE DFRLHTVTAV RKSSAVLEIH 350
    PESSSRFTSA HVMDGESHSN DGDCGKK 377
    Length:377
    Mass (Da):42,018
    Last modified:July 5, 2004 - v1
    Checksum:i26036DC9248B1596
    GO
    Isoform 2 (identifier: Q6VZZ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         353-353: S → V
         354-377: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:353
    Mass (Da):39,496
    Checksum:i31AA0FC48D7547EE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 863Missing in AAP72135. (PubMed:14623098)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei353 – 3531S → V in isoform 2. 1 PublicationVSP_014041
    Alternative sequencei354 – 37724Missing in isoform 2. 1 PublicationVSP_014042Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288426 mRNA. Translation: AAP72135.1.
    BC125611 mRNA. Translation: AAI25612.1.
    BC132010 mRNA. Translation: AAI32011.1.
    AY255592 mRNA. Translation: AAO85104.1.
    AK039525 mRNA. Translation: BAC30373.1.
    AY318865 mRNA. Translation: AAR08201.1.
    BK001605 Genomic DNA. Translation: DAA01972.1.
    CCDSiCCDS37619.1. [Q6VZZ7-1]
    RefSeqiNP_861418.2. NM_181753.4. [Q6VZZ7-1]
    XP_006524515.1. XM_006524452.1. [Q6VZZ7-1]
    UniGeneiMm.184937.

    Genome annotation databases

    EnsembliENSMUST00000068355; ENSMUSP00000063542; ENSMUSG00000043972. [Q6VZZ7-1]
    GeneIDi353344.
    KEGGimmu:353344.
    UCSCiuc008coq.1. mouse. [Q6VZZ7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288426 mRNA. Translation: AAP72135.1 .
    BC125611 mRNA. Translation: AAI25612.1 .
    BC132010 mRNA. Translation: AAI32011.1 .
    AY255592 mRNA. Translation: AAO85104.1 .
    AK039525 mRNA. Translation: BAC30373.1 .
    AY318865 mRNA. Translation: AAR08201.1 .
    BK001605 Genomic DNA. Translation: DAA01972.1 .
    CCDSi CCDS37619.1. [Q6VZZ7-1 ]
    RefSeqi NP_861418.2. NM_181753.4. [Q6VZZ7-1 ]
    XP_006524515.1. XM_006524452.1. [Q6VZZ7-1 ]
    UniGenei Mm.184937.

    3D structure databases

    ProteinModelPortali Q6VZZ7.
    SMRi Q6VZZ7. Positions 56-313.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6VZZ7.

    Proteomic databases

    PRIDEi Q6VZZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068355 ; ENSMUSP00000063542 ; ENSMUSG00000043972 . [Q6VZZ7-1 ]
    GeneIDi 353344.
    KEGGi mmu:353344.
    UCSCi uc008coq.1. mouse. [Q6VZZ7-1 ]

    Organism-specific databases

    CTDi 221391.
    MGIi MGI:2662912. Opn5.

    Phylogenomic databases

    eggNOGi NOG145389.
    GeneTreei ENSGT00690000101836.
    HOGENOMi HOG000115272.
    HOVERGENi HBG058348.
    InParanoidi Q059L5.
    KOi K08385.
    OMAi LAAIWAY.
    OrthoDBi EOG77M8NX.
    PhylomeDBi Q6VZZ7.
    TreeFami TF324998.

    Miscellaneous databases

    NextBioi 400417.
    PROi Q6VZZ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6VZZ7.
    CleanExi MM_OPN5.
    Genevestigatori Q6VZZ7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002962. Peropsin.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01244. PEROPSIN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-228.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-377 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    5. "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue."
      Tarttelin E.E., Bellingham J., Hankins M.W., Foster R.G., Lucas R.J.
      FEBS Lett. 554:410-416(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 1).
      Strain: C3H.

    Entry informationi

    Entry nameiOPN5_MOUSE
    AccessioniPrimary (citable) accession number: Q6VZZ7
    Secondary accession number(s): Q059L5
    , Q7TQP1, Q80T51, Q8BYI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3