ID   PAP1_CNPV               Reviewed;         472 AA.
AC   Q6VZL8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   28-JUN-2023, entry version 61.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
GN   Name=PAPL; OrderedLocusNames=CNPV129;
OS   Canarypox virus (CNPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=44088;
OH   NCBI_TaxID=9134; Serinus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ATCC VR-111 / Wheatley C93;
RX   PubMed=14671117; DOI=10.1128/jvi.78.1.353-366.2004;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of canarypox virus.";
RL   J. Virol. 78:353-366(2004).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AY318871; AAR83475.1; -; Genomic_DNA.
DR   RefSeq; NP_955152.1; NC_005309.1.
DR   SMR; Q6VZL8; -.
DR   GeneID; 2700390; -.
DR   KEGG; vg:2700390; -.
DR   OrthoDB; 3428at10239; -.
DR   Proteomes; UP000168164; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd20919; polyA_pol_Pox; 1.
DR   Gene3D; 1.20.1270.320; Poxvirus poly(A) polymerase, N domain; 1.
DR   Gene3D; 3.30.460.60; Poxvirus poly(A) polymerase, nucleotidyltransferase domain; 1.
DR   InterPro; IPR004976; PolyA_pol_cat_Poxvir.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; PolyA_pol_nucTrfase_Poxvir.
DR   InterPro; IPR038419; PolyA_pol_nucTrfase_sf_Poxvir.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; Poly(A) polymerase catalytic subunit-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..472
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000308926"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        196
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   472 AA;  56015 MW;  5661DB73F7ED3A44 CRC64;
     MDRRNQITSV IREYLGRNPV PKEYEVLKKQ TLKLSKIINF NKDTFFFLIK KNKYTFFKDL
     NVSDEEIQER IDEYFTKQRR ARRLGNLLAI VELQKLLVSS FTKTLGVLTT KALEYYPSNI
     RLDYSFMEKI ADNILDSYNV VKPSEEVKGR HKVSDLVLHV NKIMEEYLRR HSNSCICYGS
     YSLHLLNKKI EYGDIDILQT NARIFLINIA FLIRFITGRC VVLLKVPFLK NYVVIHDENL
     NHVMDSFNIK QSTMDKIPKI MIDNMYIVDP CIQLLNTIKM FSQIDRLEDI HTKFDKLSIR
     LGTLLEYTRY RYSILLDSES ILDVKYKIDI QNRKIILDFK KYNLNYIKCY FFLDEDELKK
     LIRKTPKTDD YIDLEAVTNS EYMILNKTMY TYFSNTTLLR SKDELHPITI NALTSHALLY
     HVITKKFYDD LLGDLIRSLM IVEKVPVYEI IPRDKKRGKH TIIDIEKDVV FH
//