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Q6VZL8

- PAP1_CNPV

UniProt

Q6VZL8 - PAP1_CNPV

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Canarypox virus (CNPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei194 – 1941By similarity
    Active sitei196 – 1961By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    Ordered Locus Names:CNPV129
    OrganismiCanarypox virus (CNPV)
    Taxonomic identifieri44088 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
    Virus hostiSerinus [TaxID: 9134]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Poly(A) polymerase catalytic subunitPRO_0000308926Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6VZL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6VZL8-1 [UniParc]FASTAAdd to Basket

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    MDRRNQITSV IREYLGRNPV PKEYEVLKKQ TLKLSKIINF NKDTFFFLIK    50
    KNKYTFFKDL NVSDEEIQER IDEYFTKQRR ARRLGNLLAI VELQKLLVSS 100
    FTKTLGVLTT KALEYYPSNI RLDYSFMEKI ADNILDSYNV VKPSEEVKGR 150
    HKVSDLVLHV NKIMEEYLRR HSNSCICYGS YSLHLLNKKI EYGDIDILQT 200
    NARIFLINIA FLIRFITGRC VVLLKVPFLK NYVVIHDENL NHVMDSFNIK 250
    QSTMDKIPKI MIDNMYIVDP CIQLLNTIKM FSQIDRLEDI HTKFDKLSIR 300
    LGTLLEYTRY RYSILLDSES ILDVKYKIDI QNRKIILDFK KYNLNYIKCY 350
    FFLDEDELKK LIRKTPKTDD YIDLEAVTNS EYMILNKTMY TYFSNTTLLR 400
    SKDELHPITI NALTSHALLY HVITKKFYDD LLGDLIRSLM IVEKVPVYEI 450
    IPRDKKRGKH TIIDIEKDVV FH 472
    Length:472
    Mass (Da):56,015
    Last modified:July 5, 2004 - v1
    Checksum:i5661DB73F7ED3A44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY318871 Genomic DNA. Translation: AAR83475.1.
    RefSeqiNP_955152.1. NC_005309.1.

    Genome annotation databases

    GeneIDi2700390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY318871 Genomic DNA. Translation: AAR83475.1 .
    RefSeqi NP_955152.1. NC_005309.1.

    3D structure databases

    ProteinModelPortali Q6VZL8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2700390.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate ATCC VR-111 / Wheatley C93.

    Entry informationi

    Entry nameiPAP1_CNPV
    AccessioniPrimary (citable) accession number: Q6VZL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3