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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Canarypox virus (CNPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei194 – 1941By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:CNPV129
OrganismiCanarypox virus (CNPV)
Taxonomic identifieri44088 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostiSerinus [TaxID: 9134]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Poly(A) polymerase catalytic subunitPRO_0000308926Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6VZL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6VZL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRRNQITSV IREYLGRNPV PKEYEVLKKQ TLKLSKIINF NKDTFFFLIK
60 70 80 90 100
KNKYTFFKDL NVSDEEIQER IDEYFTKQRR ARRLGNLLAI VELQKLLVSS
110 120 130 140 150
FTKTLGVLTT KALEYYPSNI RLDYSFMEKI ADNILDSYNV VKPSEEVKGR
160 170 180 190 200
HKVSDLVLHV NKIMEEYLRR HSNSCICYGS YSLHLLNKKI EYGDIDILQT
210 220 230 240 250
NARIFLINIA FLIRFITGRC VVLLKVPFLK NYVVIHDENL NHVMDSFNIK
260 270 280 290 300
QSTMDKIPKI MIDNMYIVDP CIQLLNTIKM FSQIDRLEDI HTKFDKLSIR
310 320 330 340 350
LGTLLEYTRY RYSILLDSES ILDVKYKIDI QNRKIILDFK KYNLNYIKCY
360 370 380 390 400
FFLDEDELKK LIRKTPKTDD YIDLEAVTNS EYMILNKTMY TYFSNTTLLR
410 420 430 440 450
SKDELHPITI NALTSHALLY HVITKKFYDD LLGDLIRSLM IVEKVPVYEI
460 470
IPRDKKRGKH TIIDIEKDVV FH
Length:472
Mass (Da):56,015
Last modified:July 5, 2004 - v1
Checksum:i5661DB73F7ED3A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318871 Genomic DNA. Translation: AAR83475.1.
RefSeqiNP_955152.1. NC_005309.1.

Genome annotation databases

GeneIDi2700390.
KEGGivg:2700390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY318871 Genomic DNA. Translation: AAR83475.1.
RefSeqiNP_955152.1. NC_005309.1.

3D structure databases

ProteinModelPortaliQ6VZL8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2700390.
KEGGivg:2700390.

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate ATCC VR-111 / Wheatley C93.

Entry informationi

Entry nameiPAP1_CNPV
AccessioniPrimary (citable) accession number: Q6VZL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.