ID   Q6VYI4_MOUSE            Unreviewed;       304 AA.
AC   Q6VYI4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 154.
DE   SubName: Full=TAR DNA binding protein {ECO:0000313|Ensembl:ENSMUSP00000093386.4};
DE   SubName: Full=TARDBP S9 {ECO:0000313|EMBL:AAP92691.1};
GN   Name=Tardbp {ECO:0000313|Ensembl:ENSMUSP00000093386.4,
GN   ECO:0000313|MGI:MGI:2387629};
GN   Synonyms=TARDBP {ECO:0000313|EMBL:AAP92691.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAP92691.1};
RN   [1] {ECO:0000313|EMBL:AAP92691.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Shen J.C.K., Wang I.-F., Wang H.-Y.;
RT   "Structural and Functional Aspects of the Eukaryoyic TDP gene Family.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000093386.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000093386.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000093386.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000093386.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AY319516; AAP92691.1; -; mRNA.
DR   RefSeq; NP_001008545.1; NM_001008545.2.
DR   ProteomicsDB; 341033; -.
DR   Antibodypedia; 1854; 1088 antibodies from 47 providers.
DR   DNASU; 230908; -.
DR   Ensembl; ENSMUST00000095719.10; ENSMUSP00000093386.4; ENSMUSG00000041459.16.
DR   Ensembl; ENSMUST00000172073.8; ENSMUSP00000130963.2; ENSMUSG00000041459.16.
DR   GeneID; 230908; -.
DR   UCSC; uc008vve.1; mouse.
DR   AGR; MGI:2387629; -.
DR   CTD; 23435; -.
DR   MGI; MGI:2387629; Tardbp.
DR   VEuPathDB; HostDB:ENSMUSG00000041459; -.
DR   GeneTree; ENSGT00940000154343; -.
DR   OrthoDB; 3127428at2759; -.
DR   BioGRID-ORCS; 230908; 31 hits in 81 CRISPR screens.
DR   ChiTaRS; Tardbp; mouse.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000041459; Expressed in presomitic mesoderm and 270 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd19609; NTD_TDP-43; 1.
DR   CDD; cd12321; RRM1_TDP43; 1.
DR   CDD; cd12322; RRM2_TDP43; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR041105; TDP43_N.
DR   PANTHER; PTHR48033; RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48033:SF9; TAR DNA-BINDING PROTEIN 43; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF18694; TDP43_N; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   1: Evidence at protein level;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|EPD:Q6VYI4,
KW   ECO:0007829|MaxQB:Q6VYI4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          104..200
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          191..262
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
SQ   SEQUENCE   304 AA;  34157 MW;  673D0F3BFD53E888 CRC64;
     MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI
     LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL
     KDYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS
     KQSPDEPLRS RKVFVGRCTE DMTAEELQQF FCQYGEVVDV FIPKPFRAFA FVTFADDKVA
     QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQVHLI SNVYGRSTSL
     KVVL
//