SOSTDC1

Functionⁱ

Can activate or inhibit Wnt signaling in a context-dependent manner. Activates the canonical Wnt pathway whereby acts through Disheveled proteins and beta-catenin. Antagonises Wnt signaling through the canonical pathways presumably by blocking accessibility of certain WNTs to their receptors. Induces posterior neural markers via components of the canonical Wnt pathway.1 Publication

GO - Biological processⁱ

Wnt signaling pathway Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Wnt signaling pathway

Biological process

Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sclerostin domain-containing protein 1 Alternative name(s): Wnt-signaling modulator
Gene namesⁱ	Name:SOSTDC1 Synonyms:WISE
Organismⁱ	Gallus gallus (Chicken)
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Chromosome 2

Subcellular locationⁱ

Secreted

GO - Cellular componentⁱ

extracellular space Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000033184	23 – 206	Sclerostin domain-containing protein 1Add BLAST		184

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	75 ↔ 133	PROSITE-ProRule annotation
Disulfide bondⁱ	89 ↔ 147	PROSITE-ProRule annotation
Disulfide bondⁱ	100 ↔ 163	PROSITE-ProRule annotation
Disulfide bondⁱ	104 ↔ 165	PROSITE-ProRule annotation
Glycosylationⁱ	173	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q6VYA3.

PaxDbⁱ

Q6VYA3.

Expressionⁱ

Developmental stageⁱ

Expression was first detected broadly at stage 9, and then localised in the posterior surface ectoderm overlying the presomitic mesoderm by stage 10-11 embryo.1 Publication

Gene expression databases

Bgeeⁱ	ENSGALG00000010797.

Bgeeⁱ

ENSGALG00000010797.

Interactionⁱ

Subunit structureⁱ

Interacts with LRP6.1 Publication

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000017538.

STRINGⁱ

9031.ENSGALP00000017538.

Structureⁱ

3D structure databases

SMRⁱ	Q6VYA3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	75 – 170	CTCKPROSITE-ProRule annotationAdd BLAST		96

Sequence similaritiesⁱ

Belongs to the sclerostin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IIVA. Eukaryota. ENOG410YEMP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014900.
HOGENOMⁱ	HOG000252934.
HOVERGENⁱ	HBG003729.
InParanoidⁱ	Q6VYA3.
OMAⁱ	AKPAQHH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13DX.
PhylomeDBⁱ	Q6VYA3.
TreeFamⁱ	TF353019.

Family and domain databases

Gene3Dⁱ	2.10.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR006207. Cys_knot_C. IPR029034. Cystine-knot_cytokine. IPR008835. Sclerostin/SOSTDC1.
PANTHERⁱ	PTHR14903. PTHR14903. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05463. Sclerostin. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01225. CTCK_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6VYA3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLSAIHFYG LLLACTFTRS YSAFKNDATE ILYSHVVKPA PASPSSNSTL 
        60         70         80         90        100
NQARNGGRHY AGTGSDRNNR VQVGCRELRS TKYISDGQCT SINPLKELVC 
       110        120        130        140        150
AGECLPLPLL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG 
       160        170        180        190        200
SIRTYKITVV TACKCKRYTR QHNESSHNFE GTSQAKPVQH HKERKRASKS 

SKHSTS

Length:206

Mass (Da):23,144

Last modified:July 5, 2004 - v1

Checksum:ⁱ75F438854599CEAD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY319926 mRNA. Translation: AAQ57626.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_989704.1. NM_204373.1. XP_015136747.1. XM_015281261.1.
UniGeneⁱ	Gga.9261.

Genome annotation databases

Ensemblⁱ	ENSGALT00000080778; ENSGALP00000044773; ENSGALG00000036836.
GeneIDⁱ	378800.
KEGGⁱ	gga:378800.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY319926 mRNA. Translation: AAQ57626.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_989704.1. NM_204373.1. XP_015136747.1. XM_015281261.1.
UniGeneⁱ	Gga.9261.

3D structure databases

SMRⁱ	Q6VYA3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000017538.

STRINGⁱ

9031.ENSGALP00000017538.

Proteomic databases

PaxDbⁱ	Q6VYA3.

PaxDbⁱ

Q6VYA3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSGALT00000080778; ENSGALP00000044773; ENSGALG00000036836.
GeneIDⁱ	378800.
KEGGⁱ	gga:378800.

Organism-specific databases

CTDⁱ	25928.

CTDⁱ

25928.

Phylogenomic databases

eggNOGⁱ	ENOG410IIVA. Eukaryota. ENOG410YEMP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014900.
HOGENOMⁱ	HOG000252934.
HOVERGENⁱ	HBG003729.
InParanoidⁱ	Q6VYA3.
OMAⁱ	AKPAQHH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13DX.
PhylomeDBⁱ	Q6VYA3.
TreeFamⁱ	TF353019.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6VYA3.

PROⁱ

PR:Q6VYA3.

Gene expression databases

Bgeeⁱ	ENSGALG00000010797.

Bgeeⁱ

ENSGALG00000010797.

Family and domain databases

Gene3Dⁱ	2.10.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR006207. Cys_knot_C. IPR029034. Cystine-knot_cytokine. IPR008835. Sclerostin/SOSTDC1.
PANTHERⁱ	PTHR14903. PTHR14903. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05463. Sclerostin. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01225. CTCK_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOSD1_CHICK
Accessionⁱ	Q6VYA3Primary (citable) accession number: Q6VYA3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
	Last sequence update:	July 5, 2004
	Last modified:	May 10, 2017
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6VYA3 (SOSD1_CHICK)

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Sclerostin domain-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ