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Protein

Vitamin D 25-hydroxylase

Gene

Cyp2r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D2 and D3.1 Publication

Catalytic activityi

Calciol + O2 + [reduced NADPH--hemoprotein reductase] = calcidiol + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250Substrate; via carbonyl oxygenBy similarity1
Metal bindingi448Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.13.159 3474
ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism
R-MMU-211916 Vitamins

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D 25-hydroxylase (EC:1.14.14.241 Publication)
Alternative name(s):
Cytochrome P450 2R1
Gene namesi
Name:Cyp2r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2449771 Cyp2r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517791 – 501Vitamin D 25-hydroxylaseAdd BLAST501

Proteomic databases

MaxQBiQ6VVW9
PaxDbiQ6VVW9
PRIDEiQ6VVW9

PTM databases

iPTMnetiQ6VVW9
PhosphoSitePlusiQ6VVW9

Expressioni

Tissue specificityi

Highly expressed in the liver and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000030670
ExpressionAtlasiQ6VVW9 baseline and differential
GenevisibleiQ6VVW9 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032908

Structurei

3D structure databases

ProteinModelPortaliQ6VVW9
SMRiQ6VVW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiQ6VVW9
KOiK07419
OMAiRFTYEDT
OrthoDBiEOG091G0BT8
PhylomeDBiQ6VVW9
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q6VVW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELPGARAC AGALAGALLL LLFVLVVRQL LRQRRPAGFP PGPPRLPFVG
60 70 80 90 100
NICSLALSAD LPHVYMRKQS RVYGEIFSLD LGGISTVVLN GYDVVKECLV
110 120 130 140 150
HQSEIFADRP CLPLFMKMTK MGGLLNSRYG RGWIDHRRLA VNSFHYFGSG
160 170 180 190 200
QKSFESKILE ETWSLIDAIE TYKGGPFDLK QLITNAVSNI TNLILFGERF
210 220 230 240 250
TYEDTDFQHM IELFSENVEL AASAPVFLYN AFPWIGILPF GKHQRLFRNA
260 270 280 290 300
DVVYDFLSRL IEKAAVNRKP HLPHHFVDAY LDEMDQGQND PLSTFSKENL
310 320 330 340 350
IFSVGELIIA GTETTTNVLR WAILFMALYP NIQGQVHKEI DLIVGHNRRP
360 370 380 390 400
SWEYKCKMPY TEAVLHEVLR FCNIVPLGIF HATSEDAVVR GYSIPKGTTV
410 420 430 440 450
ITNLYSVHFD EKYWKDPDMF YPERFLDSNG YFTKKEALIP FSLGRRHCLG
460 470 480 490 500
EQLARMEMFL FFTSLLQQFH LHFPHELVPN LKPRLGMTLQ PQPYLICAER

R
Length:501
Mass (Da):57,313
Last modified:July 5, 2004 - v1
Checksum:iC1A1BAD71E630A98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323818 mRNA Translation: AAQ23115.1
CCDSiCCDS21761.1
RefSeqiNP_796356.2, NM_177382.4
UniGeneiMm.108037
Mm.401952

Genome annotation databases

EnsembliENSMUST00000032908; ENSMUSP00000032908; ENSMUSG00000030670
GeneIDi244209
KEGGimmu:244209
UCSCiuc009jid.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2R1_MOUSE
AccessioniPrimary (citable) accession number: Q6VVW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health