Q6VU69 (Q6VU69_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Laminin alpha 3 splice variant a EMBL AAQ72569.1

Submitted name:
Laminin subunit alpha-3 Ensembl ENSP00000466557

Gene names

Name:

LAMA3 EMBL AAQ72569.1 Ensembl ENSP00000466557

Organism

Homo sapiens (Human) [Reference proteome] EMBL AAQ72569.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1668 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: InterPro regulation of cell adhesion Inferred from electronic annotation. Source: InterPro regulation of cell migration Inferred from electronic annotation. Source: InterPro regulation of embryonic development Inferred from electronic annotation. Source: InterPro
Cellular_component	laminin-1 complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6VU69 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9EBF5FC45637645C	FASTA	1,668	184,054
	10 20 30 40 50 60 MPPAVRRSAC SMGWLWIFGA ALGQCLGYSS QQQRVPFLQP PGQSQLQASY VEFRPSQGCS 70 80 90 100 110 120 PGYYRDHKGL YTGRCVPCNC NGHSNQCQDG SGICVNCQHN TAGEHCERCQ EGYYGNAVHG 130 140 150 160 170 180 SCRACPCPHT NSFATGCVVN GGDVRCSCKA GYTGTQCERC APGYFGNPQK FGGSCQPCSC 190 200 210 220 230 240 NSNGQLGSCH PLTGDCINQE PKDSSPAEEC DDCDSCVMTL LNDLATMGEQ LRLVKSQLQG 250 260 270 280 290 300 LSASAGLLEQ MRHMETQAKD LRNQLLNYRS AISNHGSKIE GLERELTDLN QEFETLQEKA 310 320 330 340 350 360 QVNSRKAQTL NNNVNRATQS AKELDVKIKN VIRNVHMLNR IRTWQKTHQG ENNGLANSIR 370 380 390 400 410 420 DSLNEYEAKL SDLRARLQEA AAQAKQANGL NQENERALGA IQRQVKEINS LQSDFTKYLT 430 440 450 460 470 480 TADSSLLQTN IALQLMEKSQ KEYEKLAASL NEARQELSDK VRELSRSAGK TSLVEEAEKH 490 500 510 520 530 540 ARSLQELAKQ LEEIKRNASG DELVRCAVDA ATAYENILNA IKAAEDAANR AASASESALQ 550 560 570 580 590 600 TVIKEDLPRK AKTLSSNSDK LLNEAKMTQK KLKQEVSPAL NNLQQTLNIV TVQKEVIDTN 610 620 630 640 650 660 LTTLRDGLHG IQRGDIDAMI SSAKSMVRKA NDITDEVLDG LNPIQTDVER IKDTYGRTQN 670 680 690 700 710 720 EDFKKALTDA DNSVNKLTNK LPDLWRKIES INQQLLPLGN ISDNMDRIRE LIQQARDAAS 730 740 750 760 770 780 KVAVPMRFNG KSGVEVRLPN DLEDLKGYTS LSLFLQRPNS RENGGTENMF VMYLGNKDAS 790 800 810 820 830 840 RDYIGMAVVD GQLTCVYNLG DREAELQVDQ ILTKSETKEA VMDRVKFQRI YQFARLNYTK 850 860 870 880 890 900 GATSSKPETP GVYDMDGRNS NTLLNLDPEN VVFYVGGYPP DFKLPSRLSF PPYKGCIELD 910 920 930 940 950 960 DLNENVLSLY NFKKTFNLNT TEVEPCRRRK EESDKNYFEG TGYARVPTQP HAPIPTFGQT 970 980 990 1000 1010 1020 IQTTVDRGLL FFAENGDRFI SLNIEDGKLM VRYKLNSELP KERGVGDAIN NGRDHSIQIK 1030 1040 1050 1060 1070 1080 IGKLQKRMWI NVDVQNTIID GEVFDFSTYY LGGIPIAIRE RFNISTPAFR GCMKNLKKTS 1090 1100 1110 1120 1130 1140 GVVRLNDTVG VTKKCSEDWK LVRSASFSRG GQLSFTDLGL PPTDHLQASF GFQTFQPSGI 1150 1160 1170 1180 1190 1200 LLDHQTWTRN LQVTLEDGYI ELSTSDSGSP IFKSPQTYMD GLLHYVSVIS DNSGLRLLID 1210 1220 1230 1240 1250 1260 DQLLRNSKRL KHISSSRQSL RLGGSNFEGC ISNVFVQRLS LSPEVLDLTS NSLKRDVSLG 1270 1280 1290 1300 1310 1320 GCSLNKPPFL MLLKGSTRFN KTKTFRINQL LQDTPVASPR SVKVWQDACS PLPKTQANHG 1330 1340 1350 1360 1370 1380 ALQFGDIPTS HLLFKLPQEL LKPRSQFAVD MQTTSSRGLV FHTGTKNSFM ALYLSKGRLV 1390 1400 1410 1420 1430 1440 FALGTDGKKL RIKSKEKCND GKWHTVVFGH DGEKGRLVVD GLRAREGSLP GNSTISIRAP 1450 1460 1470 1480 1490 1500 VYLGSPPSGK PKSLPTNSFV GCLKNFQLDS KPLYTPSSSF GVSSCLGGPL EKGIYFSEEG 1510 1520 1530 1540 1550 1560 GHVVLAHSVL LGPEFKLVFS IRPRSLTGIL IHIGSQPGKH LCVYLEAGKV TASMDSGAGG 1570 1580 1590 1600 1610 1620 TSTSVTPKQS LCDGQWHSVA VTIKQHILHL ELDTDSSYTA GQIPFPPAST QEPLHLGGAP 1630 1640 1650 1660 ANLTTLRIPV WKSFFGCLRN IHVNHIPVPV TEALEVQGPV SLNGCPDQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An unusual N-terminal deletion of the laminin alpha3a isoform leads to the chronic granulation tissue disorder laryngo-onycho-cutaneous syndrome." McLean W.H.I., Irvine A.D., Hamill K.J., Whittock N.V., Coleman-Campbell C.M., Mellerio J.E., Ashton G.S., Dopping-Hepenstal P.J.H., Eady R.A.J., Jamil T., Phillips R.J., Shabbir S.G., Haroon T.S., Khurshid K., Moore J.E., Page B., Darling J., Atherton D.J. , Van Steensel M.A.M., Munro C.S., Smith F.J.D., McGrath J.A. Hum. Mol. Genet. 12:2395-2409(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	McLean W.H.I. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Ensembl Submitted (NOV-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010754 Genomic DNA. No translation available. AC067796 Genomic DNA. No translation available. AC090366 Genomic DNA. No translation available. AY327114 mRNA. Translation: AAQ72569.1.
IPI	IPI00895830.
RefSeq	NP_001121190.1. NM_001127718.1.
UniGene	Hs.436367.
3D structure databases
ModBase	Search...
Protocols and materials databases
DNASU	3909.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000587184; ENSP00000466557; ENSG00000053747.
GeneID	3909.
KEGG	hsa:3909.
UCSC	uc002kut.4. human.
Organism-specific databases
CTD	3909.
HGNC	HGNC:6483. LAMA3.
PharmGKB	PA30272.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG100777.
KO	K06240.
Family and domain databases
Gene3D	2.60.120.200. 5 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR002049. EGF_laminin. IPR001791. Laminin_G. IPR009254. Laminin_I. IPR010307. Laminin_II. [Graphical view]
Pfam	PF00053. Laminin_EGF. 2 hits. PF02210. Laminin_G_2. 5 hits. PF06008. Laminin_I. 2 hits. PF06009. Laminin_II. 1 hit. [Graphical view]
SMART	SM00180. EGF_Lam. 2 hits. SM00282. LamG. 5 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 5 hits.
PROSITE	PS01248. EGF_LAM_1. 2 hits. PS50027. EGF_LAM_2. 2 hits. PS50025. LAM_G_DOMAIN. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LAMA3. human.
GenomeRNAi	3909.
NextBio	15345.

Entry information

Entry name

Q6VU69_HUMAN

Accession

Primary (citable) accession number: Q6VU69

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.