ID   Q6VN45_NOTEU            Unreviewed;       183 AA.
AC   Q6VN45;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Transcription factor Otx2 {ECO:0000313|EMBL:AAQ73531.1};
DE   Flags: Fragment;
GN   Name=Otx2 {ECO:0000313|EMBL:AAQ73531.1};
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315 {ECO:0000313|EMBL:AAQ73531.1};
RN   [1] {ECO:0000313|EMBL:AAQ73531.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11504847;
RA   Germot A., Lecointre G., Plouhinec J.L., Le Mentec C., Girardot F.,
RA   Mazan S.;
RT   "Structural evolution of Otx genes in craniates.";
RL   Mol. Biol. Evol. 18:1668-1678(2001).
RN   [2] {ECO:0000313|EMBL:AAQ73531.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12654938; DOI=10.1093/molbev/msg085;
RA   Plouhinec J.L., Sauka-Spengler T., Germot A., Le Mentec C., Cabana T.,
RA   Harrison G., Pieau C., Sire J.Y., Veron G., Mazan S.;
RT   "The mammalian Crx genes are highly divergent representatives of the Otx5
RT   gene family, a gnathostome orthology class of orthodenticle-related
RT   homeogenes involved in the differentiation of retinal photoreceptors and
RT   circadian entrainment.";
RL   Mol. Biol. Evol. 20:513-521(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000256|ARBA:ARBA00006503}.
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DR   EMBL; AY337233; AAQ73531.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6VN45; -.
DR   HOGENOM; CLU_064370_0_0_1; -.
DR   TreeFam; TF351179; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR003022; Otx2_TF.
DR   InterPro; IPR003025; Otx_TF.
DR   InterPro; IPR013851; Otx_TF_C.
DR   PANTHER; PTHR45793; HOMEOBOX PROTEIN; 1.
DR   PANTHER; PTHR45793:SF2; HOMEOBOX PROTEIN OTX2; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   PRINTS; PR01257; OTX2HOMEOBOX.
DR   PRINTS; PR01255; OTXHOMEOBOX.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155}.
FT   DOMAIN          64..145
FT                   /note="Transcription factor Otx C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03529"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAQ73531.1"
FT   NON_TER         183
FT                   /evidence="ECO:0000313|EMBL:AAQ73531.1"
SQ   SEQUENCE   183 AA;  19241 MW;  2CA0A91D4BFFC941 CRC64;
     RAKCRQQQQQ QQNGGQNKVR PAKKKSSPVR EVSSESGTSG QFTPPSSTSV PAISSSSAPV
     SIWSPASISP LSDPLSTSSS CMQRSYPMTY TQASGYSQGY AGSTSYFGGM DCGSYLTPMH
     HQLPGPGATL SPMGTNAVTS HLNQSTASLT TQGYGASSLG FNSTTDCLDY KDQTASWKLN
     FNA
//