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Protein
Submitted name:

Transcription factor Otx2

Gene

Otx2

Organism
Macropus eugenii (Tammar wallaby)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. cell fate specification Source: Ensembl
  3. diencephalon morphogenesis Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. endoderm development Source: Ensembl
  6. eye photoreceptor cell fate commitment Source: Ensembl
  7. inner ear morphogenesis Source: Ensembl
  8. metencephalon development Source: Ensembl
  9. midbrain development Source: Ensembl
  10. neuron fate determination Source: Ensembl
  11. primitive streak formation Source: Ensembl
  12. protein complex assembly Source: Ensembl
  13. somite rostral/caudal axis specification Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor Otx2Imported
Gene namesi
Name:Otx2Imported
OrganismiMacropus eugenii (Tammar wallaby)Imported
Taxonomic identifieri9315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaMacropodidaeMacropus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. growth cone Source: Ensembl
  3. nucleus Source: Ensembl
  4. protein complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000082677.
HOVERGENiHBG004028.
OrthoDBiEOG74J98P.
TreeFamiTF351179.

Family and domain databases

InterProiIPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.

Sequencei

Sequence statusi: Fragment.

Q6VN45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RAKCRQQQQQ QQNGGQNKVR PAKKKSSPVR EVSSESGTSG QFTPPSSTSV
60 70 80 90 100
PAISSSSAPV SIWSPASISP LSDPLSTSSS CMQRSYPMTY TQASGYSQGY
110 120 130 140 150
AGSTSYFGGM DCGSYLTPMH HQLPGPGATL SPMGTNAVTS HLNQSTASLT
160 170 180
TQGYGASSLG FNSTTDCLDY KDQTASWKLN FNA
Length:183
Mass (Da):19,241
Last modified:July 5, 2004 - v1
Checksum:i2CA0A91D4BFFC941
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei183 – 1831Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337233 Genomic DNA. Translation: AAQ73531.1.

Genome annotation databases

EnsembliENSMEUT00000000823; ENSMEUP00000000761; ENSMEUG00000000827.
ENSMEUT00000000829; ENSMEUP00000000765; ENSMEUG00000000827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337233 Genomic DNA. Translation: AAQ73531.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMEUT00000000823; ENSMEUP00000000761; ENSMEUG00000000827.
ENSMEUT00000000829; ENSMEUP00000000765; ENSMEUG00000000827.

Phylogenomic databases

HOGENOMiHOG000082677.
HOVERGENiHBG004028.
OrthoDBiEOG74J98P.
TreeFamiTF351179.

Family and domain databases

InterProiIPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
ProtoNetiSearch...

Publicationsi

  1. "Structural evolution of Otx genes in craniates."
    Germot A., Lecointre G., Plouhinec J.L., Le Mentec C., Girardot F., Mazan S.
    Mol. Biol. Evol. 18:1668-1678(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The mammalian Crx genes are highly divergent representatives of the Otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment."
    Plouhinec J.L., Sauka-Spengler T., Germot A., Le Mentec C., Cabana T., Harrison G., Pieau C., Sire J.Y., Veron G., Mazan S.
    Mol. Biol. Evol. 20:513-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6VN45_MACEU
AccessioniPrimary (citable) accession number: Q6VN45
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.