Q6VN20 (RBP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ran-binding protein 10
Short name=RanBP10

Gene names

Name:	RANBP10
Synonyms:	KIAA1464

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase By similarity. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function By similarity. May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway. Ref.4
Subunit structure	May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. May interact with TUBB5 By similarity. Ref.1 Ref.4 Ref.5
Subcellular location	Cytoplasm › cytosol. Nucleus. Note: Predominantly cytoplasmic. Ref.4
Tissue specificity	Broadly expressed, with highest levels in skeletal muscle. Ref.1
Domain	The SPRY domain mediates the interaction with MET By similarity.
Sequence similarities	Belongs to the RANBP9/10 family. Contains 1 B30.2/SPRY domain. Contains 1 CTLH domain. Contains 1 LisH domain.
Sequence caution	The sequence BAA95988.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	microtubule cytoskeleton organization Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic microtubule Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	Ran guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 620	620	Ran-binding protein 10		PRO_0000305237
Regions
	Domain	35 – 222	188	B30.2/SPRY
	Domain	253 – 285	33	LisH
	Domain	291 – 348	58	CTLH
	Compositional bias	346 – 453	108	Ser-rich
Amino acid modifications
	Modified residue	365	1	Phosphoserine Ref.6 Ref.7
	Modified residue	369	1	Phosphoserine Ref.6 Ref.7 Ref.9
Experimental info
	Sequence conflict	223	1	L → P in AAH99917. Ref.3
	Sequence conflict	455	1	M → V in AAH99917. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6VN20 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 66744ADBCB36D308	FASTA	620	67,257
	10 20 30 40 50 60 MAAATADPGA GNPQPGDSSG GGAGGGLPSP GEQELSRRLQ RLYPAVNQQE TPLPRSWSPK 70 80 90 100 110 120 DKYNYIGLSQ GNLRVHYKGH GKNHKDAASV RATHPIPAAC GIYYFEVKIV SKGRDGYMGI 130 140 150 160 170 180 GLSAQGVNMN RLPGWDKHSY GYHGDDGHSF CSSGTGQPYG PTFTTGDVIG CCVNLINGTC 190 200 210 220 230 240 FYTKNGHSLG IAFTDLPANL YPTVGLQTPG EIVDANFGQQ PFLFDIEDYM REWRAKVQGT 250 260 270 280 290 300 VHCFPISARL GEWQAVLQNM VSSYLVHHGY CATATAFARM TETPIQEEQA SIKNRQKIQK 310 320 330 340 350 360 LVLEGRVGEA IETTQRFYPG LLEHNPNLLF MLKCRQFVEM VNGTDSEVRS LSSRSPKSQD 370 380 390 400 410 420 SYPGSPSLSP RHGPSSSHMH NTGADSPSCS NGVASTKSKQ NHSKYPAPSS SSSSSSSSSS 430 440 450 460 470 480 SSPSSVNYSE SNSTDSTKSQ HHSSTSNQET SDSEMEMEAE HYPNGVLGSM STRIVNGAYK 490 500 510 520 530 540 HEDLQTDESS MDDRHPRRQL CGGNQAATER IILFGRELQA LSEQLGREYG KNLAHTEMLQ 550 560 570 580 590 600 DAFSLLAYSD PWSCPVGQQL DPIQREPVCA ALNSAILESQ NLPKQPPLML ALGQASECLR 610 620 LMARAGLGSC SFARVDDYLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling." Wang D., Li Z., Schoen S.R., Messing E.M., Wu G. Biochem. Biophys. Res. Commun. 313:320-326(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH RAN AND MET.
[2]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"RanBP10 acts as a novel coactivator for the androgen receptor." Harada N., Yokoyama T., Yamaji R., Nakano Y., Inui H. Biochem. Biophys. Res. Commun. 368:121-125(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, HOMODIMERIZATION, INTERACTION WITH AR AND RANBP9, SUBCELLULAR LOCATION.
[5]	"RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules." Schulze H., Dose M., Korpal M., Meyer I., Italiano J.E. Jr., Shivdasani R.A. J. Biol. Chem. 283:14109-14119(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TUBB1.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365 AND SER-369, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365 AND SER-369, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-369, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY337313 mRNA. Translation: AAR01220.1. AB040897 mRNA. Translation: BAA95988.1. Different initiation. BC099917 mRNA. Translation: AAH99917.1. BC121176 mRNA. Translation: AAI21177.1. BC121177 mRNA. Translation: AAI21178.1.
IPI	IPI00039864.
RefSeq	NP_065901.1. NM_020850.1.
UniGene	Hs.368569.
3D structure databases
ProteinModelPortal	Q6VN20.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6VN20. 5 interactions.
STRING	9606.ENSP00000316589.
PTM databases
PhosphoSite	Q6VN20.
Polymorphism databases
DMDM	74710336.
Proteomic databases
PaxDb	Q6VN20.
PRIDE	Q6VN20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317506; ENSP00000316589; ENSG00000141084.
GeneID	57610.
KEGG	hsa:57610.
UCSC	uc002eud.3. human.
Organism-specific databases
CTD	57610.
GeneCards	GC16M067757.
H-InvDB	HIX0013157.
HGNC	HGNC:29285. RANBP10.
HPA	HPA045523.
MIM	614031. gene.
neXtProt	NX_Q6VN20.
PharmGKB	PA134929520.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316575.
HOGENOM	HOG000008133.
HOVERGEN	HBG053444.
InParanoid	Q6VN20.
OMA	PAVNQHE.
Enzyme and pathway databases
Pathway_Interaction_DB	met_pathway. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met).
Gene expression databases
ArrayExpress	Q6VN20.
Bgee	Q6VN20.
CleanEx	HS_RANBP10.
Genevestigator	Q6VN20.
Family and domain databases
InterPro	IPR001870. B30.2/SPRY. IPR008985. ConA-like_lec_gl_sf. IPR013144. CRA_dom. IPR024964. CTLH/CRA. IPR006595. CTLH_C. IPR006594. LisH_dimerisation. IPR013720. LisH_dimerisation_subgr. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. [Graphical view]
Pfam	PF10607. CLTH. 1 hit. PF08513. LisH. 1 hit. PF00622. SPRY. 1 hit. [Graphical view]
SMART	SM00757. CRA. 1 hit. SM00668. CTLH. 1 hit. SM00667. LisH. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50897. CTLH. 1 hit. PS50896. LISH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57610.
NextBio	64259.
SOURCE	Search...

Entry information

Entry name

RBP10_HUMAN

Accession

Primary (citable) accession number: Q6VN20
Secondary accession number(s): A4FTY2, Q9P264

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.