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Protein

Ran-binding protein 10

Gene

RANBP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.By similarity1 Publication

Enzyme and pathway databases

ReactomeiR-HSA-8851805 MET activates RAS signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 10
Short name:
RanBP10
Gene namesi
Name:RANBP10
Synonyms:KIAA1464
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000141084.10
HGNCiHGNC:29285 RANBP10
MIMi614031 gene
neXtProtiNX_Q6VN20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57610
OpenTargetsiENSG00000141084
PharmGKBiPA134929520

Polymorphism and mutation databases

BioMutaiRANBP10
DMDMi74710336

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003052372 – 620Ran-binding protein 10Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei362PhosphotyrosineBy similarity1
Modified residuei365PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1
Modified residuei369PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei451PhosphoserineBy similarity1
Modified residuei453PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6VN20
MaxQBiQ6VN20
PaxDbiQ6VN20
PeptideAtlasiQ6VN20
PRIDEiQ6VN20

PTM databases

iPTMnetiQ6VN20
PhosphoSitePlusiQ6VN20
SwissPalmiQ6VN20

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000141084
CleanExiHS_RANBP10
ExpressionAtlasiQ6VN20 baseline and differential
GenevisibleiQ6VN20 HS

Interactioni

Subunit structurei

May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. May interact with TUBB5 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121657, 63 interactors
IntActiQ6VN20, 28 interactors
MINTiQ6VN20
STRINGi9606.ENSP00000316589

Structurei

3D structure databases

ProteinModelPortaliQ6VN20
SMRiQ6VN20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 222B30.2/SPRYPROSITE-ProRule annotationAdd BLAST188
Domaini253 – 285LisHPROSITE-ProRule annotationAdd BLAST33
Domaini291 – 348CTLHPROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 453Ser-richAdd BLAST108

Domaini

The SPRY domain mediates the interaction with MET.By similarity

Sequence similaritiesi

Belongs to the RANBP9/10 family.Curated

Phylogenomic databases

eggNOGiKOG1477 Eukaryota
ENOG410XPCC LUCA
GeneTreeiENSGT00530000063160
HOGENOMiHOG000008133
HOVERGENiHBG053444
InParanoidiQ6VN20
PhylomeDBiQ6VN20
TreeFamiTF331658

Family and domain databases

CDDicd12909 SPRY_RanBP9_10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR003877 SPRY_dom
IPR035782 SPRY_RanBP9/10
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6VN20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATADPGA GNPQPGDSSG GGAGGGLPSP GEQELSRRLQ RLYPAVNQQE
60 70 80 90 100
TPLPRSWSPK DKYNYIGLSQ GNLRVHYKGH GKNHKDAASV RATHPIPAAC
110 120 130 140 150
GIYYFEVKIV SKGRDGYMGI GLSAQGVNMN RLPGWDKHSY GYHGDDGHSF
160 170 180 190 200
CSSGTGQPYG PTFTTGDVIG CCVNLINGTC FYTKNGHSLG IAFTDLPANL
210 220 230 240 250
YPTVGLQTPG EIVDANFGQQ PFLFDIEDYM REWRAKVQGT VHCFPISARL
260 270 280 290 300
GEWQAVLQNM VSSYLVHHGY CATATAFARM TETPIQEEQA SIKNRQKIQK
310 320 330 340 350
LVLEGRVGEA IETTQRFYPG LLEHNPNLLF MLKCRQFVEM VNGTDSEVRS
360 370 380 390 400
LSSRSPKSQD SYPGSPSLSP RHGPSSSHMH NTGADSPSCS NGVASTKSKQ
410 420 430 440 450
NHSKYPAPSS SSSSSSSSSS SSPSSVNYSE SNSTDSTKSQ HHSSTSNQET
460 470 480 490 500
SDSEMEMEAE HYPNGVLGSM STRIVNGAYK HEDLQTDESS MDDRHPRRQL
510 520 530 540 550
CGGNQAATER IILFGRELQA LSEQLGREYG KNLAHTEMLQ DAFSLLAYSD
560 570 580 590 600
PWSCPVGQQL DPIQREPVCA ALNSAILESQ NLPKQPPLML ALGQASECLR
610 620
LMARAGLGSC SFARVDDYLH
Length:620
Mass (Da):67,257
Last modified:July 5, 2004 - v1
Checksum:i66744ADBCB36D308
GO
Isoform 2 (identifier: Q6VN20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     450-450: T → TSNPWLQLERRPNQAAPTTPPGPTPTSTPPH

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):58,086
Checksum:i27F62F491CD5FC48
GO
Isoform 3 (identifier: Q6VN20-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-189: Missing.
     450-450: T → TSNPWLQLERRPNQAAPTTPPGPTPTSTPPH

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):64,542
Checksum:i38CB7523ECEFF09D
GO

Sequence cautioni

The sequence BAA95988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223L → P in AAH99917 (PubMed:15489334).Curated1
Sequence conflicti455M → V in AAH99917 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558391 – 117Missing in isoform 2. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_055840134 – 189Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_055841450T → TSNPWLQLERRPNQAAPTTP PGPTPTSTPPH in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY337313 mRNA Translation: AAR01220.1
AB040897 mRNA Translation: BAA95988.1 Different initiation.
AK295530 mRNA Translation: BAG58442.1
AK298806 mRNA Translation: BAG60941.1
AC010530 Genomic DNA No translation available.
AC040162 Genomic DNA No translation available.
BC099917 mRNA Translation: AAH99917.1
BC121176 mRNA Translation: AAI21177.1
BC121177 mRNA Translation: AAI21178.1
CCDSiCCDS32469.1 [Q6VN20-1]
CCDS81999.1 [Q6VN20-3]
RefSeqiNP_001307167.1, NM_001320238.1 [Q6VN20-2]
NP_001307168.1, NM_001320239.1 [Q6VN20-3]
NP_001307169.1, NM_001320240.1
NP_065901.1, NM_020850.2 [Q6VN20-1]
UniGeneiHs.368569

Genome annotation databases

EnsembliENST00000317506; ENSP00000316589; ENSG00000141084 [Q6VN20-1]
ENST00000448631; ENSP00000392808; ENSG00000141084 [Q6VN20-3]
GeneIDi57610
KEGGihsa:57610
UCSCiuc002eud.4 human [Q6VN20-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBP10_HUMAN
AccessioniPrimary (citable) accession number: Q6VN20
Secondary accession number(s): A4FTY2
, B4DID0, B4DQH9, E7EW27, Q9P264
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health