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Q6VMP0

- Q6VMP0_HUMAN

UniProt

Q6VMP0 - Q6VMP0_HUMAN

Protein
Submitted name:

Mutant PAX6 protein

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cell fate determination Source: Ensembl
    4. cerebral cortex regionalization Source: Ensembl
    5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
    6. dorsal/ventral axis specification Source: Ensembl
    7. embryonic camera-type eye morphogenesis Source: Ensembl
    8. eye photoreceptor cell development Source: Ensembl
    9. forebrain anterior/posterior pattern specification Source: Ensembl
    10. forebrain dorsal/ventral pattern formation Source: Ensembl
    11. forebrain-midbrain boundary formation Source: Ensembl
    12. hindbrain development Source: Ensembl
    13. keratinocyte differentiation Source: Ensembl
    14. lacrimal gland development Source: Ensembl
    15. lens development in camera-type eye Source: Ensembl
    16. negative regulation of epithelial cell proliferation Source: Ensembl
    17. negative regulation of neuron differentiation Source: Ensembl
    18. neuron migration Source: Ensembl
    19. oligodendrocyte cell fate specification Source: Ensembl
    20. pancreatic A cell development Source: Ensembl
    21. pituitary gland development Source: Ensembl
    22. positive regulation of cell fate specification Source: Ensembl
    23. positive regulation of epithelial cell differentiation Source: Ensembl
    24. positive regulation of neuroblast proliferation Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. protein localization to organelle Source: Ensembl
    27. regulation of cell migration Source: Ensembl
    28. regulation of timing of cell differentiation Source: Ensembl
    29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
    30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
    31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
    32. salivary gland morphogenesis Source: Ensembl
    33. signal transduction involved in regulation of gene expression Source: Ensembl
    34. smoothened signaling pathway Source: Ensembl
    35. type B pancreatic cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mutant PAX6 proteinImported
    Gene namesi
    Name:PAX6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6VMP0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6VMP0.
    BgeeiQ6VMP0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6VMP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 paired domain.UniRule annotation

    Keywords - Domaini

    Paired boxUniRule annotation

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6VMP0-1 [UniParc]FASTAAdd to Basket

    « Hide

    HSGVNQLGGV FVNGRPLPDS TRQKIVELAH SGARP                   35
    Length:35
    Mass (Da):3,695
    Last modified:July 5, 2004 - v1
    Checksum:i15F1A90B672AA480
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY337852 Genomic DNA. Translation: AAR10412.1.
    UniGeneiHs.270303.
    Hs.611376.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY337852 Genomic DNA. Translation: AAR10412.1 .
    UniGenei Hs.270303.
    Hs.611376.

    3D structure databases

    ProteinModelPortali Q6VMP0.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6VMP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q6VMP0.
    Bgeei Q6VMP0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6VMP0_HUMAN
    AccessioniPrimary (citable) accession number: Q6VMP0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.