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Protein

Prolactin-releasing peptide receptor

Gene

Prlhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • neuropeptide Y receptor activity Source: InterPro

GO - Biological processi

  • feeding behavior Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • hormone metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-releasing peptide receptor
Short name:
PrRP receptor
Short name:
PrRPR
Alternative name(s):
G-protein coupled receptor 10
Gene namesi
Name:Prlhr
Synonyms:Gm339, Gpr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2135956. Prlhr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262ExtracellularSequence analysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini84 – 10118CytoplasmicSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini123 – 1264ExtracellularSequence analysis
Transmembranei127 – 14721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini148 – 17528CytoplasmicSequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini197 – 22327ExtracellularSequence analysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini245 – 27632CytoplasmicSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini298 – 31720ExtracellularSequence analysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini339 – 37032CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased nociceptive thresholds, increased stress-induced analgesia and reduced morphine tolerance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Prolactin-releasing peptide receptorPRO_0000069525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 211PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6VMN6.
PRIDEiQ6VMN6.

PTM databases

iPTMnetiQ6VMN6.
PhosphoSiteiQ6VMN6.

Expressioni

Gene expression databases

CleanExiMM_PRLHR.

Interactioni

Subunit structurei

Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063114.

Structurei

3D structure databases

ProteinModelPortaliQ6VMN6.
SMRiQ6VMN6. Positions 62-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni365 – 3706Required for interaction with GRIP1, GRIP2 and PICK1By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG101109.
InParanoidiQ6VMN6.
KOiK04314.
OMAiFIYAWLH.
OrthoDBiEOG75B85N.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001402. Prolrel_pep_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01018. PRPRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6VMN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLSTETTG DPDLSSGLLP ASSTPANQSA EASEGNLSAT VPRAAAVTPF
60 70 80 90 100
QSLQLVHQLK GLIVMLYSIV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG
110 120 130 140 150
NLALSDVLMC AACVPLTLAY AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF
160 170 180 190 200
TLTTIALDRY VVLVHPLRRR ISLRLSAYAV LGIWALSAVL ALPAAVHTYH
210 220 230 240 250
VELKPHDVSL CEEFWGSQER QRQIYAWGLL LGTYLLPLLA ILLSYVRVSV
260 270 280 290 300
KLRNRVVPGS VTQSQADWDR ARRRRTFCLL VVVVVVFAVC WLPLHIFNLL
310 320 330 340 350
RDLDPRAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKML
360 370
LSWPRKIVPH GQNMTVSVVI
Length:370
Mass (Da):41,182
Last modified:July 27, 2011 - v2
Checksum:i83341A7F96D09C39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091S → R in AAQ84215 (PubMed:14742914).Curated
Sequence conflicti209 – 2091S → R in AAI25650 (PubMed:15489334).Curated
Sequence conflicti209 – 2091S → R in AAI25652 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338238 mRNA. Translation: AAQ84215.1.
AC167713 Genomic DNA. No translation available.
AC170185 Genomic DNA. No translation available.
BC125649 mRNA. Translation: AAI25650.1.
BC125651 mRNA. Translation: AAI25652.1.
CCDSiCCDS29940.1.
RefSeqiNP_963909.2. NM_201615.2.
XP_006527120.1. XM_006527057.2.
UniGeneiMm.377241.

Genome annotation databases

EnsembliENSMUST00000051277; ENSMUSP00000063114; ENSMUSG00000045052.
GeneIDi226278.
KEGGimmu:226278.
UCSCiuc008ibu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338238 mRNA. Translation: AAQ84215.1.
AC167713 Genomic DNA. No translation available.
AC170185 Genomic DNA. No translation available.
BC125649 mRNA. Translation: AAI25650.1.
BC125651 mRNA. Translation: AAI25652.1.
CCDSiCCDS29940.1.
RefSeqiNP_963909.2. NM_201615.2.
XP_006527120.1. XM_006527057.2.
UniGeneiMm.377241.

3D structure databases

ProteinModelPortaliQ6VMN6.
SMRiQ6VMN6. Positions 62-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063114.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6VMN6.
PhosphoSiteiQ6VMN6.

Proteomic databases

PaxDbiQ6VMN6.
PRIDEiQ6VMN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051277; ENSMUSP00000063114; ENSMUSG00000045052.
GeneIDi226278.
KEGGimmu:226278.
UCSCiuc008ibu.2. mouse.

Organism-specific databases

CTDi2834.
MGIiMGI:2135956. Prlhr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG101109.
InParanoidiQ6VMN6.
KOiK04314.
OMAiFIYAWLH.
OrthoDBiEOG75B85N.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.

Miscellaneous databases

PROiQ6VMN6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PRLHR.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001402. Prolrel_pep_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01018. PRPRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice."
    Gu W., Geddes B.J., Zhang C., Foley K.P., Stricker-Krongrad A.
    J. Mol. Neurosci. 22:93-103(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10."
    Laurent P., Becker J.A.J., Valverde O., Ledent C., de Kerchove d'Exaerde A., Schiffmann S.N., Maldonado R., Vassart G., Parmentier M.
    Nat. Neurosci. 8:1735-1741(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPRLHR_MOUSE
AccessioniPrimary (citable) accession number: Q6VMN6
Secondary accession number(s): E9QJU3, Q059H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.