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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Leucoagaricus gongylophorus (Leaf-cutting ant fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi543 – 5431Zinc; catalyticPROSITE-ProRule annotation
Active sitei544 – 5441PROSITE-ProRule annotation
Metal bindingi547 – 5471Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiLeucoagaricus gongylophorus (Leaf-cutting ant fungus)
Taxonomic identifieri79220 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeLeucoagaricus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
BLAST
Chaini20 – 760741Mitochondrial intermediate peptidasePRO_0000343202Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6VMB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6VMB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARSVRTLV VSPKTVFRFR GCLFEKHVST ASADDRAIVS LFDSPHAAFK
60 70 80 90 100
YPSTISTGLF GHSQLSHPNA FISLAEATLV RAQLLTDRIL RARSSRDELL
110 120 130 140 150
KVVKNLDRLS DMLCSVIDLA ELIRNAHPDR NWATAGHHVY EQLCEFMNVL
160 170 180 190 200
NTHVGLYEVL KLVLADASIV KTLSPEAYQT ALIFWRDFEK SAINLPPEER
210 220 230 240 250
QKFVSLSSDI LVLGREFLEN ANAPRPPASI KPEHMVGIKD KGLGVRLQLQ
260 270 280 290 300
AQFTRRDLLV YPGSLQAQMI MRSAPDEEPR RRMYIAANSS TDQQIXTLER
310 320 330 340 350
LLKTRAELAR LVGRSSFAHM TLDDKMAKTP ENVMNFLGAL IGQTRPFARR
360 370 380 390 400
ALKTLSARKQ AHHGLSSLPT IQAWDRDFYC PPEPPAPPIP LPPLTLGTIF
410 420 430 440 450
MGLSRLFKYL YGITLRPTEA QTGEVWHSDV HKLEVIDEDK GLIGWIYADL
460 470 480 490 500
FARHGKSSGA AHYTVRCSRR TDLDDDLGDG GLTGHEELIQ QNLEFEKVKR
510 520 530 540 550
HKIPNQDGVY QLPLVVLLCE FTRPSVLKGA TVLEWHDVMT LFHEMGHAML
560 570 580 590 600
AMVGRTEYQN VSGTRCATDF VELPSILMEH FLSSPVVLSL FDLDGTHSLR
610 620 630 640 650
QVGNTHEDPC HSIDTFSQII LASLDQIYHS PAVLDNSTFS TTDELENLTV
660 670 680 690 700
SKGVIPHVPS TSFQTQFGHL FGYGATYYSY LFDRAIASRV WKKVFEKDPL
710 720 730 740 750
KREVGEKYKL EVLRWGGGRD PWKMVSKLLD ASELEKGDAE AMREVGRWRI
760
EDEVGLPGRH
Length:760
Mass (Da):85,580
Last modified:July 5, 2004 - v1
Checksum:i66EDF1623874E4A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338827 Genomic DNA. Translation: AAR22310.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338827 Genomic DNA. Translation: AAR22310.1.

3D structure databases

ProteinModelPortaliQ6VMB4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SAR 000701-1.

Entry informationi

Entry nameiPMIP_LEUGO
AccessioniPrimary (citable) accession number: Q6VMB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.