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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Leucoagaricus gongylophorus (Leaf-cutting ant fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi543Zinc; catalyticPROSITE-ProRule annotation1
Active sitei544PROSITE-ProRule annotation1
Metal bindingi547Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiLeucoagaricus gongylophorus (Leaf-cutting ant fungus)
Taxonomic identifieri79220 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeLeucoagaricus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000034320220 – 760Mitochondrial intermediate peptidaseAdd BLAST741

Structurei

3D structure databases

ProteinModelPortaliQ6VMB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

CDDicd06457. M3A_MIP. 1 hit.
Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR033851. M3A_MIP.
IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PANTHERiPTHR11804:SF5. PTHR11804:SF5. 2 hits.
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6VMB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARSVRTLV VSPKTVFRFR GCLFEKHVST ASADDRAIVS LFDSPHAAFK
60 70 80 90 100
YPSTISTGLF GHSQLSHPNA FISLAEATLV RAQLLTDRIL RARSSRDELL
110 120 130 140 150
KVVKNLDRLS DMLCSVIDLA ELIRNAHPDR NWATAGHHVY EQLCEFMNVL
160 170 180 190 200
NTHVGLYEVL KLVLADASIV KTLSPEAYQT ALIFWRDFEK SAINLPPEER
210 220 230 240 250
QKFVSLSSDI LVLGREFLEN ANAPRPPASI KPEHMVGIKD KGLGVRLQLQ
260 270 280 290 300
AQFTRRDLLV YPGSLQAQMI MRSAPDEEPR RRMYIAANSS TDQQIXTLER
310 320 330 340 350
LLKTRAELAR LVGRSSFAHM TLDDKMAKTP ENVMNFLGAL IGQTRPFARR
360 370 380 390 400
ALKTLSARKQ AHHGLSSLPT IQAWDRDFYC PPEPPAPPIP LPPLTLGTIF
410 420 430 440 450
MGLSRLFKYL YGITLRPTEA QTGEVWHSDV HKLEVIDEDK GLIGWIYADL
460 470 480 490 500
FARHGKSSGA AHYTVRCSRR TDLDDDLGDG GLTGHEELIQ QNLEFEKVKR
510 520 530 540 550
HKIPNQDGVY QLPLVVLLCE FTRPSVLKGA TVLEWHDVMT LFHEMGHAML
560 570 580 590 600
AMVGRTEYQN VSGTRCATDF VELPSILMEH FLSSPVVLSL FDLDGTHSLR
610 620 630 640 650
QVGNTHEDPC HSIDTFSQII LASLDQIYHS PAVLDNSTFS TTDELENLTV
660 670 680 690 700
SKGVIPHVPS TSFQTQFGHL FGYGATYYSY LFDRAIASRV WKKVFEKDPL
710 720 730 740 750
KREVGEKYKL EVLRWGGGRD PWKMVSKLLD ASELEKGDAE AMREVGRWRI
760
EDEVGLPGRH
Length:760
Mass (Da):85,580
Last modified:July 5, 2004 - v1
Checksum:i66EDF1623874E4A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338827 Genomic DNA. Translation: AAR22310.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY338827 Genomic DNA. Translation: AAR22310.1.

3D structure databases

ProteinModelPortaliQ6VMB4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM03.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd06457. M3A_MIP. 1 hit.
Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR033851. M3A_MIP.
IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PANTHERiPTHR11804:SF5. PTHR11804:SF5. 2 hits.
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMIP_LEUGO
AccessioniPrimary (citable) accession number: Q6VMB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.