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Q6VMB4

- PMIP_LEUGO

UniProt

Q6VMB4 - PMIP_LEUGO

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Leucoagaricus gongylophorus (Leaf-cutting ant fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi543 – 5431Zinc; catalyticPROSITE-ProRule annotation
    Active sitei544 – 5441PROSITE-ProRule annotation
    Metal bindingi547 – 5471Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Synonyms:MIP
    OrganismiLeucoagaricus gongylophorus (Leaf-cutting ant fungus)
    Taxonomic identifieri79220 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeLeucoagaricus

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
    BLAST
    Chaini20 – 760741Mitochondrial intermediate peptidasePRO_0000343202Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6VMB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6VMB4-1 [UniParc]FASTAAdd to Basket

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    MLARSVRTLV VSPKTVFRFR GCLFEKHVST ASADDRAIVS LFDSPHAAFK    50
    YPSTISTGLF GHSQLSHPNA FISLAEATLV RAQLLTDRIL RARSSRDELL 100
    KVVKNLDRLS DMLCSVIDLA ELIRNAHPDR NWATAGHHVY EQLCEFMNVL 150
    NTHVGLYEVL KLVLADASIV KTLSPEAYQT ALIFWRDFEK SAINLPPEER 200
    QKFVSLSSDI LVLGREFLEN ANAPRPPASI KPEHMVGIKD KGLGVRLQLQ 250
    AQFTRRDLLV YPGSLQAQMI MRSAPDEEPR RRMYIAANSS TDQQIXTLER 300
    LLKTRAELAR LVGRSSFAHM TLDDKMAKTP ENVMNFLGAL IGQTRPFARR 350
    ALKTLSARKQ AHHGLSSLPT IQAWDRDFYC PPEPPAPPIP LPPLTLGTIF 400
    MGLSRLFKYL YGITLRPTEA QTGEVWHSDV HKLEVIDEDK GLIGWIYADL 450
    FARHGKSSGA AHYTVRCSRR TDLDDDLGDG GLTGHEELIQ QNLEFEKVKR 500
    HKIPNQDGVY QLPLVVLLCE FTRPSVLKGA TVLEWHDVMT LFHEMGHAML 550
    AMVGRTEYQN VSGTRCATDF VELPSILMEH FLSSPVVLSL FDLDGTHSLR 600
    QVGNTHEDPC HSIDTFSQII LASLDQIYHS PAVLDNSTFS TTDELENLTV 650
    SKGVIPHVPS TSFQTQFGHL FGYGATYYSY LFDRAIASRV WKKVFEKDPL 700
    KREVGEKYKL EVLRWGGGRD PWKMVSKLLD ASELEKGDAE AMREVGRWRI 750
    EDEVGLPGRH 760
    Length:760
    Mass (Da):85,580
    Last modified:July 5, 2004 - v1
    Checksum:i66EDF1623874E4A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY338827 Genomic DNA. Translation: AAR22310.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY338827 Genomic DNA. Translation: AAR22310.1 .

    3D structure databases

    ProteinModelPortali Q6VMB4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
      James T.Y., Kuees U., Rehner S.A., Vilgalys R.
      Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SAR 000701-1.

    Entry informationi

    Entry nameiPMIP_LEUGO
    AccessioniPrimary (citable) accession number: Q6VMB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3