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Q6VMB4

- PMIP_LEUGO

UniProt

Q6VMB4 - PMIP_LEUGO

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, MIP
Organism
Leucoagaricus gongylophorus (Leaf-cutting ant fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi543 – 5431Zinc; catalytic By similarity
Active sitei544 – 5441 By similarity
Metal bindingi547 – 5471Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MIP
OrganismiLeucoagaricus gongylophorus (Leaf-cutting ant fungus)
Taxonomic identifieri79220 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeLeucoagaricus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1919Mitochondrion Reviewed prediction
Add
BLAST
Chaini20 – 760741Mitochondrial intermediate peptidase
PRO_0000343202Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6VMB4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6VMB4-1 [UniParc]FASTAAdd to Basket

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MLARSVRTLV VSPKTVFRFR GCLFEKHVST ASADDRAIVS LFDSPHAAFK    50
YPSTISTGLF GHSQLSHPNA FISLAEATLV RAQLLTDRIL RARSSRDELL 100
KVVKNLDRLS DMLCSVIDLA ELIRNAHPDR NWATAGHHVY EQLCEFMNVL 150
NTHVGLYEVL KLVLADASIV KTLSPEAYQT ALIFWRDFEK SAINLPPEER 200
QKFVSLSSDI LVLGREFLEN ANAPRPPASI KPEHMVGIKD KGLGVRLQLQ 250
AQFTRRDLLV YPGSLQAQMI MRSAPDEEPR RRMYIAANSS TDQQIXTLER 300
LLKTRAELAR LVGRSSFAHM TLDDKMAKTP ENVMNFLGAL IGQTRPFARR 350
ALKTLSARKQ AHHGLSSLPT IQAWDRDFYC PPEPPAPPIP LPPLTLGTIF 400
MGLSRLFKYL YGITLRPTEA QTGEVWHSDV HKLEVIDEDK GLIGWIYADL 450
FARHGKSSGA AHYTVRCSRR TDLDDDLGDG GLTGHEELIQ QNLEFEKVKR 500
HKIPNQDGVY QLPLVVLLCE FTRPSVLKGA TVLEWHDVMT LFHEMGHAML 550
AMVGRTEYQN VSGTRCATDF VELPSILMEH FLSSPVVLSL FDLDGTHSLR 600
QVGNTHEDPC HSIDTFSQII LASLDQIYHS PAVLDNSTFS TTDELENLTV 650
SKGVIPHVPS TSFQTQFGHL FGYGATYYSY LFDRAIASRV WKKVFEKDPL 700
KREVGEKYKL EVLRWGGGRD PWKMVSKLLD ASELEKGDAE AMREVGRWRI 750
EDEVGLPGRH 760
Length:760
Mass (Da):85,580
Last modified:July 5, 2004 - v1
Checksum:i66EDF1623874E4A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY338827 Genomic DNA. Translation: AAR22310.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY338827 Genomic DNA. Translation: AAR22310.1 .

3D structure databases

ProteinModelPortali Q6VMB4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the gene encoding mitochondrial intermediate peptidase and its cosegregation with the A mating-type locus of mushroom fungi."
    James T.Y., Kuees U., Rehner S.A., Vilgalys R.
    Fungal Genet. Biol. 41:381-390(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SAR 000701-1.

Entry informationi

Entry nameiPMIP_LEUGO
AccessioniPrimary (citable) accession number: Q6VMB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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