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Protein

RNA-binding protein NOB1

Gene

Nob1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in mRNA degradation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi268 – 2681ZincBy similarity
Metal bindingi271 – 2711ZincBy similarity
Metal bindingi283 – 2831ZincBy similarity
Metal bindingi286 – 2861ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein NOB1
Gene namesi
Name:Nob1
Synonyms:Nob1p
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi735222. Nob1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 410409RNA-binding protein NOB1PRO_0000233269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991PhosphoserineBy similarity
Modified residuei323 – 3231PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6VEU1.
PRIDEiQ6VEU1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021890.
GenevisibleiQ6VEU1. RN.

Interactioni

Subunit structurei

May interact with UPF2.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031905.

Structurei

3D structure databases

ProteinModelPortaliQ6VEU1.
SMRiQ6VEU1. Positions 258-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 108104PINcAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 19717Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the NOB1 family.Curated
Contains 1 PINc domain.Curated

Phylogenomic databases

eggNOGiKOG2463. Eukaryota.
COG1439. LUCA.
GeneTreeiENSGT00390000015857.
HOGENOMiHOG000159692.
HOVERGENiHBG057385.
InParanoidiQ6VEU1.
KOiK11883.
OMAiLHINWNR.
OrthoDBiEOG091G0C8H.
PhylomeDBiQ6VEU1.
TreeFamiTF105838.

Family and domain databases

InterProiIPR014881. NOB1_Zn-bd.
IPR002716. PIN_dom.
IPR033411. Ribonuclease_PIN.
IPR033461. WRNPLPNID.
[Graphical view]
PfamiPF08772. NOB1_Zn_bind. 1 hit.
PF17146. PIN_6. 1 hit.
PF15017. WRNPLPNID. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF144206. SSF144206. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6VEU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVEHVVAD AGAFLRDAPL QDIGKNIYTI REVVREIRDK ATRRRLAVLP
60 70 80 90 100
YELRFKEPFP EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV
110 120 130 140 150
SHLKKEPEKV KVSSSIQHPE TPLHISGFHL PSKSKALQET VDHGPPADGS
160 170 180 190 200
ENLEFSSFMF WRNPLPNIDH ELQQLLIDGR EEEEEEEEEE EEEDELEDSD
210 220 230 240 250
DDGGGWITPS NIKQIQHESE QCDIPKDVQV GCVTTDFAMQ NVLLQMGLHV
260 270 280 290 300
LAVNGMLVRE ARSYILRCHG CFKTTSDMNR VFCGHCGNKT LKKVSVTIND
310 320 330 340 350
DGTLHMHFSR NPKVLNPRGL RYSLPTPKGG KYAVNPHLTE DQRFPQLRLS
360 370 380 390 400
HKARQKTNVF APDYIAGVSP FAENDISSRS AILQVRDSML GAGRRRLNPN
410
ASRKKFVKKR
Length:410
Mass (Da):46,425
Last modified:July 5, 2004 - v1
Checksum:i9F7F843A52310F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341886 mRNA. Translation: AAQ24170.1.
BC126076 mRNA. Translation: AAI26077.1.
RefSeqiNP_954517.1. NM_199086.1.
UniGeneiRn.102586.

Genome annotation databases

EnsembliENSRNOT00000034386; ENSRNOP00000031905; ENSRNOG00000021890.
GeneIDi291996.
KEGGirno:291996.
UCSCiRGD:735222. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341886 mRNA. Translation: AAQ24170.1.
BC126076 mRNA. Translation: AAI26077.1.
RefSeqiNP_954517.1. NM_199086.1.
UniGeneiRn.102586.

3D structure databases

ProteinModelPortaliQ6VEU1.
SMRiQ6VEU1. Positions 258-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031905.

Proteomic databases

PaxDbiQ6VEU1.
PRIDEiQ6VEU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034386; ENSRNOP00000031905; ENSRNOG00000021890.
GeneIDi291996.
KEGGirno:291996.
UCSCiRGD:735222. rat.

Organism-specific databases

CTDi28987.
RGDi735222. Nob1.

Phylogenomic databases

eggNOGiKOG2463. Eukaryota.
COG1439. LUCA.
GeneTreeiENSGT00390000015857.
HOGENOMiHOG000159692.
HOVERGENiHBG057385.
InParanoidiQ6VEU1.
KOiK11883.
OMAiLHINWNR.
OrthoDBiEOG091G0C8H.
PhylomeDBiQ6VEU1.
TreeFamiTF105838.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ6VEU1.

Gene expression databases

BgeeiENSRNOG00000021890.
GenevisibleiQ6VEU1. RN.

Family and domain databases

InterProiIPR014881. NOB1_Zn-bd.
IPR002716. PIN_dom.
IPR033411. Ribonuclease_PIN.
IPR033461. WRNPLPNID.
[Graphical view]
PfamiPF08772. NOB1_Zn_bind. 1 hit.
PF17146. PIN_6. 1 hit.
PF15017. WRNPLPNID. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF144206. SSF144206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOB1_RAT
AccessioniPrimary (citable) accession number: Q6VEU1
Secondary accession number(s): A0JN09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.