Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6VEQ5

- WASH2_HUMAN

UniProt

Q6VEQ5 - WASH2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

WAS protein family homolog 2

Gene

WASH2P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.By similarity

GO - Molecular functioni

  1. alpha-tubulin binding Source: UniProtKB

GO - Biological processi

  1. Arp2/3 complex-mediated actin nucleation Source: UniProtKB
  2. endosomal transport Source: UniProtKB
  3. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WAS protein family homolog 2
Alternative name(s):
CXYorf1-like protein on chromosome 2
Protein FAM39B
Gene namesi
Name:WASH2P
Synonyms:FAM39B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:33145. WASH2P.

Subcellular locationi

Early endosome membrane By similarity. Recycling endosome membrane By similarity
Note: Localization to the endodome membrane is mediated via its interaction with FAM21.By similarity

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. membrane Source: UniProtKB-KW
  3. recycling endosome Source: UniProtKB
  4. WASH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465WAS protein family homolog 2PRO_0000257971Add
BLAST

Proteomic databases

PaxDbiQ6VEQ5.
PRIDEiQ6VEQ5.

Expressioni

Gene expression databases

GenevestigatoriQ6VEQ5.

Organism-specific databases

HPAiHPA002689.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6VEQ5. 4 interactions.
MINTiMINT-7008897.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini361 – 38323WH2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 167167WHD1Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi268 – 33063Pro-richAdd
BLAST
Compositional biasi340 – 3478Poly-Ser

Sequence similaritiesi

Belongs to the WASH1 family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG86663.
HOGENOMiHOG000007381.
HOVERGENiHBG066686.
InParanoidiQ6VEQ5.
PhylomeDBiQ6VEQ5.

Family and domain databases

InterProiIPR028290. WASH1.
IPR021854. WASH1_WAHD.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR23331. PTHR23331. 1 hit.
PfamiPF11945. WASH_WAHD. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6VEQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPVRMQHSL AGQTYAVPLI QPDLRREEAV QQMADALQYL QKVSGDIFSR
60 70 80 90 100
ISQQVEQSRS QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPERL
110 120 130 140 150
QEYGSIFTGA QDPGLQRRPR HRIQSKHRPL DERALQEKLK DFPVCVSTKP
160 170 180 190 200
EPEDDAEEGL GGLPSNISSV SSLLLFNTTE NLYKKYVFLD PLAGAVTKTH
210 220 230 240 250
VMLGAETEEK LFDAPLSISK REQLEQQVPE NYFYVPDLGQ VPEIDVPSYL
260 270 280 290 300
PDLPGIANDL MYIADLGPGI APSAPGTIPE LPTFHTEVAE PLKVDLQDGV
310 320 330 340 350
LTPPPPPPPP PPAPEVLASA PPLPPSTAAP VGQGARQDDS SSSASPSVQG
360 370 380 390 400
APREVVDPSG GRATLLESIR QAGGIGKAKL RSMKERKLEK KKQKEQEQVR
410 420 430 440 450
ATSQGGHLMS DLFNKLVMRR KGISGKGPGA GEGPGGAFAR VSDSIPPLPP
460
PQQPQAEEDE DDWES
Length:465
Mass (Da):50,312
Last modified:January 19, 2010 - v2
Checksum:i54FD1BB405E391DF
GO

Sequence cautioni

The sequence AL078621 differs from that shown. Reason: Erroneous termination at position 25. Translated as Arg.Curated
The sequence AL078621 differs from that shown. Reason: Erroneous termination at position 180. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078621 Genomic DNA. No translation available.
AY341936 mRNA. Translation: AAQ76875.1.
UniGeneiHs.446466.
Hs.459573.
Hs.709408.

Genome annotation databases

UCSCiuc002tkh.3. human.

Polymorphism databases

DMDMi284018148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078621 Genomic DNA. No translation available.
AY341936 mRNA. Translation: AAQ76875.1 .
UniGenei Hs.446466.
Hs.459573.
Hs.709408.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6VEQ5. 4 interactions.
MINTi MINT-7008897.

Polymorphism databases

DMDMi 284018148.

Proteomic databases

PaxDbi Q6VEQ5.
PRIDEi Q6VEQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc002tkh.3. human.

Organism-specific databases

GeneCardsi GC02P114341.
H-InvDB HIX0000004.
HIX0023492.
HIX0094926.
HIX0195874.
HGNCi HGNC:33145. WASH2P.
HPAi HPA002689.
neXtProti NX_Q6VEQ5.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86663.
HOGENOMi HOG000007381.
HOVERGENi HBG066686.
InParanoidi Q6VEQ5.
PhylomeDBi Q6VEQ5.

Miscellaneous databases

PROi Q6VEQ5.

Gene expression databases

Genevestigatori Q6VEQ5.

Family and domain databases

InterProi IPR028290. WASH1.
IPR021854. WASH1_WAHD.
IPR003124. WH2_dom.
[Graphical view ]
PANTHERi PTHR23331. PTHR23331. 1 hit.
Pfami PF11945. WASH_WAHD. 1 hit.
[Graphical view ]
PROSITEi PS51082. WH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Diverse fates of paralogs following segmental duplication of telomeric genes."
    Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
    Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-465, GENE DUPLICATION.
  3. Cited for: GENE DUPLICATION.
  4. "Human subtelomeric WASH genes encode a new subclass of the WASP family."
    Linardopoulou E.V., Parghi S.S., Friedman C., Osborn G.E., Parkhurst S.M., Trask B.J.
    PLoS Genet. 3:E237-E237(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE DUPLICATION.

Entry informationi

Entry nameiWASH2_HUMAN
AccessioniPrimary (citable) accession number: Q6VEQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 19, 2010
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3