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Q6VEQ5 (WASH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WAS protein family homolog 2
Alternative name(s):
CXYorf1-like protein on chromosome 2
Protein FAM39B
Gene names
Name:WASH2P
Synonyms:FAM39B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting By similarity.

Subunit structure

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct By similarity.

Subcellular location

Early endosome membrane By similarity. Recycling endosome membrane By similarity. Note: Localization to the endodome membrane is mediated via its interaction with FAM21 By similarity.

Miscellaneous

WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (Ref.4). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene.

Sequence similarities

Belongs to the WASH1 family.

Contains 1 WH2 domain.

Sequence caution

The sequence AL078621 differs from that shown. Reason: Erroneous termination at position 25. Translated as Arg.

The sequence AL078621 differs from that shown. Reason: Erroneous termination at position 180. Translated as Glu.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465WAS protein family homolog 2
PRO_0000257971

Regions

Domain361 – 38323WH2
Region1 – 167167WHD1
Compositional bias268 – 33063Pro-rich
Compositional bias340 – 3478Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q6VEQ5 [UniParc].

Last modified January 19, 2010. Version 2.
Checksum: 54FD1BB405E391DF

FASTA46550,312
        10         20         30         40         50         60 
MTPVRMQHSL AGQTYAVPLI QPDLRREEAV QQMADALQYL QKVSGDIFSR ISQQVEQSRS 

        70         80         90        100        110        120 
QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPERL QEYGSIFTGA QDPGLQRRPR 

       130        140        150        160        170        180 
HRIQSKHRPL DERALQEKLK DFPVCVSTKP EPEDDAEEGL GGLPSNISSV SSLLLFNTTE 

       190        200        210        220        230        240 
NLYKKYVFLD PLAGAVTKTH VMLGAETEEK LFDAPLSISK REQLEQQVPE NYFYVPDLGQ 

       250        260        270        280        290        300 
VPEIDVPSYL PDLPGIANDL MYIADLGPGI APSAPGTIPE LPTFHTEVAE PLKVDLQDGV 

       310        320        330        340        350        360 
LTPPPPPPPP PPAPEVLASA PPLPPSTAAP VGQGARQDDS SSSASPSVQG APREVVDPSG 

       370        380        390        400        410        420 
GRATLLESIR QAGGIGKAKL RSMKERKLEK KKQKEQEQVR ATSQGGHLMS DLFNKLVMRR 

       430        440        450        460 
KGISGKGPGA GEGPGGAFAR VSDSIPPLPP PQQPQAEEDE DDWES 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Diverse fates of paralogs following segmental duplication of telomeric genes."
Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-465, GENE DUPLICATION.
[3]"Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region."
Ciccodicola A., D'Esposito M., Esposito T., Gianfrancesco F., Migliaccio C., Miano M.G., Matarazzo M.R., Vacca M., Franze A., Cuccurese M., Cocchia M., Curci A., Terracciano A., Torino A., Cocchia S., Mercadante G., Pannone E., Archidiacono N. expand/collapse author list , Rocchi M., Schlessinger D., D'Urso M.
Hum. Mol. Genet. 9:395-401(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE DUPLICATION.
[4]"Human subtelomeric WASH genes encode a new subclass of the WASP family."
Linardopoulou E.V., Parghi S.S., Friedman C., Osborn G.E., Parkhurst S.M., Trask B.J.
PLoS Genet. 3:E237-E237(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE DUPLICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL078621 Genomic DNA. No translation available.
AY341936 mRNA. Translation: AAQ76875.1.
UniGeneHs.446466.
Hs.459573.
Hs.709408.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6VEQ5. 4 interactions.
MINTMINT-7008897.

Polymorphism databases

DMDM284018148.

Proteomic databases

PaxDbQ6VEQ5.
PRIDEQ6VEQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc002tkh.3. human.

Organism-specific databases

GeneCardsGC02P114341.
H-InvDBHIX0000004.
HIX0023492.
HIX0094926.
HIX0195874.
HGNCHGNC:33145. WASH2P.
HPAHPA002689.
neXtProtNX_Q6VEQ5.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86663.
HOGENOMHOG000007381.
HOVERGENHBG066686.
InParanoidQ6VEQ5.
PhylomeDBQ6VEQ5.

Gene expression databases

GenevestigatorQ6VEQ5.

Family and domain databases

InterProIPR028290. WASH1.
IPR021854. WASH1_WAHD.
IPR003124. WH2_dom.
[Graphical view]
PANTHERPTHR23331. PTHR23331. 1 hit.
PfamPF11945. WASH_WAHD. 1 hit.
[Graphical view]
PROSITEPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ6VEQ5.

Entry information

Entry nameWASH2_HUMAN
AccessionPrimary (citable) accession number: Q6VEQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM