Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6VEQ5

- WASH2_HUMAN

UniProt

Q6VEQ5 - WASH2_HUMAN

Protein

WAS protein family homolog 2

Gene

WASH2P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (19 Jan 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.By similarity

    GO - Molecular functioni

    1. alpha-tubulin binding Source: UniProtKB

    GO - Biological processi

    1. Arp2/3 complex-mediated actin nucleation Source: UniProtKB
    2. endosomal transport Source: UniProtKB
    3. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WAS protein family homolog 2
    Alternative name(s):
    CXYorf1-like protein on chromosome 2
    Protein FAM39B
    Gene namesi
    Name:WASH2P
    Synonyms:FAM39B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:33145. WASH2P.

    Subcellular locationi

    Early endosome membrane By similarity. Recycling endosome membrane By similarity
    Note: Localization to the endodome membrane is mediated via its interaction with FAM21.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. early endosome membrane Source: UniProtKB-SubCell
    3. recycling endosome Source: UniProtKB
    4. recycling endosome membrane Source: UniProtKB-SubCell
    5. WASH complex Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465WAS protein family homolog 2PRO_0000257971Add
    BLAST

    Proteomic databases

    PaxDbiQ6VEQ5.
    PRIDEiQ6VEQ5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6VEQ5.

    Organism-specific databases

    HPAiHPA002689.

    Interactioni

    Subunit structurei

    Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via WHD1 region) with FAM21C; the interaction is direct By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ6VEQ5. 4 interactions.
    MINTiMINT-7008897.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini361 – 38323WH2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 167167WHD1Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi268 – 33063Pro-richAdd
    BLAST
    Compositional biasi340 – 3478Poly-Ser

    Sequence similaritiesi

    Belongs to the WASH1 family.Curated
    Contains 1 WH2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG86663.
    HOGENOMiHOG000007381.
    HOVERGENiHBG066686.
    InParanoidiQ6VEQ5.
    PhylomeDBiQ6VEQ5.

    Family and domain databases

    InterProiIPR028290. WASH1.
    IPR021854. WASH1_WAHD.
    IPR003124. WH2_dom.
    [Graphical view]
    PANTHERiPTHR23331. PTHR23331. 1 hit.
    PfamiPF11945. WASH_WAHD. 1 hit.
    [Graphical view]
    PROSITEiPS51082. WH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6VEQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPVRMQHSL AGQTYAVPLI QPDLRREEAV QQMADALQYL QKVSGDIFSR    50
    ISQQVEQSRS QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPERL 100
    QEYGSIFTGA QDPGLQRRPR HRIQSKHRPL DERALQEKLK DFPVCVSTKP 150
    EPEDDAEEGL GGLPSNISSV SSLLLFNTTE NLYKKYVFLD PLAGAVTKTH 200
    VMLGAETEEK LFDAPLSISK REQLEQQVPE NYFYVPDLGQ VPEIDVPSYL 250
    PDLPGIANDL MYIADLGPGI APSAPGTIPE LPTFHTEVAE PLKVDLQDGV 300
    LTPPPPPPPP PPAPEVLASA PPLPPSTAAP VGQGARQDDS SSSASPSVQG 350
    APREVVDPSG GRATLLESIR QAGGIGKAKL RSMKERKLEK KKQKEQEQVR 400
    ATSQGGHLMS DLFNKLVMRR KGISGKGPGA GEGPGGAFAR VSDSIPPLPP 450
    PQQPQAEEDE DDWES 465
    Length:465
    Mass (Da):50,312
    Last modified:January 19, 2010 - v2
    Checksum:i54FD1BB405E391DF
    GO

    Sequence cautioni

    The sequence AL078621 differs from that shown. Reason: Erroneous termination at position 25. Translated as Arg.
    The sequence AL078621 differs from that shown. Reason: Erroneous termination at position 180. Translated as Glu.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL078621 Genomic DNA. No translation available.
    AY341936 mRNA. Translation: AAQ76875.1.
    UniGeneiHs.446466.
    Hs.459573.
    Hs.709408.

    Genome annotation databases

    UCSCiuc002tkh.3. human.

    Polymorphism databases

    DMDMi284018148.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL078621 Genomic DNA. No translation available.
    AY341936 mRNA. Translation: AAQ76875.1 .
    UniGenei Hs.446466.
    Hs.459573.
    Hs.709408.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6VEQ5. 4 interactions.
    MINTi MINT-7008897.

    Polymorphism databases

    DMDMi 284018148.

    Proteomic databases

    PaxDbi Q6VEQ5.
    PRIDEi Q6VEQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc002tkh.3. human.

    Organism-specific databases

    GeneCardsi GC02P114341.
    H-InvDB HIX0000004.
    HIX0023492.
    HIX0094926.
    HIX0195874.
    HGNCi HGNC:33145. WASH2P.
    HPAi HPA002689.
    neXtProti NX_Q6VEQ5.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86663.
    HOGENOMi HOG000007381.
    HOVERGENi HBG066686.
    InParanoidi Q6VEQ5.
    PhylomeDBi Q6VEQ5.

    Miscellaneous databases

    PROi Q6VEQ5.

    Gene expression databases

    Genevestigatori Q6VEQ5.

    Family and domain databases

    InterProi IPR028290. WASH1.
    IPR021854. WASH1_WAHD.
    IPR003124. WH2_dom.
    [Graphical view ]
    PANTHERi PTHR23331. PTHR23331. 1 hit.
    Pfami PF11945. WASH_WAHD. 1 hit.
    [Graphical view ]
    PROSITEi PS51082. WH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Diverse fates of paralogs following segmental duplication of telomeric genes."
      Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
      Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 202-465, GENE DUPLICATION.
    3. Cited for: GENE DUPLICATION.
    4. "Human subtelomeric WASH genes encode a new subclass of the WASP family."
      Linardopoulou E.V., Parghi S.S., Friedman C., Osborn G.E., Parkhurst S.M., Trask B.J.
      PLoS Genet. 3:E237-E237(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE DUPLICATION.

    Entry informationi

    Entry nameiWASH2_HUMAN
    AccessioniPrimary (citable) accession number: Q6VEQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals (PubMed:18159949). It is therefore difficult to determine which gene is functional or not. The telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q. Paralogous regions contain 7 transcriptional units. Duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 and 15. The chromosome 16 copy seems to be a pseudogene.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3