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Protein
Submitted name:

Mutant mismatch repair protein

Gene

MSH2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mutant mismatch repair proteinImported
Gene namesi
Name:MSH2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ6VBB7.
PRIDEiQ6VBB7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000233146.

Structurei

3D structure databases

ProteinModelPortaliQ6VBB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 8251MutS_IIInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0219. Eukaryota.
COG0249. LUCA.

Family and domain databases

InterProiIPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
[Graphical view]
PANTHERiPTHR11361:SF35. PTHR11361:SF35. 1 hit.
PfamiPF05188. MutS_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6VBB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SPGNLSQFED ILFGNNDMSA SIGVVGVKMS AVDGQRQVGV GYVDSIQKKL
60 70 80 90
GLCEFPDNDQ FSNLEALLIQ IGPKECVLPG GETAGDMGKL RQ
Length:92
Mass (Da):9,744
Last modified:July 5, 2004 - v1
Checksum:i9933C10076E1E1E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei92 – 921Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344477 Genomic DNA. Translation: AAQ23475.1.
UniGeneiHs.597656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344477 Genomic DNA. Translation: AAQ23475.1.
UniGeneiHs.597656.

3D structure databases

ProteinModelPortaliQ6VBB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000233146.

Proteomic databases

PaxDbiQ6VBB7.
PRIDEiQ6VBB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0219. Eukaryota.
COG0249. LUCA.

Miscellaneous databases

ChiTaRSiMSH2. human.

Family and domain databases

InterProiIPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR032642. Msh2.
[Graphical view]
PANTHERiPTHR11361:SF35. PTHR11361:SF35. 1 hit.
PfamiPF05188. MutS_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human mutator hMSH2 gene exon 3 missense mutation in an early onset rectal cancer patient."
    Rajkumar T., Soumittra N., Nirmala N.K., Pandey D., Mahajan V.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6VBB7_HUMAN
AccessioniPrimary (citable) accession number: Q6VBB7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.