ID   FX4L4_HUMAN             Reviewed;         416 AA.
AC   Q8WXT5; Q5RIB4; Q6VB85;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=Forkhead box protein D4-like 4 {ECO:0000305};
DE            Short=FOXD4-like 4 {ECO:0000305};
DE   AltName: Full=Forkhead box protein D4-like 2 {ECO:0000312|HGNC:HGNC:23762};
DE   AltName: Full=Forkhead box protein D4B {ECO:0000305|PubMed:12234674};
DE   AltName: Full=Myeloid factor-gamma {ECO:0000312|EMBL:AAL73342.1};
GN   Name=FOXD4L4 {ECO:0000312|HGNC:HGNC:23762};
GN   Synonyms=FOXD4B {ECO:0000303|PubMed:12234674}, FOXD4L2
GN   {ECO:0000312|HGNC:HGNC:23762};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12234674; DOI=10.1016/s0378-1119(02)00702-3;
RA   Freyaldenhoven B.S., Fried C., Wielckens K.;
RT   "FOXD4a and FOXD4b, two new winged helix transcription factors, are
RT   expressed in human leukemia cell lines.";
RL   Gene 294:131-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15233989; DOI=10.1016/j.ygeno.2004.03.001;
RA   Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C.,
RA   Ledbetter D.H.;
RT   "Diverse fates of paralogs following segmental duplication of telomeric
RT   genes.";
RL   Genomics 84:239-247(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=12421752; DOI=10.1101/gr.338402;
RA   Fan Y., Newman T., Linardopoulou E., Trask B.J.;
RT   "Gene content and function of the ancestral chromosome fusion site in human
RT   chromosome 2q13-2q14.1 and paralogous regions.";
RL   Genome Res. 12:1663-1672(2002).
CC   -!- INTERACTION:
CC       Q8WXT5; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-12911102, EBI-726739;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; AF343005; AAL73342.1; -; Genomic_DNA.
DR   EMBL; AY344641; AAQ76879.1; -; mRNA.
DR   EMBL; BX284632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS75845.1; -.
DR   RefSeq; NP_954714.2; NM_199244.3.
DR   AlphaFoldDB; Q8WXT5; -.
DR   SMR; Q8WXT5; -.
DR   BioGRID; 131556; 1.
DR   IntAct; Q8WXT5; 1.
DR   STRING; 9606.ENSP00000366630; -.
DR   BioMuta; FOXD4L4; -.
DR   DMDM; 158518651; -.
DR   MassIVE; Q8WXT5; -.
DR   PaxDb; 9606-ENSP00000366630; -.
DR   PeptideAtlas; Q8WXT5; -.
DR   Antibodypedia; 76484; 5 antibodies from 2 providers.
DR   DNASU; 349334; -.
DR   Ensembl; ENST00000377413.3; ENSP00000366630.1; ENSG00000184659.6.
DR   GeneID; 349334; -.
DR   KEGG; hsa:349334; -.
DR   MANE-Select; ENST00000377413.3; ENSP00000366630.1; NM_199244.3; NP_954714.2.
DR   UCSC; uc004afx.2; human.
DR   AGR; HGNC:23762; -.
DR   CTD; 349334; -.
DR   DisGeNET; 349334; -.
DR   GeneCards; FOXD4L4; -.
DR   HGNC; HGNC:23762; FOXD4L4.
DR   HPA; ENSG00000184659; Not detected.
DR   MIM; 611085; gene.
DR   neXtProt; NX_Q8WXT5; -.
DR   OpenTargets; ENSG00000184659; -.
DR   PharmGKB; PA142671752; -.
DR   VEuPathDB; HostDB:ENSG00000184659; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000163353; -.
DR   HOGENOM; CLU_040357_3_1_1; -.
DR   InParanoid; Q8WXT5; -.
DR   OMA; SCICAFI; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; Q8WXT5; -.
DR   TreeFam; TF316127; -.
DR   PathwayCommons; Q8WXT5; -.
DR   SignaLink; Q8WXT5; -.
DR   BioGRID-ORCS; 349334; 59 hits in 673 CRISPR screens.
DR   GenomeRNAi; 349334; -.
DR   Pharos; Q8WXT5; Tdark.
DR   PRO; PR:Q8WXT5; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8WXT5; Protein.
DR   Bgee; ENSG00000184659; Expressed in right uterine tube and 35 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd20048; FH_FOXD4-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR   PANTHER; PTHR11829:SF350; FORKHEAD BOX PROTEIN D4-LIKE 3-RELATED; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..416
FT                   /note="Forkhead box protein D4-like 4"
FT                   /id="PRO_0000091825"
FT   DNA_BIND        108..202
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..47
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        280
FT                   /note="G -> A (in Ref. 1; AAL73342)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   416 AA;  45892 MW;  CA8FCD2D09B5CBC8 CRC64;
     MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ
     VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
     ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
     YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
     APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS
     PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
     ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC
//