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Q6VB85

- FX4L2_HUMAN

UniProt

Q6VB85 - FX4L2_HUMAN

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Protein
Forkhead box protein D4-like 2
Gene
FOXD4L2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi108 – 20295Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  3. double-stranded DNA binding Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. axon extension involved in axon guidance Source: RefGenome
  2. branching involved in ureteric bud morphogenesis Source: RefGenome
  3. cartilage development Source: RefGenome
  4. enteric nervous system development Source: RefGenome
  5. iridophore differentiation Source: RefGenome
  6. kidney development Source: RefGenome
  7. lateral line nerve glial cell development Source: RefGenome
  8. melanocyte differentiation Source: RefGenome
  9. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  10. neural crest cell migration Source: RefGenome
  11. pattern specification process Source: RefGenome
  12. peripheral nervous system development Source: RefGenome
  13. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  14. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  15. sympathetic nervous system development Source: RefGenome
  16. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 2
Short name:
FOXD4-like 2
Gene namesi
Name:FOXD4L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:24813. FOXD4L2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Forkhead box protein D4-like 2
PRO_0000311964Add
BLAST

Proteomic databases

PaxDbiQ6VB85.
PRIDEiQ6VB85.

Expressioni

Gene expression databases

BgeeiQ6VB85.
CleanExiHS_FOXD4L2.
GenevestigatoriQ6VB85.

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366814.

Structurei

3D structure databases

ProteinModelPortaliQ6VB85.
SMRiQ6VB85. Positions 108-203.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 30191Pro-rich
Add
BLAST
Compositional biasi375 – 3784Poly-Pro

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOVERGENiHBG051641.
InParanoidiQ6VB85.
KOiK09397.
OrthoDBiEOG7C8GHD.
PhylomeDBiQ6VB85.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6VB85-1 [UniParc]FASTAAdd to Basket

« Hide

MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF    50
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS 100
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP 150
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR 200
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY 250
PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS 300
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG 350
ATATCSSDHQ ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP 400
PRARCWAGTC RPRRRC 416
Length:416
Mass (Da):45,892
Last modified:April 5, 2011 - v2
Checksum:iCA8FCD2D09B5CBC8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91P → L in AAQ76879. 1 Publication
Sequence conflicti47 – 471R → S in AAQ76879. 1 Publication
Sequence conflicti232 – 2321H → R in AAQ76879. 1 Publication
Sequence conflicti276 – 2761R → P in AAQ76879. 1 Publication
Sequence conflicti378 – 3781L → P in AAQ76879. 1 Publication
Sequence conflicti390 – 3901I → IR in AAQ76879. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY344641 mRNA. Translation: AAQ76879.1.
AC129778 Genomic DNA. No translation available.
RefSeqiNP_954714.2. NM_199244.3.
UniGeneiHs.449471.
Hs.712520.

Genome annotation databases

EnsembliENST00000377590; ENSP00000366814; ENSG00000204828.
GeneIDi349334.
KEGGihsa:100036519.
hsa:349334.
UCSCiuc004acn.3. human.

Polymorphism databases

DMDMi327478510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY344641 mRNA. Translation: AAQ76879.1 .
AC129778 Genomic DNA. No translation available.
RefSeqi NP_954714.2. NM_199244.3.
UniGenei Hs.449471.
Hs.712520.

3D structure databases

ProteinModelPortali Q6VB85.
SMRi Q6VB85. Positions 108-203.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366814.

Polymorphism databases

DMDMi 327478510.

Proteomic databases

PaxDbi Q6VB85.
PRIDEi Q6VB85.

Protocols and materials databases

DNASUi 349334.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377590 ; ENSP00000366814 ; ENSG00000204828 .
GeneIDi 349334.
KEGGi hsa:100036519.
hsa:349334.
UCSCi uc004acn.3. human.

Organism-specific databases

CTDi 349334.
GeneCardsi GC09P042717.
HGNCi HGNC:24813. FOXD4L2.
HPAi HPA012836.
MIMi 611085. gene.
neXtProti NX_Q6VB85.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOVERGENi HBG051641.
InParanoidi Q6VB85.
KOi K09397.
OrthoDBi EOG7C8GHD.
PhylomeDBi Q6VB85.
TreeFami TF316127.

Miscellaneous databases

PROi Q6VB85.
SOURCEi Search...

Gene expression databases

Bgeei Q6VB85.
CleanExi HS_FOXD4L2.
Genevestigatori Q6VB85.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diverse fates of paralogs following segmental duplication of telomeric genes."
    Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
    Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
    Fan Y., Newman T., Linardopoulou E., Trask B.J.
    Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFX4L2_HUMAN
AccessioniPrimary (citable) accession number: Q6VB85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi