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Q6VB85 (FX4L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein D4-like 2

Short name=FOXD4-like 2
Gene names
Name:FOXD4L2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Miscellaneous

5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence. Our sequences are in agreement with HGNC nomenclature.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon extension involved in axon guidance

Inferred from Biological aspect of Ancestor. Source: RefGenome

branching involved in ureteric bud morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

cartilage development

Inferred from Biological aspect of Ancestor. Source: RefGenome

enteric nervous system development

Inferred from Biological aspect of Ancestor. Source: RefGenome

iridophore differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

kidney development

Inferred from Biological aspect of Ancestor. Source: RefGenome

lateral line nerve glial cell development

Inferred from Biological aspect of Ancestor. Source: RefGenome

melanocyte differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

neural crest cell migration

Inferred from Biological aspect of Ancestor. Source: RefGenome

pattern specification process

Inferred from Biological aspect of Ancestor. Source: RefGenome

peripheral nervous system development

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

sympathetic nervous system development

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Forkhead box protein D4-like 2
PRO_0000311964

Regions

DNA binding108 – 20295Fork-head
Compositional bias211 – 30191Pro-rich
Compositional bias375 – 3784Poly-Pro

Experimental info

Sequence conflict91P → L in AAQ76879. Ref.1
Sequence conflict471R → S in AAQ76879. Ref.1
Sequence conflict2321H → R in AAQ76879. Ref.1
Sequence conflict2761R → P in AAQ76879. Ref.1
Sequence conflict3781L → P in AAQ76879. Ref.1
Sequence conflict3901I → IR in AAQ76879. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6VB85 [UniParc].

Last modified April 5, 2011. Version 2.
Checksum: CA8FCD2D09B5CBC8

FASTA41645,892
        10         20         30         40         50         60 
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ 

        70         80         90        100        110        120 
VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA 

       130        140        150        160        170        180 
ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN 

       190        200        210        220        230        240 
YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP 

       250        260        270        280        290        300 
APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS 

       310        320        330        340        350        360 
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ 

       370        380        390        400        410 
ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC 

« Hide

References

« Hide 'large scale' references
[1]"Diverse fates of paralogs following segmental duplication of telomeric genes."
Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C., Ledbetter D.H.
Genomics 84:239-247(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions."
Fan Y., Newman T., Linardopoulou E., Trask B.J.
Genome Res. 12:1663-1672(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY344641 mRNA. Translation: AAQ76879.1.
AC129778 Genomic DNA. No translation available.
RefSeqNP_954714.2. NM_199244.3.
UniGeneHs.449471.
Hs.712520.

3D structure databases

ProteinModelPortalQ6VB85.
SMRQ6VB85. Positions 108-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000366814.

Polymorphism databases

DMDM327478510.

Proteomic databases

PaxDbQ6VB85.
PRIDEQ6VB85.

Protocols and materials databases

DNASU349334.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377590; ENSP00000366814; ENSG00000204828.
GeneID349334.
KEGGhsa:100036519.
hsa:349334.
UCSCuc004acn.3. human.

Organism-specific databases

CTD349334.
GeneCardsGC09P042717.
HGNCHGNC:24813. FOXD4L2.
HPAHPA012836.
MIM611085. gene.
neXtProtNX_Q6VB85.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOVERGENHBG051641.
InParanoidQ6VB85.
KOK09397.
OrthoDBEOG7C8GHD.
PhylomeDBQ6VB85.
TreeFamTF316127.

Gene expression databases

BgeeQ6VB85.
CleanExHS_FOXD4L2.
GenevestigatorQ6VB85.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ6VB85.
SOURCESearch...

Entry information

Entry nameFX4L2_HUMAN
AccessionPrimary (citable) accession number: Q6VB85
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM