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Protein

Forkhead box protein D4-like 3

Gene

FOXD4L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 3
Short name:
FOXD4-like 3
Gene namesi
Name:FOXD4L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18523. FOXD4L3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941846.

Polymorphism and mutation databases

BioMutaiFOXD4L3.
DMDMi317373356.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Forkhead box protein D4-like 3PRO_0000301980Add
BLAST

Proteomic databases

PaxDbiQ6VB84.
PeptideAtlasiQ6VB84.
PRIDEiQ6VB84.

Expressioni

Organism-specific databases

HPAiHPA012836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341961.

Structurei

3D structure databases

ProteinModelPortaliQ6VB84.
SMRiQ6VB84. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ6VB84.
KOiK09397.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ6VB84.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6VB84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Length:417
Mass (Da):45,820
Last modified:January 11, 2011 - v2
Checksum:i1FD6BD6801493FCE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → P in AAQ76880 (PubMed:15233989).Curated
Sequence conflicti47 – 471S → R in AAQ76880 (PubMed:15233989).Curated
Sequence conflicti289 – 2891A → D in AAQ76880 (PubMed:15233989).Curated
Sequence conflicti344 – 3441I → V in AAQ76880 (PubMed:15233989).Curated
Sequence conflicti366 – 3661R → K in AAQ76880 (PubMed:15233989).Curated
Sequence conflicti416 – 4161P → R in AAQ76880 (PubMed:15233989).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344642 mRNA. Translation: AAQ76880.1.
AL353608 Genomic DNA. Translation: CAI41168.1.
CCDSiCCDS43833.1.
RefSeqiNP_954586.4. NM_199135.4.
UniGeneiHs.449471.

Genome annotation databases

EnsembliENST00000342833; ENSP00000341961; ENSG00000187559.
GeneIDi286380.
KEGGihsa:286380.
UCSCiuc004agm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344642 mRNA. Translation: AAQ76880.1.
AL353608 Genomic DNA. Translation: CAI41168.1.
CCDSiCCDS43833.1.
RefSeqiNP_954586.4. NM_199135.4.
UniGeneiHs.449471.

3D structure databases

ProteinModelPortaliQ6VB84.
SMRiQ6VB84. Positions 108-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341961.

Polymorphism and mutation databases

BioMutaiFOXD4L3.
DMDMi317373356.

Proteomic databases

PaxDbiQ6VB84.
PeptideAtlasiQ6VB84.
PRIDEiQ6VB84.

Protocols and materials databases

DNASUi286380.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342833; ENSP00000341961; ENSG00000187559.
GeneIDi286380.
KEGGihsa:286380.
UCSCiuc004agm.2. human.

Organism-specific databases

CTDi286380.
GeneCardsiFOXD4L3.
HGNCiHGNC:18523. FOXD4L3.
HPAiHPA012836.
MIMi611086. gene.
neXtProtiNX_Q6VB84.
PharmGKBiPA134941846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ6VB84.
KOiK09397.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ6VB84.
TreeFamiTF316127.

Miscellaneous databases

GenomeRNAii286380.
PROiQ6VB84.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFX4L3_HUMAN
AccessioniPrimary (citable) accession number: Q6VB84
Secondary accession number(s): Q5JTX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.