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Protein

Forkhead box protein D4-like 3

Gene

FOXD4L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 202Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 3
Short name:
FOXD4-like 3
Gene namesi
Name:FOXD4L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187559.5.
HGNCiHGNC:18523. FOXD4L3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941846.

Polymorphism and mutation databases

BioMutaiFOXD4L3.
DMDMi317373356.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019801 – 417Forkhead box protein D4-like 3Add BLAST417

Proteomic databases

PaxDbiQ6VB84.
PeptideAtlasiQ6VB84.
PRIDEiQ6VB84.

Expressioni

Gene expression databases

BgeeiENSG00000187559.

Organism-specific databases

HPAiHPA012836.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMS2Q6ZRY44EBI-11961494,EBI-11987469

Protein-protein interaction databases

IntActiQ6VB84. 15 interactors.
STRINGi9606.ENSP00000341961.

Structurei

3D structure databases

ProteinModelPortaliQ6VB84.
SMRiQ6VB84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ6VB84.
KOiK09397.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ6VB84.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6VB84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Length:417
Mass (Da):45,820
Last modified:January 11, 2011 - v2
Checksum:i1FD6BD6801493FCE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → P in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti47S → R in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti289A → D in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti344I → V in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti366R → K in AAQ76880 (PubMed:15233989).Curated1
Sequence conflicti416P → R in AAQ76880 (PubMed:15233989).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY344642 mRNA. Translation: AAQ76880.1.
AL353608 Genomic DNA. No translation available.
CCDSiCCDS43833.1.
RefSeqiNP_954586.4. NM_199135.4.
UniGeneiHs.449471.

Genome annotation databases

EnsembliENST00000342833; ENSP00000341961; ENSG00000187559.
GeneIDi286380.
KEGGihsa:286380.
UCSCiuc004agm.2. human.

Similar proteinsi

Entry informationi

Entry nameiFX4L3_HUMAN
AccessioniPrimary (citable) accession number: Q6VB84
Secondary accession number(s): Q5JTX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot