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Protein

Histidine-containing phosphotransfer protein 2

Gene

AHP2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay (By similarity). Functions as positive regulator of the cytokinin signaling pathway. May play a regulatory role in salt and drought tolerance during plant development (PubMed:24578505).By similarity1 Publication

Miscellaneous

Plant silencing simultaneously OHP1 and OHP2 exhibit phenotypes for a deficiency in cytokinin signaling, including dwarfism with reduced internode lengths, enhanced lateral root growth, early leaf senescence, and reduced tiller numbers and fertility.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytokinin signaling pathway, Sensory transduction, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine-containing phosphotransfer protein 2Curated
Alternative name(s):
OsAHP21 Publication
OsHP1Imported
OsHpt31 Publication
Gene namesi
Name:AHP21 Publication
Synonyms:HP1Imported, OHP21 Publication
Ordered Locus Names:Os09g0567400Imported, LOC_Os09g39400Curated
ORF Names:OJ1155_H10.30Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Dwarf, narrow leaf, small grain and low fertility phenotypes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476151 – 149Histidine-containing phosphotransfer protein 2Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphohistidinePROSITE-ProRule annotation1

Post-translational modificationi

Two-component system major event consists of a His-to-Asp phosphorelay between a sensor histidine kinase (HK) and a response regulator (RR). In plants, the His-to-Asp phosphorelay involves an additional intermediate named Histidine-containing phosphotransfer protein (HPt). This multistep phosphorelay consists of a His-Asp-His-Asp sequential transfer of a phosphate group between first an His and an Asp of the HK protein, followed by the transfer to a conserved His of the HPt protein and finally the transfer to an Asp in the receiver domain of the RR protein.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6VAK4

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

ExpressionAtlasiQ6VAK4 differential
GenevisibleiQ6VAK4 OS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi39947.LOC_Os09g39400.1

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 19Combined sources18
Helixi25 – 34Combined sources10
Helixi42 – 65Combined sources24
Beta strandi67 – 69Combined sources3
Helixi72 – 89Combined sources18
Helixi92 – 106Combined sources15
Helixi110 – 142Combined sources33

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YVIX-ray2.00A/B2-149[»]
2Q4FX-ray2.00A/B2-149[»]
ProteinModelPortaliQ6VAK4
SMRiQ6VAK4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6VAK4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 144HPtPROSITE-ProRule annotationAdd BLAST106

Domaini

Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.Curated

Phylogenomic databases

eggNOGiKOG4747 Eukaryota
COG2198 LUCA
HOGENOMiHOG000272680
InParanoidiQ6VAK4
KOiK14490
OMAiRNAFYEM
OrthoDBiEOG09360S25

Family and domain databases

CDDicd00088 HPT, 1 hit
Gene3Di1.20.120.160, 1 hit
InterProiView protein in InterPro
IPR036641 HPT_dom_sf
IPR008207 Sig_transdc_His_kin_Hpt_dom
PfamiView protein in Pfam
PF01627 Hpt, 1 hit
SUPFAMiSSF47226 SSF47226, 1 hit
PROSITEiView protein in PROSITE
PS50894 HPT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6VAK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRDQL TALLSSMFSQ GLVDEQFQQL QMLQDEGGTP GFVSEVVTLF
60 70 80 90 100
CDDADRIINE IATLLEQPVV NFDKVDAYVH QLKGSSASVG AQKVKFTCMQ
110 120 130 140
FRQFCQDKSR DGCLMALAVV RNDFYDLRNK FQTMLQLEQQ IQAYDPKQQ
Length:149
Mass (Da):16,811
Last modified:July 5, 2004 - v1
Checksum:i38CAED8B091225D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BR000249 Genomic DNA Translation: FAA00253.1
AY345241 mRNA Translation: AAQ24029.1
AP005558 Genomic DNA Translation: BAD46253.1
AP008215 Genomic DNA Translation: BAF25875.1
AP014965 Genomic DNA Translation: BAT09475.1
CM000146 Genomic DNA Translation: EEE70257.1
RefSeqiXP_015611768.1, XM_015756282.1
UniGeneiOs.4702

Genome annotation databases

EnsemblPlantsiOs09t0567400-01; Os09t0567400-01; Os09g0567400
Os09t0567400-02; Os09t0567400-02; Os09g0567400
GeneIDi4347886
GrameneiOs09t0567400-01; Os09t0567400-01; Os09g0567400
Os09t0567400-02; Os09t0567400-02; Os09g0567400
KEGGiosa:4347886

Similar proteinsi

Entry informationi

Entry nameiOHP2_ORYSJ
AccessioniPrimary (citable) accession number: Q6VAK4
Secondary accession number(s): A0A0P0XRE0, Q0IZJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations

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