Reviewed,
UniProtKB/Swiss-Prot Q6VAB6 (KSR2_HUMAN)
Last modified
June 16, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Kinase suppressor of Ras 2 Short name=hKSR2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 950 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Ref.3 Ref.5 |
| Subunit structure | Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF. Ref.3 |
| Subcellular location | Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. |
| Tissue specificity | Mainly expressed in brain and kidney. Ref.3 |
| Domain | The protein kinase domain is predicted to be catalytically inactive. |
| Post-translational modification | Phosphorylated on Ser-474 by MARK3 By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Phorbol-ester binding Zinc-finger |
| Ligand | Metal-binding Zinc |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | intracellular signaling cascade Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro diacylglycerol bindingInferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activityInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6VAB6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6VAB6-2) The sequence of this isoform differs from the canonical sequence as follows: 1-303: Missing. 304-329: GFTALHRSKSHEFQLGHRVDEAHTPK → MYNKKAKMEPNASESAIPARRQRQPR 740-742: SLC → RPV 743-950: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 950 | 950 | Kinase suppressor of Ras 2 | PRO_0000086231 | |||||
Regions | |||||||||
| Domain | 666 – 931 | 266 | Protein kinase | ||||||
| Zinc finger | 412 – 456 | 45 | Phorbol-ester/DAG-type | ||||||
| Compositional bias | 181 – 293 | 113 | Pro-rich | ||||||
| Compositional bias | 510 – 550 | 41 | Pro-rich | ||||||
Sites | |||||||||
| Metal binding | 413 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 425 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 428 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 438 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 441 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 446 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 449 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 456 | 1 | Zinc 1 By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 474 | 1 | Phosphoserine; by MARK3 By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 303 | 303 | Missing in isoform 2. | VSP_012234 | |||||
| Alternative sequence | 304 – 329 | 26 | GFTAL…AHTPK → MYNKKAKMEPNASESAIPAR RQRQPR in isoform 2. | VSP_012235 | |||||
| Alternative sequence | 740 – 742 | 3 | SLC → RPV in isoform 2. | VSP_012236 | |||||
| Alternative sequence | 743 – 950 | 208 | Missing in isoform 2. | VSP_012237 | |||||
| Natural variant | 676 | 1 | R → S in a lung adenocarcinoma sample; somatic mutation. Ref.6 | VAR_040659 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AK098831 mRNA. Translation: BAC05426.1. AC073864 Genomic DNA. No translation available. AC079127 Genomic DNA. No translation available. AC084291 Genomic DNA. No translation available. AC092936 Genomic DNA. No translation available. AY345972 mRNA. Translation: AAQ24226.1. BC107106 mRNA. Translation: AAI07107.1. BC107107 mRNA. Translation: AAI07108.1. BC127603 mRNA. Translation: AAI27604.1. | |
| IPI | IPI00167121. IPI00414043. |
| RefSeq | NP_775869.3. |
| UniGene | Hs.375836 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KBE based on UniProtKB Q61097. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q6VAB6. |
Genome annotation databases | |
| Ensembl | ENSG00000171435. Homo sapiens. [Contig view] |
| GeneID | 283455. |
| KEGG | hsa:283455. |
Organism-specific databases | |
| GeneCards | GC12M116370. |
| H-InvDB | HIX0018992. |
| HGNC | HGNC:18610. KSR2. |
| MIM | 610737. gene. |
| PharmGKB | PA134867759. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q6VAB6. |
| HOVERGEN | Q6VAB6. |
Gene expression databases | |
| ArrayExpress | Q6VAB6. |
| Bgee | Q6VAB6. |
| CleanEx | HS_KSR2. |
| GermOnline | ENSG00000171435. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002219. DAG_PE_bd. IPR000719. Prot_kinase_core. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| Pfam | PF00130. C1_1. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00109. C1. 1 hit. [Graphical view] |
| PROSITE | PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 93924. |
| SOURCE | Search... |
Entry information
| Entry name | KSR2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6VAB6 Secondary accession number(s): A0PJT2, Q3B828, Q8N775 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


