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Protein

Zinc finger protein 562

Gene

ZNF562

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 562
Gene namesi
Name:ZNF562
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171466.9
HGNCiHGNC:25950 ZNF562
neXtProtiNX_Q6V9R5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54811
OpenTargetsiENSG00000171466
PharmGKBiPA134941707

Polymorphism and mutation databases

BioMutaiZNF562
DMDMi146291105

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476521 – 426Zinc finger protein 562Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6V9R5
MaxQBiQ6V9R5
PaxDbiQ6V9R5
PeptideAtlasiQ6V9R5
PRIDEiQ6V9R5

PTM databases

iPTMnetiQ6V9R5
PhosphoSitePlusiQ6V9R5

Expressioni

Gene expression databases

BgeeiENSG00000171466
CleanExiHS_ZNF562
ExpressionAtlasiQ6V9R5 baseline and differential
GenevisibleiQ6V9R5 HS

Organism-specific databases

HPAiHPA055332
HPA062397

Interactioni

Protein-protein interaction databases

BioGridi120168, 11 interactors
STRINGi9606.ENSP00000410734

Structurei

3D structure databases

ProteinModelPortaliQ6V9R5
SMRiQ6V9R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 120KRABPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6V9R5
KOiK09228
OMAiKLCENCG
OrthoDBiEOG091G02KC
PhylomeDBiQ6V9R5
TreeFamiTF341966

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6V9R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFDMSHGF FPREPICPFE EKTKIGTMVE DHRSNSYQDS VTFDDVAVEF
60 70 80 90 100
TPEEWALLDT TQKYLYRDVM LENYMNLASV DFFFCLTSEW EIQPRTKRSS
110 120 130 140 150
LQQGFLKNQI FTGIQMQTRS YSGWKLCENC GEVFSEQFCL KTHMRAQNGG
160 170 180 190 200
NTFEGNCYGK DSISVHKEAS IGQELSKFNP CGKVFTLTPG LAVHLEILNG
210 220 230 240 250
RQPYKCKECG KGFKYFASLD NHMGIHIGEK LCEFQECERA ITTSSHLKQC
260 270 280 290 300
VAVHTGKKSE KTKNCGKSFT NFSQLSAHAK THKGEKSFEC KECGRSFRNS
310 320 330 340 350
SSFNVHIQIH TGIKPHKCTE CGKAFTRSTH LTQHVRTHTG IKPYECKECG
360 370 380 390 400
QAFTQYTGLA IHIRNHTGEK PYQCKECGKA FNRSSTLTQH RRIHTGEKPY
410 420
ECVECGKTFI TSSHRSKHLK THSGER
Length:426
Mass (Da):48,563
Last modified:May 1, 2007 - v2
Checksum:iCB285FD3A92C1C14
GO
Isoform 2 (identifier: Q6V9R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     73-80: NYMNLASV → MSAFDMSH

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):40,122
Checksum:iD29D585EEA83BEEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237C → Y in AAQ54330 (Ref. 2) Curated1
Sequence conflicti305V → I in AAQ54330 (Ref. 2) Curated1
Sequence conflicti379K → R in BAA90935 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023936178F → L1 PublicationCorresponds to variant dbSNP:rs1059194Ensembl.1
Natural variantiVAR_023937205K → E1 PublicationCorresponds to variant dbSNP:rs1059199Ensembl.1
Natural variantiVAR_059922260E → K. Corresponds to variant dbSNP:rs1059199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163791 – 72Missing in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_01638073 – 80NYMNLASV → MSAFDMSH in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000086 mRNA Translation: BAA90935.1
AY346375 mRNA Translation: AAQ54330.1
CH471106 Genomic DNA Translation: EAW84044.1
BC109062 mRNA Translation: AAI09063.2
CCDSiCCDS12217.1 [Q6V9R5-2]
CCDS45956.1 [Q6V9R5-1]
RefSeqiNP_001123503.1, NM_001130031.1 [Q6V9R5-1]
NP_001123504.1, NM_001130032.1 [Q6V9R5-1]
NP_001287814.1, NM_001300885.1
NP_060126.2, NM_017656.3 [Q6V9R5-2]
XP_005259998.1, XM_005259941.3 [Q6V9R5-1]
UniGeneiHs.371107

Genome annotation databases

EnsembliENST00000293648; ENSP00000293648; ENSG00000171466 [Q6V9R5-2]
ENST00000453372; ENSP00000410734; ENSG00000171466 [Q6V9R5-1]
GeneIDi54811
KEGGihsa:54811
UCSCiuc002mlx.4 human [Q6V9R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN562_HUMAN
AccessioniPrimary (citable) accession number: Q6V9R5
Secondary accession number(s): Q32MN2, Q9NXS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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