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Protein

Zinc finger protein 562

Gene

ZNF562

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 562
Gene namesi
Name:ZNF562
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25950. ZNF562.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941707.

Polymorphism and mutation databases

BioMutaiZNF562.
DMDMi146291105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Zinc finger protein 562PRO_0000047652Add
BLAST

Proteomic databases

MaxQBiQ6V9R5.
PaxDbiQ6V9R5.
PRIDEiQ6V9R5.

PTM databases

iPTMnetiQ6V9R5.
PhosphoSiteiQ6V9R5.

Expressioni

Gene expression databases

BgeeiQ6V9R5.
CleanExiHS_ZNF562.
ExpressionAtlasiQ6V9R5. baseline and differential.
GenevisibleiQ6V9R5. HS.

Organism-specific databases

HPAiHPA055332.

Interactioni

Protein-protein interaction databases

BioGridi120168. 11 interactions.
STRINGi9606.ENSP00000410734.

Structurei

3D structure databases

ProteinModelPortaliQ6V9R5.
SMRiQ6V9R5. Positions 35-82, 127-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12080KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6V9R5.
KOiK09228.
OMAiKLCENCG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6V9R5.
TreeFamiTF341966.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6V9R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFDMSHGF FPREPICPFE EKTKIGTMVE DHRSNSYQDS VTFDDVAVEF
60 70 80 90 100
TPEEWALLDT TQKYLYRDVM LENYMNLASV DFFFCLTSEW EIQPRTKRSS
110 120 130 140 150
LQQGFLKNQI FTGIQMQTRS YSGWKLCENC GEVFSEQFCL KTHMRAQNGG
160 170 180 190 200
NTFEGNCYGK DSISVHKEAS IGQELSKFNP CGKVFTLTPG LAVHLEILNG
210 220 230 240 250
RQPYKCKECG KGFKYFASLD NHMGIHIGEK LCEFQECERA ITTSSHLKQC
260 270 280 290 300
VAVHTGKKSE KTKNCGKSFT NFSQLSAHAK THKGEKSFEC KECGRSFRNS
310 320 330 340 350
SSFNVHIQIH TGIKPHKCTE CGKAFTRSTH LTQHVRTHTG IKPYECKECG
360 370 380 390 400
QAFTQYTGLA IHIRNHTGEK PYQCKECGKA FNRSSTLTQH RRIHTGEKPY
410 420
ECVECGKTFI TSSHRSKHLK THSGER
Length:426
Mass (Da):48,563
Last modified:May 1, 2007 - v2
Checksum:iCB285FD3A92C1C14
GO
Isoform 2 (identifier: Q6V9R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     73-80: NYMNLASV → MSAFDMSH

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):40,122
Checksum:iD29D585EEA83BEEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371C → Y in AAQ54330 (Ref. 2) Curated
Sequence conflicti305 – 3051V → I in AAQ54330 (Ref. 2) Curated
Sequence conflicti379 – 3791K → R in BAA90935 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti178 – 1781F → L.1 Publication
Corresponds to variant rs1059194 [ dbSNP | Ensembl ].
VAR_023936
Natural varianti205 – 2051K → E.1 Publication
Corresponds to variant rs1059199 [ dbSNP | Ensembl ].
VAR_023937
Natural varianti260 – 2601E → K.
Corresponds to variant rs1059199 [ dbSNP | Ensembl ].
VAR_059922

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_016379Add
BLAST
Alternative sequencei73 – 808NYMNLASV → MSAFDMSH in isoform 2. 1 PublicationVSP_016380

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000086 mRNA. Translation: BAA90935.1.
AY346375 mRNA. Translation: AAQ54330.1.
CH471106 Genomic DNA. Translation: EAW84044.1.
BC109062 mRNA. Translation: AAI09063.2.
CCDSiCCDS12217.1. [Q6V9R5-2]
CCDS45956.1. [Q6V9R5-1]
RefSeqiNP_001123503.1. NM_001130031.1. [Q6V9R5-1]
NP_001123504.1. NM_001130032.1. [Q6V9R5-1]
NP_001287814.1. NM_001300885.1.
NP_060126.2. NM_017656.3. [Q6V9R5-2]
XP_005259998.1. XM_005259941.2. [Q6V9R5-1]
XP_011526399.1. XM_011528097.1. [Q6V9R5-1]
UniGeneiHs.371107.

Genome annotation databases

EnsembliENST00000293648; ENSP00000293648; ENSG00000171466. [Q6V9R5-2]
ENST00000453372; ENSP00000410734; ENSG00000171466. [Q6V9R5-1]
GeneIDi54811.
KEGGihsa:54811.
UCSCiuc002mlx.4. human. [Q6V9R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000086 mRNA. Translation: BAA90935.1.
AY346375 mRNA. Translation: AAQ54330.1.
CH471106 Genomic DNA. Translation: EAW84044.1.
BC109062 mRNA. Translation: AAI09063.2.
CCDSiCCDS12217.1. [Q6V9R5-2]
CCDS45956.1. [Q6V9R5-1]
RefSeqiNP_001123503.1. NM_001130031.1. [Q6V9R5-1]
NP_001123504.1. NM_001130032.1. [Q6V9R5-1]
NP_001287814.1. NM_001300885.1.
NP_060126.2. NM_017656.3. [Q6V9R5-2]
XP_005259998.1. XM_005259941.2. [Q6V9R5-1]
XP_011526399.1. XM_011528097.1. [Q6V9R5-1]
UniGeneiHs.371107.

3D structure databases

ProteinModelPortaliQ6V9R5.
SMRiQ6V9R5. Positions 35-82, 127-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120168. 11 interactions.
STRINGi9606.ENSP00000410734.

PTM databases

iPTMnetiQ6V9R5.
PhosphoSiteiQ6V9R5.

Polymorphism and mutation databases

BioMutaiZNF562.
DMDMi146291105.

Proteomic databases

MaxQBiQ6V9R5.
PaxDbiQ6V9R5.
PRIDEiQ6V9R5.

Protocols and materials databases

DNASUi54811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293648; ENSP00000293648; ENSG00000171466. [Q6V9R5-2]
ENST00000453372; ENSP00000410734; ENSG00000171466. [Q6V9R5-1]
GeneIDi54811.
KEGGihsa:54811.
UCSCiuc002mlx.4. human. [Q6V9R5-1]

Organism-specific databases

CTDi54811.
GeneCardsiZNF562.
HGNCiHGNC:25950. ZNF562.
HPAiHPA055332.
neXtProtiNX_Q6V9R5.
PharmGKBiPA134941707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6V9R5.
KOiK09228.
OMAiKLCENCG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6V9R5.
TreeFamiTF341966.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii54811.
NextBioi57533.
PROiQ6V9R5.

Gene expression databases

BgeeiQ6V9R5.
CleanExiHS_ZNF562.
ExpressionAtlasiQ6V9R5. baseline and differential.
GenevisibleiQ6V9R5. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-178 AND GLU-205.
    Tissue: Colon.
  2. Zhou G., Yu R., Cao L., Ke R., Li H., Shen C., Zhong G., Lin L., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiZN562_HUMAN
AccessioniPrimary (citable) accession number: Q6V9R5
Secondary accession number(s): Q32MN2, Q9NXS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 1, 2007
Last modified: March 16, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.