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Protein

Zinc finger protein 562

Gene

ZNF562

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 562
Gene namesi
Name:ZNF562
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171466.9.
HGNCiHGNC:25950. ZNF562.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54811.
OpenTargetsiENSG00000171466.
PharmGKBiPA134941707.

Polymorphism and mutation databases

BioMutaiZNF562.
DMDMi146291105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476521 – 426Zinc finger protein 562Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ6V9R5.
MaxQBiQ6V9R5.
PaxDbiQ6V9R5.
PeptideAtlasiQ6V9R5.
PRIDEiQ6V9R5.

PTM databases

iPTMnetiQ6V9R5.
PhosphoSitePlusiQ6V9R5.

Expressioni

Gene expression databases

BgeeiENSG00000171466.
CleanExiHS_ZNF562.
ExpressionAtlasiQ6V9R5. baseline and differential.
GenevisibleiQ6V9R5. HS.

Organism-specific databases

HPAiHPA055332.
HPA062397.

Interactioni

Protein-protein interaction databases

BioGridi120168. 11 interactors.
STRINGi9606.ENSP00000410734.

Structurei

3D structure databases

ProteinModelPortaliQ6V9R5.
SMRiQ6V9R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 120KRABPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6V9R5.
KOiK09228.
OMAiKLCENCG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6V9R5.
TreeFamiTF341966.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6V9R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAFDMSHGF FPREPICPFE EKTKIGTMVE DHRSNSYQDS VTFDDVAVEF
60 70 80 90 100
TPEEWALLDT TQKYLYRDVM LENYMNLASV DFFFCLTSEW EIQPRTKRSS
110 120 130 140 150
LQQGFLKNQI FTGIQMQTRS YSGWKLCENC GEVFSEQFCL KTHMRAQNGG
160 170 180 190 200
NTFEGNCYGK DSISVHKEAS IGQELSKFNP CGKVFTLTPG LAVHLEILNG
210 220 230 240 250
RQPYKCKECG KGFKYFASLD NHMGIHIGEK LCEFQECERA ITTSSHLKQC
260 270 280 290 300
VAVHTGKKSE KTKNCGKSFT NFSQLSAHAK THKGEKSFEC KECGRSFRNS
310 320 330 340 350
SSFNVHIQIH TGIKPHKCTE CGKAFTRSTH LTQHVRTHTG IKPYECKECG
360 370 380 390 400
QAFTQYTGLA IHIRNHTGEK PYQCKECGKA FNRSSTLTQH RRIHTGEKPY
410 420
ECVECGKTFI TSSHRSKHLK THSGER
Length:426
Mass (Da):48,563
Last modified:May 1, 2007 - v2
Checksum:iCB285FD3A92C1C14
GO
Isoform 2 (identifier: Q6V9R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     73-80: NYMNLASV → MSAFDMSH

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):40,122
Checksum:iD29D585EEA83BEEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237C → Y in AAQ54330 (Ref. 2) Curated1
Sequence conflicti305V → I in AAQ54330 (Ref. 2) Curated1
Sequence conflicti379K → R in BAA90935 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023936178F → L1 PublicationCorresponds to variant dbSNP:rs1059194Ensembl.1
Natural variantiVAR_023937205K → E1 PublicationCorresponds to variant dbSNP:rs1059199Ensembl.1
Natural variantiVAR_059922260E → K. Corresponds to variant dbSNP:rs1059199Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163791 – 72Missing in isoform 2. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_01638073 – 80NYMNLASV → MSAFDMSH in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000086 mRNA. Translation: BAA90935.1.
AY346375 mRNA. Translation: AAQ54330.1.
CH471106 Genomic DNA. Translation: EAW84044.1.
BC109062 mRNA. Translation: AAI09063.2.
CCDSiCCDS12217.1. [Q6V9R5-2]
CCDS45956.1. [Q6V9R5-1]
RefSeqiNP_001123503.1. NM_001130031.1. [Q6V9R5-1]
NP_001123504.1. NM_001130032.1. [Q6V9R5-1]
NP_001287814.1. NM_001300885.1.
NP_060126.2. NM_017656.3. [Q6V9R5-2]
XP_005259998.1. XM_005259941.3. [Q6V9R5-1]
UniGeneiHs.371107.

Genome annotation databases

EnsembliENST00000293648; ENSP00000293648; ENSG00000171466. [Q6V9R5-2]
ENST00000453372; ENSP00000410734; ENSG00000171466. [Q6V9R5-1]
GeneIDi54811.
KEGGihsa:54811.
UCSCiuc002mlx.4. human. [Q6V9R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN562_HUMAN
AccessioniPrimary (citable) accession number: Q6V9R5
Secondary accession number(s): Q32MN2, Q9NXS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 1, 2007
Last modified: September 27, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families