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Protein

Interleukin-6

Gene

IL6

Organism
Bubalus bubalis (Domestic water buffalo)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiBubalus bubalis (Domestic water buffalo)
Taxonomic identifieri89462 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBubalus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001557430 – 208Interleukin-6Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi72 ↔ 78By similarity
Modified residuei81PhosphoserineBy similarity1
Disulfide bondi101 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6V919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000471
OrthoDBiEOG091G0NW5

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6V919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSRFTSAFT PFAVSLGLLL VMTSAFPTPG PLGEDFKNDT TPGRLLLTTP
60 70 80 90 100
EKTEALIKRM VDKISAMRKE ICEKNDECES SKDTLAENKL NLPKMEEKDG
110 120 130 140 150
CFQSGFNQAI CLIRTTAGLL EYQIYLDYLQ NEYEGNRENV RDLRKNIRTL
160 170 180 190 200
IQILKQKIAD LITTPATNTD LLEKMQSSNE WVKNAKIILI LRNLENFLQF

SLRAIRMK
Length:208
Mass (Da):23,773
Last modified:July 5, 2004 - v1
Checksum:i0C3F0374C52E7342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY347710 mRNA Translation: AAQ54301.1
RefSeqiNP_001277909.1, NM_001290980.1

Genome annotation databases

GeneIDi102415101

Similar proteinsi

Entry informationi

Entry nameiIL6_BUBBU
AccessioniPrimary (citable) accession number: Q6V919
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: December 20, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program