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Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.By similarity

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processThyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.21.99.4)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478101 – 244Type I iodothyronine deiodinaseAdd BLAST244

Proteomic databases

PRIDEiQ6V915

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000021400

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWHX Eukaryota
ENOG4112999 LUCA
HOVERGENiHBG000099
InParanoidiQ6V915
KOiK01562

Family and domain databases

InterProiView protein in InterPro
IPR000643 Iodothyronine_deiodinase
IPR008261 Iodothyronine_deiodinase_AS
IPR027252 Iodothyronine_deiodinase_I/III
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11781 PTHR11781, 1 hit
PfamiView protein in Pfam
PF00837 T4_deiodinase, 1 hit
PIRSFiPIRSF001330 IOD, 1 hit
PIRSF500144 IODI_III, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS01205 T4_DEIODINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6V915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSQLGLWL RRLWVLFQVA LQVAVGKVFL ILFPSRVKQH IVAMNRKNPH
60 70 80 90 100
FSYDNWAPTL YSVQYFWFVL KVRWQRLEDR TEPGGLAPNC PVVRLSGQRC
110 120 130 140 150
SIWDFMKGNR PLVLNFGSCT UPSFLFKFDQ FKRLIEDFCS IADFLIIYIE
160 170 180 190 200
EAHASDGWAF KNNVNIRNHR NLQDRLQAAC LLLDRSPRCP VVVDTMKNQS
210 220 230 240
SRLYAALPER LYVLQAGRIL YKGKPGPWNY HPEEVRAVLE KLHS
Length:244
Mass (Da):28,489
Last modified:February 26, 2008 - v2
Checksum:i99615C88CF077288
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei121Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY347714 mRNA Translation: AAQ92943.1
RefSeqiNP_001009267.1, NM_001009267.1

Genome annotation databases

GeneIDi493798
KEGGifca:493798

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiIOD1_FELCA
AccessioniPrimary (citable) accession number: Q6V915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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