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Q6V915 (IOD1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type I iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene names
Name:DIO1
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney By similarity.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Type I iodothyronine deiodinase
PRO_0000247810

Regions

Transmembrane13 – 3321Helical; Potential

Sites

Active site1211 By similarity

Amino acid modifications

Non-standard residue1211Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q6V915 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 99615C88CF077288

FASTA24428,489
        10         20         30         40         50         60 
MGLSQLGLWL RRLWVLFQVA LQVAVGKVFL ILFPSRVKQH IVAMNRKNPH FSYDNWAPTL 

        70         80         90        100        110        120 
YSVQYFWFVL KVRWQRLEDR TEPGGLAPNC PVVRLSGQRC SIWDFMKGNR PLVLNFGSCT 

       130        140        150        160        170        180 
UPSFLFKFDQ FKRLIEDFCS IADFLIIYIE EAHASDGWAF KNNVNIRNHR NLQDRLQAAC 

       190        200        210        220        230        240 
LLLDRSPRCP VVVDTMKNQS SRLYAALPER LYVLQAGRIL YKGKPGPWNY HPEEVRAVLE 


KLHS 

« Hide

References

[1]"Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase."
Kuiper G.G.J.M., Wassen F., Klootwijk W., van Toor H., Kaptein E., Visser T.J.
Endocrinology 144:5411-5421(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY347714 mRNA. Translation: AAQ92943.1.
RefSeqNP_001009267.1. NM_001009267.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493798.
KEGGfca:493798.

Organism-specific databases

CTD1733.

Phylogenomic databases

HOVERGENHBG000099.
KOK01562.

Family and domain databases

InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD1_FELCA
AccessionPrimary (citable) accession number: Q6V915
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 26, 2008
Last modified: February 19, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families