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Q6V915

- IOD1_FELCA

UniProt

Q6V915 - IOD1_FELCA

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Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney (By similarity).By similarity

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei121 – 1211PROSITE-ProRule annotation

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Type I iodothyronine deiodinasePRO_0000247810Add
BLAST

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099.
InParanoidiQ6V915.
KOiK01562.

Family and domain databases

InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6V915-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLSQLGLWL RRLWVLFQVA LQVAVGKVFL ILFPSRVKQH IVAMNRKNPH
60 70 80 90 100
FSYDNWAPTL YSVQYFWFVL KVRWQRLEDR TEPGGLAPNC PVVRLSGQRC
110 120 130 140 150
SIWDFMKGNR PLVLNFGSCT UPSFLFKFDQ FKRLIEDFCS IADFLIIYIE
160 170 180 190 200
EAHASDGWAF KNNVNIRNHR NLQDRLQAAC LLLDRSPRCP VVVDTMKNQS
210 220 230 240
SRLYAALPER LYVLQAGRIL YKGKPGPWNY HPEEVRAVLE KLHS
Length:244
Mass (Da):28,489
Last modified:February 26, 2008 - v2
Checksum:i99615C88CF077288
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei121 – 1211Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY347714 mRNA. Translation: AAQ92943.1.
RefSeqiNP_001009267.1. NM_001009267.1.

Genome annotation databases

GeneIDi493798.
KEGGifca:493798.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY347714 mRNA. Translation: AAQ92943.1 .
RefSeqi NP_001009267.1. NM_001009267.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 493798.
KEGGi fca:493798.

Organism-specific databases

CTDi 1733.

Phylogenomic databases

HOVERGENi HBG000099.
InParanoidi Q6V915.
KOi K01562.

Family and domain databases

InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase."
    Kuiper G.G.J.M., Wassen F., Klootwijk W., van Toor H., Kaptein E., Visser T.J.
    Endocrinology 144:5411-5421(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiIOD1_FELCA
AccessioniPrimary (citable) accession number: Q6V915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3