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Protein

Rhotekin

Gene

Rtkn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Rhotekin
Gene namesi
Name:RtknImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi727874 Rtkn

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339421 – 548RhotekinAdd BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei93PhosphoserineBy similarity1
Modified residuei217Asymmetric dimethylarginineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei504PhosphoserineCombined sources1
Modified residuei513PhosphoserineBy similarity1
Modified residuei528PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6V7V2
PRIDEiQ6V7V2

PTM databases

iPTMnetiQ6V7V2
PhosphoSitePlusiQ6V7V2

Expressioni

Gene expression databases

BgeeiENSRNOG00000009022
GenevisibleiQ6V7V2 RN

Interactioni

Subunit structurei

Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi255562, 1 interactor
IntActiQ6V7V2, 1 interactor
MINTiQ6V7V2
STRINGi10116.ENSRNOP00000032233

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 85REM-1PROSITE-ProRule annotationAdd BLAST76
Domaini296 – 403PHSequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi465 – 468Poly-ProSequence analysis4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIHF Eukaryota
ENOG410ZX8Y LUCA
GeneTreeiENSGT00390000000104
HOGENOMiHOG000015094
HOVERGENiHBG059480
InParanoidiQ6V7V2
OMAiAERSPCR
OrthoDBiEOG091G09OJ
PhylomeDBiQ6V7V2

Family and domain databases

InterProiView protein in InterPro
IPR012966 AHD
IPR011072 HR1_rho-bd
IPR001849 PH_domain
IPR030471 RTKN
PANTHERiPTHR21538:SF19 PTHR21538:SF19, 1 hit
PfamiView protein in Pfam
PF08174 Anillin, 1 hit
SMARTiView protein in SMART
SM00742 Hr1, 1 hit
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51860 REM_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6V7V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDRLRILED LNMLYIRQMA LSLEDTELQR KLDHEIRMRE GACKLLAACS
60 70 80 90 100
QREQALEATK SLLVCNSRIL SYMGELQRRK EAQVLGKTGR RPSDSVQPPE
110 120 130 140 150
RSPCRGRVCI SDLRIPLMWK DTEYFKNKGD LHRWAVFLLL QLGEQIQDTE
160 170 180 190 200
MVLVDRTLTD ISFQNNAIFA EAGPDFELRL ELYGACVEEE GALAGAPKRL
210 220 230 240 250
ATKLSSSLGR SSGKRVRASL DSAGGSGNSP ILLPTPAVGG PRYHLLAHTT
260 270 280 290 300
LTLAAVQDGF RTHDLTLTSH EENPAWLPLY GSMCCRLVAQ PLCMTQPTAS
310 320 330 340 350
GTLRVQQAGE LQSGTLVHGV LKGTNLFCYW RSEDADSGQE PLFTILINKE
360 370 380 390 400
TRVRAGELEQ APEWPFTLSI SNRYGDDEVT NTLQVQSRDA LQSWMEALWQ
410 420 430 440 450
LFLDMSQWKH CCDEVMKIET PAPRKPPQAL AKQGSLYHEM AIEPLEDIAA
460 470 480 490 500
VTDILAQREG TRLEPPPPWL AMFTDQPALR SSCSPASVPT WTQPLPWGRP
510 520 530 540
RTFSLDAVPA DHSLGPSRSV APLPPQRSPQ SRGFYSKSQL STWLQSPV
Length:548
Mass (Da):61,154
Last modified:July 5, 2004 - v1
Checksum:iA10A358EC6108B4E
GO
Isoform 21 Publication (identifier: Q6V7V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-372: Missing.

Show »
Length:314
Mass (Da):35,907
Checksum:i5CFB283D81D0F47E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052007139 – 372Missing in isoform 2. 1 PublicationAdd BLAST234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY348867 mRNA Translation: AAQ55227.1
AY348868 mRNA Translation: AAQ55228.1
RefSeqiNP_908935.1, NM_184046.1 [Q6V7V2-1]
XP_008761258.1, XM_008763036.2 [Q6V7V2-1]
XP_008761277.1, XM_008763055.2 [Q6V7V2-1]
XP_017448493.1, XM_017593004.1 [Q6V7V2-1]
XP_017458304.1, XM_017602815.1 [Q6V7V2-1]
XP_017458305.1, XM_017602816.1 [Q6V7V2-1]
UniGeneiRn.233799

Genome annotation databases

EnsembliENSRNOT00000031964; ENSRNOP00000032233; ENSRNOG00000009022 [Q6V7V2-1]
ENSRNOT00000079547; ENSRNOP00000069449; ENSRNOG00000059679 [Q6V7V2-1]
GeneIDi103692165
297383
KEGGirno:103692165
rno:297383
UCSCiRGD:727874 rat [Q6V7V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRTKN_RAT
AccessioniPrimary (citable) accession number: Q6V7V2
Secondary accession number(s): Q6V7V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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