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Protein

Rhotekin

Gene

Rtkn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhotekin
Gene namesi
Name:RtknImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi727874. Rtkn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548RhotekinPRO_0000233942Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei93 – 931PhosphoserineBy similarity
Modified residuei219 – 2191PhosphoserineBy similarity
Modified residuei504 – 5041PhosphoserineCombined sources
Modified residuei528 – 5281PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6V7V2.
PRIDEiQ6V7V2.

Expressioni

Gene expression databases

GenevisibleiQ6V7V2. RN.

Interactioni

Subunit structurei

Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6V7V2. 1 interaction.
MINTiMINT-7215749.
STRINGi10116.ENSRNOP00000032233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 8664REMSequence analysisAdd
BLAST
Domaini296 – 403108PHSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi465 – 4684Poly-ProSequence analysis

Sequence similaritiesi

Contains 1 PH domain.Sequence analysis
Contains 1 REM (Hr1) repeat.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IIHF. Eukaryota.
ENOG410ZX8Y. LUCA.
GeneTreeiENSGT00390000000104.
HOGENOMiHOG000015094.
HOVERGENiHBG059480.
InParanoidiQ6V7V2.
OMAiAERSPCR.
OrthoDBiEOG72VH6J.
PhylomeDBiQ6V7V2.

Family and domain databases

InterProiIPR012966. AHD.
IPR011072. HR1_rho-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF08174. Anillin. 1 hit.
[Graphical view]
SMARTiSM00742. Hr1. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6V7V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDRLRILED LNMLYIRQMA LSLEDTELQR KLDHEIRMRE GACKLLAACS
60 70 80 90 100
QREQALEATK SLLVCNSRIL SYMGELQRRK EAQVLGKTGR RPSDSVQPPE
110 120 130 140 150
RSPCRGRVCI SDLRIPLMWK DTEYFKNKGD LHRWAVFLLL QLGEQIQDTE
160 170 180 190 200
MVLVDRTLTD ISFQNNAIFA EAGPDFELRL ELYGACVEEE GALAGAPKRL
210 220 230 240 250
ATKLSSSLGR SSGKRVRASL DSAGGSGNSP ILLPTPAVGG PRYHLLAHTT
260 270 280 290 300
LTLAAVQDGF RTHDLTLTSH EENPAWLPLY GSMCCRLVAQ PLCMTQPTAS
310 320 330 340 350
GTLRVQQAGE LQSGTLVHGV LKGTNLFCYW RSEDADSGQE PLFTILINKE
360 370 380 390 400
TRVRAGELEQ APEWPFTLSI SNRYGDDEVT NTLQVQSRDA LQSWMEALWQ
410 420 430 440 450
LFLDMSQWKH CCDEVMKIET PAPRKPPQAL AKQGSLYHEM AIEPLEDIAA
460 470 480 490 500
VTDILAQREG TRLEPPPPWL AMFTDQPALR SSCSPASVPT WTQPLPWGRP
510 520 530 540
RTFSLDAVPA DHSLGPSRSV APLPPQRSPQ SRGFYSKSQL STWLQSPV
Length:548
Mass (Da):61,154
Last modified:July 5, 2004 - v1
Checksum:iA10A358EC6108B4E
GO
Isoform 21 Publication (identifier: Q6V7V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-372: Missing.

Show »
Length:314
Mass (Da):35,907
Checksum:i5CFB283D81D0F47E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei139 – 372234Missing in isoform 2. 1 PublicationVSP_052007Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY348867 mRNA. Translation: AAQ55227.1.
AY348868 mRNA. Translation: AAQ55228.1.
RefSeqiNP_908935.1. NM_184046.1. [Q6V7V2-1]
XP_008761258.1. XM_008763036.1. [Q6V7V2-1]
XP_008761277.1. XM_008763055.1. [Q6V7V2-1]
UniGeneiRn.233799.

Genome annotation databases

EnsembliENSRNOT00000031964; ENSRNOP00000032233; ENSRNOG00000009022. [Q6V7V2-1]
ENSRNOT00000079547; ENSRNOP00000069449; ENSRNOG00000059679. [Q6V7V2-1]
GeneIDi103692165.
297383.
KEGGirno:103692165.
rno:297383.
UCSCiRGD:727874. rat. [Q6V7V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY348867 mRNA. Translation: AAQ55227.1.
AY348868 mRNA. Translation: AAQ55228.1.
RefSeqiNP_908935.1. NM_184046.1. [Q6V7V2-1]
XP_008761258.1. XM_008763036.1. [Q6V7V2-1]
XP_008761277.1. XM_008763055.1. [Q6V7V2-1]
UniGeneiRn.233799.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6V7V2. 1 interaction.
MINTiMINT-7215749.
STRINGi10116.ENSRNOP00000032233.

Proteomic databases

PaxDbiQ6V7V2.
PRIDEiQ6V7V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031964; ENSRNOP00000032233; ENSRNOG00000009022. [Q6V7V2-1]
ENSRNOT00000079547; ENSRNOP00000069449; ENSRNOG00000059679. [Q6V7V2-1]
GeneIDi103692165.
297383.
KEGGirno:103692165.
rno:297383.
UCSCiRGD:727874. rat. [Q6V7V2-1]

Organism-specific databases

CTDi6242.
RGDi727874. Rtkn.

Phylogenomic databases

eggNOGiENOG410IIHF. Eukaryota.
ENOG410ZX8Y. LUCA.
GeneTreeiENSGT00390000000104.
HOGENOMiHOG000015094.
HOVERGENiHBG059480.
InParanoidiQ6V7V2.
OMAiAERSPCR.
OrthoDBiEOG72VH6J.
PhylomeDBiQ6V7V2.

Enzyme and pathway databases

ReactomeiR-RNO-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

NextBioi642160.
PROiQ6V7V2.

Gene expression databases

GenevisibleiQ6V7V2. RN.

Family and domain databases

InterProiIPR012966. AHD.
IPR011072. HR1_rho-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF08174. Anillin. 1 hit.
[Graphical view]
SMARTiSM00742. Hr1. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of rat rhotekin's two splicing isoform."
    Zhou G., Huang X., Yu L.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Sprague-DawleyImported.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRTKN_RAT
AccessioniPrimary (citable) accession number: Q6V7V2
Secondary accession number(s): Q6V7V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.