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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2M
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000004182421 – 119Beta-2-microglobulinAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 100PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005012.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi41 – 53Combined sources13
Beta strandi56 – 61Combined sources6
Beta strandi82 – 90Combined sources9
Beta strandi98 – 103Combined sources6
Beta strandi107 – 109Combined sources3
Beta strandi111 – 114Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JTTX-ray2.80B/E/H21-119[»]
3RWCX-ray2.50B/E21-119[»]
3RWDX-ray2.60B/E21-119[»]
3RWEX-ray2.40B21-119[»]
3RWFX-ray2.60B21-119[»]
3RWGX-ray2.10B21-119[»]
3RWHX-ray2.60B/E21-119[»]
3RWIX-ray2.01B21-119[»]
4ZFZX-ray1.76B/E/H/K20-119[»]
ProteinModelPortaliQ6V7J5.
SMRiQ6V7J5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6V7J5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 114Ig-like C1-typeAdd BLAST90

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ6V7J5.
KOiK08055.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6V7J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPPENGKP NFLNCYVSGF
60 70 80 90 100
HPSDIEVDLL KNGEKMGKVE HSDLSFSKDW SFYLLYYTEF TPNEKDEYAC
110
RVNHVTLSGP RTVKWDRDM
Length:119
Mass (Da):13,626
Last modified:July 5, 2004 - v1
Checksum:i511F59EF5FB64D71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349163 mRNA. Translation: AAR01874.1.
AY445834 mRNA. Translation: AAR11482.1.
RefSeqiNP_001040602.1. NM_001047137.1.
UniGeneiMmu.5037.

Genome annotation databases

GeneIDi712428.
KEGGimcc:712428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349163 mRNA. Translation: AAR01874.1.
AY445834 mRNA. Translation: AAR11482.1.
RefSeqiNP_001040602.1. NM_001047137.1.
UniGeneiMmu.5037.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JTTX-ray2.80B/E/H21-119[»]
3RWCX-ray2.50B/E21-119[»]
3RWDX-ray2.60B/E21-119[»]
3RWEX-ray2.40B21-119[»]
3RWFX-ray2.60B21-119[»]
3RWGX-ray2.10B21-119[»]
3RWHX-ray2.60B/E21-119[»]
3RWIX-ray2.01B21-119[»]
4ZFZX-ray1.76B/E/H/K20-119[»]
ProteinModelPortaliQ6V7J5.
SMRiQ6V7J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi712428.
KEGGimcc:712428.

Organism-specific databases

CTDi567.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ6V7J5.
KOiK08055.

Miscellaneous databases

EvolutionaryTraceiQ6V7J5.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2MG_MACMU
AccessioniPrimary (citable) accession number: Q6V7J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.