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Protein

Uncharacterized protein C4orf22

Gene

C4orf22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf22
Gene namesi
Name:C4orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000197826.11
HGNCiHGNC:28554 C4orf22
neXtProtiNX_Q6V702

Pathology & Biotechi

Organism-specific databases

DisGeNETi255119
OpenTargetsiENSG00000197826
PharmGKBiPA145008853

Polymorphism and mutation databases

BioMutaiC4orf22
DMDMi296439464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019551 – 233Uncharacterized protein C4orf22Add BLAST233

Proteomic databases

PeptideAtlasiQ6V702
PRIDEiQ6V702

PTM databases

iPTMnetiQ6V702
PhosphoSitePlusiQ6V702

Expressioni

Gene expression databases

BgeeiENSG00000197826
CleanExiHS_C4orf22
ExpressionAtlasiQ6V702 baseline and differential
GenevisibleiQ6V702 HS

Organism-specific databases

HPAiHPA043383

Interactioni

Protein-protein interaction databases

BioGridi129077, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6V702
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000016547
HOGENOMiHOG000255608
HOVERGENiHBG098178
InParanoidiQ6V702
OMAiDIVFYDW
OrthoDBiEOG091G0HDS
PhylomeDBiQ6V702
TreeFamiTF323286

Family and domain databases

InterProiView protein in InterPro
IPR027887 DUF4464
PANTHERiPTHR33588 PTHR33588, 1 hit
PfamiView protein in Pfam
PF14713 DUF4464, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q6V702-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQEEGLKAL DNIVTQFNAY EDFLDSQITT VDLYYLEDET LARQLVELGY
60 70 80 90 100
RGTGERVKRE DFEARKAAIE IARLAERAQQ KTLTSAGKDL QDNFLTALAM
110 120 130 140 150
REEDNRSGKL SSVIFIRDRN SHGQEISGYI DYAHRLKTED FEVYFTGKKR
160 170 180 190 200
LLPRPTDISF YNWDADIAVS NSSPNYQVIA DNPEGLLFRY KRDRKILNVD
210 220 230
PKAQPGDNST RITILTELYV QAVIFDHISR RKT
Length:233
Mass (Da):26,869
Last modified:May 18, 2010 - v4
Checksum:iD57F4BA59DDC2D65
GO
Isoform 1 (identifier: Q6V702-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: S → SLNQQETDAAHILKKQLA

Show »
Length:250
Mass (Da):28,772
Checksum:i54FBA8623174E3C0
GO
Isoform 3 (identifier: Q6V702-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-156: SVIFIRDRNS...GKKRLLPRPT → AGVQWHHLGS...PPHPVRDLYS
     157-233: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:156
Mass (Da):17,763
Checksum:i60983A5B774ADDE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68A → V in AAQ56723 (Ref. 1) Curated1
Sequence conflicti119R → G in AAQ56723 (Ref. 1) Curated1
Isoform 1 (identifier: Q6V702-1)
Sequence conflicti122I → T in AAQ56723 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034913138T → M. Corresponds to variant dbSNP:rs11947742Ensembl.1
Natural variantiVAR_034914220V → I3 PublicationsCorresponds to variant dbSNP:rs1052325Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037233111S → SLNQQETDAAHILKKQLA in isoform 1. 1 Publication1
Alternative sequenceiVSP_037234112 – 156SVIFI…LPRPT → AGVQWHHLGSLQPLPPGFKE FSCFSLPSGWDYRHAPPHPV RDLYS in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_037235157 – 233Missing in isoform 3. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349359 mRNA Translation: AAQ56723.1
AK128642 mRNA Translation: BAC87545.1
AC021127 Genomic DNA No translation available.
AC093876 Genomic DNA No translation available.
AC093883 Genomic DNA No translation available.
AC098822 Genomic DNA No translation available.
AC105917 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05864.1
BC034296 mRNA Translation: AAH34296.1
CCDSiCCDS3587.1 [Q6V702-2]
CCDS56336.1 [Q6V702-1]
RefSeqiNP_001193926.1, NM_001206997.1 [Q6V702-1]
NP_689983.2, NM_152770.2 [Q6V702-2]
UniGeneiHs.527104

Genome annotation databases

EnsembliENST00000358105; ENSP00000350818; ENSG00000197826 [Q6V702-2]
ENST00000508675; ENSP00000425786; ENSG00000197826 [Q6V702-1]
GeneIDi255119
KEGGihsa:255119
UCSCiuc003hmf.3 human [Q6V702-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD022_HUMAN
AccessioniPrimary (citable) accession number: Q6V702
Secondary accession number(s): E7EQ13, Q6ZQY4, Q8N4G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 88 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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