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Protein

Uncharacterized protein C4orf22

Gene

C4orf22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf22
Gene namesi
Name:C4orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28554. C4orf22.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008853.

Polymorphism and mutation databases

BioMutaiC4orf22.
DMDMi296439464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Uncharacterized protein C4orf22PRO_0000301955Add
BLAST

Proteomic databases

PeptideAtlasiQ6V702.
PRIDEiQ6V702.

PTM databases

iPTMnetiQ6V702.
PhosphoSiteiQ6V702.

Expressioni

Gene expression databases

BgeeiQ6V702.
CleanExiHS_C4orf22.
ExpressionAtlasiQ6V702. baseline and differential.
GenevisibleiQ6V702. HS.

Organism-specific databases

HPAiHPA043383.

Interactioni

Protein-protein interaction databases

BioGridi129077. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6V702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000016547.
HOGENOMiHOG000255608.
HOVERGENiHBG098178.
InParanoidiQ6V702.
OMAiWRTRKIF.
OrthoDBiEOG718KDR.
PhylomeDBiQ6V702.
TreeFamiTF323286.

Family and domain databases

InterProiIPR027887. DUF4464.
[Graphical view]
PfamiPF14713. DUF4464. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q6V702-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQEEGLKAL DNIVTQFNAY EDFLDSQITT VDLYYLEDET LARQLVELGY
60 70 80 90 100
RGTGERVKRE DFEARKAAIE IARLAERAQQ KTLTSAGKDL QDNFLTALAM
110 120 130 140 150
REEDNRSGKL SSVIFIRDRN SHGQEISGYI DYAHRLKTED FEVYFTGKKR
160 170 180 190 200
LLPRPTDISF YNWDADIAVS NSSPNYQVIA DNPEGLLFRY KRDRKILNVD
210 220 230
PKAQPGDNST RITILTELYV QAVIFDHISR RKT
Length:233
Mass (Da):26,869
Last modified:May 18, 2010 - v4
Checksum:iD57F4BA59DDC2D65
GO
Isoform 1 (identifier: Q6V702-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: S → SLNQQETDAAHILKKQLA

Show »
Length:250
Mass (Da):28,772
Checksum:i54FBA8623174E3C0
GO
Isoform 3 (identifier: Q6V702-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-156: SVIFIRDRNS...GKKRLLPRPT → AGVQWHHLGS...PPHPVRDLYS
     157-233: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:156
Mass (Da):17,763
Checksum:i60983A5B774ADDE5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681A → V in AAQ56723 (Ref. 1) Curated
Sequence conflicti119 – 1191R → G in AAQ56723 (Ref. 1) Curated
Isoform 1 (identifier: Q6V702-1)
Sequence conflicti122 – 1221I → T in AAQ56723 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381T → M.
Corresponds to variant rs11947742 [ dbSNP | Ensembl ].
VAR_034913
Natural varianti220 – 2201V → I.3 Publications
Corresponds to variant rs1052325 [ dbSNP | Ensembl ].
VAR_034914

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei111 – 1111S → SLNQQETDAAHILKKQLA in isoform 1. 1 PublicationVSP_037233
Alternative sequencei112 – 15645SVIFI…LPRPT → AGVQWHHLGSLQPLPPGFKE FSCFSLPSGWDYRHAPPHPV RDLYS in isoform 3. 1 PublicationVSP_037234Add
BLAST
Alternative sequencei157 – 23377Missing in isoform 3. 1 PublicationVSP_037235Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349359 mRNA. Translation: AAQ56723.1.
AK128642 mRNA. Translation: BAC87545.1.
AC021127 Genomic DNA. No translation available.
AC093876 Genomic DNA. No translation available.
AC093883 Genomic DNA. No translation available.
AC098822 Genomic DNA. No translation available.
AC105917 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05864.1.
BC034296 mRNA. Translation: AAH34296.1.
CCDSiCCDS3587.1. [Q6V702-2]
CCDS56336.1. [Q6V702-1]
RefSeqiNP_001193926.1. NM_001206997.1. [Q6V702-1]
NP_689983.2. NM_152770.2. [Q6V702-2]
UniGeneiHs.527104.

Genome annotation databases

EnsembliENST00000358105; ENSP00000350818; ENSG00000197826. [Q6V702-2]
ENST00000508675; ENSP00000425786; ENSG00000197826. [Q6V702-1]
GeneIDi255119.
KEGGihsa:255119.
UCSCiuc003hmf.3. human. [Q6V702-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY349359 mRNA. Translation: AAQ56723.1.
AK128642 mRNA. Translation: BAC87545.1.
AC021127 Genomic DNA. No translation available.
AC093876 Genomic DNA. No translation available.
AC093883 Genomic DNA. No translation available.
AC098822 Genomic DNA. No translation available.
AC105917 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05864.1.
BC034296 mRNA. Translation: AAH34296.1.
CCDSiCCDS3587.1. [Q6V702-2]
CCDS56336.1. [Q6V702-1]
RefSeqiNP_001193926.1. NM_001206997.1. [Q6V702-1]
NP_689983.2. NM_152770.2. [Q6V702-2]
UniGeneiHs.527104.

3D structure databases

ProteinModelPortaliQ6V702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129077. 2 interactions.

PTM databases

iPTMnetiQ6V702.
PhosphoSiteiQ6V702.

Polymorphism and mutation databases

BioMutaiC4orf22.
DMDMi296439464.

Proteomic databases

PeptideAtlasiQ6V702.
PRIDEiQ6V702.

Protocols and materials databases

DNASUi255119.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358105; ENSP00000350818; ENSG00000197826. [Q6V702-2]
ENST00000508675; ENSP00000425786; ENSG00000197826. [Q6V702-1]
GeneIDi255119.
KEGGihsa:255119.
UCSCiuc003hmf.3. human. [Q6V702-2]

Organism-specific databases

CTDi255119.
GeneCardsiC4orf22.
HGNCiHGNC:28554. C4orf22.
HPAiHPA043383.
neXtProtiNX_Q6V702.
PharmGKBiPA145008853.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000016547.
HOGENOMiHOG000255608.
HOVERGENiHBG098178.
InParanoidiQ6V702.
OMAiWRTRKIF.
OrthoDBiEOG718KDR.
PhylomeDBiQ6V702.
TreeFamiTF323286.

Miscellaneous databases

ChiTaRSiC4orf22. human.
GenomeRNAii255119.
PROiQ6V702.

Gene expression databases

BgeeiQ6V702.
CleanExiHS_C4orf22.
ExpressionAtlasiQ6V702. baseline and differential.
GenevisibleiQ6V702. HS.

Family and domain databases

InterProiIPR027887. DUF4464.
[Graphical view]
PfamiPF14713. DUF4464. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Zhou G., Yu R., Zheng G., Li H., Shen C., Ke R., Li M., Xiao W., Lin L., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-220.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Trachea.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-220.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-220.
    Tissue: Brain.

Entry informationi

Entry nameiCD022_HUMAN
AccessioniPrimary (citable) accession number: Q6V702
Secondary accession number(s): E7EQ13, Q6ZQY4, Q8N4G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 80 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.