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Protein

Kelch-like protein 6

Gene

Klhl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: UniProtKB
  • germinal center formation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 6
Gene namesi
Name:Klhl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2686922 Klhl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Mice show impaired antigen-dependent germinal center formation and B-cell antigen receptor (BCR) signaling. The number of mature B-cells is reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191071 – 619Kelch-like protein 6Add BLAST619

Proteomic databases

EPDiQ6V595
PaxDbiQ6V595
PeptideAtlasiQ6V595
PRIDEiQ6V595

PTM databases

PhosphoSitePlusiQ6V595

Expressioni

Tissue specificityi

Expressed in embryonic blood vessel endothelial cells but not in the vasculature of adult organs. In adults, detected at high levels in hematopoietic and lymphoid organs.1 Publication

Inductioni

Up-regulated during germinal center formation.1 Publication

Gene expression databases

BgeeiENSMUSG00000043008
CleanExiMM_KLHL6
ExpressionAtlasiQ6V595 baseline and differential
GenevisibleiQ6V595 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053023

Structurei

3D structure databases

ProteinModelPortaliQ6V595
SMRiQ6V595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 137BTBPROSITE-ProRule annotationAdd BLAST68
Domaini172 – 274BACKAdd BLAST103
Repeati318 – 365Kelch 1Add BLAST48
Repeati376 – 419Kelch 2Add BLAST44
Repeati420 – 466Kelch 3Add BLAST47
Repeati468 – 514Kelch 4Add BLAST47
Repeati515 – 556Kelch 5Add BLAST42
Repeati558 – 604Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000230817
HOVERGENiHBG108068
InParanoidiQ6V595
KOiK10444
OMAiRHKQSER
OrthoDBiEOG091G037V
PhylomeDBiQ6V595
TreeFamiTF351654

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029851 KLHL6
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24411:SF4 PTHR24411:SF4, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6V595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQRGACTM SDVVERSLEG PLALTTDKSS QKRGDLVEIL TGEKVKFDDT
60 70 80 90 100
RLSLILQNGL ETLREENALT DVILCVDVQE FSCHRVVLAA ASNYFRAMFC
110 120 130 140 150
NDLKEKYEKR IIIKGVDAET MHTLLVYTYT SKALITKQNV QRVLEAANLF
160 170 180 190 200
QFLQLVDACA SFLTEALNPE NCIGILRLAD THSLDSLKMQ VQSYIIQNFV
210 220 230 240 250
QILNSEEFLE LPVDTLYHIL RSDDLCVTEE AQVFETVMSW VRHKQSERLC
260 270 280 290 300
LLPCVLENVR LPLLDPWYFV EMVEADPLIR QCPEVFPLLQ EARMYHLSGN
310 320 330 340 350
EIISERTKPR MHEFQSEVFM IIGGCTKDER FVAEVTCLDP LRRSRLEVAK
360 370 380 390 400
LPLTEHELES ENKKWVEFAC VTLKNEVYIS GGKETQHDVW KYNSSINKWI
410 420 430 440 450
QIEYLNIGRW RHKMVVLGGK VYVLGGFDGL QRINNVETYD PFHNCWSEAA
460 470 480 490 500
PLHVHVSSFA ATSHKKKLYV IGGGPNGKLA TDKTQCYDPS TNKWVLKSAM
510 520 530 540 550
PVEAKCINAV SFQDHIYVVG GAMRALYAYS PLEDSWCLVT QLSHERASCG
560 570 580 590 600
IAPCNNKLYI TGGRDEKNEV IATVLCWDPE AQKLTEECVL PRGVSHHGSV
610
TIRKSYTHIR RVVPGAVSV
Length:619
Mass (Da):70,191
Last modified:September 1, 2009 - v2
Checksum:i18A89D05C6378666
GO

Sequence cautioni

The sequence AAI00569 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139N → K in AAQ56719 (PubMed:12617994).Curated1
Sequence conflicti161S → N in AAI00569 (PubMed:15489334).Curated1
Sequence conflicti194Y → C in AAQ56719 (PubMed:12617994).Curated1
Sequence conflicti335V → A in AAI00569 (PubMed:15489334).Curated1
Sequence conflicti428D → G in AAI00569 (PubMed:15489334).Curated1
Sequence conflicti448E → G in AAI00569 (PubMed:15489334).Curated1
Sequence conflicti486C → W in AAQ56719 (PubMed:12617994).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164558 Genomic DNA No translation available.
BC100568 mRNA Translation: AAI00569.1 Different initiation.
AY350736 mRNA Translation: AAQ56719.1
CCDSiCCDS28041.2
RefSeqiNP_899246.2, NM_183390.3
UniGeneiMm.86699

Genome annotation databases

EnsembliENSMUST00000058839; ENSMUSP00000053023; ENSMUSG00000043008
GeneIDi239743
KEGGimmu:239743
UCSCiuc007ypg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLHL6_MOUSE
AccessioniPrimary (citable) accession number: Q6V595
Secondary accession number(s): Q497G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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