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Protein

Kelch-like protein 6

Gene

Klhl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.1 Publication

GO - Biological processi

  • B cell receptor signaling pathway Source: UniProtKB
  • germinal center formation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 6
Gene namesi
Name:Klhl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2686922. Klhl6.

Pathology & Biotechi

Disruption phenotypei

Mice show impaired antigen-dependent germinal center formation and B-cell antigen receptor (BCR) signaling. The number of mature B-cells is reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Kelch-like protein 6PRO_0000119107Add
BLAST

Proteomic databases

EPDiQ6V595.
MaxQBiQ6V595.
PaxDbiQ6V595.
PeptideAtlasiQ6V595.
PRIDEiQ6V595.

PTM databases

PhosphoSiteiQ6V595.

Expressioni

Tissue specificityi

Expressed in embryonic blood vessel endothelial cells but not in the vasculature of adult organs. In adults, detected at high levels in hematopoietic and lymphoid organs.1 Publication

Inductioni

Up-regulated during germinal center formation.1 Publication

Gene expression databases

BgeeiQ6V595.
CleanExiMM_KLHL6.
ExpressionAtlasiQ6V595. baseline and differential.
GenevisibleiQ6V595. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053023.

Structurei

3D structure databases

ProteinModelPortaliQ6V595.
SMRiQ6V595. Positions 60-296, 316-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 13768BTBPROSITE-ProRule annotationAdd
BLAST
Domaini172 – 274103BACKAdd
BLAST
Repeati318 – 36548Kelch 1Add
BLAST
Repeati376 – 41944Kelch 2Add
BLAST
Repeati420 – 46647Kelch 3Add
BLAST
Repeati468 – 51447Kelch 4Add
BLAST
Repeati515 – 55642Kelch 5Add
BLAST
Repeati558 – 60447Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ6V595.
KOiK10444.
OMAiVQNYIIQ.
OrthoDBiEOG7HHWRM.
PhylomeDBiQ6V595.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24411:SF4. PTHR24411:SF4. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6V595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQRGACTM SDVVERSLEG PLALTTDKSS QKRGDLVEIL TGEKVKFDDT
60 70 80 90 100
RLSLILQNGL ETLREENALT DVILCVDVQE FSCHRVVLAA ASNYFRAMFC
110 120 130 140 150
NDLKEKYEKR IIIKGVDAET MHTLLVYTYT SKALITKQNV QRVLEAANLF
160 170 180 190 200
QFLQLVDACA SFLTEALNPE NCIGILRLAD THSLDSLKMQ VQSYIIQNFV
210 220 230 240 250
QILNSEEFLE LPVDTLYHIL RSDDLCVTEE AQVFETVMSW VRHKQSERLC
260 270 280 290 300
LLPCVLENVR LPLLDPWYFV EMVEADPLIR QCPEVFPLLQ EARMYHLSGN
310 320 330 340 350
EIISERTKPR MHEFQSEVFM IIGGCTKDER FVAEVTCLDP LRRSRLEVAK
360 370 380 390 400
LPLTEHELES ENKKWVEFAC VTLKNEVYIS GGKETQHDVW KYNSSINKWI
410 420 430 440 450
QIEYLNIGRW RHKMVVLGGK VYVLGGFDGL QRINNVETYD PFHNCWSEAA
460 470 480 490 500
PLHVHVSSFA ATSHKKKLYV IGGGPNGKLA TDKTQCYDPS TNKWVLKSAM
510 520 530 540 550
PVEAKCINAV SFQDHIYVVG GAMRALYAYS PLEDSWCLVT QLSHERASCG
560 570 580 590 600
IAPCNNKLYI TGGRDEKNEV IATVLCWDPE AQKLTEECVL PRGVSHHGSV
610
TIRKSYTHIR RVVPGAVSV
Length:619
Mass (Da):70,191
Last modified:September 1, 2009 - v2
Checksum:i18A89D05C6378666
GO

Sequence cautioni

The sequence AAI00569.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391N → K in AAQ56719 (PubMed:12617994).Curated
Sequence conflicti161 – 1611S → N in AAI00569 (PubMed:15489334).Curated
Sequence conflicti194 – 1941Y → C in AAQ56719 (PubMed:12617994).Curated
Sequence conflicti335 – 3351V → A in AAI00569 (PubMed:15489334).Curated
Sequence conflicti428 – 4281D → G in AAI00569 (PubMed:15489334).Curated
Sequence conflicti448 – 4481E → G in AAI00569 (PubMed:15489334).Curated
Sequence conflicti486 – 4861C → W in AAQ56719 (PubMed:12617994).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164558 Genomic DNA. No translation available.
BC100568 mRNA. Translation: AAI00569.1. Different initiation.
AY350736 mRNA. Translation: AAQ56719.1.
CCDSiCCDS28041.2.
RefSeqiNP_899246.2. NM_183390.3.
UniGeneiMm.86699.

Genome annotation databases

EnsembliENSMUST00000058839; ENSMUSP00000053023; ENSMUSG00000043008.
GeneIDi239743.
KEGGimmu:239743.
UCSCiuc007ypg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164558 Genomic DNA. No translation available.
BC100568 mRNA. Translation: AAI00569.1. Different initiation.
AY350736 mRNA. Translation: AAQ56719.1.
CCDSiCCDS28041.2.
RefSeqiNP_899246.2. NM_183390.3.
UniGeneiMm.86699.

3D structure databases

ProteinModelPortaliQ6V595.
SMRiQ6V595. Positions 60-296, 316-618.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053023.

PTM databases

PhosphoSiteiQ6V595.

Proteomic databases

EPDiQ6V595.
MaxQBiQ6V595.
PaxDbiQ6V595.
PeptideAtlasiQ6V595.
PRIDEiQ6V595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058839; ENSMUSP00000053023; ENSMUSG00000043008.
GeneIDi239743.
KEGGimmu:239743.
UCSCiuc007ypg.2. mouse.

Organism-specific databases

CTDi89857.
MGIiMGI:2686922. Klhl6.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ6V595.
KOiK10444.
OMAiVQNYIIQ.
OrthoDBiEOG7HHWRM.
PhylomeDBiQ6V595.
TreeFamiTF351654.

Miscellaneous databases

PROiQ6V595.
SOURCEiSearch...

Gene expression databases

BgeeiQ6V595.
CleanExiMM_KLHL6.
ExpressionAtlasiQ6V595. baseline and differential.
GenevisibleiQ6V595. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24411:SF4. PTHR24411:SF4. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.
  3. "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells."
    Gupta-Rossi N., Storck S., Griebel P.J., Reynaud C.-A., Weill J.-C., Dahan A.
    Mol. Immunol. 39:791-799(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-619.
    Strain: BALB/cJ.
  4. "The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation."
    Kroll J., Shi X., Caprioli A., Liu H.-H., Waskow C., Lin K.-M., Miyazaki T., Rodewald H.-R., Sato T.N.
    Mol. Cell. Biol. 25:8531-8540(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKLHL6_MOUSE
AccessioniPrimary (citable) accession number: Q6V595
Secondary accession number(s): Q497G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 1, 2009
Last modified: July 6, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.