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Protein

8-hydroxygeraniol dehydrogenase

Gene

10HGO

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Dehydrogenase involved in the biosynthesis of oxogeranial from hydroxygeraniol, a precursor of the terpenoid indole alkaloids such as vinblastine and vincristine.1 Publication

Miscellaneous

The recommended numbering of geraniol gives (6E)-8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol and (6E)-8-oxogeranial as the product rather than 10-oxogeranial as used in most publications.

Catalytic activityi

(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH.1 Publication

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Zinc 1; catalyticBy similarity1
Metal bindingi72Zinc 1; catalyticBy similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi117Zinc 2By similarity1
Metal bindingi166Zinc 1; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NADP, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
8-hydroxygeraniol dehydrogenase (EC:1.1.1.324)
Short name:
Cr10HGO
Gene namesi
Name:10HGO
OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifieri4058 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004189791 – 3608-hydroxygeraniol dehydrogenaseAdd BLAST360

Expressioni

Tissue specificityi

Present in seedlings and vascular tissues (at protein level). Restricted to the epidermis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6V4H0.
SMRiQ6V4H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like_sf.
IPR036291. NAD(P)-bd_dom_sf.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6V4H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSPEVEHP VKAFGWAARD TSGHLSPFHF SRRATGEHDV QFKVLYCGIC
60 70 80 90 100
HSDLHMIKNE WGFTKYPIVP GHEIVGIVTE VGSKVEKFKV GDKVGVGCLV
110 120 130 140 150
GSCRKCDMCT KDLENYCPGQ ILTYSATYTD GTTTYGGYSD LMVADEHFVI
160 170 180 190 200
RWPENLPMDI GAPLLCAGIT TYSPLRYFGL DKPGTHVGVV GLGGLGHVAV
210 220 230 240 250
KFAKAFGAKV TVISTSESKK QEALEKLGAD SFLVSRDPEQ MKAAAASLDG
260 270 280 290 300
IIDTVSAIHP IMPLLSILKS HGKLILVGAP EKPLELPSFP LIAGRKIIAG
310 320 330 340 350
SAIGGLKETQ EMIDFAAKHN VLPDVELVSM DYVNTAMERL LKADVKYRFV
360
IDVANTLKSA
Length:360
Mass (Da):38,937
Last modified:July 5, 2004 - v1
Checksum:iAB701A2D8921005E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352047 mRNA. Translation: AAQ55962.1.

Similar proteinsi

Entry informationi

Entry namei10HGO_CATRO
AccessioniPrimary (citable) accession number: Q6V4H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families