Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynein regulatory complex subunit 7

Gene

Drc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 7
Alternative name(s):
Coiled-coil domain-containing protein 135
Coiled-coil domain-containing protein lobo homolog
Spermatogenesis-related gene in late stages of spermatogenesis cells protein
Gene namesi
Name:Drc7
Synonyms:Ccdc135, Gm770, Srgl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2685616. Drc7.

Subcellular locationi

  • Cell projectionciliumflagellum By similarity
  • Cytoplasmcytoskeletoncilium axoneme By similarity

  • Note: Associated with the outer doublet microtubules (OD).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Dynein regulatory complex subunit 7PRO_0000279436Add
BLAST

Proteomic databases

PaxDbiQ6V3W6.
PRIDEiQ6V3W6.

PTM databases

PhosphoSiteiQ6V3W6.

Expressioni

Tissue specificityi

Isoform 1 is expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Isoform 1 is strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Isoform 1 is expressed in diplotene and pachytene spermytocytes, round and elongating spermatids. Expressed in testis, kidney, ovary, thymus and spleen. Expressed in ciliated cells.3 Publications

Gene expression databases

BgeeiQ6V3W6.
CleanExiMM_CCDC135.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053972.

Structurei

3D structure databases

ProteinModelPortaliQ6V3W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 3333Sequence AnalysisAdd
BLAST
Coiled coili258 – 29538Sequence AnalysisAdd
BLAST
Coiled coili679 – 71032Sequence AnalysisAdd
BLAST
Coiled coili784 – 80926Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the DRC7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG76407.
GeneTreeiENSGT00390000004913.
HOGENOMiHOG000007476.
HOVERGENiHBG107597.
InParanoidiQ6V3W6.
OMAiLLYQYET.
OrthoDBiEOG7VB2DW.
TreeFamiTF323665.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6V3W6-1) [UniParc]FASTAAdd to basket

Also known as: SRG-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLREKVEE EEEAEREEAA ERAERTEKLE RVTKSAEVSR EGTILSQDEL
60 70 80 90 100
RDLEGKLMAI EIPTQADHSV ISQAPVDVTK LPPSYTTNSL KEEHLLLVAD
110 120 130 140 150
NFSRQYSHLC PDRVPLFLHP LNECNVPKFV STTLRPTLMP YPELYNWDSC
160 170 180 190 200
AQFVSDFLTM VPLVDPLKPP THLYSSTTVL KCQKGNCFDF STLLCSMLIG
210 220 230 240 250
SGYDAYCVNG YGSLDLCLMD LTREVCPLTV KAKEIVKKKE KTVPKKYSIK
260 270 280 290 300
PPRDLTSKFE QEQEEKRIQE IKDLEQRRLK EEEDRILEAE KAKPDPLHGL
310 320 330 340 350
RVHSWVLVLA GKREVPESFF IDPLTARSYS TKDEHFLGIE SLWNHKNYWI
360 370 380 390 400
NMQDCWNCCK DLIFDLGDPV RWEYMLLGTD KPHLSLTEED EEGLDDDDDD
410 420 430 440 450
VEDLGKEEED KSFDMPSSWV SQIEITPEEF ETRCPSGKKV IQYKKAQLEK
460 470 480 490 500
WSPYLNNNGL VCRLTTYEDQ QCTKVLEIKE WYQNREDMLE LKHINKTTGL
510 520 530 540 550
HVDYFKPGHP QALCVHSYKS MLPEMDRVME FYKKIRVDGL VKREETPMTM
560 570 580 590 600
TEYYEGRSDF LAYRHVNFGP RVKKLSQSSV ESNPRPMVKI TERFSRNPEK
610 620 630 640 650
PADEDVAERL FLIVEERIQL RYHCRDDYIT ASKREFLRRM EVDSKGNKII
660 670 680 690 700
MTPEMCISYE VEPMEHTKKL LYQYETMNQL KNEEKLSRHQ AWESELEVLE
710 720 730 740 750
ILKLREEEEE AHTLTISIYD TKRNEKSKEY REAMERVLHE EHLRQVEAQL
760 770 780 790 800
DYLAPFLAQL PPGEKLTRWQ AVRLKDECLS DFKQRLIDKA NLIQARFEKE
810 820 830 840 850
TQELQKKQQW YQENQVTLTP EDENLYLSYC SQAMFRIRIL EQRLNRHKEL
860 870
APLKYLALEE KLYKDPRLID FVKVFV
Length:876
Mass (Da):103,269
Last modified:February 22, 2012 - v4
Checksum:iDD009EA45F68AEF0
GO
Isoform 2 (identifier: Q6V3W6-2) [UniParc]FASTAAdd to basket

Also known as: SRG-S

The sequence of this isoform differs from the canonical sequence as follows:
     288-295: EAEKAKPD → VGLHDTAL
     296-876: Missing.

Show »
Length:295
Mass (Da):33,781
Checksum:i9869D3FA8DA2382B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91Missing in AAQ55489 (PubMed:16804880).Curated
Sequence conflicti603 – 6031D → G in AAQ55489 (PubMed:16804880).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei288 – 2958EAEKAKPD → VGLHDTAL in isoform 2. 1 PublicationVSP_023440
Alternative sequencei296 – 876581Missing in isoform 2. 1 PublicationVSP_023441Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352586 mRNA. Translation: AAQ55489.2.
AC103935 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11157.1.
BC117982 mRNA. Translation: AAI17983.1.
BC117983 mRNA. Translation: AAI17984.1.
CCDSiCCDS40444.1. [Q6V3W6-1]
RefSeqiNP_001036180.2. NM_001042715.3. [Q6V3W6-1]
XP_006531195.1. XM_006531132.1. [Q6V3W6-1]
UniGeneiMm.277112.

Genome annotation databases

EnsembliENSMUST00000058479; ENSMUSP00000053972; ENSMUSG00000031786. [Q6V3W6-1]
GeneIDi330830.
KEGGimmu:330830.
UCSCiuc009mxr.1. mouse. [Q6V3W6-2]
uc009mxs.1. mouse. [Q6V3W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352586 mRNA. Translation: AAQ55489.2.
AC103935 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11157.1.
BC117982 mRNA. Translation: AAI17983.1.
BC117983 mRNA. Translation: AAI17984.1.
CCDSiCCDS40444.1. [Q6V3W6-1]
RefSeqiNP_001036180.2. NM_001042715.3. [Q6V3W6-1]
XP_006531195.1. XM_006531132.1. [Q6V3W6-1]
UniGeneiMm.277112.

3D structure databases

ProteinModelPortaliQ6V3W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053972.

PTM databases

PhosphoSiteiQ6V3W6.

Proteomic databases

PaxDbiQ6V3W6.
PRIDEiQ6V3W6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058479; ENSMUSP00000053972; ENSMUSG00000031786. [Q6V3W6-1]
GeneIDi330830.
KEGGimmu:330830.
UCSCiuc009mxr.1. mouse. [Q6V3W6-2]
uc009mxs.1. mouse. [Q6V3W6-1]

Organism-specific databases

CTDi84229.
MGIiMGI:2685616. Drc7.

Phylogenomic databases

eggNOGiNOG76407.
GeneTreeiENSGT00390000004913.
HOGENOMiHOG000007476.
HOVERGENiHBG107597.
InParanoidiQ6V3W6.
OMAiLLYQYET.
OrthoDBiEOG7VB2DW.
TreeFamiTF323665.

Miscellaneous databases

NextBioi399582.
PROiQ6V3W6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6V3W6.
CleanExiMM_CCDC135.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene SRG-L expressed in late stages of mouse spermatogenic cells."
    Guo R., Ma P.P., Ma J., Ge Y.H., Xue S.P., Han D.S.
    Acta Biochim. Biophys. Sin. 36:315-322(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  2. "Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells."
    Ma Q., Wang H., Guo R., Wang H., Ge Y., Ma J., Xue S., Han D.
    Mol. Reprod. Dev. 73:1075-1083(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Tissue expression patterns identify mouse cilia genes."
    McClintock T.S., Glasser C.E., Bose S.C., Bergman D.A.
    Physiol. Genomics 32:198-206(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDRC7_MOUSE
AccessioniPrimary (citable) accession number: Q6V3W6
Secondary accession number(s): G3X9B0, Q148T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 22, 2012
Last modified: June 24, 2015
This is version 67 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.