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Q6V3W6

- CC135_MOUSE

UniProt

Q6V3W6 - CC135_MOUSE

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Protein
Coiled-coil domain-containing protein lobo homolog
Gene
Ccdc135, Gm770, Srgl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in sperm motility By similarity. Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis.1 Publication

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein lobo homolog
Alternative name(s):
Coiled-coil domain-containing protein 135
Spermatogenesis-related gene in late stages of spermatogenesis cells protein
Gene namesi
Name:Ccdc135
Synonyms:Gm770, Srgl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2685616. Ccdc135.

Subcellular locationi

Cell projectionciliumflagellum By similarity

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
  2. cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Coiled-coil domain-containing protein lobo homolog
PRO_0000279436Add
BLAST

Proteomic databases

PaxDbiQ6V3W6.
PRIDEiQ6V3W6.

PTM databases

PhosphoSiteiQ6V3W6.

Expressioni

Tissue specificityi

Isoform 1 is expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Isoform 1 is strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Isoform 1 is expressed in diplotene and pachytene spermytocytes, round and elongating spermatids. Expressed in testis, kidney, ovary, thymus and spleen. Expressed in ciliated cells.3 Publications

Gene expression databases

BgeeiQ6V3W6.
CleanExiMM_CCDC135.
GenevestigatoriQ6V3W6.

Structurei

3D structure databases

ProteinModelPortaliQ6V3W6.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 3333 Reviewed prediction
Add
BLAST
Coiled coili258 – 29538 Reviewed prediction
Add
BLAST
Coiled coili679 – 71032 Reviewed prediction
Add
BLAST
Coiled coili784 – 80926 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CCDC135 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG76407.
GeneTreeiENSGT00390000004913.
HOGENOMiHOG000007476.
HOVERGENiHBG107597.
InParanoidiQ6V3W6.
OMAiLLYQYET.
OrthoDBiEOG7VB2DW.
TreeFamiTF323665.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6V3W6-1) [UniParc]FASTAAdd to Basket

Also known as: SRG-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEVLREKVEE EEEAEREEAA ERAERTEKLE RVTKSAEVSR EGTILSQDEL    50
RDLEGKLMAI EIPTQADHSV ISQAPVDVTK LPPSYTTNSL KEEHLLLVAD 100
NFSRQYSHLC PDRVPLFLHP LNECNVPKFV STTLRPTLMP YPELYNWDSC 150
AQFVSDFLTM VPLVDPLKPP THLYSSTTVL KCQKGNCFDF STLLCSMLIG 200
SGYDAYCVNG YGSLDLCLMD LTREVCPLTV KAKEIVKKKE KTVPKKYSIK 250
PPRDLTSKFE QEQEEKRIQE IKDLEQRRLK EEEDRILEAE KAKPDPLHGL 300
RVHSWVLVLA GKREVPESFF IDPLTARSYS TKDEHFLGIE SLWNHKNYWI 350
NMQDCWNCCK DLIFDLGDPV RWEYMLLGTD KPHLSLTEED EEGLDDDDDD 400
VEDLGKEEED KSFDMPSSWV SQIEITPEEF ETRCPSGKKV IQYKKAQLEK 450
WSPYLNNNGL VCRLTTYEDQ QCTKVLEIKE WYQNREDMLE LKHINKTTGL 500
HVDYFKPGHP QALCVHSYKS MLPEMDRVME FYKKIRVDGL VKREETPMTM 550
TEYYEGRSDF LAYRHVNFGP RVKKLSQSSV ESNPRPMVKI TERFSRNPEK 600
PADEDVAERL FLIVEERIQL RYHCRDDYIT ASKREFLRRM EVDSKGNKII 650
MTPEMCISYE VEPMEHTKKL LYQYETMNQL KNEEKLSRHQ AWESELEVLE 700
ILKLREEEEE AHTLTISIYD TKRNEKSKEY REAMERVLHE EHLRQVEAQL 750
DYLAPFLAQL PPGEKLTRWQ AVRLKDECLS DFKQRLIDKA NLIQARFEKE 800
TQELQKKQQW YQENQVTLTP EDENLYLSYC SQAMFRIRIL EQRLNRHKEL 850
APLKYLALEE KLYKDPRLID FVKVFV 876
Length:876
Mass (Da):103,269
Last modified:February 22, 2012 - v4
Checksum:iDD009EA45F68AEF0
GO
Isoform 2 (identifier: Q6V3W6-2) [UniParc]FASTAAdd to Basket

Also known as: SRG-S

The sequence of this isoform differs from the canonical sequence as follows:
     288-295: EAEKAKPD → VGLHDTAL
     296-876: Missing.

Show »
Length:295
Mass (Da):33,781
Checksum:i9869D3FA8DA2382B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei288 – 2958EAEKAKPD → VGLHDTAL in isoform 2.
VSP_023440
Alternative sequencei296 – 876581Missing in isoform 2.
VSP_023441Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91Missing in AAQ55489. 1 Publication
Sequence conflicti603 – 6031D → G in AAQ55489. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY352586 mRNA. Translation: AAQ55489.2.
AC103935 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11157.1.
BC117982 mRNA. Translation: AAI17983.1.
BC117983 mRNA. Translation: AAI17984.1.
CCDSiCCDS40444.1. [Q6V3W6-1]
RefSeqiNP_001036180.2. NM_001042715.3. [Q6V3W6-1]
XP_006531195.1. XM_006531132.1. [Q6V3W6-1]
UniGeneiMm.277112.

Genome annotation databases

EnsembliENSMUST00000058479; ENSMUSP00000053972; ENSMUSG00000031786. [Q6V3W6-1]
GeneIDi330830.
KEGGimmu:330830.
UCSCiuc009mxr.1. mouse. [Q6V3W6-2]
uc009mxs.1. mouse. [Q6V3W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY352586 mRNA. Translation: AAQ55489.2 .
AC103935 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11157.1 .
BC117982 mRNA. Translation: AAI17983.1 .
BC117983 mRNA. Translation: AAI17984.1 .
CCDSi CCDS40444.1. [Q6V3W6-1 ]
RefSeqi NP_001036180.2. NM_001042715.3. [Q6V3W6-1 ]
XP_006531195.1. XM_006531132.1. [Q6V3W6-1 ]
UniGenei Mm.277112.

3D structure databases

ProteinModelPortali Q6V3W6.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6V3W6.

Proteomic databases

PaxDbi Q6V3W6.
PRIDEi Q6V3W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058479 ; ENSMUSP00000053972 ; ENSMUSG00000031786 . [Q6V3W6-1 ]
GeneIDi 330830.
KEGGi mmu:330830.
UCSCi uc009mxr.1. mouse. [Q6V3W6-2 ]
uc009mxs.1. mouse. [Q6V3W6-1 ]

Organism-specific databases

CTDi 84229.
MGIi MGI:2685616. Ccdc135.

Phylogenomic databases

eggNOGi NOG76407.
GeneTreei ENSGT00390000004913.
HOGENOMi HOG000007476.
HOVERGENi HBG107597.
InParanoidi Q6V3W6.
OMAi LLYQYET.
OrthoDBi EOG7VB2DW.
TreeFami TF323665.

Miscellaneous databases

NextBioi 399582.
PROi Q6V3W6.
SOURCEi Search...

Gene expression databases

Bgeei Q6V3W6.
CleanExi MM_CCDC135.
Genevestigatori Q6V3W6.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene SRG-L expressed in late stages of mouse spermatogenic cells."
    Guo R., Ma P.P., Ma J., Ge Y.H., Xue S.P., Han D.S.
    Acta Biochim. Biophys. Sin. 36:315-322(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  2. "Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells."
    Ma Q., Wang H., Guo R., Wang H., Ge Y., Ma J., Xue S., Han D.
    Mol. Reprod. Dev. 73:1075-1083(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Tissue expression patterns identify mouse cilia genes."
    McClintock T.S., Glasser C.E., Bose S.C., Bergman D.A.
    Physiol. Genomics 32:198-206(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCC135_MOUSE
AccessioniPrimary (citable) accession number: Q6V3W6
Secondary accession number(s): G3X9B0, Q148T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 22, 2012
Last modified: July 9, 2014
This is version 60 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi