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Q6V3W6

- CC135_MOUSE

UniProt

Q6V3W6 - CC135_MOUSE

Protein

Coiled-coil domain-containing protein lobo homolog

Gene

Ccdc135

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 4 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    May be involved in sperm motility By similarity. Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis.By similarity1 Publication

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. spermatogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein lobo homolog
    Alternative name(s):
    Coiled-coil domain-containing protein 135
    Spermatogenesis-related gene in late stages of spermatogenesis cells protein
    Gene namesi
    Name:Ccdc135
    Synonyms:Gm770, Srgl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2685616. Ccdc135.

    Subcellular locationi

    Cell projectionciliumflagellum By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB-KW
    2. cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Cell projection, Cilium, Flagellum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Coiled-coil domain-containing protein lobo homologPRO_0000279436Add
    BLAST

    Proteomic databases

    PaxDbiQ6V3W6.
    PRIDEiQ6V3W6.

    PTM databases

    PhosphoSiteiQ6V3W6.

    Expressioni

    Tissue specificityi

    Isoform 1 is expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Isoform 1 is strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Isoform 1 is expressed in diplotene and pachytene spermytocytes, round and elongating spermatids. Expressed in testis, kidney, ovary, thymus and spleen. Expressed in ciliated cells.3 Publications

    Gene expression databases

    BgeeiQ6V3W6.
    CleanExiMM_CCDC135.
    GenevestigatoriQ6V3W6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6V3W6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 3333Sequence AnalysisAdd
    BLAST
    Coiled coili258 – 29538Sequence AnalysisAdd
    BLAST
    Coiled coili679 – 71032Sequence AnalysisAdd
    BLAST
    Coiled coili784 – 80926Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC135 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG76407.
    GeneTreeiENSGT00390000004913.
    HOGENOMiHOG000007476.
    HOVERGENiHBG107597.
    InParanoidiQ6V3W6.
    OMAiLLYQYET.
    OrthoDBiEOG7VB2DW.
    TreeFamiTF323665.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6V3W6-1) [UniParc]FASTAAdd to Basket

    Also known as: SRG-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVLREKVEE EEEAEREEAA ERAERTEKLE RVTKSAEVSR EGTILSQDEL    50
    RDLEGKLMAI EIPTQADHSV ISQAPVDVTK LPPSYTTNSL KEEHLLLVAD 100
    NFSRQYSHLC PDRVPLFLHP LNECNVPKFV STTLRPTLMP YPELYNWDSC 150
    AQFVSDFLTM VPLVDPLKPP THLYSSTTVL KCQKGNCFDF STLLCSMLIG 200
    SGYDAYCVNG YGSLDLCLMD LTREVCPLTV KAKEIVKKKE KTVPKKYSIK 250
    PPRDLTSKFE QEQEEKRIQE IKDLEQRRLK EEEDRILEAE KAKPDPLHGL 300
    RVHSWVLVLA GKREVPESFF IDPLTARSYS TKDEHFLGIE SLWNHKNYWI 350
    NMQDCWNCCK DLIFDLGDPV RWEYMLLGTD KPHLSLTEED EEGLDDDDDD 400
    VEDLGKEEED KSFDMPSSWV SQIEITPEEF ETRCPSGKKV IQYKKAQLEK 450
    WSPYLNNNGL VCRLTTYEDQ QCTKVLEIKE WYQNREDMLE LKHINKTTGL 500
    HVDYFKPGHP QALCVHSYKS MLPEMDRVME FYKKIRVDGL VKREETPMTM 550
    TEYYEGRSDF LAYRHVNFGP RVKKLSQSSV ESNPRPMVKI TERFSRNPEK 600
    PADEDVAERL FLIVEERIQL RYHCRDDYIT ASKREFLRRM EVDSKGNKII 650
    MTPEMCISYE VEPMEHTKKL LYQYETMNQL KNEEKLSRHQ AWESELEVLE 700
    ILKLREEEEE AHTLTISIYD TKRNEKSKEY REAMERVLHE EHLRQVEAQL 750
    DYLAPFLAQL PPGEKLTRWQ AVRLKDECLS DFKQRLIDKA NLIQARFEKE 800
    TQELQKKQQW YQENQVTLTP EDENLYLSYC SQAMFRIRIL EQRLNRHKEL 850
    APLKYLALEE KLYKDPRLID FVKVFV 876
    Length:876
    Mass (Da):103,269
    Last modified:February 22, 2012 - v4
    Checksum:iDD009EA45F68AEF0
    GO
    Isoform 2 (identifier: Q6V3W6-2) [UniParc]FASTAAdd to Basket

    Also known as: SRG-S

    The sequence of this isoform differs from the canonical sequence as follows:
         288-295: EAEKAKPD → VGLHDTAL
         296-876: Missing.

    Show »
    Length:295
    Mass (Da):33,781
    Checksum:i9869D3FA8DA2382B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91Missing in AAQ55489. (PubMed:16804880)Curated
    Sequence conflicti603 – 6031D → G in AAQ55489. (PubMed:16804880)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei288 – 2958EAEKAKPD → VGLHDTAL in isoform 2. 1 PublicationVSP_023440
    Alternative sequencei296 – 876581Missing in isoform 2. 1 PublicationVSP_023441Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY352586 mRNA. Translation: AAQ55489.2.
    AC103935 Genomic DNA. No translation available.
    CH466525 Genomic DNA. Translation: EDL11157.1.
    BC117982 mRNA. Translation: AAI17983.1.
    BC117983 mRNA. Translation: AAI17984.1.
    CCDSiCCDS40444.1. [Q6V3W6-1]
    RefSeqiNP_001036180.2. NM_001042715.3. [Q6V3W6-1]
    XP_006531195.1. XM_006531132.1. [Q6V3W6-1]
    UniGeneiMm.277112.

    Genome annotation databases

    EnsembliENSMUST00000058479; ENSMUSP00000053972; ENSMUSG00000031786. [Q6V3W6-1]
    GeneIDi330830.
    KEGGimmu:330830.
    UCSCiuc009mxr.1. mouse. [Q6V3W6-2]
    uc009mxs.1. mouse. [Q6V3W6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY352586 mRNA. Translation: AAQ55489.2 .
    AC103935 Genomic DNA. No translation available.
    CH466525 Genomic DNA. Translation: EDL11157.1 .
    BC117982 mRNA. Translation: AAI17983.1 .
    BC117983 mRNA. Translation: AAI17984.1 .
    CCDSi CCDS40444.1. [Q6V3W6-1 ]
    RefSeqi NP_001036180.2. NM_001042715.3. [Q6V3W6-1 ]
    XP_006531195.1. XM_006531132.1. [Q6V3W6-1 ]
    UniGenei Mm.277112.

    3D structure databases

    ProteinModelPortali Q6V3W6.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6V3W6.

    Proteomic databases

    PaxDbi Q6V3W6.
    PRIDEi Q6V3W6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058479 ; ENSMUSP00000053972 ; ENSMUSG00000031786 . [Q6V3W6-1 ]
    GeneIDi 330830.
    KEGGi mmu:330830.
    UCSCi uc009mxr.1. mouse. [Q6V3W6-2 ]
    uc009mxs.1. mouse. [Q6V3W6-1 ]

    Organism-specific databases

    CTDi 84229.
    MGIi MGI:2685616. Ccdc135.

    Phylogenomic databases

    eggNOGi NOG76407.
    GeneTreei ENSGT00390000004913.
    HOGENOMi HOG000007476.
    HOVERGENi HBG107597.
    InParanoidi Q6V3W6.
    OMAi LLYQYET.
    OrthoDBi EOG7VB2DW.
    TreeFami TF323665.

    Miscellaneous databases

    NextBioi 399582.
    PROi Q6V3W6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6V3W6.
    CleanExi MM_CCDC135.
    Genevestigatori Q6V3W6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel gene SRG-L expressed in late stages of mouse spermatogenic cells."
      Guo R., Ma P.P., Ma J., Ge Y.H., Xue S.P., Han D.S.
      Acta Biochim. Biophys. Sin. 36:315-322(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Testis.
    2. "Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells."
      Ma Q., Wang H., Guo R., Wang H., Ge Y., Ma J., Xue S., Han D.
      Mol. Reprod. Dev. 73:1075-1083(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Tissue expression patterns identify mouse cilia genes."
      McClintock T.S., Glasser C.E., Bose S.C., Bergman D.A.
      Physiol. Genomics 32:198-206(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCC135_MOUSE
    AccessioniPrimary (citable) accession number: Q6V3W6
    Secondary accession number(s): G3X9B0, Q148T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 61 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3