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Q6V3W6

- CC135_MOUSE

UniProt

Q6V3W6 - CC135_MOUSE

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Protein

Coiled-coil domain-containing protein lobo homolog

Gene

Ccdc135

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in sperm motility (By similarity). Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis.By similarity1 Publication

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein lobo homolog
Alternative name(s):
Coiled-coil domain-containing protein 135
Spermatogenesis-related gene in late stages of spermatogenesis cells protein
Gene namesi
Name:Ccdc135
Synonyms:Gm770, Srgl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2685616. Ccdc135.

Subcellular locationi

Cell projectionciliumflagellum By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. motile cilium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Coiled-coil domain-containing protein lobo homologPRO_0000279436Add
BLAST

Proteomic databases

PaxDbiQ6V3W6.
PRIDEiQ6V3W6.

PTM databases

PhosphoSiteiQ6V3W6.

Expressioni

Tissue specificityi

Isoform 1 is expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Isoform 1 is strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Isoform 1 is expressed in diplotene and pachytene spermytocytes, round and elongating spermatids. Expressed in testis, kidney, ovary, thymus and spleen. Expressed in ciliated cells.3 Publications

Gene expression databases

BgeeiQ6V3W6.
CleanExiMM_CCDC135.
GenevestigatoriQ6V3W6.

Structurei

3D structure databases

ProteinModelPortaliQ6V3W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 3333Sequence AnalysisAdd
BLAST
Coiled coili258 – 29538Sequence AnalysisAdd
BLAST
Coiled coili679 – 71032Sequence AnalysisAdd
BLAST
Coiled coili784 – 80926Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC135 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG76407.
GeneTreeiENSGT00390000004913.
HOGENOMiHOG000007476.
HOVERGENiHBG107597.
InParanoidiQ6V3W6.
OMAiLLYQYET.
OrthoDBiEOG7VB2DW.
TreeFamiTF323665.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6V3W6-1) [UniParc]FASTAAdd to Basket

Also known as: SRG-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLREKVEE EEEAEREEAA ERAERTEKLE RVTKSAEVSR EGTILSQDEL
60 70 80 90 100
RDLEGKLMAI EIPTQADHSV ISQAPVDVTK LPPSYTTNSL KEEHLLLVAD
110 120 130 140 150
NFSRQYSHLC PDRVPLFLHP LNECNVPKFV STTLRPTLMP YPELYNWDSC
160 170 180 190 200
AQFVSDFLTM VPLVDPLKPP THLYSSTTVL KCQKGNCFDF STLLCSMLIG
210 220 230 240 250
SGYDAYCVNG YGSLDLCLMD LTREVCPLTV KAKEIVKKKE KTVPKKYSIK
260 270 280 290 300
PPRDLTSKFE QEQEEKRIQE IKDLEQRRLK EEEDRILEAE KAKPDPLHGL
310 320 330 340 350
RVHSWVLVLA GKREVPESFF IDPLTARSYS TKDEHFLGIE SLWNHKNYWI
360 370 380 390 400
NMQDCWNCCK DLIFDLGDPV RWEYMLLGTD KPHLSLTEED EEGLDDDDDD
410 420 430 440 450
VEDLGKEEED KSFDMPSSWV SQIEITPEEF ETRCPSGKKV IQYKKAQLEK
460 470 480 490 500
WSPYLNNNGL VCRLTTYEDQ QCTKVLEIKE WYQNREDMLE LKHINKTTGL
510 520 530 540 550
HVDYFKPGHP QALCVHSYKS MLPEMDRVME FYKKIRVDGL VKREETPMTM
560 570 580 590 600
TEYYEGRSDF LAYRHVNFGP RVKKLSQSSV ESNPRPMVKI TERFSRNPEK
610 620 630 640 650
PADEDVAERL FLIVEERIQL RYHCRDDYIT ASKREFLRRM EVDSKGNKII
660 670 680 690 700
MTPEMCISYE VEPMEHTKKL LYQYETMNQL KNEEKLSRHQ AWESELEVLE
710 720 730 740 750
ILKLREEEEE AHTLTISIYD TKRNEKSKEY REAMERVLHE EHLRQVEAQL
760 770 780 790 800
DYLAPFLAQL PPGEKLTRWQ AVRLKDECLS DFKQRLIDKA NLIQARFEKE
810 820 830 840 850
TQELQKKQQW YQENQVTLTP EDENLYLSYC SQAMFRIRIL EQRLNRHKEL
860 870
APLKYLALEE KLYKDPRLID FVKVFV
Length:876
Mass (Da):103,269
Last modified:February 22, 2012 - v4
Checksum:iDD009EA45F68AEF0
GO
Isoform 2 (identifier: Q6V3W6-2) [UniParc]FASTAAdd to Basket

Also known as: SRG-S

The sequence of this isoform differs from the canonical sequence as follows:
     288-295: EAEKAKPD → VGLHDTAL
     296-876: Missing.

Show »
Length:295
Mass (Da):33,781
Checksum:i9869D3FA8DA2382B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91Missing in AAQ55489. (PubMed:16804880)Curated
Sequence conflicti603 – 6031D → G in AAQ55489. (PubMed:16804880)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei288 – 2958EAEKAKPD → VGLHDTAL in isoform 2. 1 PublicationVSP_023440
Alternative sequencei296 – 876581Missing in isoform 2. 1 PublicationVSP_023441Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352586 mRNA. Translation: AAQ55489.2.
AC103935 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11157.1.
BC117982 mRNA. Translation: AAI17983.1.
BC117983 mRNA. Translation: AAI17984.1.
CCDSiCCDS40444.1. [Q6V3W6-1]
RefSeqiNP_001036180.2. NM_001042715.3. [Q6V3W6-1]
XP_006531195.1. XM_006531132.1. [Q6V3W6-1]
UniGeneiMm.277112.

Genome annotation databases

EnsembliENSMUST00000058479; ENSMUSP00000053972; ENSMUSG00000031786. [Q6V3W6-1]
GeneIDi330830.
KEGGimmu:330830.
UCSCiuc009mxr.1. mouse. [Q6V3W6-2]
uc009mxs.1. mouse. [Q6V3W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352586 mRNA. Translation: AAQ55489.2 .
AC103935 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11157.1 .
BC117982 mRNA. Translation: AAI17983.1 .
BC117983 mRNA. Translation: AAI17984.1 .
CCDSi CCDS40444.1. [Q6V3W6-1 ]
RefSeqi NP_001036180.2. NM_001042715.3. [Q6V3W6-1 ]
XP_006531195.1. XM_006531132.1. [Q6V3W6-1 ]
UniGenei Mm.277112.

3D structure databases

ProteinModelPortali Q6V3W6.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6V3W6.

Proteomic databases

PaxDbi Q6V3W6.
PRIDEi Q6V3W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058479 ; ENSMUSP00000053972 ; ENSMUSG00000031786 . [Q6V3W6-1 ]
GeneIDi 330830.
KEGGi mmu:330830.
UCSCi uc009mxr.1. mouse. [Q6V3W6-2 ]
uc009mxs.1. mouse. [Q6V3W6-1 ]

Organism-specific databases

CTDi 84229.
MGIi MGI:2685616. Ccdc135.

Phylogenomic databases

eggNOGi NOG76407.
GeneTreei ENSGT00390000004913.
HOGENOMi HOG000007476.
HOVERGENi HBG107597.
InParanoidi Q6V3W6.
OMAi LLYQYET.
OrthoDBi EOG7VB2DW.
TreeFami TF323665.

Miscellaneous databases

NextBioi 399582.
PROi Q6V3W6.
SOURCEi Search...

Gene expression databases

Bgeei Q6V3W6.
CleanExi MM_CCDC135.
Genevestigatori Q6V3W6.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene SRG-L expressed in late stages of mouse spermatogenic cells."
    Guo R., Ma P.P., Ma J., Ge Y.H., Xue S.P., Han D.S.
    Acta Biochim. Biophys. Sin. 36:315-322(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  2. "Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells."
    Ma Q., Wang H., Guo R., Wang H., Ge Y., Ma J., Xue S., Han D.
    Mol. Reprod. Dev. 73:1075-1083(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Tissue expression patterns identify mouse cilia genes."
    McClintock T.S., Glasser C.E., Bose S.C., Bergman D.A.
    Physiol. Genomics 32:198-206(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCC135_MOUSE
AccessioniPrimary (citable) accession number: Q6V3W6
Secondary accession number(s): G3X9B0, Q148T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 62 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3