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Protein

Dynein regulatory complex subunit 7

Gene

Drc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 7
Alternative name(s):
Coiled-coil domain-containing protein 135
Coiled-coil domain-containing protein lobo homolog
Spermatogenesis-related gene in late stages of spermatogenesis cells protein
Gene namesi
Name:Drc7
Synonyms:Ccdc135, Gm770, Srgl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2685616 Drc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794361 – 876Dynein regulatory complex subunit 7Add BLAST876

Proteomic databases

PaxDbiQ6V3W6
PRIDEiQ6V3W6

PTM databases

iPTMnetiQ6V3W6
PhosphoSitePlusiQ6V3W6

Expressioni

Tissue specificityi

Isoform 1 is expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Isoform 1 is strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Isoform 1 is expressed in diplotene and pachytene spermytocytes, round and elongating spermatids. Expressed in testis, kidney, ovary, thymus and spleen. Expressed in ciliated cells.3 Publications

Gene expression databases

BgeeiENSMUSG00000031786
CleanExiMM_CCDC135

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts with TCTE1/DRC5 (PubMed:28630322).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053972

Structurei

3D structure databases

ProteinModelPortaliQ6V3W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 33Sequence analysisAdd BLAST33
Coiled coili258 – 295Sequence analysisAdd BLAST38
Coiled coili679 – 710Sequence analysisAdd BLAST32
Coiled coili784 – 809Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the DRC7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IERK Eukaryota
ENOG410XS7V LUCA
GeneTreeiENSGT00390000004913
HOGENOMiHOG000007476
HOVERGENiHBG107597
InParanoidiQ6V3W6
OMAiKCWYKEF
OrthoDBiEOG091G0C1W
TreeFamiTF323665

Family and domain databases

InterProiView protein in InterPro
IPR033551 DRC7/lobo
PANTHERiPTHR35249 PTHR35249, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6V3W6-1) [UniParc]FASTAAdd to basket
Also known as: SRG-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLREKVEE EEEAEREEAA ERAERTEKLE RVTKSAEVSR EGTILSQDEL
60 70 80 90 100
RDLEGKLMAI EIPTQADHSV ISQAPVDVTK LPPSYTTNSL KEEHLLLVAD
110 120 130 140 150
NFSRQYSHLC PDRVPLFLHP LNECNVPKFV STTLRPTLMP YPELYNWDSC
160 170 180 190 200
AQFVSDFLTM VPLVDPLKPP THLYSSTTVL KCQKGNCFDF STLLCSMLIG
210 220 230 240 250
SGYDAYCVNG YGSLDLCLMD LTREVCPLTV KAKEIVKKKE KTVPKKYSIK
260 270 280 290 300
PPRDLTSKFE QEQEEKRIQE IKDLEQRRLK EEEDRILEAE KAKPDPLHGL
310 320 330 340 350
RVHSWVLVLA GKREVPESFF IDPLTARSYS TKDEHFLGIE SLWNHKNYWI
360 370 380 390 400
NMQDCWNCCK DLIFDLGDPV RWEYMLLGTD KPHLSLTEED EEGLDDDDDD
410 420 430 440 450
VEDLGKEEED KSFDMPSSWV SQIEITPEEF ETRCPSGKKV IQYKKAQLEK
460 470 480 490 500
WSPYLNNNGL VCRLTTYEDQ QCTKVLEIKE WYQNREDMLE LKHINKTTGL
510 520 530 540 550
HVDYFKPGHP QALCVHSYKS MLPEMDRVME FYKKIRVDGL VKREETPMTM
560 570 580 590 600
TEYYEGRSDF LAYRHVNFGP RVKKLSQSSV ESNPRPMVKI TERFSRNPEK
610 620 630 640 650
PADEDVAERL FLIVEERIQL RYHCRDDYIT ASKREFLRRM EVDSKGNKII
660 670 680 690 700
MTPEMCISYE VEPMEHTKKL LYQYETMNQL KNEEKLSRHQ AWESELEVLE
710 720 730 740 750
ILKLREEEEE AHTLTISIYD TKRNEKSKEY REAMERVLHE EHLRQVEAQL
760 770 780 790 800
DYLAPFLAQL PPGEKLTRWQ AVRLKDECLS DFKQRLIDKA NLIQARFEKE
810 820 830 840 850
TQELQKKQQW YQENQVTLTP EDENLYLSYC SQAMFRIRIL EQRLNRHKEL
860 870
APLKYLALEE KLYKDPRLID FVKVFV
Length:876
Mass (Da):103,269
Last modified:February 22, 2012 - v4
Checksum:iDD009EA45F68AEF0
GO
Isoform 2 (identifier: Q6V3W6-2) [UniParc]FASTAAdd to basket
Also known as: SRG-S

The sequence of this isoform differs from the canonical sequence as follows:
     288-295: EAEKAKPD → VGLHDTAL
     296-876: Missing.

Show »
Length:295
Mass (Da):33,781
Checksum:i9869D3FA8DA2382B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9Missing in AAQ55489 (PubMed:16804880).Curated1
Sequence conflicti603D → G in AAQ55489 (PubMed:16804880).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023440288 – 295EAEKAKPD → VGLHDTAL in isoform 2. 1 Publication8
Alternative sequenceiVSP_023441296 – 876Missing in isoform 2. 1 PublicationAdd BLAST581

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY352586 mRNA Translation: AAQ55489.2
AC103935 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11157.1
BC117982 mRNA Translation: AAI17983.1
BC117983 mRNA Translation: AAI17984.1
CCDSiCCDS40444.1 [Q6V3W6-1]
RefSeqiNP_001036180.2, NM_001042715.3 [Q6V3W6-1]
XP_006531195.1, XM_006531132.2 [Q6V3W6-1]
UniGeneiMm.277112

Genome annotation databases

EnsembliENSMUST00000058479; ENSMUSP00000053972; ENSMUSG00000031786 [Q6V3W6-1]
GeneIDi330830
KEGGimmu:330830
UCSCiuc009mxr.1 mouse [Q6V3W6-2]
uc009mxs.1 mouse [Q6V3W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDRC7_MOUSE
AccessioniPrimary (citable) accession number: Q6V3W6
Secondary accession number(s): G3X9B0, Q148T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 22, 2012
Last modified: May 23, 2018
This is version 82 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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