Q6V1X1 (DPP8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dipeptidyl peptidase 8
Short name=DP8
EC=3.4.14.5

Alternative name(s):
Dipeptidyl peptidase IV-related protein 1
Short name=DPRP-1
Dipeptidyl peptidase VIII
Short name=DPP VIII
Prolyl dipeptidase DPP8

Gene names

Name:	DPP8
Synonyms:	DPRP1
ORF Names:	MSTP097, MSTP135, MSTP141

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	898 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function. Ref.1
Catalytic activity	Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. Ref.1 Ref.2 Ref.7
Enzyme regulation	Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives. Ref.1 Ref.2 Ref.9
Subcellular location	Cytoplasm Ref.1 Ref.2 Ref.7.
Tissue specificity	Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. Ref.1 Ref.2
Induction	In activated T-cells. Ref.1 Ref.2 Ref.9
Sequence similarities	Belongs to the peptidase S9B family. DPPIV subfamily.
Biophysicochemical properties	Kinetic parameters: KM=208 µM for Ala-Pro-AMC Ref.2 Ref.7 Ref.8 KM=130 µM for Ala-Pro-AFC KM=120 µM for H-Ala-Pro-pNa KM=1420 µM for H-Ala-Ala-pNa KM=310 µM for H-Arg-Pro-pNa KM=2050 µM for H-Asp-Pro-pNa KM=480 µM for H-Gly-Pro-pNa pH dependence: Optimum pH is 7.4-8.5. Little activity below pH 6.5.
Sequence caution	The sequence AAQ13623.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAQ13650.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAQ13657.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA91059.1 differs from that shown. Reason: Frameshift at position 486. The sequence BAB55395.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Molecular function	Aminopeptidase Hydrolase Protease Serine protease
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Traceable author statement Ref.1. Source: UniProtKB proteolysis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Non-traceable author statement Ref.1. Source: UniProtKB membrane Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay. Source: HPA
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW dipeptidyl-peptidase activity Non-traceable author statement Ref.1. Source: UniProtKB serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6V1X1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6V1X1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     723-773: Missing.

Isoform 3 (identifier: Q6V1X1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Isoform 4 (identifier: Q6V1X1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     674-773: Missing.

Isoform 5 (identifier: Q6V1X1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     674-722: Missing.

Isoform 6 (identifier: Q6V1X1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     358-530: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 898	898	Dipeptidyl peptidase 8		PRO_0000122413
Sites
	Active site	755	1	Charge relay system Probable
	Active site	833	1	Charge relay system Probable
	Active site	865	1	Charge relay system Probable
Amino acid modifications
	Modified residue	331	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	1 – 16	16	Missing in isoform 3 and isoform 4.		VSP_013860
	Alternative sequence	358 – 530	173	Missing in isoform 6.		VSP_013861
	Alternative sequence	674 – 773	100	Missing in isoform 4.		VSP_013862
	Alternative sequence	674 – 722	49	Missing in isoform 5.		VSP_013863
	Alternative sequence	723 – 773	51	Missing in isoform 2.		VSP_013864
Experimental info
	Mutagenesis	275	1	E → K: 13-fold reduction in affinity for Ala-Pro-AFC; no effect on subcellular location. Ref.7
	Mutagenesis	755	1	S → A: Abolishes activity; no effect on subcellular location. Ref.7
	Mutagenesis	833	1	D → A: Abolishes activity; no effect on subcellular location. Ref.7
	Mutagenesis	865	1	H → A: Abolishes activity; no effect on subcellular location. Ref.7
	Sequence conflict	233	1	S → G in BC040203. Ref.5
	Sequence conflict	570	1	G → S in BAB55395. Ref.4
	Sequence conflict	673	1	Q → K in AAQ13650. Ref.6
	Sequence conflict	686	1	Y → F in AAQ13650. Ref.6
	Sequence conflict	693 – 694	2	AS → PF in AAQ13650. Ref.6
	Sequence conflict	701	1	V → G in AAQ13650. Ref.6
	Sequence conflict	709	1	H → P in AAQ13650. Ref.6
	Sequence conflict	720	1	Y → F in AAQ13650. Ref.6
	Sequence conflict	799 – 803	5	PDQNE → LTRMN in AAQ13623. Ref.6
	Sequence conflict	820	1	S → F in AAQ13623. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 60B0D036F026DE2A	FASTA	898	103,358
	10 20 30 40 50 60 MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ 70 80 90 100 110 120 LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK 130 140 150 160 170 180 TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF 190 200 210 220 230 240 QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN 250 260 270 280 290 300 IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR 310 320 330 340 350 360 ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI 370 380 390 400 410 420 DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM 430 440 450 460 470 480 ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY 490 500 510 520 530 540 KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF 550 560 570 580 590 600 EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY 610 620 630 640 650 660 KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK 670 680 690 700 710 720 KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY 730 740 750 760 770 780 KMGQIEIDDQ VEGLQYLASR YDFIDLDRVG IHGWSYGGYL SLMALMQRSD IFRVAIAGAP 790 800 810 820 830 840 VTLWIFYDTG YTERYMGHPD QNEQGYYLGS VAMQAEKFPS EPNRLLLLHG FLDENVHFAH 850 860 870 880 890 TSILLSFLVR AGKPYDLQIY PQERHSIRVP ESGEHYELHL LHYLQENLGS RIAALKVI
	Isoform 2 [UniParc]. Checksum: AB07EF0087231B56	FASTA	847	97,464
	10 20 30 40 50 60 MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ 70 80 90 100 110 120 LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK 130 140 150 160 170 180 TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF 190 200 210 220 230 240 QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN 250 260 270 280 290 300 IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR 310 320 330 340 350 360 ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI 370 380 390 400 410 420 DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM 430 440 450 460 470 480 ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY 490 500 510 520 530 540 KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF 550 560 570 580 590 600 EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY 610 620 630 640 650 660 KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK 670 680 690 700 710 720 KYPTVLFIYG GPQVQLVNNR FKGVKYFRLN TLASLGYVVV VIDNRGSCHR GLKFEGAFKY 730 740 750 760 770 780 KMVAIAGAPV TLWIFYDTGY TERYMGHPDQ NEQGYYLGSV AMQAEKFPSE PNRLLLLHGF 790 800 810 820 830 840 LDENVHFAHT SILLSFLVRA GKPYDLQIYP QERHSIRVPE SGEHYELHLL HYLQENLGSR IAALKVI
	Isoform 3 [UniParc]. Checksum: AD801C302DB4652B	FASTA	882	101,422
	10 20 30 40 50 60 MAAAMETEQL GVEIFETADC EENIESQDRP KLEPFYVERY SWSQLKKLLA DTRKYHGYMM 70 80 90 100 110 120 AKAPHDFMFV KRNDPDGPHS DRIYYLAMSG ENRENTLFYS EIPKTINRAA VLMLSWKPLL 130 140 150 160 170 180 DLFQATLDYG MYSREEELLR ERKRIGTVGI ASYDYHQGSG TFLFQAGSGI YHVKDGGPQG 190 200 210 220 230 240 FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNIVTREE RRLTYVHNEL 250 260 270 280 290 300 ANMEEDARSA GVATFVLQEE FDRYSGYWWC PKAETTPSGG KILRILYEEN DESEVEIIHV 310 320 330 340 350 360 TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIMIDAEGRI IDVIDKELIQ PFEILFEGVE 370 380 390 400 410 420 YIARAGWTPE GKYAWSILLD RSQTRLQIVL ISPELFIPVE DDVMERQRLI ESVPDSVTPL 430 440 450 460 470 480 IIYEETTDIW INIHDIFHVF PQSHEEEIEF IFASECKTGF RHLYKITSIL KESKYKRSSG 490 500 510 520 530 540 GLPAPSDFKC PIKEEIAITS GEWEVLGRHG SNIQVDEVRR LVYFEGTKDS PLEHHLYVVS 550 560 570 580 590 600 YVNPGEVTRL TDRGYSHSCC ISQHCDFFIS KYSNQKNPHC VSLYKLSSPE DDPTCKTKEF 610 620 630 640 650 660 WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL QPGKKYPTVL FIYGGPQVQL 670 680 690 700 710 720 VNNRFKGVKY FRLNTLASLG YVVVVIDNRG SCHRGLKFEG AFKYKMGQIE IDDQVEGLQY 730 740 750 760 770 780 LASRYDFIDL DRVGIHGWSY GGYLSLMALM QRSDIFRVAI AGAPVTLWIF YDTGYTERYM 790 800 810 820 830 840 GHPDQNEQGY YLGSVAMQAE KFPSEPNRLL LLHGFLDENV HFAHTSILLS FLVRAGKPYD 850 860 870 880 LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI
	Isoform 4 [UniParc]. Checksum: 784922477DB8F5B5	FASTA	782	89,908
	10 20 30 40 50 60 MAAAMETEQL GVEIFETADC EENIESQDRP KLEPFYVERY SWSQLKKLLA DTRKYHGYMM 70 80 90 100 110 120 AKAPHDFMFV KRNDPDGPHS DRIYYLAMSG ENRENTLFYS EIPKTINRAA VLMLSWKPLL 130 140 150 160 170 180 DLFQATLDYG MYSREEELLR ERKRIGTVGI ASYDYHQGSG TFLFQAGSGI YHVKDGGPQG 190 200 210 220 230 240 FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNIVTREE RRLTYVHNEL 250 260 270 280 290 300 ANMEEDARSA GVATFVLQEE FDRYSGYWWC PKAETTPSGG KILRILYEEN DESEVEIIHV 310 320 330 340 350 360 TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIMIDAEGRI IDVIDKELIQ PFEILFEGVE 370 380 390 400 410 420 YIARAGWTPE GKYAWSILLD RSQTRLQIVL ISPELFIPVE DDVMERQRLI ESVPDSVTPL 430 440 450 460 470 480 IIYEETTDIW INIHDIFHVF PQSHEEEIEF IFASECKTGF RHLYKITSIL KESKYKRSSG 490 500 510 520 530 540 GLPAPSDFKC PIKEEIAITS GEWEVLGRHG SNIQVDEVRR LVYFEGTKDS PLEHHLYVVS 550 560 570 580 590 600 YVNPGEVTRL TDRGYSHSCC ISQHCDFFIS KYSNQKNPHC VSLYKLSSPE DDPTCKTKEF 610 620 630 640 650 660 WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL QPGKKYPTVL FIYGGPQVAI 670 680 690 700 710 720 AGAPVTLWIF YDTGYTERYM GHPDQNEQGY YLGSVAMQAE KFPSEPNRLL LLHGFLDENV 730 740 750 760 770 780 HFAHTSILLS FLVRAGKPYD LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI
	Isoform 5 [UniParc]. Checksum: 4B6C88F29CA55475	FASTA	849	97,739
	10 20 30 40 50 60 MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ 70 80 90 100 110 120 LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK 130 140 150 160 170 180 TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF 190 200 210 220 230 240 QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN 250 260 270 280 290 300 IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR 310 320 330 340 350 360 ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIDVI 370 380 390 400 410 420 DKELIQPFEI LFEGVEYIAR AGWTPEGKYA WSILLDRSQT RLQIVLISPE LFIPVEDDVM 430 440 450 460 470 480 ERQRLIESVP DSVTPLIIYE ETTDIWINIH DIFHVFPQSH EEEIEFIFAS ECKTGFRHLY 490 500 510 520 530 540 KITSILKESK YKRSSGGLPA PSDFKCPIKE EIAITSGEWE VLGRHGSNIQ VDEVRRLVYF 550 560 570 580 590 600 EGTKDSPLEH HLYVVSYVNP GEVTRLTDRG YSHSCCISQH CDFFISKYSN QKNPHCVSLY 610 620 630 640 650 660 KLSSPEDDPT CKTKEFWATI LDSAGPLPDY TPPEIFSFES TTGFTLYGML YKPHDLQPGK 670 680 690 700 710 720 KYPTVLFIYG GPQGQIEIDD QVEGLQYLAS RYDFIDLDRV GIHGWSYGGY LSLMALMQRS 730 740 750 760 770 780 DIFRVAIAGA PVTLWIFYDT GYTERYMGHP DQNEQGYYLG SVAMQAEKFP SEPNRLLLLH 790 800 810 820 830 840 GFLDENVHFA HTSILLSFLV RAGKPYDLQI YPQERHSIRV PESGEHYELH LLHYLQENLG SRIAALKVI
	Isoform 6 [UniParc]. Checksum: 0476E0AEBD94131B	FASTA	725	83,398
	10 20 30 40 50 60 MWKRSEQMKI KSGKCNMAAA METEQLGVEI FETADCEENI ESQDRPKLEP FYVERYSWSQ 70 80 90 100 110 120 LKKLLADTRK YHGYMMAKAP HDFMFVKRND PDGPHSDRIY YLAMSGENRE NTLFYSEIPK 130 140 150 160 170 180 TINRAAVLML SWKPLLDLFQ ATLDYGMYSR EEELLRERKR IGTVGIASYD YHQGSGTFLF 190 200 210 220 230 240 QAGSGIYHVK DGGPQGFTQQ PLRPNLVETS CPNIRMDPKL CPADPDWIAF IHSNDIWISN 250 260 270 280 290 300 IVTREERRLT YVHNELANME EDARSAGVAT FVLQEEFDRY SGYWWCPKAE TTPSGGKILR 310 320 330 340 350 360 ILYEENDESE VEIIHVTSPM LETRRADSFR YPKTGTANPK VTFKMSEIMI DAEGRIIVDE 370 380 390 400 410 420 VRRLVYFEGT KDSPLEHHLY VVSYVNPGEV TRLTDRGYSH SCCISQHCDF FISKYSNQKN 430 440 450 460 470 480 PHCVSLYKLS SPEDDPTCKT KEFWATILDS AGPLPDYTPP EIFSFESTTG FTLYGMLYKP 490 500 510 520 530 540 HDLQPGKKYP TVLFIYGGPQ VQLVNNRFKG VKYFRLNTLA SLGYVVVVID NRGSCHRGLK 550 560 570 580 590 600 FEGAFKYKMG QIEIDDQVEG LQYLASRYDF IDLDRVGIHG WSYGGYLSLM ALMQRSDIFR 610 620 630 640 650 660 VAIAGAPVTL WIFYDTGYTE RYMGHPDQNE QGYYLGSVAM QAEKFPSEPN RLLLLHGFLD 670 680 690 700 710 720 ENVHFAHTSI LLSFLVRAGK PYDLQIYPQE RHSIRVPESG EHYELHLLHY LQENLGSRIA ALKVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8." Abbott C.A., Yu D.M.T., Woollatt E., Sutherland G.R., McCaughan G.W., Gorrell M.D. Eur. J. Biochem. 267:6140-6150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 334-898 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 540-898 (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 260-792 (ISOFORM 6), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION. Tissue: Placenta.
[2]	"Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases." Qi S.Y., Riviere P.J., Trojnar J., Junien J.-L., Akinsanya K.O. Biochem. J. 373:179-189(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), CATALYTIC ACTIVITY, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Testis.
[3]	Sha J.H., Zhou Z.M., Li J.M. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-898 (ISOFORM 2). Tissue: Hepatoma and Placenta.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[6]	Zhao B., Xu H.S., Tong Y.K., Sheng H., Qin B.M., Liu Y.Q., Liu B., Wang X.Y., Zhang Q., Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Chen J.Z., Cai M.Q. , Zheng W.Y., Teng C.Y., Liu Q., Yu L.T., Lin J., Gong Q., Zhang A.M., Gao R.L., Hui R.T. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 561-898. Tissue: Aorta.
[7]	"Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family." Ajami K., Abbott C.A., Obradovic M., Gysbers V., Kaehne T., McCaughan G.W., Gorrell M.D. Biochemistry 42:694-701(2003) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF GLU-275; SER-755; ASP-833 AND HIS-865, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
[8]	"Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cells." Chen Y.-S., Chien C.-H., Goparaju C.M., Hsu J.T.-A., Liang P.-H., Chen X. Protein Expr. Purif. 35:142-146(2004) [PubMed] [Europe PMC] [Abstract] Cited for: BIOPHYSICOCHEMICAL PROPERTIES.
[9]	"Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8." Jiaang W.-T., Chen Y.-S., Hsu T., Wu S.-H., Chien C.-H., Chang C.-N., Chang S.-P., Lee S.-J., Chen X. Bioorg. Med. Chem. Lett. 15:687-691(2005) [PubMed] [Europe PMC] [Abstract] Cited for: ENZYME REGULATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF221634 mRNA. Translation: AAG29766.1. AF221635 mRNA. Translation: AAG29767.1. AF221636 mRNA. Translation: AAG29768.1. AF221637 mRNA. Translation: AAG29769.1. AY172659 mRNA. Translation: AAO17261.1. AY354202 mRNA. Translation: AAQ63887.1. AK000290 mRNA. Translation: BAA91059.1. Frameshift. AK027826 mRNA. Translation: BAB55395.1. Different initiation. BC030688 mRNA. Translation: AAH30688.3. BC040203 mRNA. No translation available. AF176779 mRNA. Translation: AAQ13657.1. Different initiation. AF175225 mRNA. Translation: AAQ13650.1. Frameshift. AF173382 mRNA. Translation: AAQ13623.1. Frameshift.
IPI	IPI00026036. IPI00084071. IPI00307553. IPI00377128. IPI00377129. IPI00412277.
RefSeq	NP_060213.2. NM_017743.4. NP_569118.1. NM_130434.3. NP_932064.1. NM_197960.2. NP_932065.1. NM_197961.2.
UniGene	Hs.591106.
3D structure databases
ProteinModelPortal	Q6V1X1.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4539721.
Protein family/group databases
MEROPS	S09.018.
PTM databases
PhosphoSite	Q6V1X1.
Polymorphism databases
DMDM	67460301.
Proteomic databases
PaxDb	Q6V1X1.
PRIDE	Q6V1X1.
Protocols and materials databases
DNASU	54878.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300141; ENSP00000300141; ENSG00000074603. ENST00000321118; ENSP00000316373; ENSG00000074603. ENST00000321147; ENSP00000318111; ENSG00000074603. ENST00000341861; ENSP00000339208; ENSG00000074603. ENST00000358939; ENSP00000351817; ENSG00000074603. ENST00000559233; ENSP00000453954; ENSG00000074603.
GeneID	54878.
KEGG	hsa:54878.
UCSC	uc002aov.3. human. uc002aoy.3. human. uc002aoz.3. human.
Organism-specific databases
CTD	54878.
GeneCards	GC15M065734.
HGNC	HGNC:16490. DPP8.
HPA	HPA008706.
MIM	606819. gene.
neXtProt	NX_Q6V1X1.
PharmGKB	PA27470.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1506.
HOVERGEN	HBG061620.
InParanoid	Q6V1X1.
KO	K08655.
OMA	GPHGFTQ.
OrthoDB	EOG4BVRSX.
PhylomeDB	Q6V1X1.
Enzyme and pathway databases
SABIO-RK	Q6V1X1.
Gene expression databases
ArrayExpress	Q6V1X1.
Bgee	Q6V1X1.
Genevestigator	Q6V1X1.
GermOnline	ENSG00000074603. Homo sapiens.
Family and domain databases
InterPro	IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view]
Pfam	PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q6V1X1.
ChEMBL	CHEMBL4657.
GenomeRNAi	54878.
NextBio	57817.
SOURCE	Search...

Entry information

Entry name

DPP8_HUMAN

Accession

Primary (citable) accession number: Q6V1X1
Secondary accession number(s): Q7Z4C8 , Q7Z4D3, Q7Z4E1, Q8IWG7, Q8NEM5, Q96JX1, Q9HBM2, Q9HBM3, Q9HBM4, Q9HBM5, Q9NXF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.