ID   VP24_EBOZ5              Reviewed;         251 AA.
AC   Q6V1Q3;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Membrane-associated protein VP24;
DE   AltName: Full=Ebola VP24;
DE            Short=eVP24;
GN   Name=VP24;
OS   Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Filoviridae; Orthoebolavirus;
OC   Orthoebolavirus zairense; Zaire ebolavirus.
OX   NCBI_TaxID=128951;
OH   NCBI_TaxID=77231; Epomops franqueti (Franquet's epauletted fruit bat) (Epomophorus franqueti).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=77243; Myonycteris torquata (Little collared fruit bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Chain P.S.G., Ichou M.A., Malfatti S.A., Hajjaj A., Vergez L.M.,
RA   Paragas J., Do L.H., Jahrling P.B., Smith K.L., McCready P.M.,
RA   Ibrahim M.S.;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC       blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma
CC       signaling pathways. Blocks the IFN-induced nuclear accumulation of host
CC       phosphorylated STAT1 by interacting with the STAT1-binding region of
CC       host importins. Alternatively interacts also directly with host STAT1
CC       and may additionally inhibit its non-phosphorylated form. Plays a role
CC       in assembly of viral nucleocapsid and virion budding. May act as a
CC       minor matrix protein that plays a role in assembly of viral
CC       nucleocapsid and virion budding. {ECO:0000250|UniProtKB:Q05322}.
CC   -!- SUBUNIT: Interacts with host importins KPNA1, KPNA5 and KPNA6.
CC       Interacts with host STAT1. Interacts with host KEAP1; this interaction
CC       activates host transcription factor NRF2 by blocking its interaction
CC       with KEAP1. {ECO:0000250|UniProtKB:Q05322}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:Q05322};
CC       Peripheral membrane protein {ECO:0000250|UniProtKB:Q05322}. Host cell
CC       membrane {ECO:0000250|UniProtKB:Q05322}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q05322}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q05322}. Host endomembrane system
CC       {ECO:0000250|UniProtKB:Q05322}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q05322}. Note=In virion, localizes on the
CC       intravirional side of the membrane. In the host cell, it is found
CC       associated with virus-induced membrane proliferation foci and to the
CC       plasma membrane where budding takes place (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24
CC       family. {ECO:0000305}.
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DR   EMBL; AY354458; AAQ55052.1; -; Genomic_RNA.
DR   SMR; Q6V1Q3; -.
DR   Proteomes; UP000007208; Genome.
DR   GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR009433; Filo_VP24.
DR   Pfam; PF06389; Filo_VP24; 1.
DR   PIRSF; PIRSF011355; VP24; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Interferon antiviral system evasion; Membrane; Viral immunoevasion; Virion.
FT   CHAIN           1..251
FT                   /note="Membrane-associated protein VP24"
FT                   /id="PRO_0000245070"
SQ   SEQUENCE   251 AA;  28235 MW;  CAAD49C369E1C969 CRC64;
     MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT HKGMALLQRL
     KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA GIQDQLIDQS LIEPLAGALG
     LISDWLLTTN TNHFNMRTQR VKEQLSLKML SLIRSNILKF INRLDALHVV NYNGLLSSIE
     IGTQNHTIII TRTNMGFLVE LQEPDKSAMN RKKPGPAKFS LLHESTLKAF TQGSSTRMQS
     LILEFNSSLA I
//