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Q6V1Q3 (VP24_EBOZ5) Reviewed, UniProtKB/Swiss-Prot

Last modified October 31, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

Subunit structure

Binds to host importin alpha-1/KPNA1 By similarity.

Subcellular location

Virion membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity. Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and to the plasma membrane where budding takes place By similarity.

Sequence similarities

Belongs to the filoviridae membrane-associated protein VP24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Membrane-associated protein VP24
PRO_0000245070

Sequences

Sequence LengthMass (Da)Tools
Q6V1Q3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CAAD49C369E1C969

FASTA25128,235
        10         20         30         40         50         60 
MAKATGRYNL ISPKKDLEKG VVLSDLCNFL VSQTIQGWKV YWAGIEFDVT HKGMALLQRL 

        70         80         90        100        110        120 
KTNDFAPAWS MTRNLFPHLF QNPNSTIESP LWALRVILAA GIQDQLIDQS LIEPLAGALG 

       130        140        150        160        170        180 
LISDWLLTTN TNHFNMRTQR VKEQLSLKML SLIRSNILKF INRLDALHVV NYNGLLSSIE 

       190        200        210        220        230        240 
IGTQNHTIII TRTNMGFLVE LQEPDKSAMN RKKPGPAKFS LLHESTLKAF TQGSSTRMQS 

       250 
LILEFNSSLA I 

« Hide

References

[1]Chain P.S.G., Ichou M.A., Malfatti S.A., Hajjaj A., Vergez L.M., Paragas J., Do L.H., Jahrling P.B., Smith K.L., McCready P.M., Ibrahim M.S.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY354458 Genomic RNA. Translation: AAQ55052.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR009433. Filo_VP24.
[Graphical view]
PfamPF06389. Filo_VP24. 1 hit.
[Graphical view]
PIRSFPIRSF011355. VP24. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP24_EBOZ5
AccessionPrimary (citable) accession number: Q6V1Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: October 31, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families