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Q6V1P9

- PCD23_HUMAN

UniProt

Q6V1P9 - PCD23_HUMAN

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Protein

Protocadherin-23

Gene

DCHS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium-dependent cell-adhesion protein.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-23
Alternative name(s):
Cadherin-27
Cadherin-like protein CDHJ
Cadherin-like protein VR8
Protein dachsous homolog 2
Protocadherin PCDHJ
Gene namesi
Name:DCHS2
Synonyms:CDH27, CDHJ, PCDH23, PCDHJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:23111. DCHS2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29162916Protocadherin-23PRO_0000343410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi820 – 8201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1032 – 10321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1140 – 11401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1209 – 12091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1443 – 14431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1599 – 15991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1615 – 16151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1874 – 18741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2024 – 20241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2042 – 20421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2100 – 21001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2209 – 22091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2474 – 24741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2522 – 25221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2635 – 26351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6V1P9.
PRIDEiQ6V1P9.

PTM databases

PhosphoSiteiQ6V1P9.

Expressioni

Tissue specificityi

Cerebral cortex and testis.1 Publication

Gene expression databases

BgeeiQ6V1P9.
CleanExiHS_DCHS2.
ExpressionAtlasiQ6V1P9. baseline and differential.
GenevestigatoriQ6V1P9.

Interactioni

Protein-protein interaction databases

BioGridi120157. 1 interaction.
STRINGi9606.ENSP00000349768.

Structurei

3D structure databases

ProteinModelPortaliQ6V1P9.
SMRiQ6V1P9. Positions 58-240, 380-2516.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2541 – 256121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 177122Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini178 – 382205Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 480103Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini481 – 583103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini586 – 692107Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini693 – 839147Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini844 – 960117Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini949 – 1055107Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini1056 – 1165110Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1165 – 1269105Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1270 – 1374105Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1375 – 1478104Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1479 – 1583105Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1584 – 1685102Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1685 – 1787103Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini1788 – 1892105Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini1892 – 1992101Cadherin 17PROSITE-ProRule annotationAdd
BLAST
Domaini1993 – 2094102Cadherin 18PROSITE-ProRule annotationAdd
BLAST
Domaini2095 – 2210116Cadherin 19PROSITE-ProRule annotationAdd
BLAST
Domaini2211 – 2314104Cadherin 20PROSITE-ProRule annotationAdd
BLAST
Domaini2315 – 2425111Cadherin 21PROSITE-ProRule annotationAdd
BLAST
Domaini2426 – 2533108Cadherin 22PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 22 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000115466.
HOVERGENiHBG053522.
InParanoidiQ6V1P9.
KOiK16507.
OMAiDKDGHFE.
OrthoDBiEOG75TM9Z.
PhylomeDBiQ6V1P9.
TreeFamiTF330641.

Family and domain databases

Gene3Di2.60.40.60. 24 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 17 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 21 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 23 hits.
PROSITEiPS00232. CADHERIN_1. 13 hits.
PS50268. CADHERIN_2. 22 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q6V1P9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK
60 70 80 90 100
RGSPETELWG AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF
110 120 130 140 150
LSYEAPQAFR IDPHDGQICV SQDIDRERDP ATYDLLVEAK DGDEQRMTHL
160 170 180 190 200
ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS TYVTSISDET QPGTEIINVL
210 220 230 240 250
ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI LSAVNFSADK
260 270 280 290 300
EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK
310 320 330 340 350
VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ
360 370 380 390 400
DGGGLTAVIN ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK
410 420 430 440 450
AREPLNSSEP IFYRISSGDL GGKFSIHPRL GTIRTRKPLD HETQPVVVLT
460 470 480 490 500
VQAQLGSAPA CSSTEVNITV MDVNDNHPAF LRTSDEIRIS QTTPPGTALY
510 520 530 540 550
LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG SLGAGEQREL
560 570 580 590 600
TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP
610 620 630 640 650
MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD
660 670 680 690 700
YESTQTYNFR VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK
710 720 730 740 750
VEESPVPQGV IGKITAIDMD SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI
760 770 780 790 800
YVITWADGAA AFSGTDFAFS SDELQAFVLK SLFCELGEGE LINWVALDRE
810 820 830 840 850
HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP QCLPGKELHV
860 870 880 890 900
KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI
910 920 930 940 950
RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ
960 970 980 990 1000
NIRHLIIPEN LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID
1010 1020 1030 1040 1050
SSTGDLFLSK ELDYETTSHY LFRVITTDHS KNLSLSSTVF LSIDVEDQND
1060 1070 1080 1090 1100
HSPSFQDELI VISVEENVPI GTLVYVFNAK DDDGSFLNSR IQYYIESHNP
1110 1120 1130 1140 1150
GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN VTDRRLRSLT
1160 1170 1180 1190 1200
AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT
1210 1220 1230 1240 1250
YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS
1260 1270 1280 1290 1300
SSQTLTVTVL DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV
1310 1320 1330 1340 1350
NSKLQFEIMP GASFELFEIN SDTGEVVTTT ILDREIQEVF TLRVLVRDGG
1360 1370 1380 1390 1400
FPSLSSTTTI LCTVEDENDH APEFIVSSYD IEVLENQEPE VVYTVLASDM
1410 1420 1430 1440 1450
DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ ISNFTLVILC
1460 1470 1480 1490 1500
SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL
1510 1520 1530 1540 1550
SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF
1560 1570 1580 1590 1600
SAVARDCSIQ GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ
1610 1620 1630 1640 1650
TTVIVRADDL DLGPNGTVVF SFAETQSMFS IDKYTGEIQF QQNPSSEYFP
1660 1670 1680 1690 1700
IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV KISFSHHLYK GLVTENCEAG
1710 1720 1730 1740 1750
TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL TVKEPKFLDF
1760 1770 1780 1790 1800
EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ
1810 1820 1830 1840 1850
LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL
1860 1870 1880 1890 1900
DYELTSSYSL IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI
1910 1920 1930 1940 1950
TEDSLPGVIV THVSVHDVDL NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV
1960 1970 1980 1990 2000
KTLDFEEMTE YELLIQISDS VHYTEGALVV RVLDVNDNPP VFSQDFYQVT
2010 2020 2030 2040 2050
VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP KNGTIFTISP
2060 2070 2080 2090 2100
VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN
2110 2120 2130 2140 2150
LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF
2160 2170 2180 2190 2200
HSEYPYKQVG YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV
2210 2220 2230 2240 2250
LDVNDNPPNF SSLSYHTHVK ESTPLGSHIT VVSANDRDTG SHAEIIYNII
2260 2270 2280 2290 2300
SGNEKGHFYL EENTGVLYLI KPLDYEKMTK FTLTVQASDA EKKHFSFAVV
2310 2320 2330 2340 2350
FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD FDAGPYGELT
2360 2370 2380 2390 2400
YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK
2410 2420 2430 2440 2450
DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS
2460 2470 2480 2490 2500
DADAGIDGVI LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE
2510 2520 2530 2540 2550
MKIIAHSPKS DSKFASCTVF VNVSFSSEGT PLAVFASSFS ISLVVSFLVF
2560 2570 2580 2590 2600
LILICILIVM ILRHKQKDTI NNYEEKKTSS LDADLRVTRD ASVLKAFQKT
2610 2620 2630 2640 2650
DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC SVEGETAEDK
2660 2670 2680 2690 2700
EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA
2710 2720 2730 2740 2750
ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV
2760 2770 2780 2790 2800
FISGDQEVRC AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA
2810 2820 2830 2840 2850
KLKDEHLHMP GIPKEKKSFV FPPPLITAVA QPGIKAVPPR MPAVNLGQVP
2860 2870 2880 2890 2900
PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL TMQPPALSPL LREGELLGTH
2910
ISGTCHELKA EDEVQI
Length:2,916
Mass (Da):322,234
Last modified:July 5, 2004 - v1
Checksum:i25B2F4496468ABB5
GO
Isoform 4 (identifier: Q6V1P9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MRLDEITKSE...ENAKPVKETE → MSPCGRKMGE...HAPVGHCFLQ
     143-154: Missing.
     232-326: Missing.
     745-788: Missing.
     885-914: EDSSDHFKIDANNGEIRTTTILSYDYRPSY → ARHMPLKGKTAFGKQSCKKTNKQTNKILT
     915-2916: Missing.

Show »
Length:1,368
Mass (Da):149,191
Checksum:i8BBD22FA06CE9263
GO

Sequence cautioni

Isoform 4 : The sequence BAC87093.1 differs from that shown. Reason: Frameshift at position 1364.
The sequence BAA90911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAY41019.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2061 – 20611Q → R in BAA90911. (PubMed:14702039)Curated
Sequence conflicti2074 – 20741L → P in BAA90911. (PubMed:14702039)Curated
Sequence conflicti2475 – 24751K → R in BAA90911. (PubMed:14702039)Curated
Sequence conflicti2633 – 26331H → Y in BAA90911. (PubMed:14702039)Curated
Isoform 4 (identifier: Q6V1P9-4)
Sequence conflicti446 – 4461C → G in BAC87093. (PubMed:14702039)Curated
Sequence conflicti1358 – 13581K → KQ in BAC87093. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531V → A.
Corresponds to variant rs11721758 [ dbSNP | Ensembl ].
VAR_044362
Natural varianti174 – 1741H → R.1 Publication
Corresponds to variant rs10017772 [ dbSNP | Ensembl ].
VAR_044363
Natural varianti344 – 3441S → L.2 Publications
Corresponds to variant rs6858712 [ dbSNP | Ensembl ].
VAR_044364
Natural varianti827 – 8271V → I.
Corresponds to variant rs7666283 [ dbSNP | Ensembl ].
VAR_044365
Natural varianti897 – 8971N → S.
Corresponds to variant rs1352714 [ dbSNP | Ensembl ].
VAR_044366
Natural varianti1205 – 12051S → L.
Corresponds to variant rs11935573 [ dbSNP | Ensembl ].
VAR_044367
Natural varianti1480 – 14801T → R.
Corresponds to variant rs17031394 [ dbSNP | Ensembl ].
VAR_044368
Natural varianti1595 – 15951E → Q.
Corresponds to variant rs28561984 [ dbSNP | Ensembl ].
VAR_061075
Natural varianti2112 – 21121T → M.
Corresponds to variant rs17031279 [ dbSNP | Ensembl ].
VAR_044369
Natural varianti2303 – 23031S → N.
Corresponds to variant rs6824133 [ dbSNP | Ensembl ].
VAR_044370

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878MRLDE…VKETE → MSPCGRKMGEGRQQQRAPVG KLLLLPGRRDTPHGRSGSSG ARTQRSLLWLLVHVWLWAAS GSSAQLFNLTLSVDEGLPPD TLVGDIRAGLPAAQQQEGSG FFLSEDSDDSPLLDDFHVHP DTGIIRTARRLDRERRDHYS FVAATLLGAVVQVEIRVNDV NDHSPRFPLDSLQLDVSELS PPGTAFRLPGAHDPDAGLFS TQGYTLVQPSDLPKDPAGPF FQLRYRTPGPLPSPLLPGSS SPLEPLDLVLLRRLDREEAA AHRLQIEAWDGGRPRRTGLL SVELRVLDENDNPPVFEQDE YRAAVREDAQPGAEVCRVRA TDRDLGPNGFVRYSVRARQV PGAGSGGGALGDAAYFAVEE LSGVVRVWRPLDREAQAWHQ LVVEARDGGAEPEVATVRVS IAVLDVNDNRPAIHVLFLTE GGVARVSEGARPGDYVARVS VSDADCDWEKEDEATGELGV GLGDGSISLSLEGGEGDFAL LPGGPPGVFFLCVEGPLDRE SRDLYELLLVATDAGSPPLS TEETLLLRVADLNDQPPLFS QQHYKASVSEAAAPGTVVMW VSASDADEAGSDHAWLRYTV VQLSAPCNLGSLESKMVHTA ECGPSFAIDSESGVISTIRA LDREVQEAVELKVVAQDLGE PPLSATCLVSITVDDVNDNE PIFWRQVYNATIAEHAPVGH CFLQ in isoform 4. 2 PublicationsVSP_034586Add
BLAST
Alternative sequencei143 – 15412Missing in isoform 4. 2 PublicationsVSP_034587Add
BLAST
Alternative sequencei232 – 32695Missing in isoform 4. 2 PublicationsVSP_034588Add
BLAST
Alternative sequencei745 – 78844Missing in isoform 4. 2 PublicationsVSP_034589Add
BLAST
Alternative sequencei885 – 91430EDSSD…YRPSY → ARHMPLKGKTAFGKQSCKKT NKQTNKILT in isoform 4. 2 PublicationsVSP_046654Add
BLAST
Alternative sequencei915 – 29162002Missing in isoform 4. 2 PublicationsVSP_046655Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY354497 mRNA. Translation: AAR10443.1.
AK000054 mRNA. Translation: BAA90911.1. Different initiation.
AK127704 mRNA. Translation: BAC87093.1. Frameshift.
AC079298 Genomic DNA. Translation: AAY41019.1. Sequence problems.
AC110608 Genomic DNA. No translation available.
AC110775 Genomic DNA. No translation available.
BC140919 mRNA. Translation: AAI40920.1.
CCDSiCCDS3785.1. [Q6V1P9-1]
RefSeqiNP_001136024.1. NM_001142552.1.
NP_060109.2. NM_017639.3. [Q6V1P9-1]
UniGeneiHs.655664.

Genome annotation databases

GeneIDi54798.
KEGGihsa:54798.
UCSCiuc003inw.2. human. [Q6V1P9-1]

Polymorphism databases

DMDMi74762378.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY354497 mRNA. Translation: AAR10443.1 .
AK000054 mRNA. Translation: BAA90911.1 . Different initiation.
AK127704 mRNA. Translation: BAC87093.1 . Frameshift.
AC079298 Genomic DNA. Translation: AAY41019.1 . Sequence problems.
AC110608 Genomic DNA. No translation available.
AC110775 Genomic DNA. No translation available.
BC140919 mRNA. Translation: AAI40920.1 .
CCDSi CCDS3785.1. [Q6V1P9-1 ]
RefSeqi NP_001136024.1. NM_001142552.1.
NP_060109.2. NM_017639.3. [Q6V1P9-1 ]
UniGenei Hs.655664.

3D structure databases

ProteinModelPortali Q6V1P9.
SMRi Q6V1P9. Positions 58-240, 380-2516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120157. 1 interaction.
STRINGi 9606.ENSP00000349768.

PTM databases

PhosphoSitei Q6V1P9.

Polymorphism databases

DMDMi 74762378.

Proteomic databases

PaxDbi Q6V1P9.
PRIDEi Q6V1P9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 54798.
KEGGi hsa:54798.
UCSCi uc003inw.2. human. [Q6V1P9-1 ]

Organism-specific databases

CTDi 54798.
GeneCardsi GC04M155155.
H-InvDB HIX0004584.
HGNCi HGNC:23111. DCHS2.
MIMi 612486. gene.
neXtProti NX_Q6V1P9.
PharmGKBi PA134953793.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118805.
HOGENOMi HOG000115466.
HOVERGENi HBG053522.
InParanoidi Q6V1P9.
KOi K16507.
OMAi DKDGHFE.
OrthoDBi EOG75TM9Z.
PhylomeDBi Q6V1P9.
TreeFami TF330641.

Miscellaneous databases

GeneWikii DCHS2.
GenomeRNAii 54798.
NextBioi 57483.
PROi Q6V1P9.
SOURCEi Search...

Gene expression databases

Bgeei Q6V1P9.
CleanExi HS_DCHS2.
ExpressionAtlasi Q6V1P9. baseline and differential.
Genevestigatori Q6V1P9.

Family and domain databases

Gene3Di 2.60.40.60. 24 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 17 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 21 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 23 hits.
PROSITEi PS00232. CADHERIN_1. 13 hits.
PS50268. CADHERIN_2. 22 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods."
    Hoeng J.C., Ivanov N.V., Hodor P., Xia M., Wei N., Blevins R., Gerhold D., Borodovsky M., Liu Y.
    J. Mol. Biol. 337:307-317(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1902-2916 (ISOFORM 1), VARIANT LEU-344.
    Tissue: Colon.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS ARG-174 AND LEU-344.
    Tissue: Brain.

Entry informationi

Entry nameiPCD23_HUMAN
AccessioniPrimary (citable) accession number: Q6V1P9
Secondary accession number(s): B2RU14
, E9PC11, Q4W5P9, Q6ZS61, Q9NXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3