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Q6V1P9

- PCD23_HUMAN

UniProt

Q6V1P9 - PCD23_HUMAN

Protein

Protocadherin-23

Gene

DCHS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Calcium-dependent cell-adhesion protein.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin-23
    Alternative name(s):
    Cadherin-27
    Cadherin-like protein CDHJ
    Cadherin-like protein VR8
    Protein dachsous homolog 2
    Protocadherin PCDHJ
    Gene namesi
    Name:DCHS2
    Synonyms:CDH27, CDHJ, PCDH23, PCDHJ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:23111. DCHS2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953793.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 29162916Protocadherin-23PRO_0000343410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi820 – 8201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1032 – 10321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1140 – 11401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1209 – 12091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1443 – 14431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1599 – 15991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1615 – 16151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1874 – 18741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2024 – 20241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2042 – 20421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2100 – 21001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2209 – 22091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2474 – 24741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2522 – 25221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2635 – 26351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6V1P9.
    PRIDEiQ6V1P9.

    PTM databases

    PhosphoSiteiQ6V1P9.

    Expressioni

    Tissue specificityi

    Cerebral cortex and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ6V1P9.
    BgeeiQ6V1P9.
    CleanExiHS_DCHS2.
    GenevestigatoriQ6V1P9.

    Interactioni

    Protein-protein interaction databases

    BioGridi120157. 1 interaction.
    STRINGi9606.ENSP00000349768.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6V1P9.
    SMRiQ6V1P9. Positions 58-240, 380-2516.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2541 – 256121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 177122Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 382205Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 480103Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini481 – 583103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini586 – 692107Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini693 – 839147Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini844 – 960117Cadherin 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini949 – 1055107Cadherin 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1056 – 1165110Cadherin 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1165 – 1269105Cadherin 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1270 – 1374105Cadherin 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1375 – 1478104Cadherin 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1479 – 1583105Cadherin 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1584 – 1685102Cadherin 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1685 – 1787103Cadherin 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1788 – 1892105Cadherin 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1892 – 1992101Cadherin 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1993 – 2094102Cadherin 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini2095 – 2210116Cadherin 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini2211 – 2314104Cadherin 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini2315 – 2425111Cadherin 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini2426 – 2533108Cadherin 22PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 22 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000115466.
    HOVERGENiHBG053522.
    InParanoidiQ6V1P9.
    KOiK16507.
    OMAiDKDGHFE.
    OrthoDBiEOG75TM9Z.
    PhylomeDBiQ6V1P9.
    TreeFamiTF330641.

    Family and domain databases

    Gene3Di2.60.40.60. 24 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view]
    PfamiPF00028. Cadherin. 17 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 21 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 23 hits.
    PROSITEiPS00232. CADHERIN_1. 13 hits.
    PS50268. CADHERIN_2. 22 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q6V1P9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK     50
    RGSPETELWG AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF 100
    LSYEAPQAFR IDPHDGQICV SQDIDRERDP ATYDLLVEAK DGDEQRMTHL 150
    ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS TYVTSISDET QPGTEIINVL 200
    ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI LSAVNFSADK 250
    EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK 300
    VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ 350
    DGGGLTAVIN ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK 400
    AREPLNSSEP IFYRISSGDL GGKFSIHPRL GTIRTRKPLD HETQPVVVLT 450
    VQAQLGSAPA CSSTEVNITV MDVNDNHPAF LRTSDEIRIS QTTPPGTALY 500
    LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG SLGAGEQREL 550
    TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP 600
    MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD 650
    YESTQTYNFR VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK 700
    VEESPVPQGV IGKITAIDMD SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI 750
    YVITWADGAA AFSGTDFAFS SDELQAFVLK SLFCELGEGE LINWVALDRE 800
    HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP QCLPGKELHV 850
    KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI 900
    RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ 950
    NIRHLIIPEN LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID 1000
    SSTGDLFLSK ELDYETTSHY LFRVITTDHS KNLSLSSTVF LSIDVEDQND 1050
    HSPSFQDELI VISVEENVPI GTLVYVFNAK DDDGSFLNSR IQYYIESHNP 1100
    GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN VTDRRLRSLT 1150
    AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT 1200
    YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS 1250
    SSQTLTVTVL DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV 1300
    NSKLQFEIMP GASFELFEIN SDTGEVVTTT ILDREIQEVF TLRVLVRDGG 1350
    FPSLSSTTTI LCTVEDENDH APEFIVSSYD IEVLENQEPE VVYTVLASDM 1400
    DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ ISNFTLVILC 1450
    SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL 1500
    SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF 1550
    SAVARDCSIQ GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ 1600
    TTVIVRADDL DLGPNGTVVF SFAETQSMFS IDKYTGEIQF QQNPSSEYFP 1650
    IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV KISFSHHLYK GLVTENCEAG 1700
    TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL TVKEPKFLDF 1750
    EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ 1800
    LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL 1850
    DYELTSSYSL IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI 1900
    TEDSLPGVIV THVSVHDVDL NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV 1950
    KTLDFEEMTE YELLIQISDS VHYTEGALVV RVLDVNDNPP VFSQDFYQVT 2000
    VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP KNGTIFTISP 2050
    VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN 2100
    LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF 2150
    HSEYPYKQVG YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV 2200
    LDVNDNPPNF SSLSYHTHVK ESTPLGSHIT VVSANDRDTG SHAEIIYNII 2250
    SGNEKGHFYL EENTGVLYLI KPLDYEKMTK FTLTVQASDA EKKHFSFAVV 2300
    FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD FDAGPYGELT 2350
    YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK 2400
    DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS 2450
    DADAGIDGVI LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE 2500
    MKIIAHSPKS DSKFASCTVF VNVSFSSEGT PLAVFASSFS ISLVVSFLVF 2550
    LILICILIVM ILRHKQKDTI NNYEEKKTSS LDADLRVTRD ASVLKAFQKT 2600
    DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC SVEGETAEDK 2650
    EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA 2700
    ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV 2750
    FISGDQEVRC AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA 2800
    KLKDEHLHMP GIPKEKKSFV FPPPLITAVA QPGIKAVPPR MPAVNLGQVP 2850
    PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL TMQPPALSPL LREGELLGTH 2900
    ISGTCHELKA EDEVQI 2916
    Length:2,916
    Mass (Da):322,234
    Last modified:July 5, 2004 - v1
    Checksum:i25B2F4496468ABB5
    GO
    Isoform 4 (identifier: Q6V1P9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: MRLDEITKSE...ENAKPVKETE → MSPCGRKMGE...HAPVGHCFLQ
         143-154: Missing.
         232-326: Missing.
         745-788: Missing.
         885-914: EDSSDHFKIDANNGEIRTTTILSYDYRPSY → ARHMPLKGKTAFGKQSCKKTNKQTNKILT
         915-2916: Missing.

    Show »
    Length:1,368
    Mass (Da):149,191
    Checksum:i8BBD22FA06CE9263
    GO

    Sequence cautioni

    Isoform 4 : The sequence BAC87093.1 differs from that shown. Reason: Frameshift at position 1364.
    The sequence BAA90911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAY41019.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2061 – 20611Q → R in BAA90911. (PubMed:14702039)Curated
    Sequence conflicti2074 – 20741L → P in BAA90911. (PubMed:14702039)Curated
    Sequence conflicti2475 – 24751K → R in BAA90911. (PubMed:14702039)Curated
    Sequence conflicti2633 – 26331H → Y in BAA90911. (PubMed:14702039)Curated
    Isoform 4 (identifier: Q6V1P9-4)
    Sequence conflicti446 – 4461C → G in BAC87093. (PubMed:14702039)Curated
    Sequence conflicti1358 – 13581K → KQ in BAC87093. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti153 – 1531V → A.
    Corresponds to variant rs11721758 [ dbSNP | Ensembl ].
    VAR_044362
    Natural varianti174 – 1741H → R.1 Publication
    Corresponds to variant rs10017772 [ dbSNP | Ensembl ].
    VAR_044363
    Natural varianti344 – 3441S → L.2 Publications
    Corresponds to variant rs6858712 [ dbSNP | Ensembl ].
    VAR_044364
    Natural varianti827 – 8271V → I.
    Corresponds to variant rs7666283 [ dbSNP | Ensembl ].
    VAR_044365
    Natural varianti897 – 8971N → S.
    Corresponds to variant rs1352714 [ dbSNP | Ensembl ].
    VAR_044366
    Natural varianti1205 – 12051S → L.
    Corresponds to variant rs11935573 [ dbSNP | Ensembl ].
    VAR_044367
    Natural varianti1480 – 14801T → R.
    Corresponds to variant rs17031394 [ dbSNP | Ensembl ].
    VAR_044368
    Natural varianti1595 – 15951E → Q.
    Corresponds to variant rs28561984 [ dbSNP | Ensembl ].
    VAR_061075
    Natural varianti2112 – 21121T → M.
    Corresponds to variant rs17031279 [ dbSNP | Ensembl ].
    VAR_044369
    Natural varianti2303 – 23031S → N.
    Corresponds to variant rs6824133 [ dbSNP | Ensembl ].
    VAR_044370

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7878MRLDE…VKETE → MSPCGRKMGEGRQQQRAPVG KLLLLPGRRDTPHGRSGSSG ARTQRSLLWLLVHVWLWAAS GSSAQLFNLTLSVDEGLPPD TLVGDIRAGLPAAQQQEGSG FFLSEDSDDSPLLDDFHVHP DTGIIRTARRLDRERRDHYS FVAATLLGAVVQVEIRVNDV NDHSPRFPLDSLQLDVSELS PPGTAFRLPGAHDPDAGLFS TQGYTLVQPSDLPKDPAGPF FQLRYRTPGPLPSPLLPGSS SPLEPLDLVLLRRLDREEAA AHRLQIEAWDGGRPRRTGLL SVELRVLDENDNPPVFEQDE YRAAVREDAQPGAEVCRVRA TDRDLGPNGFVRYSVRARQV PGAGSGGGALGDAAYFAVEE LSGVVRVWRPLDREAQAWHQ LVVEARDGGAEPEVATVRVS IAVLDVNDNRPAIHVLFLTE GGVARVSEGARPGDYVARVS VSDADCDWEKEDEATGELGV GLGDGSISLSLEGGEGDFAL LPGGPPGVFFLCVEGPLDRE SRDLYELLLVATDAGSPPLS TEETLLLRVADLNDQPPLFS QQHYKASVSEAAAPGTVVMW VSASDADEAGSDHAWLRYTV VQLSAPCNLGSLESKMVHTA ECGPSFAIDSESGVISTIRA LDREVQEAVELKVVAQDLGE PPLSATCLVSITVDDVNDNE PIFWRQVYNATIAEHAPVGH CFLQ in isoform 4. 2 PublicationsVSP_034586Add
    BLAST
    Alternative sequencei143 – 15412Missing in isoform 4. 2 PublicationsVSP_034587Add
    BLAST
    Alternative sequencei232 – 32695Missing in isoform 4. 2 PublicationsVSP_034588Add
    BLAST
    Alternative sequencei745 – 78844Missing in isoform 4. 2 PublicationsVSP_034589Add
    BLAST
    Alternative sequencei885 – 91430EDSSD…YRPSY → ARHMPLKGKTAFGKQSCKKT NKQTNKILT in isoform 4. 2 PublicationsVSP_046654Add
    BLAST
    Alternative sequencei915 – 29162002Missing in isoform 4. 2 PublicationsVSP_046655Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY354497 mRNA. Translation: AAR10443.1.
    AK000054 mRNA. Translation: BAA90911.1. Different initiation.
    AK127704 mRNA. Translation: BAC87093.1. Frameshift.
    AC079298 Genomic DNA. Translation: AAY41019.1. Sequence problems.
    AC110608 Genomic DNA. No translation available.
    AC110775 Genomic DNA. No translation available.
    BC140919 mRNA. Translation: AAI40920.1.
    CCDSiCCDS3785.1. [Q6V1P9-1]
    RefSeqiNP_001136024.1. NM_001142552.1.
    NP_060109.2. NM_017639.3. [Q6V1P9-1]
    UniGeneiHs.655664.

    Genome annotation databases

    GeneIDi54798.
    KEGGihsa:54798.
    UCSCiuc003inw.2. human. [Q6V1P9-1]

    Polymorphism databases

    DMDMi74762378.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY354497 mRNA. Translation: AAR10443.1 .
    AK000054 mRNA. Translation: BAA90911.1 . Different initiation.
    AK127704 mRNA. Translation: BAC87093.1 . Frameshift.
    AC079298 Genomic DNA. Translation: AAY41019.1 . Sequence problems.
    AC110608 Genomic DNA. No translation available.
    AC110775 Genomic DNA. No translation available.
    BC140919 mRNA. Translation: AAI40920.1 .
    CCDSi CCDS3785.1. [Q6V1P9-1 ]
    RefSeqi NP_001136024.1. NM_001142552.1.
    NP_060109.2. NM_017639.3. [Q6V1P9-1 ]
    UniGenei Hs.655664.

    3D structure databases

    ProteinModelPortali Q6V1P9.
    SMRi Q6V1P9. Positions 58-240, 380-2516.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120157. 1 interaction.
    STRINGi 9606.ENSP00000349768.

    PTM databases

    PhosphoSitei Q6V1P9.

    Polymorphism databases

    DMDMi 74762378.

    Proteomic databases

    PaxDbi Q6V1P9.
    PRIDEi Q6V1P9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54798.
    KEGGi hsa:54798.
    UCSCi uc003inw.2. human. [Q6V1P9-1 ]

    Organism-specific databases

    CTDi 54798.
    GeneCardsi GC04M155155.
    H-InvDB HIX0004584.
    HGNCi HGNC:23111. DCHS2.
    MIMi 612486. gene.
    neXtProti NX_Q6V1P9.
    PharmGKBi PA134953793.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000115466.
    HOVERGENi HBG053522.
    InParanoidi Q6V1P9.
    KOi K16507.
    OMAi DKDGHFE.
    OrthoDBi EOG75TM9Z.
    PhylomeDBi Q6V1P9.
    TreeFami TF330641.

    Miscellaneous databases

    GeneWikii DCHS2.
    GenomeRNAii 54798.
    NextBioi 57483.
    PROi Q6V1P9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6V1P9.
    Bgeei Q6V1P9.
    CleanExi HS_DCHS2.
    Genevestigatori Q6V1P9.

    Family and domain databases

    Gene3Di 2.60.40.60. 24 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view ]
    Pfami PF00028. Cadherin. 17 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 21 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 23 hits.
    PROSITEi PS00232. CADHERIN_1. 13 hits.
    PS50268. CADHERIN_2. 22 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods."
      Hoeng J.C., Ivanov N.V., Hodor P., Xia M., Wei N., Blevins R., Gerhold D., Borodovsky M., Liu Y.
      J. Mol. Biol. 337:307-317(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1902-2916 (ISOFORM 1), VARIANT LEU-344.
      Tissue: Colon.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS ARG-174 AND LEU-344.
      Tissue: Brain.

    Entry informationi

    Entry nameiPCD23_HUMAN
    AccessioniPrimary (citable) accession number: Q6V1P9
    Secondary accession number(s): B2RU14
    , E9PC11, Q4W5P9, Q6ZS61, Q9NXU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3