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Protein

Protocadherin-23

Gene

DCHS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-dependent cell-adhesion protein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-33236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-23
Alternative name(s):
Cadherin-27
Cadherin-like protein CDHJ
Cadherin-like protein VR8
Protein dachsous homolog 2
Protocadherin PCDHJ
Gene namesi
Name:DCHS2
Synonyms:CDH27, CDHJ, PCDH23, PCDHJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23111. DCHS2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2541 – 2561HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54798.
OpenTargetsiENSG00000197410.
PharmGKBiPA134953793.

Polymorphism and mutation databases

BioMutaiDCHS2.
DMDMi74762378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434101 – 2916Protocadherin-23Add BLAST2916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1
Glycosylationi539N-linked (GlcNAc...)Sequence analysis1
Glycosylationi673N-linked (GlcNAc...)Sequence analysis1
Glycosylationi820N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1032N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1209N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1443N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1599N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1615N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1874N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2024N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2042N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2209N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2635N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6V1P9.
PeptideAtlasiQ6V1P9.
PRIDEiQ6V1P9.

PTM databases

iPTMnetiQ6V1P9.
PhosphoSitePlusiQ6V1P9.

Expressioni

Tissue specificityi

Cerebral cortex and testis.1 Publication

Gene expression databases

BgeeiENSG00000197410.
CleanExiHS_DCHS2.
ExpressionAtlasiQ6V1P9. baseline and differential.
GenevisibleiQ6V1P9. HS.

Organism-specific databases

HPAiHPA064159.

Interactioni

Protein-protein interaction databases

BioGridi120157. 1 interactor.
STRINGi9606.ENSP00000349768.

Structurei

3D structure databases

ProteinModelPortaliQ6V1P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 177Cadherin 1PROSITE-ProRule annotationAdd BLAST122
Domaini178 – 382Cadherin 2PROSITE-ProRule annotationAdd BLAST205
Domaini378 – 480Cadherin 3PROSITE-ProRule annotationAdd BLAST103
Domaini481 – 583Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini586 – 692Cadherin 5PROSITE-ProRule annotationAdd BLAST107
Domaini693 – 839Cadherin 6PROSITE-ProRule annotationAdd BLAST147
Domaini844 – 960Cadherin 7PROSITE-ProRule annotationAdd BLAST117
Domaini949 – 1055Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1056 – 1165Cadherin 9PROSITE-ProRule annotationAdd BLAST110
Domaini1165 – 1269Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1270 – 1374Cadherin 11PROSITE-ProRule annotationAdd BLAST105
Domaini1375 – 1478Cadherin 12PROSITE-ProRule annotationAdd BLAST104
Domaini1479 – 1583Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1584 – 1685Cadherin 14PROSITE-ProRule annotationAdd BLAST102
Domaini1685 – 1787Cadherin 15PROSITE-ProRule annotationAdd BLAST103
Domaini1788 – 1892Cadherin 16PROSITE-ProRule annotationAdd BLAST105
Domaini1892 – 1992Cadherin 17PROSITE-ProRule annotationAdd BLAST101
Domaini1993 – 2094Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2095 – 2210Cadherin 19PROSITE-ProRule annotationAdd BLAST116
Domaini2211 – 2314Cadherin 20PROSITE-ProRule annotationAdd BLAST104
Domaini2315 – 2425Cadherin 21PROSITE-ProRule annotationAdd BLAST111
Domaini2426 – 2533Cadherin 22PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Contains 22 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
KOG3594. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000115466.
HOVERGENiHBG053522.
InParanoidiQ6V1P9.
KOiK16507.
OMAiHYLFRVV.
OrthoDBiEOG091G0023.
PhylomeDBiQ6V1P9.
TreeFamiTF330641.

Family and domain databases

Gene3Di2.60.40.60. 24 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 19 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 21 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 23 hits.
PROSITEiPS00232. CADHERIN_1. 13 hits.
PS50268. CADHERIN_2. 22 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q6V1P9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK
60 70 80 90 100
RGSPETELWG AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF
110 120 130 140 150
LSYEAPQAFR IDPHDGQICV SQDIDRERDP ATYDLLVEAK DGDEQRMTHL
160 170 180 190 200
ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS TYVTSISDET QPGTEIINVL
210 220 230 240 250
ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI LSAVNFSADK
260 270 280 290 300
EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK
310 320 330 340 350
VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ
360 370 380 390 400
DGGGLTAVIN ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK
410 420 430 440 450
AREPLNSSEP IFYRISSGDL GGKFSIHPRL GTIRTRKPLD HETQPVVVLT
460 470 480 490 500
VQAQLGSAPA CSSTEVNITV MDVNDNHPAF LRTSDEIRIS QTTPPGTALY
510 520 530 540 550
LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG SLGAGEQREL
560 570 580 590 600
TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP
610 620 630 640 650
MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD
660 670 680 690 700
YESTQTYNFR VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK
710 720 730 740 750
VEESPVPQGV IGKITAIDMD SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI
760 770 780 790 800
YVITWADGAA AFSGTDFAFS SDELQAFVLK SLFCELGEGE LINWVALDRE
810 820 830 840 850
HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP QCLPGKELHV
860 870 880 890 900
KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI
910 920 930 940 950
RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ
960 970 980 990 1000
NIRHLIIPEN LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID
1010 1020 1030 1040 1050
SSTGDLFLSK ELDYETTSHY LFRVITTDHS KNLSLSSTVF LSIDVEDQND
1060 1070 1080 1090 1100
HSPSFQDELI VISVEENVPI GTLVYVFNAK DDDGSFLNSR IQYYIESHNP
1110 1120 1130 1140 1150
GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN VTDRRLRSLT
1160 1170 1180 1190 1200
AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT
1210 1220 1230 1240 1250
YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS
1260 1270 1280 1290 1300
SSQTLTVTVL DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV
1310 1320 1330 1340 1350
NSKLQFEIMP GASFELFEIN SDTGEVVTTT ILDREIQEVF TLRVLVRDGG
1360 1370 1380 1390 1400
FPSLSSTTTI LCTVEDENDH APEFIVSSYD IEVLENQEPE VVYTVLASDM
1410 1420 1430 1440 1450
DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ ISNFTLVILC
1460 1470 1480 1490 1500
SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL
1510 1520 1530 1540 1550
SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF
1560 1570 1580 1590 1600
SAVARDCSIQ GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ
1610 1620 1630 1640 1650
TTVIVRADDL DLGPNGTVVF SFAETQSMFS IDKYTGEIQF QQNPSSEYFP
1660 1670 1680 1690 1700
IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV KISFSHHLYK GLVTENCEAG
1710 1720 1730 1740 1750
TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL TVKEPKFLDF
1760 1770 1780 1790 1800
EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ
1810 1820 1830 1840 1850
LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL
1860 1870 1880 1890 1900
DYELTSSYSL IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI
1910 1920 1930 1940 1950
TEDSLPGVIV THVSVHDVDL NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV
1960 1970 1980 1990 2000
KTLDFEEMTE YELLIQISDS VHYTEGALVV RVLDVNDNPP VFSQDFYQVT
2010 2020 2030 2040 2050
VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP KNGTIFTISP
2060 2070 2080 2090 2100
VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN
2110 2120 2130 2140 2150
LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF
2160 2170 2180 2190 2200
HSEYPYKQVG YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV
2210 2220 2230 2240 2250
LDVNDNPPNF SSLSYHTHVK ESTPLGSHIT VVSANDRDTG SHAEIIYNII
2260 2270 2280 2290 2300
SGNEKGHFYL EENTGVLYLI KPLDYEKMTK FTLTVQASDA EKKHFSFAVV
2310 2320 2330 2340 2350
FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD FDAGPYGELT
2360 2370 2380 2390 2400
YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK
2410 2420 2430 2440 2450
DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS
2460 2470 2480 2490 2500
DADAGIDGVI LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE
2510 2520 2530 2540 2550
MKIIAHSPKS DSKFASCTVF VNVSFSSEGT PLAVFASSFS ISLVVSFLVF
2560 2570 2580 2590 2600
LILICILIVM ILRHKQKDTI NNYEEKKTSS LDADLRVTRD ASVLKAFQKT
2610 2620 2630 2640 2650
DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC SVEGETAEDK
2660 2670 2680 2690 2700
EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA
2710 2720 2730 2740 2750
ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV
2760 2770 2780 2790 2800
FISGDQEVRC AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA
2810 2820 2830 2840 2850
KLKDEHLHMP GIPKEKKSFV FPPPLITAVA QPGIKAVPPR MPAVNLGQVP
2860 2870 2880 2890 2900
PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL TMQPPALSPL LREGELLGTH
2910
ISGTCHELKA EDEVQI
Length:2,916
Mass (Da):322,234
Last modified:July 5, 2004 - v1
Checksum:i25B2F4496468ABB5
GO
Isoform 4 (identifier: Q6V1P9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MRLDEITKSE...ENAKPVKETE → MSPCGRKMGE...HAPVGHCFLQ
     143-154: Missing.
     232-326: Missing.
     745-788: Missing.
     885-914: EDSSDHFKIDANNGEIRTTTILSYDYRPSY → ARHMPLKGKTAFGKQSCKKTNKQTNKILT
     915-2916: Missing.

Show »
Length:1,368
Mass (Da):149,191
Checksum:i8BBD22FA06CE9263
GO

Sequence cautioni

The sequence AAY41019 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA90911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Isoform 4 : The sequence BAC87093 differs from that shown. Reason: Frameshift at position 1364.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2061Q → R in BAA90911 (PubMed:14702039).Curated1
Sequence conflicti2074L → P in BAA90911 (PubMed:14702039).Curated1
Sequence conflicti2475K → R in BAA90911 (PubMed:14702039).Curated1
Sequence conflicti2633H → Y in BAA90911 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q6V1P9-4)
Sequence conflicti446C → G in BAC87093 (PubMed:14702039).Curated1
Sequence conflicti1358K → KQ in BAC87093 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044362153V → A.Corresponds to variant rs11721758dbSNPEnsembl.1
Natural variantiVAR_044363174H → R.1 PublicationCorresponds to variant rs10017772dbSNPEnsembl.1
Natural variantiVAR_044364344S → L.2 PublicationsCorresponds to variant rs6858712dbSNPEnsembl.1
Natural variantiVAR_044365827V → I.Corresponds to variant rs7666283dbSNPEnsembl.1
Natural variantiVAR_044366897N → S.Corresponds to variant rs1352714dbSNPEnsembl.1
Natural variantiVAR_0443671205S → L.Corresponds to variant rs11935573dbSNPEnsembl.1
Natural variantiVAR_0443681480T → R.Corresponds to variant rs17031394dbSNPEnsembl.1
Natural variantiVAR_0610751595E → Q.Corresponds to variant rs28561984dbSNPEnsembl.1
Natural variantiVAR_0443692112T → M.Corresponds to variant rs17031279dbSNPEnsembl.1
Natural variantiVAR_0443702303S → N.Corresponds to variant rs6824133dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0345861 – 78MRLDE…VKETE → MSPCGRKMGEGRQQQRAPVG KLLLLPGRRDTPHGRSGSSG ARTQRSLLWLLVHVWLWAAS GSSAQLFNLTLSVDEGLPPD TLVGDIRAGLPAAQQQEGSG FFLSEDSDDSPLLDDFHVHP DTGIIRTARRLDRERRDHYS FVAATLLGAVVQVEIRVNDV NDHSPRFPLDSLQLDVSELS PPGTAFRLPGAHDPDAGLFS TQGYTLVQPSDLPKDPAGPF FQLRYRTPGPLPSPLLPGSS SPLEPLDLVLLRRLDREEAA AHRLQIEAWDGGRPRRTGLL SVELRVLDENDNPPVFEQDE YRAAVREDAQPGAEVCRVRA TDRDLGPNGFVRYSVRARQV PGAGSGGGALGDAAYFAVEE LSGVVRVWRPLDREAQAWHQ LVVEARDGGAEPEVATVRVS IAVLDVNDNRPAIHVLFLTE GGVARVSEGARPGDYVARVS VSDADCDWEKEDEATGELGV GLGDGSISLSLEGGEGDFAL LPGGPPGVFFLCVEGPLDRE SRDLYELLLVATDAGSPPLS TEETLLLRVADLNDQPPLFS QQHYKASVSEAAAPGTVVMW VSASDADEAGSDHAWLRYTV VQLSAPCNLGSLESKMVHTA ECGPSFAIDSESGVISTIRA LDREVQEAVELKVVAQDLGE PPLSATCLVSITVDDVNDNE PIFWRQVYNATIAEHAPVGH CFLQ in isoform 4. 2 PublicationsAdd BLAST78
Alternative sequenceiVSP_034587143 – 154Missing in isoform 4. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_034588232 – 326Missing in isoform 4. 2 PublicationsAdd BLAST95
Alternative sequenceiVSP_034589745 – 788Missing in isoform 4. 2 PublicationsAdd BLAST44
Alternative sequenceiVSP_046654885 – 914EDSSD…YRPSY → ARHMPLKGKTAFGKQSCKKT NKQTNKILT in isoform 4. 2 PublicationsAdd BLAST30
Alternative sequenceiVSP_046655915 – 2916Missing in isoform 4. 2 PublicationsAdd BLAST2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY354497 mRNA. Translation: AAR10443.1.
AK000054 mRNA. Translation: BAA90911.1. Different initiation.
AK127704 mRNA. Translation: BAC87093.1. Frameshift.
AC079298 Genomic DNA. Translation: AAY41019.1. Sequence problems.
AC110608 Genomic DNA. No translation available.
AC110775 Genomic DNA. No translation available.
BC140919 mRNA. Translation: AAI40920.1.
CCDSiCCDS3785.1. [Q6V1P9-1]
RefSeqiNP_001136024.1. NM_001142552.1.
NP_060109.2. NM_017639.3. [Q6V1P9-1]
UniGeneiHs.655664.

Genome annotation databases

EnsembliENST00000623607; ENSP00000485514; ENSG00000197410. [Q6V1P9-1]
GeneIDi54798.
KEGGihsa:54798.
UCSCiuc003inw.2. human. [Q6V1P9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY354497 mRNA. Translation: AAR10443.1.
AK000054 mRNA. Translation: BAA90911.1. Different initiation.
AK127704 mRNA. Translation: BAC87093.1. Frameshift.
AC079298 Genomic DNA. Translation: AAY41019.1. Sequence problems.
AC110608 Genomic DNA. No translation available.
AC110775 Genomic DNA. No translation available.
BC140919 mRNA. Translation: AAI40920.1.
CCDSiCCDS3785.1. [Q6V1P9-1]
RefSeqiNP_001136024.1. NM_001142552.1.
NP_060109.2. NM_017639.3. [Q6V1P9-1]
UniGeneiHs.655664.

3D structure databases

ProteinModelPortaliQ6V1P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120157. 1 interactor.
STRINGi9606.ENSP00000349768.

PTM databases

iPTMnetiQ6V1P9.
PhosphoSitePlusiQ6V1P9.

Polymorphism and mutation databases

BioMutaiDCHS2.
DMDMi74762378.

Proteomic databases

PaxDbiQ6V1P9.
PeptideAtlasiQ6V1P9.
PRIDEiQ6V1P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000623607; ENSP00000485514; ENSG00000197410. [Q6V1P9-1]
GeneIDi54798.
KEGGihsa:54798.
UCSCiuc003inw.2. human. [Q6V1P9-1]

Organism-specific databases

CTDi54798.
DisGeNETi54798.
GeneCardsiDCHS2.
H-InvDBHIX0004584.
HGNCiHGNC:23111. DCHS2.
HPAiHPA064159.
MIMi612486. gene.
neXtProtiNX_Q6V1P9.
OpenTargetsiENSG00000197410.
PharmGKBiPA134953793.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
KOG3594. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000115466.
HOVERGENiHBG053522.
InParanoidiQ6V1P9.
KOiK16507.
OMAiHYLFRVV.
OrthoDBiEOG091G0023.
PhylomeDBiQ6V1P9.
TreeFamiTF330641.

Enzyme and pathway databases

BioCyciZFISH:G66-33236-MONOMER.

Miscellaneous databases

GeneWikiiDCHS2.
GenomeRNAii54798.
PROiQ6V1P9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197410.
CleanExiHS_DCHS2.
ExpressionAtlasiQ6V1P9. baseline and differential.
GenevisibleiQ6V1P9. HS.

Family and domain databases

Gene3Di2.60.40.60. 24 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 19 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 21 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 23 hits.
PROSITEiPS00232. CADHERIN_1. 13 hits.
PS50268. CADHERIN_2. 22 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCD23_HUMAN
AccessioniPrimary (citable) accession number: Q6V1P9
Secondary accession number(s): B2RU14
, E9PC11, Q4W5P9, Q6ZS61, Q9NXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.