Q6V1P9 (PCD23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protocadherin-23

Alternative name(s):
Cadherin-27
Cadherin-like protein CDHJ
Cadherin-like protein VR8
Protein dachsous homolog 2
Protocadherin PCDHJ

Gene names

Name:	DCHS2
Synonyms:	CDH27, CDHJ, PCDH23, PCDHJ

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2916 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Calcium-dependent cell-adhesion protein By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Cerebral cortex and testis. Ref.1
Sequence similarities	Contains 22 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q6V1P9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6V1P9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1957: Missing.

Isoform 3 (identifier: Q6V1P9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: MRLDEITKSE...ENAKPVKETE → MSPCGRKMGE...HAPVGHCFLQ
     143-154: Missing.
     232-326: Missing.
     745-788: Missing.
     885-911: EDSSDHFKIDANNGEIRTTTILSYDYR → ARHMPLKGKTAFGKQSCKKQTNKQTKS
     912-2916: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2916	2916	Protocadherin-23		PRO_0000343410
Regions
	Transmembrane	2541 – 2561	21	Helical; Potential
	Domain	56 – 177	122	Cadherin 1
	Domain	178 – 382	205	Cadherin 2
	Domain	378 – 480	103	Cadherin 3
	Domain	481 – 583	103	Cadherin 4
	Domain	586 – 692	107	Cadherin 5
	Domain	693 – 839	147	Cadherin 6
	Domain	844 – 960	117	Cadherin 7
	Domain	949 – 1055	107	Cadherin 8
	Domain	1056 – 1165	110	Cadherin 9
	Domain	1165 – 1269	105	Cadherin 10
	Domain	1270 – 1374	105	Cadherin 11
	Domain	1375 – 1478	104	Cadherin 12
	Domain	1479 – 1583	105	Cadherin 13
	Domain	1584 – 1685	102	Cadherin 14
	Domain	1685 – 1787	103	Cadherin 15
	Domain	1788 – 1892	105	Cadherin 16
	Domain	1892 – 1992	101	Cadherin 17
	Domain	1993 – 2094	102	Cadherin 18
	Domain	2095 – 2210	116	Cadherin 19
	Domain	2211 – 2314	104	Cadherin 20
	Domain	2315 – 2425	111	Cadherin 21
	Domain	2426 – 2533	108	Cadherin 22
Amino acid modifications
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	245	1	N-linked (GlcNAc...) Potential
	Glycosylation	406	1	N-linked (GlcNAc...) Potential
	Glycosylation	467	1	N-linked (GlcNAc...) Potential
	Glycosylation	539	1	N-linked (GlcNAc...) Potential
	Glycosylation	673	1	N-linked (GlcNAc...) Potential
	Glycosylation	820	1	N-linked (GlcNAc...) Potential
	Glycosylation	1032	1	N-linked (GlcNAc...) Potential
	Glycosylation	1140	1	N-linked (GlcNAc...) Potential
	Glycosylation	1209	1	N-linked (GlcNAc...) Potential
	Glycosylation	1443	1	N-linked (GlcNAc...) Potential
	Glycosylation	1599	1	N-linked (GlcNAc...) Potential
	Glycosylation	1615	1	N-linked (GlcNAc...) Potential
	Glycosylation	1874	1	N-linked (GlcNAc...) Potential
	Glycosylation	2024	1	N-linked (GlcNAc...) Potential
	Glycosylation	2042	1	N-linked (GlcNAc...) Potential
	Glycosylation	2100	1	N-linked (GlcNAc...) Potential
	Glycosylation	2209	1	N-linked (GlcNAc...) Potential
	Glycosylation	2474	1	N-linked (GlcNAc...) Potential
	Glycosylation	2522	1	N-linked (GlcNAc...) Potential
	Glycosylation	2635	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 1957	1957	Missing in isoform 2.		VSP_034585
	Alternative sequence	1 – 78	78	MRLDE…VKETE → MSPCGRKMGEGRQQQRAPVG KLLLLPGRRDTPHGRSGSSG ARTQRSLLWLLVHVWLWAAS GSSAQLFNLTLSVDEGLPPD TLVGDIRAGLPAAQQQEGSG FFLSEDSDDSPLLDDFHVHP DTGIIRTARRLDRERRDHYS FVAATLLGAVVQVEIRVNDV NDHSPRFPLDSLQLDVSELS PPGTAFRLPGAHDPDAGLFS TQGYTLVQPSDLPKDPAGPF FQLRYRTPGPLPSPLLPGSS SPLEPLDLVLLRRLDREEAA AHRLQIEAWDGGRPRRTGLL SVELRVLDENDNPPVFEQDE YRAAVREDAQPGAEVCRVRA TDRDLGPNGFVRYSVRARQV PGAGSGGGALGDAAYFAVEE LSGVVRVWRPLDREAQAWHQ LVVEARDGGAEPEVATVRVS IAVLDVNDNRPAIHVLFLTE GGVARVSEGARPGDYVARVS VSDADGDWEKEDEATGELGV GLGDGSISLSLEGGEGDFAL LPGGPPGVFFLCVEGPLDRE SRDLYELLLVATDAGSPPLS TEETLLLRVADLNDQPPLFS QQHYKASVSEAAAPGTVVMW VSASDADEAGSDHAWLRYTV VQLSAPCNLGSLESKMVHTA ECGPSFAIDSESGVISTIRA LDREVQEAVELKVVAQDLGE PPLSATCLVSITVDDVNDNE PIFWRQVYNATIAEHAPVGH CFLQ in isoform 3.		VSP_034586
	Alternative sequence	143 – 154	12	Missing in isoform 3.		VSP_034587
	Alternative sequence	232 – 326	95	Missing in isoform 3.		VSP_034588
	Alternative sequence	745 – 788	44	Missing in isoform 3.		VSP_034589
	Alternative sequence	885 – 911	27	EDSSD…SYDYR → ARHMPLKGKTAFGKQSCKKQ TNKQTKS in isoform 3.		VSP_034590
	Alternative sequence	912 – 2916	2005	Missing in isoform 3.		VSP_034591
	Natural variant	153	1	V → A. Corresponds to variant rs11721758 [ dbSNP | Ensembl ].		VAR_044362
	Natural variant	174	1	H → R. Corresponds to variant rs10017772 [ dbSNP | Ensembl ].		VAR_044363
	Natural variant	344	1	S → L. Ref.2 Corresponds to variant rs6858712 [ dbSNP | Ensembl ].		VAR_044364
	Natural variant	827	1	V → I. Corresponds to variant rs7666283 [ dbSNP | Ensembl ].		VAR_044365
	Natural variant	897	1	N → S. Corresponds to variant rs1352714 [ dbSNP | Ensembl ].		VAR_044366
	Natural variant	1205	1	S → L. Corresponds to variant rs11935573 [ dbSNP | Ensembl ].		VAR_044367
	Natural variant	1480	1	T → R. Corresponds to variant rs17031394 [ dbSNP | Ensembl ].		VAR_044368
	Natural variant	1595	1	E → Q. Corresponds to variant rs28561984 [ dbSNP | Ensembl ].		VAR_061075
	Natural variant	2112	1	T → M. Corresponds to variant rs17031279 [ dbSNP | Ensembl ].		VAR_044369
	Natural variant	2303	1	S → N. Corresponds to variant rs6824133 [ dbSNP | Ensembl ].		VAR_044370
Experimental info
	Sequence conflict	2061	1	Q → R in BAA90911. Ref.2
	Sequence conflict	2074	1	L → P in BAA90911. Ref.2
	Sequence conflict	2475	1	K → R in BAA90911. Ref.2
	Sequence conflict	2633	1	H → Y in BAA90911. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 25B2F4496468ABB5	FASTA	2,916	322,234
	10 20 30 40 50 60 MRLDEITKSE NEDGEKKMFT QQFESTDACV YEVYVKINSI VKSQSQCGLK RGSPETELWG 70 80 90 100 110 120 AIVFRSQEEN AKPVKETEVT ASDADSGLYG FIEYSLYDGF LSYEAPQAFR IDPHDGQICV 130 140 150 160 170 180 SQDIDRERDP ATYDLLVEAK DGDEQRMTHL ALVKGGLSAQ AFVRVDLEDV NDNHPVFNPS 190 200 210 220 230 240 TYVTSISDET QPGTEIINVL ATDQDSGIYG TVAYELIPGN VSSLFTIDST TGLYSPEVEI 250 260 270 280 290 300 LSAVNFSADK EVMNSLEMFL PLLRHFKKVE RDEEAAEKKF EASRGWFMRF KGRRHLHYLK 310 320 330 340 350 360 VQDEAASADG EAAARYVANL AKILGEGIIY LTLPLSHLES TTLSLMVSAQ DGGGLTAVIN 370 380 390 400 410 420 ADVTIHIFQT TLAPAEFERP KYTFLVYEDV PEDSPIGTVK AREPLNSSEP IFYRISSGDL 430 440 450 460 470 480 GGKFSIHPRL GTIRTRKPLD HETQPVVVLT VQAQLGSAPA CSSTEVNITV MDVNDNHPAF 490 500 510 520 530 540 LRTSDEIRIS QTTPPGTALY LARAEDRDSG RNGLIRYSIA SPQPGVFAID RALGVLFLNG 550 560 570 580 590 600 SLGAGEQREL TLTLRAEDQG VHPQAALLVL TVVIEKREHS PSWTFEHLVY QVEVSESLSP 610 620 630 640 650 660 MTQMLQTQAH PLGPQRAASP LRYSLEPSVD SAMFGIRPYT GWIYLRRQFD YESTQTYNFR 670 680 690 700 710 720 VFAWIPEDGF LQNVSTTVIV RVWDENDNSP TFLHDVLFLK VEESPVPQGV IGKITAIDMD 730 740 750 760 770 780 SGKNGQLLYF LLSDGKFFKM NPNTGPAGTI YVITWADGAA AFSGTDFAFS SDELQAFVLK 790 800 810 820 830 840 SLFCELGEGE LINWVALDRE HRGHHEMTVL VTDRGSPPRN ATMAVYVSVT DINDNRPFFP 850 860 870 880 890 900 QCLPGKELHV KVLEGQPVNM LVTTVFAKDP DEGNNAEVTY SVSSEDSSDH FKIDANNGEI 910 920 930 940 950 960 RTTTILSYDY RPSYRMSVIA TDQGVPPLQG QAVVNIQVIP LSKGRAIMSQ NIRHLIIPEN 970 980 990 1000 1010 1020 LKPTKIMSLI KSSDHLQQHY NGKLHFSIVA DDKDGHFEID SSTGDLFLSK ELDYETTSHY 1030 1040 1050 1060 1070 1080 LFRVITTDHS KNLSLSSTVF LSIDVEDQND HSPSFQDELI VISVEENVPI GTLVYVFNAK 1090 1100 1110 1120 1130 1140 DDDGSFLNSR IQYYIESHNP GTNPFLIHPS FGTLVTVSRL DRESIPTVIL TVTASDQAVN 1150 1160 1170 1180 1190 1200 VTDRRLRSLT AQIVILDVND HNPTFISFPN AHVKEDVTVG SLVHHITAHD PDEGRNGKVT 1210 1220 1230 1240 1250 1260 YSILSGNENM TFMLDESSGL LTTTCPLDYE MKTQHILTVL ALDDGTPALS SSQTLTVTVL 1270 1280 1290 1300 1310 1320 DVNDEAPVFK QHLYEASVKE NQNPGEFVTR VEALDRDSGV NSKLQFEIMP GASFELFEIN 1330 1340 1350 1360 1370 1380 SDTGEVVTTT ILDREIQEVF TLRVLVRDGG FPSLSSTTTI LCTVEDENDH APEFIVSSYD 1390 1400 1410 1420 1430 1440 IEVLENQEPE VVYTVLASDM DAGNNRAVEY HIIDGNTDEC FTINEMSGEL STTRALDREQ 1450 1460 1470 1480 1490 1500 ISNFTLVILC SDLGDPPRSS VIHLQVRVLD ANDHSPSFPT LYYQSSVRED AEVGTVVLVL 1510 1520 1530 1540 1550 1560 SAVDKDEGLN GQTEYFLTDE ASGAFTIDPM SGTLKTSNTL DREARSQHTF SAVARDCSIQ 1570 1580 1590 1600 1610 1620 GSRSTTVIIK VYVTDVNDND PVLEQNPFDV FLSPESPTNQ TTVIVRADDL DLGPNGTVVF 1630 1640 1650 1660 1670 1680 SFAETQSMFS IDKYTGEIQF QQNPSSEYFP IWLQLKVTDQ GIPARTTTGL LVIHMEGEDV 1690 1700 1710 1720 1730 1740 KISFSHHLYK GLVTENCEAG TSIVTVKAFA PDSIQDSMKY SIFSGNEDGV LSLCSKSGQL 1750 1760 1770 1780 1790 1800 TVKEPKFLDF EVRNEVQLIV LAESSGHRAY CKVAVLIQDE NDNSPCFEQS IYQASVSESQ 1810 1820 1830 1840 1850 1860 LYNAHVIQVF ATDLDSGLNG LIEYSILSGN QEEAFQIDAL SGVITTKAIL DYELTSSYSL 1870 1880 1890 1900 1910 1920 IVQATDKGMP RLSNTTVIKV QVTDINDNAP AFLPSEAVEI TEDSLPGVIV THVSVHDVDL 1930 1940 1950 1960 1970 1980 NSAFIFSFAK ESNPGTKFAI DQNTGVVVLV KTLDFEEMTE YELLIQISDS VHYTEGALVV 1990 2000 2010 2020 2030 2040 RVLDVNDNPP VFSQDFYQVT VPESIPVGYS VLTLSATDLE SNENISYRIL SSSKEFSIDP 2050 2060 2070 2080 2090 2100 KNGTIFTISP VLLLDTISTT QFLVEASDGG NPDLRALTLV EIGIEDMNNY APEFTVKSYN 2110 2120 2130 2140 2150 2160 LSLSEDALVG STLVTFSNID HDWTRENTYV EYSIISGNSQ NNFHVETKFF HSEYPYKQVG 2170 2180 2190 2200 2210 2220 YLVLLHSLDR EASASHELVI LASDSGCPPL SSTAVISIQV LDVNDNPPNF SSLSYHTHVK 2230 2240 2250 2260 2270 2280 ESTPLGSHIT VVSANDRDTG SHAEIIYNII SGNEKGHFYL EENTGVLYLI KPLDYEKMTK 2290 2300 2310 2320 2330 2340 FTLTVQASDA EKKHFSFAVV FVSVLDDNDH APQFMFSSFS CIVPENLPIS STICSINALD 2350 2360 2370 2380 2390 2400 FDAGPYGELT YSIVSPCFLT HGMSYDHDLF LIDPLTGDIH AKQILDYENG NKYCLTVQAK 2410 2420 2430 2440 2450 2460 DKGDATASLV VWVDIEGIDE FEPIFTQDQY FFTLPEKNKD RQLIGRVEAS DADAGIDGVI 2470 2480 2490 2500 2510 2520 LYSLGTSSPF FSVNKTNGNI YLIRALPLIK SQLNKEDTLE MKIIAHSPKS DSKFASCTVF 2530 2540 2550 2560 2570 2580 VNVSFSSEGT PLAVFASSFS ISLVVSFLVF LILICILIVM ILRHKQKDTI NNYEEKKTSS 2590 2600 2610 2620 2630 2640 LDADLRVTRD ASVLKAFQKT DDCSNEVVPV DATPEWLSLI SIMEKDIVNL YRHSNSSGHC 2650 2660 2670 2680 2690 2700 SVEGETAEDK EIQRINEHPY RKCSDSALSD HESRVPDSGI PRDSDQLSCL SGETDVMVTA 2710 2720 2730 2740 2750 2760 ETAEASQTFG EGDQGEGCST TCAQNNVLPQ TVQKREAKES ILADVRKESV FISGDQEVRC 2770 2780 2790 2800 2810 2820 AALSTQTTSD HDGKDNYHWN YLLSWEPKFQ PLASVFNDIA KLKDEHLHMP GIPKEKKSFV 2830 2840 2850 2860 2870 2880 FPPPLITAVA QPGIKAVPPR MPAVNLGQVP PKHPRSPIPY HLGSLPEGMT PNFSPSLSLL 2890 2900 2910 TMQPPALSPL LREGELLGTH ISGTCHELKA EDEVQI
	Isoform 2 [UniParc]. Checksum: 6E38A65AC08CE8BB	FASTA	959	105,922
	10 20 30 40 50 60 MTEYELLIQI SDSVHYTEGA LVVRVLDVND NPPVFSQDFY QVTVPESIPV GYSVLTLSAT 70 80 90 100 110 120 DLESNENISY RILSSSKEFS IDPKNGTIFT ISPVLLLDTI STTQFLVEAS DGGNPDLRAL 130 140 150 160 170 180 TLVEIGIEDM NNYAPEFTVK SYNLSLSEDA LVGSTLVTFS NIDHDWTREN TYVEYSIISG 190 200 210 220 230 240 NSQNNFHVET KFFHSEYPYK QVGYLVLLHS LDREASASHE LVILASDSGC PPLSSTAVIS 250 260 270 280 290 300 IQVLDVNDNP PNFSSLSYHT HVKESTPLGS HITVVSANDR DTGSHAEIIY NIISGNEKGH 310 320 330 340 350 360 FYLEENTGVL YLIKPLDYEK MTKFTLTVQA SDAEKKHFSF AVVFVSVLDD NDHAPQFMFS 370 380 390 400 410 420 SFSCIVPENL PISSTICSIN ALDFDAGPYG ELTYSIVSPC FLTHGMSYDH DLFLIDPLTG 430 440 450 460 470 480 DIHAKQILDY ENGNKYCLTV QAKDKGDATA SLVVWVDIEG IDEFEPIFTQ DQYFFTLPEK 490 500 510 520 530 540 NKDRQLIGRV EASDADAGID GVILYSLGTS SPFFSVNKTN GNIYLIRALP LIKSQLNKED 550 560 570 580 590 600 TLEMKIIAHS PKSDSKFASC TVFVNVSFSS EGTPLAVFAS SFSISLVVSF LVFLILICIL 610 620 630 640 650 660 IVMILRHKQK DTINNYEEKK TSSLDADLRV TRDASVLKAF QKTDDCSNEV VPVDATPEWL 670 680 690 700 710 720 SLISIMEKDI VNLYRHSNSS GHCSVEGETA EDKEIQRINE HPYRKCSDSA LSDHESRVPD 730 740 750 760 770 780 SGIPRDSDQL SCLSGETDVM VTAETAEASQ TFGEGDQGEG CSTTCAQNNV LPQTVQKREA 790 800 810 820 830 840 KESILADVRK ESVFISGDQE VRCAALSTQT TSDHDGKDNY HWNYLLSWEP KFQPLASVFN 850 860 870 880 890 900 DIAKLKDEHL HMPGIPKEKK SFVFPPPLIT AVAQPGIKAV PPRMPAVNLG QVPPKHPRSP 910 920 930 940 950 IPYHLGSLPE GMTPNFSPSL SLLTMQPPAL SPLLREGELL GTHISGTCHE LKAEDEVQI
	Isoform 3 [UniParc]. Checksum: C2C7FFEE64B0F66A	FASTA	1,366	148,919
	10 20 30 40 50 60 MSPCGRKMGE GRQQQRAPVG KLLLLPGRRD TPHGRSGSSG ARTQRSLLWL LVHVWLWAAS 70 80 90 100 110 120 GSSAQLFNLT LSVDEGLPPD TLVGDIRAGL PAAQQQEGSG FFLSEDSDDS PLLDDFHVHP 130 140 150 160 170 180 DTGIIRTARR LDRERRDHYS FVAATLLGAV VQVEIRVNDV NDHSPRFPLD SLQLDVSELS 190 200 210 220 230 240 PPGTAFRLPG AHDPDAGLFS TQGYTLVQPS DLPKDPAGPF FQLRYRTPGP LPSPLLPGSS 250 260 270 280 290 300 SPLEPLDLVL LRRLDREEAA AHRLQIEAWD GGRPRRTGLL SVELRVLDEN DNPPVFEQDE 310 320 330 340 350 360 YRAAVREDAQ PGAEVCRVRA TDRDLGPNGF VRYSVRARQV PGAGSGGGAL GDAAYFAVEE 370 380 390 400 410 420 LSGVVRVWRP LDREAQAWHQ LVVEARDGGA EPEVATVRVS IAVLDVNDNR PAIHVLFLTE 430 440 450 460 470 480 GGVARVSEGA RPGDYVARVS VSDADGDWEK EDEATGELGV GLGDGSISLS LEGGEGDFAL 490 500 510 520 530 540 LPGGPPGVFF LCVEGPLDRE SRDLYELLLV ATDAGSPPLS TEETLLLRVA DLNDQPPLFS 550 560 570 580 590 600 QQHYKASVSE AAAPGTVVMW VSASDADEAG SDHAWLRYTV VQLSAPCNLG SLESKMVHTA 610 620 630 640 650 660 ECGPSFAIDS ESGVISTIRA LDREVQEAVE LKVVAQDLGE PPLSATCLVS ITVDDVNDNE 670 680 690 700 710 720 PIFWRQVYNA TIAEHAPVGH CFLQVTASDA DSGLYGFIEY SLYDGFLSYE APQAFRIDPH 730 740 750 760 770 780 DGQICVSQDI DRERDPATYD LLVEAKDGGG LSAQAFVRVD LEDVNDNHPV FNPSTYVTSI 790 800 810 820 830 840 SDETQPGTEI INVLATDQDS GIYGTVAYEL IPGNVSSLFT IDSTTGIIYL TLPLSHLEST 850 860 870 880 890 900 TLSLMVSAQD GGGLTAVINA DVTIHIFQTT LAPAEFERPK YTFLVYEDVP EDSPIGTVKA 910 920 930 940 950 960 REPLNSSEPI FYRISSGDLG GKFSIHPRLG TIRTRKPLDH ETQPVVVLTV QAQLGSAPAC 970 980 990 1000 1010 1020 SSTEVNITVM DVNDNHPAFL RTSDEIRISQ TTPPGTALYL ARAEDRDSGR NGLIRYSIAS 1030 1040 1050 1060 1070 1080 PQPGVFAIDR ALGVLFLNGS LGAGEQRELT LTLRAEDQGV HPQAALLVLT VVIEKREHSP 1090 1100 1110 1120 1130 1140 SWTFEHLVYQ VEVSESLSPM TQMLQTQAHP LGPQRAASPL RYSLEPSVDS AMFGIRPYTG 1150 1160 1170 1180 1190 1200 WIYLRRQFDY ESTQTYNFRV FAWIPEDGFL QNVSTTVIVR VWDENDNSPT FLHDVLFLKV 1210 1220 1230 1240 1250 1260 EESPVPQGVI GKITAIDMDS GKNGQLLYFL LSDGKFFKMN PNTGELINWV ALDREHRGHH 1270 1280 1290 1300 1310 1320 EMTVLVTDRG SPPRNATMAV YVSVTDINDN RPFFPQCLPG KELHVKVLEG QPVNMLVTTV 1330 1340 1350 1360 FAKDPDEGNN AEVTYSVSSA RHMPLKGKTA FGKQSCKKQT NKQTKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of new human cadherin genes using a combination of protein motif search and gene finding methods." Hoeng J.C., Ivanov N.V., Hodor P., Xia M., Wei N., Blevins R., Gerhold D., Borodovsky M., Liu Y. J. Mol. Biol. 337:307-317(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT LEU-344. Tissue: Colon.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY354497 mRNA. Translation: AAR10443.1. AK000054 mRNA. Translation: BAA90911.1. AK127704 mRNA. Translation: BAC87093.1. AC079298 Genomic DNA. Translation: AAY41019.1.
IPI	IPI00014829. IPI00399257. IPI00896525.
RefSeq	NP_001136024.1. NM_001142552.1. NP_060109.2. NM_017639.3.
UniGene	Hs.655664.
3D structure databases
HSSP	HSSP built from PDB template 1NCJ based on UniProtKB P15116.
ProteinModelPortal	Q6V1P9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000349768.
PTM databases
PhosphoSite	Q6V1P9.
Polymorphism databases
DMDM	74762378.
Proteomic databases
PaxDb	Q6V1P9.
PRIDE	Q6V1P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357232; ENSP00000349768; ENSG00000197410.
GeneID	54798.
KEGG	hsa:54798.
UCSC	uc003inw.2. human.
Organism-specific databases
CTD	54798.
GeneCards	GC04M155155.
H-InvDB	HIX0004584.
HGNC	HGNC:23111. DCHS2.
MIM	612486. gene.
neXtProt	NX_Q6V1P9.
PharmGKB	PA134953793.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000115466.
HOVERGEN	HBG053522.
InParanoid	Q6V1P9.
KO	K16507.
OMA	DKDGHFE.
OrthoDB	EOG4KSPHV.
Gene expression databases
ArrayExpress	Q6V1P9.
Bgee	Q6V1P9.
CleanEx	HS_DCHS2.
Genevestigator	Q6V1P9.
Family and domain databases
Gene3D	2.60.40.60. 24 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 17 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 21 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 22 hits.
PROSITE	PS00232. CADHERIN_1. 13 hits. PS50268. CADHERIN_2. 22 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54798.
NextBio	57483.
SOURCE	Search...

Entry information

Entry name

PCD23_HUMAN

Accession

Primary (citable) accession number: Q6V1P9
Secondary accession number(s): Q4W5P9, Q6ZS61, Q9NXU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.