Q6V0L0 (CP26C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 26C1
EC=1.14.-.-

Gene names

Name:

CYP26C1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Detected in most tissues at very low level. Ref.1
Induction	By retinoic acid. Ref.1
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from sequence or structural similarity. Source: BHF-UCL central nervous system development Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of retinoic acid receptor signaling pathway Non-traceable author statement Ref.1. Source: BHF-UCL neural crest cell development Inferred from sequence or structural similarity. Source: BHF-UCL organelle fusion Inferred from sequence or structural similarity. Source: BHF-UCL retinoic acid catabolic process Inferred from direct assay Ref.1. Source: BHF-UCL xenobiotic metabolic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro retinoic acid 4-hydroxylase activity Inferred from direct assay Ref.1. Source: BHF-UCL retinoic acid binding Inferred from direct assay Ref.1. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	Cytochrome P450 26C1		PRO_0000051987
Regions
	Transmembrane	9 – 29	21	Helical; Potential
Sites
	Metal binding	459	1	Iron (heme axial ligand) Potential
Natural variations
	Natural variant	245	1	R → Q. Corresponds to variant rs11187265 [ dbSNP | Ensembl ].		VAR_022886
Experimental info
	Sequence conflict	447	1	F → L in AAQ55485. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6V0L0 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 5401DF5646E51060	FASTA	522	57,111
	10 20 30 40 50 60 MFPWGLSCLS VLGAAGTALL CAGLLLSLAQ HLWTLRWMLS RDRASTLPLP KGSMGWPFFG 70 80 90 100 110 120 ETLHWLVQGS RFHSSRRERY GTVFKTHLLG RPVIRVSGAE NVRTILLGEH RLVRSQWPQS 130 140 150 160 170 180 AHILLGSHTL LGAVGEPHRR RRKVLARVFS RAALERYVPR LQGALRHEVR SWCAAGGPVS 190 200 210 220 230 240 VYDASKALTF RMAARILLGL RLDEAQCATL ARTFEQLVEN LFSLPLDVPF SGLRKGIRAR 250 260 270 280 290 300 DQLHRHLEGA ISEKLHEDKA AEPGDALDLI IHSARELGHE PSMQELKESA VELLFAAFFT 310 320 330 340 350 360 TASASTSLVL LLLQHPAAIA KIREELVAQG LGRACGCAPG AAGGSEGPPP DCGCEPDLSL 370 380 390 400 410 420 AALGRLRYVD CVVKEVLRLL PPVSGGYRTA LRTFELDGYQ IPKGWSVMYS IRDTHETAAV 430 440 450 460 470 480 YRSPPEGFDP ERFGAAREDS RGASSRFHYI PFGGGARSCL GQELAQAVLQ LLAVELVRTA 490 500 510 520 RWELATPAFP AMQTVPIVHP VDGLRLFFHP LTPSVAGNGL CL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid." Taimi M., Helvig C., Wisniewski J., Ramshaw H., White J., Amad M., Korczak B., Petkovich M. J. Biol. Chem. 279:77-85(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY356349 mRNA. Translation: AAQ55485.1. AL358613 Genomic DNA. Translation: CAH72802.2.
IPI	IPI00373823.
RefSeq	NP_899230.2. NM_183374.2.
UniGene	Hs.369993.
3D structure databases
ProteinModelPortal	Q6V0L0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000285949.
PTM databases
PhosphoSite	Q6V0L0.
Polymorphism databases
DMDM	71153209.
Proteomic databases
PaxDb	Q6V0L0.
PRIDE	Q6V0L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285949; ENSP00000285949; ENSG00000187553.
GeneID	340665.
KEGG	hsa:340665.
UCSC	uc010qns.2. human.
Organism-specific databases
CTD	340665.
GeneCards	GC10P094811.
H-InvDB	HIX0025937.
HGNC	HGNC:20577. CYP26C1.
MIM	608428. gene.
neXtProt	NX_Q6V0L0.
Orphanet	79133. Focal facial dermal dysplasia.
PharmGKB	PA134913464.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000220829.
HOVERGEN	HBG051099.
InParanoid	Q6V0L0.
KO	K12665.
OMA	DAQIADN.
OrthoDB	EOG48KRBB.
PhylomeDB	Q6V0L0.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
Bgee	Q6V0L0.
CleanEx	HS_CYP26C1.
Genevestigator	Q6V0L0.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002403. Cyt_P450_E_grp-IV. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00465. EP450IV. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	340665.
NextBio	97998.
SOURCE	Search...

Entry information

Entry name

CP26C_HUMAN

Accession

Primary (citable) accession number: Q6V0L0
Secondary accession number(s): Q5VXH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	May 29, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.