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Q6UZ82

- Q6UZ82_HUMAN

UniProt

Q6UZ82 - Q6UZ82_HUMAN

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Protein
Submitted name:

MCP1

Gene

MCP1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular calcium ion homeostasis Source: Ensembl
  3. cellular response to interferon-gamma Source: Ensembl
  4. cellular response to interleukin-1 Source: Ensembl
  5. cellular response to lipopolysaccharide Source: Ensembl
  6. cellular response to tumor necrosis factor Source: Ensembl
  7. chemokine-mediated signaling pathway Source: Ensembl
  8. helper T cell extravasation Source: Ensembl
  9. inflammatory response Source: Ensembl
  10. lymphocyte chemotaxis Source: Ensembl
  11. macrophage chemotaxis Source: Ensembl
  12. maternal process involved in parturition Source: Ensembl
  13. negative regulation of angiogenesis Source: Ensembl
  14. neutrophil chemotaxis Source: Ensembl
  15. organ regeneration Source: Ensembl
  16. positive regulation of apoptotic cell clearance Source: Ensembl
  17. positive regulation of endothelial cell proliferation Source: Ensembl
  18. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  19. positive regulation of macrophage chemotaxis Source: Ensembl
  20. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  21. positive regulation of synaptic transmission Source: Ensembl
  22. positive regulation of T cell activation Source: Ensembl
  23. regulation of vascular endothelial growth factor production Source: Ensembl
  24. response to activity Source: Ensembl
  25. response to amino acid Source: Ensembl
  26. response to antibiotic Source: Ensembl
  27. response to drug Source: Ensembl
  28. response to ethanol Source: Ensembl
  29. response to gamma radiation Source: Ensembl
  30. response to glucocorticoid Source: Ensembl
  31. response to heat Source: Ensembl
  32. response to hypoxia Source: Ensembl
  33. response to mechanical stimulus Source: Ensembl
  34. response to progesterone Source: Ensembl
  35. response to vitamin B3 Source: Ensembl
  36. response to wounding Source: Ensembl
  37. transforming growth factor beta receptor signaling pathway Source: Ensembl
  38. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MCP1Imported
Submitted name:
Monocyte chemoattractant protein-1Imported
Gene namesi
Name:MCP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6UZ82.
ExpressionAtlasiQ6UZ82. baseline and differential.

Sequencei

Sequence statusi: Fragment.

Q6UZ82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
MKVSAALLCL LLIAATFIPQ GLAQP
Length:25
Mass (Da):2,583
Last modified:July 5, 2004 - v1
Checksum:i194991DF470BFC18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei25 – 251Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY357296 Genomic DNA. Translation: AAQ75526.1.
D26087 Genomic DNA. Translation: BAA05080.1.
UniGeneiHs.303649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY357296 Genomic DNA. Translation: AAQ75526.1 .
D26087 Genomic DNA. Translation: BAA05080.1 .
UniGenei Hs.303649.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q6UZ82.
ExpressionAtlasi Q6UZ82. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The human homolog of the JE gene encodes a monocyte secretory protein."
    Rollins B.J., Stier P., Ernst T., Wong G.G.
    Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  2. "Structure of human monocyte chemotactic protein gene and its regulation by TPA."
    Shyy Y.J., Li Y.S., Kolattukudy P.E.
    Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  3. "NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene."
    Ueda A., Okuda K., Ohno S., Shirai A., Igarashi T., Matsunaga K., Fukushima J., Kawamoto S., Ishigatsubo Y., Okubo T.
    J. Immunol. 153:2052-2063(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  4. "Two New Single Nucleotide Polymorphisms (SNPs) in the MCP-1 Promoter in Patients with Carotid Atherosclerosis: Transcriptional Induction and New Protein Binding Sites."
    Nyquist P.A., Degraba T.J.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6UZ82_HUMAN
AccessioniPrimary (citable) accession number: Q6UZ82
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.