Q6UZ82 (Q6UZ82_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MCP1 EMBL AAQ75526.1

Submitted name:
Monocyte chemoattractant protein-1 EMBL BAA05080.1

Gene names

Name:

MCP1 EMBL AAQ75526.1

Organism

Homo sapiens (Human) EMBL AAQ75526.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	25 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular response to interferon-gamma Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to lipopolysaccharide Inferred from electronic annotation. Source: Compara cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara chemokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara helper T cell extravasation Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara lymphocyte chemotaxis Inferred from electronic annotation. Source: Compara macrophage chemotaxis Inferred from electronic annotation. Source: Compara maternal process involved in parturition Inferred from electronic annotation. Source: Compara negative regulation of angiogenesis Inferred from electronic annotation. Source: Compara neutrophil chemotaxis Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara positive regulation of T cell activation Inferred from electronic annotation. Source: Compara positive regulation of apoptotic cell clearance Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of immune complex clearance by monocytes and macrophages Inferred from electronic annotation. Source: Compara positive regulation of macrophage chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of nitric-oxide synthase biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara regulation of vascular endothelial growth factor production Inferred from electronic annotation. Source: Compara response to activity Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from electronic annotation. Source: Compara response to antibiotic Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to heat Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara response to vitamin B3 Inferred from electronic annotation. Source: Compara transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara vascular endothelial growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	25	1	EMBL AAQ75526.1

Sequences

	Sequence		Length	Mass (Da)
	Q6UZ82 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 194991DF470BFC18	FASTA	25	2,583
	10 20 MKVSAALLCL LLIAATFIPQ GLAQP

References

[1]	"The human homolog of the JE gene encodes a monocyte secretory protein." Rollins B.J., Stier P., Ernst T., Wong G.G. Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAA05080.1.
[2]	"Structure of human monocyte chemotactic protein gene and its regulation by TPA." Shyy Y.J., Li Y.S., Kolattukudy P.E. Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAA05080.1.
[3]	"NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene." Ueda A., Okuda K., Ohno S., Shirai A., Igarashi T., Matsunaga K., Fukushima J., Kawamoto S., Ishigatsubo Y., Okubo T. J. Immunol. 153:2052-2063(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Placenta EMBL BAA05080.1.
[4]	"Two New Single Nucleotide Polymorphisms (SNPs) in the MCP-1 Promoter in Patients with Carotid Atherosclerosis: Transcriptional Induction and New Protein Binding Sites." Nyquist P.A., Degraba T.J. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY357296 Genomic DNA. Translation: AAQ75526.1. D26087 Genomic DNA. Translation: BAA05080.1.
IPI	IPI00009308.
UniGene	Hs.303649.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6UZ82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q6UZ82.
Bgee	Q6UZ82.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

Q6UZ82_HUMAN

Accession

Primary (citable) accession number: Q6UZ82

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.