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Q6UZ82 (Q6UZ82_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Monocyte chemoattractant protein-1 EMBL BAA05080.1
Gene names
Name:MCP1 EMBL AAQ75526.1
OrganismHomo sapiens (Human) EMBL AAQ75526.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length25 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processaging

Inferred from electronic annotation. Source: Ensembl

cellular calcium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

cellular response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

chemokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

helper T cell extravasation

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

lymphocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

maternal process involved in parturition

Inferred from electronic annotation. Source: Ensembl

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic cell clearance

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of immune complex clearance by monocytes and macrophages

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Ensembl

regulation of vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from electronic annotation. Source: Ensembl

response to antibiotic

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

response to vitamin B3

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

vascular endothelial growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue251 EMBL AAQ75526.1

Sequences

Sequence LengthMass (Da)Tools
Q6UZ82 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 194991DF470BFC18

FASTA252,583
        10         20 
MKVSAALLCL LLIAATFIPQ GLAQP 

« Hide

References

[1]"The human homolog of the JE gene encodes a monocyte secretory protein."
Rollins B.J., Stier P., Ernst T., Wong G.G.
Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Placenta EMBL BAA05080.1.
[2]"Structure of human monocyte chemotactic protein gene and its regulation by TPA."
Shyy Y.J., Li Y.S., Kolattukudy P.E.
Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Placenta EMBL BAA05080.1.
[3]"NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene."
Ueda A., Okuda K., Ohno S., Shirai A., Igarashi T., Matsunaga K., Fukushima J., Kawamoto S., Ishigatsubo Y., Okubo T.
J. Immunol. 153:2052-2063(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Placenta EMBL BAA05080.1.
[4]"Two New Single Nucleotide Polymorphisms (SNPs) in the MCP-1 Promoter in Patients with Carotid Atherosclerosis: Transcriptional Induction and New Protein Binding Sites."
Nyquist P.A., Degraba T.J.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY357296 Genomic DNA. Translation: AAQ75526.1.
D26087 Genomic DNA. Translation: BAA05080.1.
UniGeneHs.303649.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Gene expression databases

ArrayExpressQ6UZ82.
BgeeQ6UZ82.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameQ6UZ82_HUMAN
AccessionPrimary (citable) accession number: Q6UZ82
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.