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Q6UZ82

- Q6UZ82_HUMAN

UniProt

Q6UZ82 - Q6UZ82_HUMAN

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Protein
Submitted name:

MCP1

Gene

MCP1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular calcium ion homeostasis Source: Ensembl
  3. cellular response to ATP Source: Ensembl
  4. cellular response to dexamethasone stimulus Source: Ensembl
  5. cellular response to drug Source: Ensembl
  6. cellular response to high density lipoprotein particle stimulus Source: Ensembl
  7. cellular response to insulin stimulus Source: Ensembl
  8. cellular response to interferon-gamma Source: Ensembl
  9. cellular response to interleukin-1 Source: Ensembl
  10. cellular response to interleukin-6 Source: Ensembl
  11. cellular response to lipopolysaccharide Source: Ensembl
  12. cellular response to macrophage colony-stimulating factor stimulus Source: Ensembl
  13. cellular response to platelet-derived growth factor stimulus Source: Ensembl
  14. cellular response to retinoic acid Source: Ensembl
  15. cellular response to tumor necrosis factor Source: Ensembl
  16. chemokine-mediated signaling pathway Source: Ensembl
  17. glial cell migration Source: Ensembl
  18. helper T cell extravasation Source: Ensembl
  19. leukocyte migration involved in inflammatory response Source: Ensembl
  20. lymphocyte chemotaxis Source: Ensembl
  21. macrophage chemotaxis Source: Ensembl
  22. maternal process involved in female pregnancy Source: Ensembl
  23. maternal process involved in parturition Source: Ensembl
  24. negative regulation of angiogenesis Source: Ensembl
  25. neutrophil chemotaxis Source: Ensembl
  26. organ regeneration Source: Ensembl
  27. positive regulation of apoptotic cell clearance Source: Ensembl
  28. positive regulation of cell-cell adhesion Source: Ensembl
  29. positive regulation of cellular extravasation Source: Ensembl
  30. positive regulation of collagen biosynthetic process Source: Ensembl
  31. positive regulation of endothelial cell proliferation Source: Ensembl
  32. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  33. positive regulation of leukocyte mediated cytotoxicity Source: Ensembl
  34. positive regulation of macrophage chemotaxis Source: Ensembl
  35. positive regulation of monocyte chemotaxis Source: Ensembl
  36. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  37. positive regulation of synaptic transmission Source: Ensembl
  38. positive regulation of T cell activation Source: Ensembl
  39. positive regulation of tumor necrosis factor production Source: Ensembl
  40. regulation of vascular endothelial growth factor production Source: Ensembl
  41. response to activity Source: Ensembl
  42. response to amino acid Source: Ensembl
  43. response to antibiotic Source: Ensembl
  44. response to ethanol Source: Ensembl
  45. response to gamma radiation Source: Ensembl
  46. response to heat Source: Ensembl
  47. response to hypoxia Source: Ensembl
  48. response to mechanical stimulus Source: Ensembl
  49. response to progesterone Source: Ensembl
  50. response to vitamin B3 Source: Ensembl
  51. response to wounding Source: Ensembl
  52. transforming growth factor beta receptor signaling pathway Source: Ensembl
  53. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MCP1Imported
Submitted name:
Monocyte chemoattractant protein-1Imported
Gene namesi
Name:MCP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. C-fiber Source: Ensembl
  3. dendrite Source: Ensembl
  4. endocytic vesicle Source: Ensembl
  5. extracellular space Source: Ensembl
  6. perikaryon Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. rough endoplasmic reticulum Source: Ensembl
  9. synapse Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6UZ82.
ExpressionAtlasiQ6UZ82. baseline and differential.

Sequencei

Sequence statusi: Fragment.

Q6UZ82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
MKVSAALLCL LLIAATFIPQ GLAQP
Length:25
Mass (Da):2,583
Last modified:July 5, 2004 - v1
Checksum:i194991DF470BFC18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei25 – 251Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY357296 Genomic DNA. Translation: AAQ75526.1.
D26087 Genomic DNA. Translation: BAA05080.1.
UniGeneiHs.303649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY357296 Genomic DNA. Translation: AAQ75526.1 .
D26087 Genomic DNA. Translation: BAA05080.1 .
UniGenei Hs.303649.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q6UZ82.
ExpressionAtlasi Q6UZ82. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The human homolog of the JE gene encodes a monocyte secretory protein."
    Rollins B.J., Stier P., Ernst T., Wong G.G.
    Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  2. "Structure of human monocyte chemotactic protein gene and its regulation by TPA."
    Shyy Y.J., Li Y.S., Kolattukudy P.E.
    Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  3. "NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene."
    Ueda A., Okuda K., Ohno S., Shirai A., Igarashi T., Matsunaga K., Fukushima J., Kawamoto S., Ishigatsubo Y., Okubo T.
    J. Immunol. 153:2052-2063(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.
  4. "Two New Single Nucleotide Polymorphisms (SNPs) in the MCP-1 Promoter in Patients with Carotid Atherosclerosis: Transcriptional Induction and New Protein Binding Sites."
    Nyquist P.A., Degraba T.J.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6UZ82_HUMAN
AccessioniPrimary (citable) accession number: Q6UZ82
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.