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Q6UZ82

- Q6UZ82_HUMAN

UniProt

Q6UZ82 - Q6UZ82_HUMAN

Protein
Submitted name:

MCP1

Gene

MCP1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular calcium ion homeostasis Source: Ensembl
    3. cellular response to interferon-gamma Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to lipopolysaccharide Source: Ensembl
    6. cellular response to tumor necrosis factor Source: Ensembl
    7. chemokine-mediated signaling pathway Source: Ensembl
    8. helper T cell extravasation Source: Ensembl
    9. inflammatory response Source: Ensembl
    10. lymphocyte chemotaxis Source: Ensembl
    11. macrophage chemotaxis Source: Ensembl
    12. maternal process involved in parturition Source: Ensembl
    13. negative regulation of angiogenesis Source: Ensembl
    14. neutrophil chemotaxis Source: Ensembl
    15. organ regeneration Source: Ensembl
    16. positive regulation of apoptotic cell clearance Source: Ensembl
    17. positive regulation of endothelial cell proliferation Source: Ensembl
    18. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
    19. positive regulation of macrophage chemotaxis Source: Ensembl
    20. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    21. positive regulation of synaptic transmission Source: Ensembl
    22. positive regulation of T cell activation Source: Ensembl
    23. regulation of vascular endothelial growth factor production Source: Ensembl
    24. response to activity Source: Ensembl
    25. response to amino acid Source: Ensembl
    26. response to antibiotic Source: Ensembl
    27. response to drug Source: Ensembl
    28. response to ethanol Source: Ensembl
    29. response to gamma radiation Source: Ensembl
    30. response to glucocorticoid Source: Ensembl
    31. response to heat Source: Ensembl
    32. response to hypoxia Source: Ensembl
    33. response to mechanical stimulus Source: Ensembl
    34. response to progesterone Source: Ensembl
    35. response to vitamin B3 Source: Ensembl
    36. transforming growth factor beta receptor signaling pathway Source: Ensembl
    37. vascular endothelial growth factor receptor signaling pathway Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MCP1Imported
    Submitted name:
    Monocyte chemoattractant protein-1Imported
    Gene namesi
    Name:MCP1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl
    3. neuronal cell body Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ6UZ82.
    BgeeiQ6UZ82.

    Sequencei

    Sequence statusi: Fragment.

    Q6UZ82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLIAATFIPQ GLAQP                              25
    Length:25
    Mass (Da):2,583
    Last modified:July 5, 2004 - v1
    Checksum:i194991DF470BFC18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei25 – 251Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY357296 Genomic DNA. Translation: AAQ75526.1.
    D26087 Genomic DNA. Translation: BAA05080.1.
    UniGeneiHs.303649.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY357296 Genomic DNA. Translation: AAQ75526.1 .
    D26087 Genomic DNA. Translation: BAA05080.1 .
    UniGenei Hs.303649.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q6UZ82.
    Bgeei Q6UZ82.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The human homolog of the JE gene encodes a monocyte secretory protein."
      Rollins B.J., Stier P., Ernst T., Wong G.G.
      Mol. Cell. Biol. 9:4687-4695(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.
    2. "Structure of human monocyte chemotactic protein gene and its regulation by TPA."
      Shyy Y.J., Li Y.S., Kolattukudy P.E.
      Biochem. Biophys. Res. Commun. 169:346-351(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.
    3. "NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene."
      Ueda A., Okuda K., Ohno S., Shirai A., Igarashi T., Matsunaga K., Fukushima J., Kawamoto S., Ishigatsubo Y., Okubo T.
      J. Immunol. 153:2052-2063(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.
    4. "Two New Single Nucleotide Polymorphisms (SNPs) in the MCP-1 Promoter in Patients with Carotid Atherosclerosis: Transcriptional Induction and New Protein Binding Sites."
      Nyquist P.A., Degraba T.J.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6UZ82_HUMAN
    AccessioniPrimary (citable) accession number: Q6UZ82
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.