Unreviewed, UniProtKB/TrEMBL Q6UY90 (Q6UY90_RAT)

Names and origin

Protein names

Submitted name:
    Patched EMBL AAQ67738.1

Gene names

Name:	Ptch1 RGD 621425
Synonyms:	Ptch RGD 621425

Organism

Rattus norvegicus (Rat) EMBL AAQ67738.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara embryonic limb morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB epidermis development Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara heart morphogenesis Inferred from electronic annotation. Source: Compara hindlimb morphogenesis Inferred from electronic annotation. Source: Compara keratinocyte proliferation Inferred from electronic annotation. Source: Compara mammary gland development Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of multicellular organism growth Inferred from sequence or structural similarity. Source: UniProtKB neural tube closure Inferred from electronic annotation. Source: Compara protein processing Inferred from sequence or structural similarity. Source: UniProtKB regulation of smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB response to drug Inferred from expression pattern. Source: RGD response to estradiol stimulus Inferred from expression pattern. Source: RGD response to mechanical stimulus Inferred from expression pattern. Source: RGD response to organic cyclic substance Inferred from expression pattern. Source: RGD response to retinoic acid Inferred from expression pattern. Source: RGD smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	hedgehog receptor activity Inferred from electronic annotation. Source: InterPro heparin binding Inferred from electronic annotation. Source: Compara patched binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6UY90-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7166D3C426BFA136	FASTA	1,434	159,258
	10 20 30 40 50 60 MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFALEQ ISKGKATGRK 70 80 90 100 110 120 APLWLRAKFQ RLLFKLGCYI QKNCGKFLVV GLLIFGAFAV GLKAANLETN VEELWVEVGG 130 140 150 160 170 180 RVSRELNYTR QKIGEEAMFN PQLMIQTPKE EGANVLTTEA LLQHLDSALQ ASRVHVYMYN 190 200 210 220 230 240 RQWKLEHLCY KSGELITETG YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL 250 260 270 280 290 300 RWTNFDPLEF LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST 310 320 330 340 350 360 KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF QLMTPKQMYE 370 380 390 400 410 420 HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN STQKVLSFTT TTLDDILKSF 430 440 450 460 470 480 SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK SQGAVGLAGV LLVALSVAAG LGLCSLIGIS 490 500 510 520 530 540 FNAATTQVLP FLALGVGVDD VFLLAHAFSE TGQNKRIPFE DRTGECLKRT GASVALTSIS 550 560 570 580 590 600 NVTAFFMAAL IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF 610 620 630 640 650 660 TSPCVSRVIQ VEPQAYTEPH SNTRYSPPPP YSSHSFAHET HITMQSTVQL RTEYDPHTHV 670 680 690 700 710 720 YYTTAEPRSE ISVQPVTITQ DTLSCQSPES TSSTRDLLSQ FSDSSLHCLE PPCTKWTLSS 730 740 750 760 770 780 FAEKHYAPFL LRPKAKVVVI LLFLGLLGVS LYGTTRVRDG LDLTDIVPRE TREYDFIAAQ 790 800 810 820 830 840 FKYFSFYNMY IVTQKADYPN IQHLLYDLHK SFSSVKYVML EENKQLPQMW LHYFRDWLQG 850 860 870 880 890 900 LQDAFDSDWE TGRIMPNNYK NGSDDGVLAY KLLVQTGSRD KPIDISQLTK QRLVDADGII 910 920 930 940 950 960 NPSAFYIYLT AWVSNDPVAY AASQANIRPH RPEWVHDKAD YMPETRLRIP AAEPIEYAQF 970 980 990 1000 1010 1020 PFYLNGLRDT SDFVEAIEKV RVICNNYTSL GLSSYPNGYP FLFWEQYISL RHWLLLAISV 1030 1040 1050 1060 1070 1080 VLACTFLVCA VFLLNPWTAG IIVMVLALMT VELFGMMGLI GIKLSAVPVV ILIASVGIGV 1090 1100 1110 1120 1130 1140 EFTVHVALAF LTAIGDKNHR AMLALEHMFA PVLDGAVSTL LGVLMLAGSE FDFIVRYFFA 1150 1160 1170 1180 1190 1200 VLAILTVLGV LNGLVLLPVL LSFFGPCPEV SPANGLNRLP TPSPEPPPSV VRFAVPPGHT 1210 1220 1230 1240 1250 1260 NNGSDSSDSE YSSQTTVSGI SEELRHYEAQ QGTGGPAHQV IVEATENPVF ARSTVVHPDS 1270 1280 1290 1300 1310 1320 RHQPPLNSRQ QPHLDSGSLS PGRQGQQPRR DPPREGLRPP PYRPRRDAFE ISTEGHSGPS 1330 1340 1350 1360 1370 1380 NRDRSGPHGA RSHNPRNPTS TAMGSSVPSY CQPITTVTAS ASVTVAVHPP PGPGRNPRGG 1390 1400 1410 1420 1430 PCPGYESYPE TDHGVFEDPH VPFHVRCERR DSKVEVIELQ DVECEERPWG SSSN

References

[1]	"Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo." Lai K., Kaspar B.K., Gage F.H., Schaffer D.V. Nat. Neurosci. 6:21-27(2003) [PubMed: 12469128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: F344 EMBL AAQ67738.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY357891 mRNA. Translation: AAQ67738.1.
IPI	IPI00396901.
RefSeq	NP_446018.1.
UniGene	Rn.102312
3D structure databases
SMR	Q6UY90. Positions 89-118.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6UY90.
Genome annotation databases
Ensembl	ENSRNOT00000026287; ENSRNOP00000026287; ENSRNOG00000019354; Rattus norvegicus. [Genome view]
GeneID	89830.
KEGG	rno:89830.
Organism-specific databases
CTD	89830.
Phylogenomic databases
eggNOG	roNOG12890.
HOVERGEN	Q6UY90.
InParanoid	Q6UY90.
OMA	RPSYCDA.
OrthoDB	EOG9B5RQR.
PhylomeDB	Q6UY90.
Gene expression databases
ArrayExpress	Q6UY90.
Genevestigator	Q6UY90.
Family and domain databases
InterPro	IPR003392. Patched. IPR000731. SSD_5TM. IPR004766. TM_rcpt_patched. [Graphical view]
Pfam	PF02460. Patched. 1 hit. [Graphical view]
TIGRFAMs	TIGR00918. 2A060602. 1 hit.
PROSITE	PS50156. SSD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	617756.

Entry information

Entry name

Q6UY90_RAT

Accession

Primary (citable) accession number: Q6UY90

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)