Q6UY67 (VP40_MABVO) Reviewed, UniProtKB/Swiss-Prot
Last modified January 9, 2013. Version 33. History...
Names and origin
|Protein names||Recommended name:|
Matrix protein VP40
Membrane-associated protein VP40
|Organism||Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975)) [Complete proteome]|
|Taxonomic identifier||482820 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Mononegavirales › Filoviridae › Marburgvirus ›|
|Virus host||Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]|
Homo sapiens (Human) [TaxID: 9606]
Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) [TaxID: 9407]
|Sequence length||303 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. May play a role in genome replication By similarity.
Interacts with host TSG101 By similarity.
Virion membrane; Peripheral membrane protein By similarity. Host late endosome membrane; Peripheral membrane protein By similarity. Host cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Host endomembrane system; Peripheral membrane protein By similarity. Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place By similarity.
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Gag-p19 contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase By similarity.
Most abundant protein in the virion.
Belongs to the filoviridae matrix protein VP40 family.
Sequence annotation (Features)
|AY358025 Genomic RNA. Translation: AAQ55257.1.|
3D structure databases
|HSSP||HSSP built from PDB template 1H2D based on UniProtKB Q05128. |
Protocols and materials databases
Family and domain databases
|InterPro||IPR008986. EV_matrix. |
|Pfam||PF07447. VP40. 1 hit. |
|PIRSF||PIRSF018327. VP40_FiloV. 1 hit. |
|SUPFAM||SSF50012. EV_matrix. 1 hit. |
|Accession||Primary (citable) accession number: Q6UY67|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families