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Q6UY63 (L_MABVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase

Including the following 3 domains:

  1. RNA-directed RNA polymerase
    EC=2.7.7.48
  2. mRNA (guanine-N(7)-)-methyltransferase
    EC=2.1.1.56
  3. mRNA guanylyltransferase
    EC=2.7.7.-
Gene names
Name:L
OrganismLake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975)) [Complete proteome]
Taxonomic identifier482820 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeMarburgvirus
Virus hostChlorocebus aethiops (Green monkey) (Cercopithecus aethiops) [TaxID: 9534]
Homo sapiens (Human) [TaxID: 9606]
Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) [TaxID: 9407]

Protein attributes

Sequence length2331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.

Subcellular location

Host cytoplasm. Virion By similarity.

Sequence similarities

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23312331RNA-directed RNA polymerase L
PRO_0000314971

Regions

Domain628 – 812185RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
Q6UY63 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F5145FBD4B5089AA

FASTA2,331267,213
        10         20         30         40         50         60 
MQHPTQYPDA RLSSPIVLDQ CDLLARSLGL YSHYSHNPKL RNCRIPHHIY RLRNSTALKT 

        70         80         90        100        110        120 
FLQNCSILTV PFHSIWDHIL TSIQYDAINH VDDFKYLLPS ELVKYANWDN EFLKTYLNKI 

       130        140        150        160        170        180 
LRLDHVFPAS ARSQCEDFSP KENPYYWGML LLVHLSQLAR RIKGQRGSLR SNWKFIGTDL 

       190        200        210        220        230        240 
ELFGIADFII FKVPVKTIIR NAVSLQASKP GLRVWYRDQN LTPYLCDDEF IVSVASYECF 

       250        260        270        280        290        300 
IMIKDVFIER YNTWEICARA WLEDSDGADY PPLDVLGELY NYGDQIIAMY LEDGFKLIKH 

       310        320        330        340        350        360 
LEPLCVSCIQ THGIFTPRKY WFQSQMIKSY YDELCDLNLK LRISDNKAEC AQNFIKTIIQ 

       370        380        390        400        410        420 
ARLTPQQYCE LFSLQKHWGH PVLYNDVALD KVKKHAQATK ILKPKVMFET FCVFKFIVAK 

       430        440        450        460        470        480 
NHYHSQGSWY KTTHDLHLTP YLRQHIVSNS FPSQAEIYQH LWEWYFVEHE PLFSTKIISD 

       490        500        510        520        530        540 
LSIFIKDRAT AVNQECWDSV FDRSVLGYNP PVRFQSKRVP EQFLGQADFS LNQILDFAEK 

       550        560        570        580        590        600 
LEYLAPSYRN FSFSLKEKEL NIGRTFGKLP YRVRNVQTLA EALLADGLAK AFPSNMMVVT 

       610        620        630        640        650        660 
EREQKEALLH QASWHHNSAS IGENAIVRGA SFVTDLEKYN LAFRYEFTRH FINYCNRCYG 

       670        680        690        700        710        720 
VKNLFDWMHF LIPLCYMHVS DFYSPPHCVT EDNRNNPPDC ANAYHYHLGG IEGLQQKLWT 

       730        740        750        760        770        780 
CISCAQITLV ELKTKLKLKS SVMGDNQCIT TLSLFPIDAP NDYQENEAEL NAARVAVELA 

       790        800        810        820        830        840 
ITTGYSGIFL KPEETFVHSG FIYFGKKQYL NGVQLPQSLK TMARCGPLSD SIFDDLQGSL 

       850        860        870        880        890        900 
ASIGTSFERG TSETRHIFPS RWIASFHSML AINLLNQNHL GFPLGFNIDI SCFKKPLTFS 

       910        920        930        940        950        960 
EKLIALITPQ VLGGLSFLNP EKLFYRNISD PLTSGLFQLK NALEFLGKGE LFYILIAKKP 

       970        980        990       1000       1010       1020 
GLADASDFVM NPLGLNVPGS REIITFLRQT VRENITITSQ NRIINSLFHI GSDLEDQKVC 

      1030       1040       1050       1060       1070       1080 
EWLLSSNPVM SRFAADIFSR TPSGKRLQVL GYLEGTRTLL ASRTISLTTE GTMLMKLREL 

      1090       1100       1110       1120       1130       1140 
TRNRWKSWFS YIDALDDDLS ESLEKFTCTV DVANFLRAYS WSDVLKGKRL IGATLPCLLE 

      1150       1160       1170       1180       1190       1200 
QFKVKWINLS EDLREQFNLS SESELTINLL PYDCKELRLG GSHDTELNYV SCALDRKVVQ 

      1210       1220       1230       1240       1250       1260 
KHPSVKRLAW TIGNRAPYIG SRTEDKIGYP PLRVNCPSAA LKEAIEMVSR LLWVTQGTAD 

      1270       1280       1290       1300       1310       1320 
REKLLIPLLN SRVNLDYQTV LNFLPTHYSG NIVHRYNDQY GQHSFMANRM SNTSTRAIIS 

      1330       1340       1350       1360       1370       1380 
TNTLGKYAGG GQAAIDSNII FQNTINLGVA VLDIALSLAK LSSASNVTFR LMLNKCCTRH 

      1390       1400       1410       1420       1430       1440 
VPSEYLFFDK PLDVDLNKYM DNELVYDNDP LCSGIKGRLG RVSRSTLSLS LNVSDIGSYD 

      1450       1460       1470       1480       1490       1500 
FPTIAAWTLG ETIVGSIFSD ESSQSTDPIS SGCTKTFVTH FLVYPVESIF YAFGANLIVE 

      1510       1520       1530       1540       1550       1560 
SLSLSRIKSI KNLSDLTFLI SSTIRNLSHR SLRILQSTFR HELVLTRLAH HIPLISLMLG 

      1570       1580       1590       1600       1610       1620 
GSAGEKSSSD AVRLFLTASY QNFIHNFSCL MKKGQSSLPV WLYFPSEGQQ LKPILKILQR 

      1630       1640       1650       1660       1670       1680 
LSDLLSPDKV QRCKTLADTC CSIDSFWVYP SKSTRTNHYY ASLNYWRDKA NKVKNTPFSH 

      1690       1700       1710       1720       1730       1740 
LINCSFLELS SHTSSVSSNQ QVTNSKYIVH PEDIPEINTR TKLIEYGSTA LQRMDIKMPP 

      1750       1760       1770       1780       1790       1800 
SEQNLVENCR PSKDIRFKDN QKITKHDQRY EKKESSQQQM SPEDNMQTLA YMHNSSPSQT 

      1810       1820       1830       1840       1850       1860 
FIKSIDVHED FDASRVILNS KINNFNLTDC TINTNLLTTP TGTEFLDTSP LQSSRYSSTP 

      1870       1880       1890       1900       1910       1920 
RERSLLSREQ ASYLYVDCSN IPSISLDPGF RNMSDQNQIQ MLINAYKRDL HACFDSNQFC 

      1930       1940       1950       1960       1970       1980 
RFTGVVSSMH YKLYDLLPPG ELRKAICLAE GEGSGARLLL KWKETDHLFF NTLATDSQQE 

      1990       2000       2010       2020       2030       2040 
AEILSGRVIP RMLYNIDRLS ALLESRRLIL NNLTIQITDI TNPLWLDSVI QYLPEDSDIL 

      2050       2060       2070       2080       2090       2100 
TMDAETTKDE TREQLYKTIV NIWTRTSPNI PKISIIKVFL LDYEGTLFLM KNAIQYYGQV 

      2110       2120       2130       2140       2150       2160 
QLKKPYSSNA KNSEWYLCCS KRRIQRLQID FPDQVGIFLI CKAMSRQRQA IPYWLKHIEK 

      2170       2180       2190       2200       2210       2220 
NYPASLHEFF LTLGFPSLES SFCHRYTIPF SEGKALFHKV QSYVRQGKQH LHSLMLDYEN 

      2230       2240       2250       2260       2270       2280 
NSPLLDLRNH FICSLRGKIT KYYNDILKLN LVIKAVEKGK NWSQLVETLP NMHSVCIVHV 

      2290       2300       2310       2320       2330 
DHECFGCEKR LLLKLDFIRN TKIAEQKLLN RVIGYILFFP FGLSKSRSLR A 

« Hide

References

[1]Bowen M.D., Thurman K., Minor E., Ibrahim M.S., Meyer R.F., Malfatti S.A., Do L.H., Smith K.L., McCready P.M., Chain P.S.G.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358025 Genomic RNA. Translation: AAQ55261.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR026890. Mononeg_mRNAcap.
IPR014023. Mononeg_RNA_pol_cat.
IPR017235. RNA-dir_pol_L_filovirus.
IPR025786. RNA-direct_RNA_pol_L.
[Graphical view]
PfamPF14318. Mononeg_mRNAcap. 1 hit.
PF00946. Mononeg_RNA_pol. 1 hit.
[Graphical view]
PIRSFPIRSF037548. RNA_pol_Filoviridae. 1 hit.
TIGRFAMsTIGR04198. paramyx_RNAcap. 1 hit.
PROSITEPS50526. RDRP_SSRNA_NEG_NONSEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_MABVO
AccessionPrimary (citable) accession number: Q6UY63
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families