Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

Gene

LINGO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4
Alternative name(s):
Leucine-rich repeat neuronal protein 6D
Gene namesi
Name:LINGO4
Synonyms:LRRN6D
ORF Names:UNQ9248/PRO34002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31814. LINGO4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 533505ExtracellularSequence analysisAdd
BLAST
Transmembranei534 – 55421HelicalSequence analysisAdd
BLAST
Topological domaini555 – 59339CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394098.

Polymorphism and mutation databases

BioMutaiLINGO4.
DMDMi74762377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 593565Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4PRO_0000324184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi435 ↔ 484PROSITE-ProRule annotation
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UY18.
PRIDEiQ6UY18.

PTM databases

iPTMnetiQ6UY18.
PhosphoSiteiQ6UY18.

Expressioni

Gene expression databases

BgeeiQ6UY18.
CleanExiHS_LINGO4.
GenevisibleiQ6UY18. HS.

Organism-specific databases

HPAiHPA060781.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357810.

Structurei

3D structure databases

ProteinModelPortaliQ6UY18.
SMRiQ6UY18. Positions 4-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 6032LRRNTAdd
BLAST
Repeati61 – 8222LRR 1Add
BLAST
Repeati85 – 10622LRR 2Add
BLAST
Repeati109 – 13022LRR 3Add
BLAST
Repeati133 – 15422LRR 4Add
BLAST
Repeati157 – 17822LRR 5Add
BLAST
Repeati181 – 20222LRR 6Add
BLAST
Repeati210 – 23122LRR 7Add
BLAST
Repeati253 – 27422LRR 8Add
BLAST
Repeati277 – 29822LRR 9Add
BLAST
Repeati301 – 32222LRR 10Add
BLAST
Repeati325 – 34622LRR 11Add
BLAST
Domaini358 – 41255LRRCTAdd
BLAST
Domaini412 – 50291Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ6UY18.
OMAiNDSLRTW.
OrthoDBiEOG715Q3P.
PhylomeDBiQ6UY18.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UY18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAATAPKQA WPPWPPLLFL LLLPGGSGGS CPAVCDCTSQ PQAVLCGHRQ
60 70 80 90 100
LEAVPGGLPL DTELLDLSGN RLWGLQQGML SRLSLLQELD LSYNQLSTLE
110 120 130 140 150
PGAFHGLQSL LTLRLQGNRL RIMGPGVFSG LSALTLLDLR LNQIVLFLDG
160 170 180 190 200
AFGELGSLQK LEVGDNHLVF VAPGAFAGLA KLSTLTLERC NLSTVPGLAL
210 220 230 240 250
ARLPALVALR LRELDIGRLP AGALRGLGQL KELEIHLWPS LEALDPGSLV
260 270 280 290 300
GLNLSSLAIT RCNLSSVPFQ ALYHLSFLRV LDLSQNPISA IPARRLSPLV
310 320 330 340 350
RLQELRLSGA CLTSIAAHAF HGLTAFHLLD VADNALQTLE ETAFPSPDKL
360 370 380 390 400
VTLRLSGNPL TCDCRLLWLL RLRRHLDFGM SPPACAGPHH VQGKSLKEFS
410 420 430 440 450
DILPPGHFTC KPALIRKSGP RWVIAEEGGH AVFSCSGDGD PAPTVSWMRP
460 470 480 490 500
HGAWLGRAGR VRVLEDGTLE IRSVQLRDRG AYVCVVSNVA GNDSLRTWLE
510 520 530 540 550
VIQVEPPNGT LSDPNITVPG IPGPFFLDSR GVAMVLAVGF LPFLTSVTLC
560 570 580 590
FGLIALWSKG KGRVKHHMTF DFVAPRPSGD KNSGGNRVTA KLF
Length:593
Mass (Da):63,774
Last modified:July 5, 2004 - v1
Checksum:i47514FD64574FA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358115 mRNA. Translation: AAQ88482.1.
AL589765 Genomic DNA. Translation: CAI17178.1.
CCDSiCCDS30855.1.
RefSeqiNP_001004432.1. NM_001004432.3.
UniGeneiHs.591477.

Genome annotation databases

EnsembliENST00000368820; ENSP00000357810; ENSG00000213171.
GeneIDi339398.
KEGGihsa:339398.
UCSCiuc001ezf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358115 mRNA. Translation: AAQ88482.1.
AL589765 Genomic DNA. Translation: CAI17178.1.
CCDSiCCDS30855.1.
RefSeqiNP_001004432.1. NM_001004432.3.
UniGeneiHs.591477.

3D structure databases

ProteinModelPortaliQ6UY18.
SMRiQ6UY18. Positions 4-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357810.

PTM databases

iPTMnetiQ6UY18.
PhosphoSiteiQ6UY18.

Polymorphism and mutation databases

BioMutaiLINGO4.
DMDMi74762377.

Proteomic databases

PaxDbiQ6UY18.
PRIDEiQ6UY18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368820; ENSP00000357810; ENSG00000213171.
GeneIDi339398.
KEGGihsa:339398.
UCSCiuc001ezf.2. human.

Organism-specific databases

CTDi339398.
GeneCardsiLINGO4.
HGNCiHGNC:31814. LINGO4.
HPAiHPA060781.
MIMi609794. gene.
neXtProtiNX_Q6UY18.
PharmGKBiPA162394098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ6UY18.
OMAiNDSLRTW.
OrthoDBiEOG715Q3P.
PhylomeDBiQ6UY18.
TreeFamiTF334360.

Miscellaneous databases

GenomeRNAii339398.
NextBioi97381.
PROiQ6UY18.
SOURCEiSearch...

Gene expression databases

BgeeiQ6UY18.
CleanExiHS_LINGO4.
GenevisibleiQ6UY18. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLIGO4_HUMAN
AccessioniPrimary (citable) accession number: Q6UY18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.