Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

Gene

LINGO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4
Alternative name(s):
Leucine-rich repeat neuronal protein 6D
Gene namesi
Name:LINGO4
Synonyms:LRRN6D
ORF Names:UNQ9248/PRO34002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31814. LINGO4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 533ExtracellularSequence analysisAdd BLAST505
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Topological domaini555 – 593CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi339398.
OpenTargetsiENSG00000213171.
PharmGKBiPA162394098.

Polymorphism and mutation databases

BioMutaiLINGO4.
DMDMi74762377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000032418429 – 593Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4Add BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi253N-linked (GlcNAc...)Sequence analysis1
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi435 ↔ 484PROSITE-ProRule annotation
Glycosylationi492N-linked (GlcNAc...)Sequence analysis1
Glycosylationi508N-linked (GlcNAc...)Sequence analysis1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UY18.
PRIDEiQ6UY18.

PTM databases

iPTMnetiQ6UY18.
PhosphoSitePlusiQ6UY18.

Expressioni

Gene expression databases

BgeeiENSG00000213171.
CleanExiHS_LINGO4.
GenevisibleiQ6UY18. HS.

Organism-specific databases

HPAiHPA060781.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000357810.

Structurei

3D structure databases

ProteinModelPortaliQ6UY18.
SMRiQ6UY18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 60LRRNTAdd BLAST32
Repeati61 – 82LRR 1Add BLAST22
Repeati85 – 106LRR 2Add BLAST22
Repeati109 – 130LRR 3Add BLAST22
Repeati133 – 154LRR 4Add BLAST22
Repeati157 – 178LRR 5Add BLAST22
Repeati181 – 202LRR 6Add BLAST22
Repeati210 – 231LRR 7Add BLAST22
Repeati253 – 274LRR 8Add BLAST22
Repeati277 – 298LRR 9Add BLAST22
Repeati301 – 322LRR 10Add BLAST22
Repeati325 – 346LRR 11Add BLAST22
Domaini358 – 412LRRCTAdd BLAST55
Domaini412 – 502Ig-like C2-typeAdd BLAST91

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ6UY18.
OMAiNDSLRTW.
OrthoDBiEOG091G047N.
PhylomeDBiQ6UY18.
TreeFamiTF334360.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UY18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAATAPKQA WPPWPPLLFL LLLPGGSGGS CPAVCDCTSQ PQAVLCGHRQ
60 70 80 90 100
LEAVPGGLPL DTELLDLSGN RLWGLQQGML SRLSLLQELD LSYNQLSTLE
110 120 130 140 150
PGAFHGLQSL LTLRLQGNRL RIMGPGVFSG LSALTLLDLR LNQIVLFLDG
160 170 180 190 200
AFGELGSLQK LEVGDNHLVF VAPGAFAGLA KLSTLTLERC NLSTVPGLAL
210 220 230 240 250
ARLPALVALR LRELDIGRLP AGALRGLGQL KELEIHLWPS LEALDPGSLV
260 270 280 290 300
GLNLSSLAIT RCNLSSVPFQ ALYHLSFLRV LDLSQNPISA IPARRLSPLV
310 320 330 340 350
RLQELRLSGA CLTSIAAHAF HGLTAFHLLD VADNALQTLE ETAFPSPDKL
360 370 380 390 400
VTLRLSGNPL TCDCRLLWLL RLRRHLDFGM SPPACAGPHH VQGKSLKEFS
410 420 430 440 450
DILPPGHFTC KPALIRKSGP RWVIAEEGGH AVFSCSGDGD PAPTVSWMRP
460 470 480 490 500
HGAWLGRAGR VRVLEDGTLE IRSVQLRDRG AYVCVVSNVA GNDSLRTWLE
510 520 530 540 550
VIQVEPPNGT LSDPNITVPG IPGPFFLDSR GVAMVLAVGF LPFLTSVTLC
560 570 580 590
FGLIALWSKG KGRVKHHMTF DFVAPRPSGD KNSGGNRVTA KLF
Length:593
Mass (Da):63,774
Last modified:July 5, 2004 - v1
Checksum:i47514FD64574FA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358115 mRNA. Translation: AAQ88482.1.
AL589765 Genomic DNA. Translation: CAI17178.1.
CCDSiCCDS30855.1.
RefSeqiNP_001004432.1. NM_001004432.3.
UniGeneiHs.591477.

Genome annotation databases

EnsembliENST00000368820; ENSP00000357810; ENSG00000213171.
GeneIDi339398.
KEGGihsa:339398.
UCSCiuc001ezf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358115 mRNA. Translation: AAQ88482.1.
AL589765 Genomic DNA. Translation: CAI17178.1.
CCDSiCCDS30855.1.
RefSeqiNP_001004432.1. NM_001004432.3.
UniGeneiHs.591477.

3D structure databases

ProteinModelPortaliQ6UY18.
SMRiQ6UY18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000357810.

PTM databases

iPTMnetiQ6UY18.
PhosphoSitePlusiQ6UY18.

Polymorphism and mutation databases

BioMutaiLINGO4.
DMDMi74762377.

Proteomic databases

PaxDbiQ6UY18.
PRIDEiQ6UY18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368820; ENSP00000357810; ENSG00000213171.
GeneIDi339398.
KEGGihsa:339398.
UCSCiuc001ezf.2. human.

Organism-specific databases

CTDi339398.
DisGeNETi339398.
GeneCardsiLINGO4.
HGNCiHGNC:31814. LINGO4.
HPAiHPA060781.
MIMi609794. gene.
neXtProtiNX_Q6UY18.
OpenTargetsiENSG00000213171.
PharmGKBiPA162394098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000246971.
HOVERGENiHBG057546.
InParanoidiQ6UY18.
OMAiNDSLRTW.
OrthoDBiEOG091G047N.
PhylomeDBiQ6UY18.
TreeFamiTF334360.

Enzyme and pathway databases

BioCyciZFISH:G66-31261-MONOMER.

Miscellaneous databases

GenomeRNAii339398.
PROiQ6UY18.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213171.
CleanExiHS_LINGO4.
GenevisibleiQ6UY18. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIGO4_HUMAN
AccessioniPrimary (citable) accession number: Q6UY18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.