ID ATL4_HUMAN Reviewed; 1074 AA. AC Q6UY14; B2RTT0; F8WAD0; Q5T5F7; Q6IPM6; Q8N643; Q9HBS6; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 31-OCT-2006, sequence version 2. DT 27-MAR-2024, entry version 172. DE RecName: Full=ADAMTS-like protein 4; DE Short=ADAMTSL-4; DE AltName: Full=Thrombospondin repeat-containing protein 1; DE Flags: Precursor; GN Name=ADAMTSL4; Synonyms=TSRC1 {ECO:0000312|EMBL:CAI15499.1}; GN ORFNames=PP1396, UNQ2803/PRO34012; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAQ88489.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [2] {ECO:0000312|EMBL:CAI15499.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH71852.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 425-1074 (ISOFORM 1), AND VARIANT PRO-193. RC TISSUE=Lung {ECO:0000312|EMBL:AAH71852.1}, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 638-1074. RX PubMed=15498874; DOI=10.1073/pnas.0404089101; RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X., RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.; RT "Large-scale cDNA transfection screening for genes related to cancer RT development and progression."; RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). RN [5] {ECO:0000305} RP IDENTIFICATION (ISOFORM 1). RX PubMed=12706885; DOI=10.1016/s0378-1119(03)00423-2; RA Buchner D.A., Meisler M.H.; RT "TSRC1, a widely expressed gene containing seven thrombospondin type I RT repeats."; RL Gene 307:23-30(2003). RN [6] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-490. RC TISSUE=Plasma; RX PubMed=16335952; DOI=10.1021/pr0502065; RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., RA Smith R.D.; RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, RT hydrazide chemistry, and mass spectrometry."; RL J. Proteome Res. 4:2070-2080(2005). RN [7] {ECO:0000305} RP FUNCTION, AND INTERACTION WITH CTSB. RX PubMed=16364318; DOI=10.1016/j.febslet.2005.12.005; RA Liu J., Guo Q., Chen B., Yu Y., Lu H., Li Y.-Y.; RT "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate RT with TNF-induced apoptosis of ovarian cancer cells OV-90."; RL FEBS Lett. 580:245-250(2006). RN [8] RP TISSUE SPECIFICITY, AND INVOLVEMENT IN ECTOL2. RX PubMed=19200529; DOI=10.1016/j.ajhg.2009.01.007; RA Ahram D., Sato T.S., Kohilan A., Tayeh M., Chen S., Leal S., Al-Salem M., RA El-Shanti H.; RT "A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated RT ectopia lentis."; RL Am. J. Hum. Genet. 84:274-278(2009). RN [9] RP GLYCOSYLATION AT ASN-490. RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200; RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., RA Ying W.T., He S.M., Qian X.H.; RT "A strategy for precise and large scale identification of core fucosylated RT glycoproteins."; RL Mol. Cell. Proteomics 8:913-923(2009). RN [10] RP INVOLVEMENT IN ECTOLP. RX PubMed=20702823; DOI=10.1167/iovs.10-5597; RA Christensen A.E., Fiskerstrand T., Knappskog P.M., Boman H., Roedahl E.; RT "A novel ADAMTSL4 mutation in autosomal recessive ectopia lentis et RT pupillae."; RL Invest. Ophthalmol. Vis. Sci. 51:6369-6373(2010). RN [11] RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FBN1, AND GLYCOSYLATION. RX PubMed=21989719; DOI=10.1167/iovs.10-5955; RA Gabriel L.A., Wang L.W., Bader H., Ho J.C., Majors A.K., Hollyfield J.G., RA Traboulsi E.I., Apte S.S.; RT "ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds RT Fibrillin-1 microfibrils and accelerates microfibril biogenesis."; RL Invest. Ophthalmol. Vis. Sci. 53:461-469(2012). RN [12] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Positive regulation of apoptosis. May facilitate FBN1 CC microfibril biogenesis. {ECO:0000269|PubMed:16364318, CC ECO:0000269|PubMed:21989719}. CC -!- SUBUNIT: Interacts with CTSB. Interacts with FBN1. CC {ECO:0000269|PubMed:16364318, ECO:0000269|PubMed:21989719}. CC -!- INTERACTION: CC Q6UY14; P07858: CTSB; NbExp=3; IntAct=EBI-742002, EBI-715062; CC Q6UY14; O75716: STK16; NbExp=3; IntAct=EBI-742002, EBI-749295; CC Q6UY14; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-742002, EBI-3957603; CC Q6UY14; P28301: Lox; Xeno; NbExp=2; IntAct=EBI-742002, EBI-642911; CC Q6UY14-3; O43184-4: ADAM12; NbExp=3; IntAct=EBI-10173507, EBI-12006944; CC Q6UY14-3; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10173507, EBI-10173507; CC Q6UY14-3; Q6ZMM2-2: ADAMTSL5; NbExp=3; IntAct=EBI-10173507, EBI-10254938; CC Q6UY14-3; P31749: AKT1; NbExp=3; IntAct=EBI-10173507, EBI-296087; CC Q6UY14-3; P05187: ALPP; NbExp=3; IntAct=EBI-10173507, EBI-1211484; CC Q6UY14-3; Q9Y4X0: AMMECR1; NbExp=3; IntAct=EBI-10173507, EBI-8583355; CC Q6UY14-3; Q9Y4X0-3: AMMECR1; NbExp=3; IntAct=EBI-10173507, EBI-12823597; CC Q6UY14-3; B3KTP4: ApoL6; NbExp=3; IntAct=EBI-10173507, EBI-10175904; CC Q6UY14-3; Q9BWW8: APOL6; NbExp=3; IntAct=EBI-10173507, EBI-11574440; CC Q6UY14-3; Q9BZE9: ASPSCR1; NbExp=3; IntAct=EBI-10173507, EBI-1993677; CC Q6UY14-3; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-10173507, EBI-12006308; CC Q6UY14-3; P54252: ATXN3; NbExp=3; IntAct=EBI-10173507, EBI-946046; CC Q6UY14-3; O95429: BAG4; NbExp=3; IntAct=EBI-10173507, EBI-2949658; CC Q6UY14-3; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-10173507, EBI-11977289; CC Q6UY14-3; P23560-2: BDNF; NbExp=3; IntAct=EBI-10173507, EBI-12275524; CC Q6UY14-3; A0A087WZT3: BOLA2-SMG1P6; NbExp=3; IntAct=EBI-10173507, EBI-12006120; CC Q6UY14-3; Q0VDD7-2: BRME1; NbExp=3; IntAct=EBI-10173507, EBI-12040255; CC Q6UY14-3; P55212: CASP6; NbExp=3; IntAct=EBI-10173507, EBI-718729; CC Q6UY14-3; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10173507, EBI-744545; CC Q6UY14-3; Q13185: CBX3; NbExp=3; IntAct=EBI-10173507, EBI-78176; CC Q6UY14-3; A0A024R9H7: CCDC26; NbExp=3; IntAct=EBI-10173507, EBI-10271580; CC Q6UY14-3; P06307: CCK; NbExp=3; IntAct=EBI-10173507, EBI-6624398; CC Q6UY14-3; Q8IYR0: CFAP206; NbExp=6; IntAct=EBI-10173507, EBI-749051; CC Q6UY14-3; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-10173507, EBI-2321769; CC Q6UY14-3; Q8IWX8: CHERP; NbExp=3; IntAct=EBI-10173507, EBI-2555370; CC Q6UY14-3; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10173507, EBI-741528; CC Q6UY14-3; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-10173507, EBI-947551; CC Q6UY14-3; P43681: CHRNA4; NbExp=3; IntAct=EBI-10173507, EBI-7132379; CC Q6UY14-3; P07510-2: CHRNG; NbExp=3; IntAct=EBI-10173507, EBI-11979451; CC Q6UY14-3; A5D8T8: CLEC18A; NbExp=3; IntAct=EBI-10173507, EBI-10173491; CC Q6UY14-3; Q9UBL6: CPNE7; NbExp=3; IntAct=EBI-10173507, EBI-744841; CC Q6UY14-3; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-10173507, EBI-12012272; CC Q6UY14-3; Q02930-3: CREB5; NbExp=6; IntAct=EBI-10173507, EBI-10192698; CC Q6UY14-3; P02511: CRYAB; NbExp=3; IntAct=EBI-10173507, EBI-739060; CC Q6UY14-3; P09228: CST2; NbExp=3; IntAct=EBI-10173507, EBI-8832659; CC Q6UY14-3; Q96SQ9: CYP2S1; NbExp=3; IntAct=EBI-10173507, EBI-8633740; CC Q6UY14-3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10173507, EBI-3867333; CC Q6UY14-3; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-10173507, EBI-742953; CC Q6UY14-3; Q14689-6: DIP2A; NbExp=3; IntAct=EBI-10173507, EBI-10233719; CC Q6UY14-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10173507, EBI-10976677; CC Q6UY14-3; Q96T75: DSCR8; NbExp=3; IntAct=EBI-10173507, EBI-10294182; CC Q6UY14-3; O95967: EFEMP2; NbExp=3; IntAct=EBI-10173507, EBI-743414; CC Q6UY14-3; O60573: EIF4E2; NbExp=3; IntAct=EBI-10173507, EBI-398610; CC Q6UY14-3; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-10173507, EBI-946972; CC Q6UY14-3; P19447: ERCC3; NbExp=3; IntAct=EBI-10173507, EBI-1183307; CC Q6UY14-3; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-10173507, EBI-371876; CC Q6UY14-3; P16930: FAH; NbExp=3; IntAct=EBI-10173507, EBI-4397076; CC Q6UY14-3; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-10173507, EBI-741626; CC Q6UY14-3; O95363: FARS2; NbExp=3; IntAct=EBI-10173507, EBI-2513774; CC Q6UY14-3; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-10173507, EBI-2510157; CC Q6UY14-3; Q969U6: FBXW5; NbExp=6; IntAct=EBI-10173507, EBI-741068; CC Q6UY14-3; P22607: FGFR3; NbExp=3; IntAct=EBI-10173507, EBI-348399; CC Q6UY14-3; P68106: FKBP1B; NbExp=3; IntAct=EBI-10173507, EBI-6693977; CC Q6UY14-3; P21333-2: FLNA; NbExp=6; IntAct=EBI-10173507, EBI-9641086; CC Q6UY14-3; P01100: FOS; NbExp=3; IntAct=EBI-10173507, EBI-852851; CC Q6UY14-3; O43559: FRS3; NbExp=3; IntAct=EBI-10173507, EBI-725515; CC Q6UY14-3; P04406: GAPDH; NbExp=3; IntAct=EBI-10173507, EBI-354056; CC Q6UY14-3; P23769: GATA2; NbExp=3; IntAct=EBI-10173507, EBI-2806671; CC Q6UY14-3; P50440: GATM; NbExp=3; IntAct=EBI-10173507, EBI-2552594; CC Q6UY14-3; P09681: GIP; NbExp=3; IntAct=EBI-10173507, EBI-8588553; CC Q6UY14-3; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-10173507, EBI-748515; CC Q6UY14-3; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10173507, EBI-745707; CC Q6UY14-3; Q9Y223: GNE; NbExp=3; IntAct=EBI-10173507, EBI-4291090; CC Q6UY14-3; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10173507, EBI-11975289; CC Q6UY14-3; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-10173507, EBI-11427343; CC Q6UY14-3; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-10173507, EBI-10181276; CC Q6UY14-3; P62993: GRB2; NbExp=3; IntAct=EBI-10173507, EBI-401755; CC Q6UY14-3; Q14957: GRIN2C; NbExp=3; IntAct=EBI-10173507, EBI-8285963; CC Q6UY14-3; P28799: GRN; NbExp=3; IntAct=EBI-10173507, EBI-747754; CC Q6UY14-3; P06396: GSN; NbExp=3; IntAct=EBI-10173507, EBI-351506; CC Q6UY14-3; P09211: GSTP1; NbExp=3; IntAct=EBI-10173507, EBI-353467; CC Q6UY14-3; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10173507, EBI-11978177; CC Q6UY14-3; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-10173507, EBI-14103818; CC Q6UY14-3; V9HW60: HEL-S-182mP; NbExp=3; IntAct=EBI-10173507, EBI-10180762; CC Q6UY14-3; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-10173507, EBI-5460660; CC Q6UY14-3; P14210: HGF; NbExp=3; IntAct=EBI-10173507, EBI-1039104; CC Q6UY14-3; P49639: HOXA1; NbExp=10; IntAct=EBI-10173507, EBI-740785; CC Q6UY14-3; P31273: HOXC8; NbExp=3; IntAct=EBI-10173507, EBI-1752118; CC Q6UY14-3; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10173507, EBI-3918847; CC Q6UY14-3; P07900: HSP90AA1; NbExp=3; IntAct=EBI-10173507, EBI-296047; CC Q6UY14-3; P04792: HSPB1; NbExp=3; IntAct=EBI-10173507, EBI-352682; CC Q6UY14-3; P01308: INS; NbExp=3; IntAct=EBI-10173507, EBI-7090529; CC Q6UY14-3; Q92551: IP6K1; NbExp=3; IntAct=EBI-10173507, EBI-751911; CC Q6UY14-3; P05107: ITGB2; NbExp=3; IntAct=EBI-10173507, EBI-300173; CC Q6UY14-3; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10173507, EBI-11051601; CC Q6UY14-3; Q15040: JOSD1; NbExp=3; IntAct=EBI-10173507, EBI-2510602; CC Q6UY14-3; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-10173507, EBI-11954971; CC Q6UY14-3; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10173507, EBI-4397613; CC Q6UY14-3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10173507, EBI-10975473; CC Q6UY14-3; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10173507, EBI-6426443; CC Q6UY14-3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10173507, EBI-11959885; CC Q6UY14-3; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10173507, EBI-11741292; CC Q6UY14-3; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10173507, EBI-10217483; CC Q6UY14-3; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-10173507, EBI-10172150; CC Q6UY14-3; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-10173507, EBI-10171774; CC Q6UY14-3; P60411: KRTAP10-9; NbExp=8; IntAct=EBI-10173507, EBI-10172052; CC Q6UY14-3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10173507, EBI-11953334; CC Q6UY14-3; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-10173507, EBI-12196745; CC Q6UY14-3; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-10173507, EBI-18395721; CC Q6UY14-3; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-10173507, EBI-10302392; CC Q6UY14-3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-10173507, EBI-739863; CC Q6UY14-3; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-10173507, EBI-10172511; CC Q6UY14-3; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10173507, EBI-11958132; CC Q6UY14-3; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10173507, EBI-11958178; CC Q6UY14-3; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10173507, EBI-11974251; CC Q6UY14-3; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-10173507, EBI-11963072; CC Q6UY14-3; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10173507, EBI-10250562; CC Q6UY14-3; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-10173507, EBI-11987425; CC Q6UY14-3; P26371: KRTAP5-9; NbExp=8; IntAct=EBI-10173507, EBI-3958099; CC Q6UY14-3; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10173507, EBI-11962084; CC Q6UY14-3; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10173507, EBI-1044640; CC Q6UY14-3; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10173507, EBI-1043191; CC Q6UY14-3; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10173507, EBI-10185730; CC Q6UY14-3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10173507, EBI-21591415; CC Q6UY14-3; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10173507, EBI-11962058; CC Q6UY14-3; Q5T7P3: LCE1B; NbExp=6; IntAct=EBI-10173507, EBI-10245913; CC Q6UY14-3; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10173507, EBI-12224199; CC Q6UY14-3; Q5T754: LCE1F; NbExp=3; IntAct=EBI-10173507, EBI-11958008; CC Q6UY14-3; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-10173507, EBI-10246607; CC Q6UY14-3; O14633: LCE2B; NbExp=6; IntAct=EBI-10173507, EBI-11478468; CC Q6UY14-3; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10173507, EBI-11973993; CC Q6UY14-3; Q5TA82: LCE2D; NbExp=6; IntAct=EBI-10173507, EBI-10246750; CC Q6UY14-3; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-10173507, EBI-9394625; CC Q6UY14-3; Q5T5A8: LCE3C; NbExp=6; IntAct=EBI-10173507, EBI-10245291; CC Q6UY14-3; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-10173507, EBI-6658837; CC Q6UY14-3; Q5T5B0: LCE3E; NbExp=6; IntAct=EBI-10173507, EBI-10245456; CC Q6UY14-3; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-10173507, EBI-10246358; CC Q6UY14-3; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-10173507, EBI-10274069; CC Q6UY14-3; A0A0S2Z5S9: LHX4; NbExp=3; IntAct=EBI-10173507, EBI-16429099; CC Q6UY14-3; P25800: LMO1; NbExp=3; IntAct=EBI-10173507, EBI-8639312; CC Q6UY14-3; P25791: LMO2; NbExp=3; IntAct=EBI-10173507, EBI-739696; CC Q6UY14-3; P25791-3: LMO2; NbExp=3; IntAct=EBI-10173507, EBI-11959475; CC Q6UY14-3; P61968: LMO4; NbExp=3; IntAct=EBI-10173507, EBI-2798728; CC Q6UY14-3; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10173507, EBI-739832; CC Q6UY14-3; Q17RB8: LONRF1; NbExp=6; IntAct=EBI-10173507, EBI-2341787; CC Q6UY14-3; Q6PJG9: LRFN4; NbExp=3; IntAct=EBI-10173507, EBI-7910762; CC Q6UY14-3; A0A024R6W8: LRRC29; NbExp=3; IntAct=EBI-10173507, EBI-10276755; CC Q6UY14-3; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-10173507, EBI-746778; CC Q6UY14-3; O60336: MAPKBP1; NbExp=6; IntAct=EBI-10173507, EBI-947402; CC Q6UY14-3; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-10173507, EBI-10172526; CC Q6UY14-3; Q13064: MKRN3; NbExp=3; IntAct=EBI-10173507, EBI-2340269; CC Q6UY14-3; Q6PF18: MORN3; NbExp=3; IntAct=EBI-10173507, EBI-9675802; CC Q6UY14-3; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-10173507, EBI-6952711; CC Q6UY14-3; Q8N6N6: NATD1; NbExp=6; IntAct=EBI-10173507, EBI-8656665; CC Q6UY14-3; Q86SG6: NEK8; NbExp=3; IntAct=EBI-10173507, EBI-1752987; CC Q6UY14-3; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-10173507, EBI-10271199; CC Q6UY14-3; Q9GZQ4: NMUR2; NbExp=3; IntAct=EBI-10173507, EBI-10303844; CC Q6UY14-3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10173507, EBI-22310682; CC Q6UY14-3; Q92570: NR4A3; NbExp=3; IntAct=EBI-10173507, EBI-13644623; CC Q6UY14-3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10173507, EBI-741158; CC Q6UY14-3; P34130: NTF4; NbExp=3; IntAct=EBI-10173507, EBI-3907456; CC Q6UY14-3; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-10173507, EBI-1210753; CC Q6UY14-3; Q96PB7: OLFM3; NbExp=3; IntAct=EBI-10173507, EBI-10292253; CC Q6UY14-3; P32242: OTX1; NbExp=3; IntAct=EBI-10173507, EBI-740446; CC Q6UY14-3; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-10173507, EBI-11956269; CC Q6UY14-3; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-10173507, EBI-10256685; CC Q6UY14-3; Q13526: PIN1; NbExp=3; IntAct=EBI-10173507, EBI-714158; CC Q6UY14-3; Q16512: PKN1; NbExp=3; IntAct=EBI-10173507, EBI-602382; CC Q6UY14-3; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10173507, EBI-769257; CC Q6UY14-3; D3DTS7: PMP22; NbExp=3; IntAct=EBI-10173507, EBI-25882629; CC Q6UY14-3; P28340: POLD1; NbExp=3; IntAct=EBI-10173507, EBI-716569; CC Q6UY14-3; O15160: POLR1C; NbExp=3; IntAct=EBI-10173507, EBI-1055079; CC Q6UY14-3; Q12837: POU4F2; NbExp=3; IntAct=EBI-10173507, EBI-17236143; CC Q6UY14-3; O43741: PRKAB2; NbExp=4; IntAct=EBI-10173507, EBI-1053424; CC Q6UY14-3; A6NJB7-2: PRR19; NbExp=3; IntAct=EBI-10173507, EBI-11998870; CC Q6UY14-3; P43115-12: PTGER3; NbExp=3; IntAct=EBI-10173507, EBI-10234038; CC Q6UY14-3; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-10173507, EBI-7199479; CC Q6UY14-3; Q15274: QPRT; NbExp=3; IntAct=EBI-10173507, EBI-739851; CC Q6UY14-3; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-10173507, EBI-948428; CC Q6UY14-3; Q8WUD1: RAB2B; NbExp=3; IntAct=EBI-10173507, EBI-5542466; CC Q6UY14-3; P62826: RAN; NbExp=3; IntAct=EBI-10173507, EBI-286642; CC Q6UY14-3; Q96PM5: RCHY1; NbExp=3; IntAct=EBI-10173507, EBI-947779; CC Q6UY14-3; O15211: RGL2; NbExp=3; IntAct=EBI-10173507, EBI-712355; CC Q6UY14-3; Q9H4E5: RHOJ; NbExp=3; IntAct=EBI-10173507, EBI-6285694; CC Q6UY14-3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10173507, EBI-396669; CC Q6UY14-3; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-10173507, EBI-4479407; CC Q6UY14-3; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10173507, EBI-11984663; CC Q6UY14-3; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10173507, EBI-748391; CC Q6UY14-3; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10173507, EBI-10313866; CC Q6UY14-3; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-10173507, EBI-11955083; CC Q6UY14-3; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-10173507, EBI-12002412; CC Q6UY14-3; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-10173507, EBI-1759386; CC Q6UY14-3; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-10173507, EBI-10311198; CC Q6UY14-3; O75093: SLIT1; NbExp=3; IntAct=EBI-10173507, EBI-947791; CC Q6UY14-3; Q92922: SMARCC1; NbExp=6; IntAct=EBI-10173507, EBI-355653; CC Q6UY14-3; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-10173507, EBI-8635958; CC Q6UY14-3; P20155: SPINK2; NbExp=3; IntAct=EBI-10173507, EBI-10200479; CC Q6UY14-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10173507, EBI-5235340; CC Q6UY14-3; O43609: SPRY1; NbExp=3; IntAct=EBI-10173507, EBI-3866665; CC Q6UY14-3; O75716: STK16; NbExp=3; IntAct=EBI-10173507, EBI-749295; CC Q6UY14-3; Q92537: SUSD6; NbExp=3; IntAct=EBI-10173507, EBI-2866213; CC Q6UY14-3; Q15560: TCEA2; NbExp=3; IntAct=EBI-10173507, EBI-710310; CC Q6UY14-3; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-10173507, EBI-11952651; CC Q6UY14-3; P01137: TGFB1; NbExp=3; IntAct=EBI-10173507, EBI-779636; CC Q6UY14-3; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-10173507, EBI-3925505; CC Q6UY14-3; Q86TG1: TMEM150A; NbExp=3; IntAct=EBI-10173507, EBI-2799342; CC Q6UY14-3; O95985: TOP3B; NbExp=3; IntAct=EBI-10173507, EBI-373403; CC Q6UY14-3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10173507, EBI-5235829; CC Q6UY14-3; Q15654: TRIP6; NbExp=3; IntAct=EBI-10173507, EBI-742327; CC Q6UY14-3; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-10173507, EBI-3918381; CC Q6UY14-3; Q9UK80: USP21; NbExp=3; IntAct=EBI-10173507, EBI-373242; CC Q6UY14-3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10173507, EBI-10249550; CC Q6UY14-3; O95231: VENTX; NbExp=3; IntAct=EBI-10173507, EBI-10191303; CC Q6UY14-3; Q2TAL6: VWC2; NbExp=6; IntAct=EBI-10173507, EBI-11957238; CC Q6UY14-3; O76024: WFS1; NbExp=3; IntAct=EBI-10173507, EBI-720609; CC Q6UY14-3; A2RRC6: ZFHX2; NbExp=3; IntAct=EBI-10173507, EBI-11994144; CC Q6UY14-3; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-10173507, EBI-373456; CC Q6UY14-3; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-10173507, EBI-744257; CC Q6UY14-3; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-10173507, EBI-740727; CC Q6UY14-3; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10173507, EBI-6427977; CC Q6UY14-3; Q53FW8; NbExp=3; IntAct=EBI-10173507, EBI-10242473; CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000269|PubMed:21989719}. Note=Colocalizes with FMN1 CC microfibrils in the eye ECM. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1 {ECO:0000269|PubMed:12706885}; CC IsoId=Q6UY14-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:12975309}; CC IsoId=Q6UY14-2; Sequence=VSP_052183, VSP_052184; CC Name=3; CC IsoId=Q6UY14-3; Sequence=VSP_055759; CC -!- TISSUE SPECIFICITY: Expressed in colon, heart, leukocyte, liver, lung, CC skeletal muscle, spleen, testis and placenta. Weaker expression in bone CC marrow, brain tissue, kidney and pancreas. Expression studies in fetal CC tissues reveal strong expression in heart, kidney, liver, lung and CC skeletal muscle, but weaker expression in fetal brain and skin. CC {ECO:0000269|PubMed:19200529}. CC -!- PTM: N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a CC threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2- CC G of the TSP type-1 repeat domains where C1 and C2 are the first and CC second cysteine residue of the repeat, respectively. Fucosylated CC repeats can then be further glycosylated by the addition of a beta-1,3- CC glucose residue by the glucosyltransferase, B3GALTL. Fucosylation CC mediates the efficient secretion of ADAMTS family members. Can also be CC C-glycosylated with one or two mannose molecules on tryptophan residues CC within the consensus sequence W-X-X-W of the TPRs. N- and C- CC glycosylations can also facilitate secretion (By similarity). CC {ECO:0000250}. CC -!- DISEASE: Ectopia lentis 2, isolated, autosomal recessive (ECTOL2) CC [MIM:225100]: An ocular abnormality characterized by partial or CC complete displacement of the lens from its space resulting from CC defective zonule formation. {ECO:0000269|PubMed:19200529}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. CC -!- DISEASE: Ectopia lentis et pupillae (ECTOLP) [MIM:225200]: An ocular CC abnormality characterized by displacement of the lenses and the pupils, CC associated with other ocular anomalies, but without systemic CC manifestations. The condition is usually bilateral, with the lenses and CC pupils displaced in opposite directions. Additional signs include CC enlarged corneal diameter, increased corneal astigmatism, increased CC anterior chamber depth, thinning and flattening of the iris with loss CC of crypts, angle malformation caused by enlarged iris processes, CC persistent pupillary membrane, loss of zonular fibers, tilted disk, and CC increased axial length. Secondary manifestations include refractive CC errors, glaucoma, early cataract development, and retinal detachment. CC Membrane formation on the posterior aspect of the iris has been CC observed both in histologic sections and on ultrasound biomicroscopy. CC {ECO:0000269|PubMed:20702823}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- CAUTION: Although similar to members of the ADAMTS family, it lacks the CC metalloprotease and disintegrin-like domains which are typical of that CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAG17217.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY358122; AAQ88489.1; -; mRNA. DR EMBL; AL356356; CAI15499.1; -; Genomic_DNA. DR EMBL; AL356356; CAI15500.2; -; Genomic_DNA. DR EMBL; BC027478; AAH27478.2; -; mRNA. DR EMBL; BC071852; AAH71852.1; -; mRNA. DR EMBL; BC094811; AAH94811.1; -; mRNA. DR EMBL; BC140800; AAI40801.1; -; mRNA. DR EMBL; AF217974; AAG17217.1; ALT_FRAME; mRNA. DR CCDS; CCDS30852.1; -. [Q6UY14-2] DR CCDS; CCDS72908.1; -. [Q6UY14-3] DR CCDS; CCDS955.1; -. [Q6UY14-1] DR RefSeq; NP_001275536.1; NM_001288607.1. DR RefSeq; NP_001275537.1; NM_001288608.1. [Q6UY14-3] DR RefSeq; NP_061905.2; NM_019032.5. [Q6UY14-1] DR RefSeq; NP_079284.2; NM_025008.4. [Q6UY14-2] DR RefSeq; XP_011507950.1; XM_011509648.2. [Q6UY14-3] DR RefSeq; XP_016856995.1; XM_017001506.1. [Q6UY14-3] DR AlphaFoldDB; Q6UY14; -. DR SMR; Q6UY14; -. DR BioGRID; 120002; 216. DR IntAct; Q6UY14; 236. DR MINT; Q6UY14; -. DR STRING; 9606.ENSP00000358035; -. DR GlyConnect; 991; 2 N-Linked glycans (1 site). DR GlyCosmos; Q6UY14; 14 sites, 5 glycans. DR GlyGen; Q6UY14; 17 sites, 2 N-linked glycans (1 site), 4 O-linked glycans (14 sites). DR iPTMnet; Q6UY14; -. DR PhosphoSitePlus; Q6UY14; -. DR BioMuta; ADAMTSL4; -. DR DMDM; 118573317; -. DR EPD; Q6UY14; -. DR MassIVE; Q6UY14; -. DR PaxDb; 9606-ENSP00000358035; -. DR PeptideAtlas; Q6UY14; -. DR ProteomicsDB; 30475; -. DR ProteomicsDB; 67693; -. [Q6UY14-1] DR ProteomicsDB; 67694; -. [Q6UY14-2] DR Antibodypedia; 1665; 110 antibodies from 20 providers. DR DNASU; 54507; -. DR Ensembl; ENST00000271643.9; ENSP00000271643.4; ENSG00000143382.16. [Q6UY14-1] DR Ensembl; ENST00000369038.6; ENSP00000358034.2; ENSG00000143382.16. [Q6UY14-1] DR Ensembl; ENST00000369039.9; ENSP00000358035.5; ENSG00000143382.16. [Q6UY14-3] DR Ensembl; ENST00000369041.9; ENSP00000358037.5; ENSG00000143382.16. [Q6UY14-2] DR Ensembl; ENST00000674043.1; ENSP00000501295.1; ENSG00000143382.16. [Q6UY14-3] DR GeneID; 54507; -. DR KEGG; hsa:54507; -. DR MANE-Select; ENST00000271643.9; ENSP00000271643.4; NM_019032.6; NP_061905.2. DR UCSC; uc001euw.5; human. [Q6UY14-1] DR AGR; HGNC:19706; -. DR CTD; 54507; -. DR DisGeNET; 54507; -. DR GeneCards; ADAMTSL4; -. DR GeneReviews; ADAMTSL4; -. DR HGNC; HGNC:19706; ADAMTSL4. DR HPA; ENSG00000143382; Low tissue specificity. DR MalaCards; ADAMTSL4; -. DR MIM; 225100; phenotype. DR MIM; 225200; phenotype. DR MIM; 610113; gene. DR neXtProt; NX_Q6UY14; -. DR OpenTargets; ENSG00000143382; -. DR Orphanet; 1885; Isolated ectopia lentis. DR PharmGKB; PA134879921; -. DR VEuPathDB; HostDB:ENSG00000143382; -. DR eggNOG; KOG3538; Eukaryota. DR eggNOG; KOG4597; Eukaryota. DR GeneTree; ENSGT00940000161136; -. DR HOGENOM; CLU_000660_6_0_1; -. DR InParanoid; Q6UY14; -. DR OMA; EVCNTEP; -. DR OrthoDB; 2910701at2759; -. DR PhylomeDB; Q6UY14; -. DR TreeFam; TF316874; -. DR PathwayCommons; Q6UY14; -. DR Reactome; R-HSA-5083635; Defective B3GALTL causes PpS. DR Reactome; R-HSA-5173214; O-glycosylation of TSR domain-containing proteins. DR SignaLink; Q6UY14; -. DR BioGRID-ORCS; 54507; 54 hits in 1158 CRISPR screens. DR ChiTaRS; ADAMTSL4; human. DR GeneWiki; ADAMTSL4; -. DR GenomeRNAi; 54507; -. DR Pharos; Q6UY14; Tbio. DR PRO; PR:Q6UY14; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q6UY14; Protein. DR Bgee; ENSG00000143382; Expressed in decidua and 138 other cell types or tissues. DR ExpressionAtlas; Q6UY14; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL. DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0002020; F:protease binding; IPI:UniProtKB. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0002064; P:epithelial cell development; IEA:Ensembl. DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central. DR GO; GO:0070285; P:pigment cell development; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB. DR Gene3D; 2.60.120.830; -; 1. DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6. DR InterPro; IPR045371; ADAMTS_CR_3. DR InterPro; IPR010294; ADAMTS_spacer1. DR InterPro; IPR010909; PLAC. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1. DR PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1. DR Pfam; PF19236; ADAMTS_CR_3; 1. DR Pfam; PF05986; ADAMTS_spacer1; 1. DR Pfam; PF08686; PLAC; 1. DR Pfam; PF19030; TSP1_ADAMTS; 5. DR Pfam; PF00090; TSP_1; 1. DR SMART; SM00209; TSP1; 6. DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6. DR PROSITE; PS50900; PLAC; 1. DR PROSITE; PS50092; TSP1; 6. DR Genevisible; Q6UY14; HS. PE 1: Evidence at protein level; KW Alternative splicing; Apoptosis; Extracellular matrix; Glycoprotein; KW Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..24 FT /evidence="ECO:0000255" FT CHAIN 25..1074 FT /note="ADAMTS-like protein 4" FT /evidence="ECO:0000255" FT /id="PRO_0000257966" FT DOMAIN 48..93 FT /note="TSP type-1 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 723..782 FT /note="TSP type-1 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 783..842 FT /note="TSP type-1 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 845..909 FT /note="TSP type-1 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 910..969 FT /note="TSP type-1 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 970..1026 FT /note="TSP type-1 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 1029..1066 FT /note="PLAC" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00233" FT REGION 77..342 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 79..95 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 132..151 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 202..239 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 490 FT /note="N-linked (GlcNAc...) (complex) asparagine" FT /evidence="ECO:0000269|PubMed:16335952, FT ECO:0000269|PubMed:19139490" FT CARBOHYD 773 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 411 FT /note="E -> EAPLLPLRHAFFLLPGAGSGDSTG (in isoform 3)" FT /evidence="ECO:0000305" FT /id="VSP_055759" FT VAR_SEQ 854..877 FT /note="CSAECGTGIQRRSVVCLGSGAALG -> VSPEPPAISCILGNHAQDTSAFPA FT (in isoform 2)" FT /evidence="ECO:0000303|PubMed:12975309, FT ECO:0000303|PubMed:15489334" FT /id="VSP_052183" FT VAR_SEQ 878..1074 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:12975309, FT ECO:0000303|PubMed:15489334" FT /id="VSP_052184" FT VARIANT 193 FT /note="A -> P (in dbSNP:rs41317515)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_061918" FT VARIANT 1028 FT /note="R -> H (in dbSNP:rs56411234)" FT /id="VAR_061919" SQ SEQUENCE 1074 AA; 116545 MW; 79AE0E5DF5488CA1 CRC64; MENWTGRPWL YLLLLLSLPQ LCLDQEVLSG HSLQTPTEEG QGPEGVWGPW VQWASCSQPC GVGVQRRSRT CQLPTVQLHP SLPLPPRPPR HPEALLPRGQ GPRPQTSPET LPLYRTQSRG RGGPLRGPAS HLGREETQEI RAARRSRLRD PIKPGMFGYG RVPFALPLHR NRRHPRSPPR SELSLISSRG EEAIPSPTPR AEPFSANGSP QTELPPTELS VHTPSPQAEP LSPETAQTEV APRTRPAPLR HHPRAQASGT EPPSPTHSLG EGGFFRASPQ PRRPSSQGWA SPQVAGRRPD PFPSVPRGRG QQGQGPWGTG GTPHGPRLEP DPQHPGAWLP LLSNGPHASS LWSLFAPSSP IPRCSGESEQ LRACSQAPCP PEQPDPRALQ CAAFNSQEFM GQLYQWEPFT EVQGSQRCEL NCRPRGFRFY VRHTEKVQDG TLCQPGAPDI CVAGRCLSPG CDGILGSGRR PDGCGVCGGD DSTCRLVSGN LTDRGGPLGY QKILWIPAGA LRLQIAQLRP SSNYLALRGP GGRSIINGNW AVDPPGSYRA GGTVFRYNRP PREEGKGESL SAEGPTTQPV DVYMIFQEEN PGVFYQYVIS SPPPILENPT PEPPVPQLQP EILRVEPPLA PAPRPARTPG TLQRQVRIPQ MPAPPHPRTP LGSPAAYWKR VGHSACSASC GKGVWRPIFL CISRESGEEL DERSCAAGAR PPASPEPCHG TPCPPYWEAG EWTSCSRSCG PGTQHRQLQC RQEFGGGGSS VPPERCGHLP RPNITQSCQL RLCGHWEVGS PWSQCSVRCG RGQRSRQVRC VGNNGDEVSE QECASGPPQP PSREACDMGP CTTAWFHSDW SSKCSAECGT GIQRRSVVCL GSGAALGPGQ GEAGAGTGQS CPTGSRPPDM RACSLGPCER TWRWYTGPWG ECSSECGSGT QRRDIICVSK LGTEFNVTSP SNCSHLPRPP ALQPCQGQAC QDRWFSTPWS PCSRSCQGGT QTREVQCLST NQTLSTRCPP QLRPSRKRPC NSQPCSQRPD DQCKDSSPHC PLVVQARLCV YPYYTATCCR SCAHVLERSP QDPS //