Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein delta homolog 2

Gene

DLK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates adipogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

SIGNORiQ6UY11.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein delta homolog 2
Short name:
DLK-2
Alternative name(s):
Epidermal growth factor-like protein 9
Short name:
EGF-like protein 9
Gene namesi
Name:DLK2
Synonyms:EGFL9
ORF Names:UNQ2903/PRO28633
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21113. DLK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 306280ExtracellularSequence analysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence analysisAdd
BLAST
Topological domaini328 – 38356CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383762.

Polymorphism and mutation databases

BioMutaiDLK2.
DMDMi55976806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 383357Protein delta homolog 2PRO_0000007534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Disulfide bondi33 ↔ 46PROSITE-ProRule annotation
Disulfide bondi48 ↔ 57PROSITE-ProRule annotation
Disulfide bondi66 ↔ 71PROSITE-ProRule annotation
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi95 ↔ 107PROSITE-ProRule annotation
Disulfide bondi101 ↔ 117PROSITE-ProRule annotation
Disulfide bondi119 ↔ 128PROSITE-ProRule annotation
Disulfide bondi135 ↔ 148PROSITE-ProRule annotation
Disulfide bondi142 ↔ 160PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi162 ↔ 171PROSITE-ProRule annotation
Disulfide bondi178 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi200 ↔ 209PROSITE-ProRule annotation
Disulfide bondi216 ↔ 227PROSITE-ProRule annotation
Disulfide bondi221 ↔ 236PROSITE-ProRule annotation
Disulfide bondi238 ↔ 247PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ6UY11.
PaxDbiQ6UY11.
PeptideAtlasiQ6UY11.
PRIDEiQ6UY11.

Expressioni

Gene expression databases

BgeeiQ6UY11.
CleanExiHS_DLK2.
ExpressionAtlasiQ6UY11. baseline and differential.
GenevisibleiQ6UY11. HS.

Organism-specific databases

HPAiHPA061223.

Interactioni

Protein-protein interaction databases

BioGridi122438. 31 interactions.
IntActiQ6UY11. 3 interactions.
STRINGi9606.ENSP00000349893.

Structurei

3D structure databases

ProteinModelPortaliQ6UY11.
SMRiQ6UY11. Positions 12-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 5832EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini62 – 8928EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini91 – 12939EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 17242EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini174 – 21037EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini212 – 24837EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG1219. Eukaryota.
ENOG410ZHP6. LUCA.
GeneTreeiENSGT00840000129708.
HOGENOMiHOG000065685.
HOVERGENiHBG051454.
InParanoidiQ6UY11.
OMAiCRCLHLV.
OrthoDBiEOG70CR6T.
PhylomeDBiQ6UY11.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UY11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSGCRCLHL VCLLCILGAP GQPVRADDCS SHCDLAHGCC APDGSCRCDP
60 70 80 90 100
GWEGLHCERC VRMPGCQHGT CHQPWQCICH SGWAGKFCDK DEHICTTQSP
110 120 130 140 150
CQNGGQCMYD GGGEYHCVCL PGFHGRDCER KAGPCEQAGS PCRNGGQCQD
160 170 180 190 200
DQGFALNFTC RCLVGFVGAR CEVNVDDCLM RPCANGATCL DGINRFSCLC
210 220 230 240 250
PEGFAGRFCT INLDDCASRP CQRGARCRDR VHDFDCLCPS GYGGKTCELV
260 270 280 290 300
LPVPDPPTTV DTPLGPTSAV VVPATGPAPH SAGAGLLRIS VKEVVRRQEA
310 320 330 340 350
GLGEPSLVAL VVFGALTAAL VLATVLLTLR AWRRGVCPPG PCCYPAPHYA
360 370 380
PACQDQECQV SMLPAGLPLP RDLPPEPGKT TAL
Length:383
Mass (Da):40,548
Last modified:July 5, 2004 - v1
Checksum:i701AC6B043863EA7
GO
Isoform 2 (identifier: Q6UY11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Note: Splicing acceptor site not canonical. No experimental confirmation available.
Show »
Length:204
Mass (Da):21,330
Checksum:i82D6A5A84D2B0E24
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti301 – 3011G → R.
Corresponds to variant rs35192247 [ dbSNP | Ensembl ].
VAR_048977

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 179179Missing in isoform 2. 1 PublicationVSP_011767Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358126 mRNA. Translation: AAQ88493.1.
AK055380 mRNA. Translation: BAG51509.1.
AL359813 Genomic DNA. Translation: CAI23224.1.
CH471081 Genomic DNA. Translation: EAX04186.1.
BC000230 mRNA. Translation: AAH00230.1.
BC006425 mRNA. Translation: AAH06425.1.
BC110320 mRNA. Translation: AAI10321.1.
CCDSiCCDS4897.1. [Q6UY11-1]
RefSeqiNP_001273584.1. NM_001286655.1.
NP_001273585.1. NM_001286656.1.
NP_076421.2. NM_023932.3. [Q6UY11-1]
NP_996262.1. NM_206539.2. [Q6UY11-1]
UniGeneiHs.337251.

Genome annotation databases

EnsembliENST00000357338; ENSP00000349893; ENSG00000171462. [Q6UY11-1]
ENST00000372488; ENSP00000361566; ENSG00000171462. [Q6UY11-1]
GeneIDi65989.
KEGGihsa:65989.
UCSCiuc003ova.5. human. [Q6UY11-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358126 mRNA. Translation: AAQ88493.1.
AK055380 mRNA. Translation: BAG51509.1.
AL359813 Genomic DNA. Translation: CAI23224.1.
CH471081 Genomic DNA. Translation: EAX04186.1.
BC000230 mRNA. Translation: AAH00230.1.
BC006425 mRNA. Translation: AAH06425.1.
BC110320 mRNA. Translation: AAI10321.1.
CCDSiCCDS4897.1. [Q6UY11-1]
RefSeqiNP_001273584.1. NM_001286655.1.
NP_001273585.1. NM_001286656.1.
NP_076421.2. NM_023932.3. [Q6UY11-1]
NP_996262.1. NM_206539.2. [Q6UY11-1]
UniGeneiHs.337251.

3D structure databases

ProteinModelPortaliQ6UY11.
SMRiQ6UY11. Positions 12-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122438. 31 interactions.
IntActiQ6UY11. 3 interactions.
STRINGi9606.ENSP00000349893.

Polymorphism and mutation databases

BioMutaiDLK2.
DMDMi55976806.

Proteomic databases

EPDiQ6UY11.
PaxDbiQ6UY11.
PeptideAtlasiQ6UY11.
PRIDEiQ6UY11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357338; ENSP00000349893; ENSG00000171462. [Q6UY11-1]
ENST00000372488; ENSP00000361566; ENSG00000171462. [Q6UY11-1]
GeneIDi65989.
KEGGihsa:65989.
UCSCiuc003ova.5. human. [Q6UY11-1]

Organism-specific databases

CTDi65989.
GeneCardsiDLK2.
HGNCiHGNC:21113. DLK2.
HPAiHPA061223.
neXtProtiNX_Q6UY11.
PharmGKBiPA162383762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG1219. Eukaryota.
ENOG410ZHP6. LUCA.
GeneTreeiENSGT00840000129708.
HOGENOMiHOG000065685.
HOVERGENiHBG051454.
InParanoidiQ6UY11.
OMAiCRCLHLV.
OrthoDBiEOG70CR6T.
PhylomeDBiQ6UY11.
TreeFamiTF351835.

Enzyme and pathway databases

SIGNORiQ6UY11.

Miscellaneous databases

GenomeRNAii65989.
PROiQ6UY11.

Gene expression databases

BgeeiQ6UY11.
CleanExiHS_DLK2.
ExpressionAtlasiQ6UY11. baseline and differential.
GenevisibleiQ6UY11. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF12661. hEGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye.

Entry informationi

Entry nameiDLK2_HUMAN
AccessioniPrimary (citable) accession number: Q6UY11
Secondary accession number(s): B3KNZ7, Q5T3T8, Q9BQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.