Q6UY09 (CEA20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 20

Gene names

Name:	CEACAM20
ORF Names:	UNQ9366/PRO34155

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 585	555	Carcinoembryonic antigen-related cell adhesion molecule 20		PRO_0000014577
Regions
	Topological domain	31 – 450	420	Extracellular Potential
	Transmembrane	451 – 471	21	Helical; Potential
	Topological domain	472 – 585	114	Cytoplasmic Potential
	Domain	58 – 154	97	Ig-like C2-type 1
	Domain	160 – 246	87	Ig-like C2-type 2
	Domain	256 – 341	86	Ig-like C2-type 3
	Domain	346 – 432	87	Ig-like C2-type 4
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	280	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Glycosylation	317	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential
	Glycosylation	415	1	N-linked (GlcNAc...) Potential
	Disulfide bond	90 ↔ 138		By similarity
	Disulfide bond	276 ↔ 324		By similarity
	Disulfide bond	375 ↔ 416		By similarity
Natural variations
	Natural variant	41	1	A → V. Corresponds to variant rs10408247 [ dbSNP | Ensembl ].		VAR_056030
	Natural variant	87	1	T → I. Corresponds to variant rs36053277 [ dbSNP | Ensembl ].		VAR_061312
	Natural variant	113	1	R → H. Corresponds to variant rs13345196 [ dbSNP | Ensembl ].		VAR_056031
	Natural variant	127	1	I → V. Corresponds to variant rs35443082 [ dbSNP | Ensembl ].		VAR_056032
	Natural variant	355	1	S → L. Corresponds to variant rs16959164 [ dbSNP | Ensembl ].		VAR_056033
	Natural variant	369	1	S → F. Corresponds to variant rs10414398 [ dbSNP | Ensembl ].		VAR_056034
	Natural variant	512	1	C → R. Corresponds to variant rs8100718 [ dbSNP | Ensembl ].		VAR_059385

Sequences

	Sequence		Length	Mass (Da)
	Q6UY09 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6E8D27BABB07E0F7	FASTA	585	64,502
	10 20 30 40 50 60 MGPADSWGHH WMGILLSASL CTVWSPPAAA QLTLNANPLD ATQSEDVVLP VFGTPRTPQI 70 80 90 100 110 120 HGRSRELAKP SIAVSPGTAI EQKDMVTFYC TTKDVNITIH WVSNNLSIVF HERMQLSKDG 130 140 150 160 170 180 KILTILIVQR EDSGTYQCEA RDALLSQRSD PIFLDVKYGP DPVEIKLESG VASGEVVEVM 190 200 210 220 230 240 EGSSMTFLAE TKSHPPCAYT WFLLDSILSH TTRTFTIHAV SREHEGLYRC LVSNSATHLS 250 260 270 280 290 300 SLGTLKVRVL ETLTMPQVVP SSLNLVENAR SVDLTCQTVN QSVNVQWFLS GQPLLPSEHL 310 320 330 340 350 360 QLSADNRTLI IHGLQRNDTG PYACEVWNWG SRARSEPLEL TINYGPDQVH ITRESASEMI 370 380 390 400 410 420 STIEAELNSS LTLQCWAESK PGAEYRWTLE HSTGEHLGEQ LIIRALTWEH DGIYNCTASN 430 440 450 460 470 480 SLTGLARSTS VLVKVVGPQS SSLSSGAIAG IVIGILAVIA VASELGYFLC IRNARRPSRK 490 500 510 520 530 540 TTEDPSHETS QPIPKEEHPT EPSSESLSPE YCNISQLQGR IRVELMQPPD LPEETYETKL 550 560 570 580 PSASRRGNSF SPWKPPPKPL MPPLRLVSTV PKNMESIYEV LGMQQ

References

[1]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358129 mRNA. Translation: AAQ88496.1.
IPI	IPI00789178.
RefSeq	NP_001096067.1. NM_001102597.1. NP_001096068.1. NM_001102598.1. NP_001096069.1. NM_001102599.1. NP_001096070.1. NM_001102600.1.
UniGene	Hs.689632.
3D structure databases
ProteinModelPortal	Q6UY09.
ModBase	Search...
PTM databases
PhosphoSite	Q6UY09.
Polymorphism databases
DMDM	73619948.
Proteomic databases
PaxDb	Q6UY09.
PRIDE	Q6UY09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	125931.
KEGG	hsa:125931.
UCSC	uc010ejn.1. human.
Organism-specific databases
CTD	125931.
GeneCards	GC19M045005.
H-InvDB	HIX0040059.
HGNC	HGNC:24879. CEACAM20.
neXtProt	NX_Q6UY09.
PharmGKB	PA142672134.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146066.
HOVERGEN	HBG063623.
InParanoid	Q6UY09.
KO	K06499.
Gene expression databases
CleanEx	HS_CEACAM20.
Genevestigator	Q6UY09.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF07679. I-set. 2 hits. [Graphical view]
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	125931.
NextBio	81568.

Entry information

Entry name

CEA20_HUMAN

Accession

Primary (citable) accession number: Q6UY09

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.