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Protein

Leucine-rich repeat-containing protein 31

Gene

LRRC31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 31
Gene namesi
Name:LRRC31
ORF Names:UNQ9367/PRO34156
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26261. LRRC31.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79782.
OpenTargetsiENSG00000114248.
PharmGKBiPA134985943.

Polymorphism and mutation databases

DMDMi74762376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002299221 – 552Leucine-rich repeat-containing protein 31Add BLAST552

Proteomic databases

MaxQBiQ6UY01.
PaxDbiQ6UY01.
PeptideAtlasiQ6UY01.
PRIDEiQ6UY01.

PTM databases

iPTMnetiQ6UY01.
PhosphoSitePlusiQ6UY01.

Expressioni

Gene expression databases

BgeeiENSG00000114248.
CleanExiHS_LRRC31.
GenevisibleiQ6UY01. HS.

Organism-specific databases

HPAiHPA037548.

Interactioni

Protein-protein interaction databases

BioGridi122882. 1 interactor.
IntActiQ6UY01. 1 interactor.
STRINGi9606.ENSP00000325978.

Structurei

3D structure databases

ProteinModelPortaliQ6UY01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati227 – 246LRR 1Add BLAST20
Repeati255 – 275LRR 2Add BLAST21
Repeati283 – 293LRR 3Add BLAST11
Repeati311 – 331LRR 4Add BLAST21
Repeati339 – 360LRR 5Add BLAST22
Repeati367 – 387LRR 6Add BLAST21
Repeati395 – 415LRR 7Add BLAST21
Repeati423 – 443LRR 8Add BLAST21
Repeati453 – 475LRR 9Add BLAST23

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000111293.
HOGENOMiHOG000082482.
InParanoidiQ6UY01.
OMAiQMHLVSK.
OrthoDBiEOG091G05YL.
PhylomeDBiQ6UY01.
TreeFamiTF331228.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UY01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQTRKKTSS EGETKPQTST VNKFLRGSNA ESRKEDNDLK TSDSQPSDWI
60 70 80 90 100
QKTATSETAK PLSSEMEWRS SMEKNEHFLQ KLGKKAVNKC LDLNNCGLTT
110 120 130 140 150
ADMKEMVALL PFLPDLEELD ISWNGFVGGT LLSITQQMHL VSKLKILRLG
160 170 180 190 200
SCRLTTDDVQ ALGEAFEMIP ELEELNLSWN SKVGGNLPLI LQKFQKGSKI
210 220 230 240 250
QMIELVDCSL TSEDGTFLGQ LLPMLQSLEV LDLSINRDIV GSLNSIAQGL
260 270 280 290 300
KSTSNLKVLK LHSCGLSQKS VKILDAAFRY LGELRKLDLS CNKDLGGGFE
310 320 330 340 350
DSPAQLVMLK HLQVLDLHQC SLTADDVMSL TQVIPLLSNL QELDLSANKK
360 370 380 390 400
MGSSSENLLS RLRFLPALKS LVINNCALES ETFTALAEAS VHLSALEVFN
410 420 430 440 450
LSWNKCVGGN LKLLLETLKL SMSLQVLRLS SCSLVTEDVA LLASVIQTGH
460 470 480 490 500
LAKLQKLDLS YNDSICDAGW TMFCQNVRFL KELIELDISL RPSNFRDCGQ
510 520 530 540 550
WFRHLLYAVT KLPQITEIGM KRWILPASQE EELECFDQDK KRSIHFDHGG

FQ
Length:552
Mass (Da):61,489
Last modified:July 5, 2004 - v1
Checksum:i27821051D1157502
GO
Isoform 2 (identifier: Q6UY01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-162: Missing.

Show »
Length:496
Mass (Da):55,327
Checksum:iD8922E375BFD7A74
GO
Isoform 3 (identifier: Q6UY01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-346: TQVIPLLSNLQELDLS → NSYLSIWENGKNSRLS
     347-552: Missing.

Show »
Length:346
Mass (Da):38,342
Checksum:iCC3693298C0D9A5C
GO
Isoform 4 (identifier: Q6UY01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-443: A → E
     444-552: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):48,776
Checksum:iCA1455B10503D07D
GO

Sequence cautioni

The sequence BAB15589 differs from that shown. Reason: Frameshift at position 539.Curated
Isoform 2 : The sequence BAB15589 differs from that shown. Reason: Frameshift at position 539.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412K → E in BAB15589 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034085322L → F.Corresponds to variant rs35923425dbSNPEnsembl.1
Natural variantiVAR_051111324A → E.Corresponds to variant rs3732452dbSNPEnsembl.1
Natural variantiVAR_051112378L → F.Corresponds to variant rs35923425dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017797107 – 162Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_017798331 – 346TQVIP…ELDLS → NSYLSIWENGKNSRLS in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_017799347 – 552Missing in isoform 3. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_055910443A → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_055911444 – 552Missing in isoform 4. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU668335 mRNA. Translation: ACF94488.1.
AY358138 mRNA. Translation: AAQ88505.1.
AK026912 mRNA. Translation: BAB15589.1. Frameshift.
AK097338 mRNA. Translation: BAC05004.1.
AC078795 Genomic DNA. No translation available.
BC117401 mRNA. Translation: AAI17402.1.
BC143569 mRNA. Translation: AAI43570.1.
BC143582 mRNA. No translation available.
CCDSiCCDS43167.1. [Q6UY01-1]
CCDS63832.1. [Q6UY01-2]
CCDS63833.1. [Q6UY01-4]
RefSeqiNP_001264056.1. NM_001277127.1. [Q6UY01-4]
NP_001264057.1. NM_001277128.1. [Q6UY01-2]
NP_079003.2. NM_024727.3. [Q6UY01-1]
XP_011511462.1. XM_011513160.2. [Q6UY01-3]
UniGeneiHs.411295.

Genome annotation databases

EnsembliENST00000264676; ENSP00000264676; ENSG00000114248. [Q6UY01-2]
ENST00000316428; ENSP00000325978; ENSG00000114248. [Q6UY01-1]
ENST00000523069; ENSP00000429145; ENSG00000114248. [Q6UY01-4]
GeneIDi79782.
KEGGihsa:79782.
UCSCiuc003fgc.3. human. [Q6UY01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU668335 mRNA. Translation: ACF94488.1.
AY358138 mRNA. Translation: AAQ88505.1.
AK026912 mRNA. Translation: BAB15589.1. Frameshift.
AK097338 mRNA. Translation: BAC05004.1.
AC078795 Genomic DNA. No translation available.
BC117401 mRNA. Translation: AAI17402.1.
BC143569 mRNA. Translation: AAI43570.1.
BC143582 mRNA. No translation available.
CCDSiCCDS43167.1. [Q6UY01-1]
CCDS63832.1. [Q6UY01-2]
CCDS63833.1. [Q6UY01-4]
RefSeqiNP_001264056.1. NM_001277127.1. [Q6UY01-4]
NP_001264057.1. NM_001277128.1. [Q6UY01-2]
NP_079003.2. NM_024727.3. [Q6UY01-1]
XP_011511462.1. XM_011513160.2. [Q6UY01-3]
UniGeneiHs.411295.

3D structure databases

ProteinModelPortaliQ6UY01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122882. 1 interactor.
IntActiQ6UY01. 1 interactor.
STRINGi9606.ENSP00000325978.

PTM databases

iPTMnetiQ6UY01.
PhosphoSitePlusiQ6UY01.

Polymorphism and mutation databases

DMDMi74762376.

Proteomic databases

MaxQBiQ6UY01.
PaxDbiQ6UY01.
PeptideAtlasiQ6UY01.
PRIDEiQ6UY01.

Protocols and materials databases

DNASUi79782.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264676; ENSP00000264676; ENSG00000114248. [Q6UY01-2]
ENST00000316428; ENSP00000325978; ENSG00000114248. [Q6UY01-1]
ENST00000523069; ENSP00000429145; ENSG00000114248. [Q6UY01-4]
GeneIDi79782.
KEGGihsa:79782.
UCSCiuc003fgc.3. human. [Q6UY01-1]

Organism-specific databases

CTDi79782.
DisGeNETi79782.
GeneCardsiLRRC31.
HGNCiHGNC:26261. LRRC31.
HPAiHPA037548.
neXtProtiNX_Q6UY01.
OpenTargetsiENSG00000114248.
PharmGKBiPA134985943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000111293.
HOGENOMiHOG000082482.
InParanoidiQ6UY01.
OMAiQMHLVSK.
OrthoDBiEOG091G05YL.
PhylomeDBiQ6UY01.
TreeFamiTF331228.

Miscellaneous databases

GenomeRNAii79782.
PROiQ6UY01.

Gene expression databases

BgeeiENSG00000114248.
CleanExiHS_LRRC31.
GenevisibleiQ6UY01. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC31_HUMAN
AccessioniPrimary (citable) accession number: Q6UY01
Secondary accession number(s): B7ZL44
, E5RJA9, Q17RA3, Q8N848, Q9H5N5, V9HW14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.