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Protein

CMRF35-like molecule 4

Gene

CD300LD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CMRF35-like molecule 4
Short name:
CLM-4
Alternative name(s):
CD300 antigen-like family member D
CMRF35-A4
CD_antigen: CD300d
Gene namesi
Name:CD300LD
Synonyms:CD300D, CMRF35A4
ORF Names:UNQ9218/PRO28686
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16848. CD300LD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 165147ExtracellularSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Topological domaini187 – 1948CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi158 – 1581R → S: Unable to reach the cell surface upon transfection. 1 Publication

Organism-specific databases

PharmGKBiPA162382124.

Polymorphism and mutation databases

BioMutaiCD300LD.
DMDMi74758584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 194176CMRF35-like molecule 4PRO_0000320126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi39 ↔ 107PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6UXZ3.
PeptideAtlasiQ6UXZ3.
PRIDEiQ6UXZ3.

PTM databases

iPTMnetiQ6UXZ3.

Expressioni

Tissue specificityi

Expression seems restricted to cells of myeloid lineage.1 Publication

Gene expression databases

CleanExiHS_CD300LD.

Organism-specific databases

HPAiHPA027756.

Interactioni

Subunit structurei

Forms complexes with the CD300 family members with exception of CD300c.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TFF1P041553EBI-4314468,EBI-743871

Protein-protein interaction databases

BioGridi137769. 1 interaction.
IntActiQ6UXZ3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6UXZ3.
SMRiQ6UXZ3. Positions 20-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 125107Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 1394Poly-Thr

Sequence similaritiesi

Belongs to the CD300 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J31V. Eukaryota.
ENOG410ZH9V. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ6UXZ3.
OMAiMENLKRD.
OrthoDBiEOG78PVBM.
PhylomeDBiQ6UXZ3.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UXZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLSPSLLLL ILPGYSIAAK ITGPTTVNGS EQGSLTVQCA YGSGWETYLK
60 70 80 90 100
WRCQGADWNY CNILVKTNGS EQEVKKNRVS IRDNQKNHVF TVTMENLKRD
110 120 130 140 150
DADSYWCGTE RPGIDLGVKV QVTINPGTQT AVSEWTTTTA SLAFTAAATQ
160 170 180 190
KTSSPLTRSP LKSTHFLFLF LLELPLLLSM LGTVLWVNRP QRRS
Length:194
Mass (Da):21,558
Last modified:July 5, 2004 - v1
Checksum:i5E3A4CB03B473E12
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61S → A.
Corresponds to variant rs493430 [ dbSNP | Ensembl ].
VAR_059386
Natural varianti89 – 891V → M.
Corresponds to variant rs783239 [ dbSNP | Ensembl ].
VAR_059387

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF137868 mRNA. Translation: ABM30606.1.
AY358148 mRNA. Translation: AAQ88515.1.
CCDSiCCDS42379.1.
RefSeqiNP_001108624.1. NM_001115152.1.
UniGeneiHs.531099.

Genome annotation databases

EnsembliENST00000375352; ENSP00000364501; ENSG00000204345.
GeneIDi100131439.
KEGGihsa:100131439.
UCSCiuc002jkz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF137868 mRNA. Translation: ABM30606.1.
AY358148 mRNA. Translation: AAQ88515.1.
CCDSiCCDS42379.1.
RefSeqiNP_001108624.1. NM_001115152.1.
UniGeneiHs.531099.

3D structure databases

ProteinModelPortaliQ6UXZ3.
SMRiQ6UXZ3. Positions 20-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137769. 1 interaction.
IntActiQ6UXZ3. 1 interaction.

PTM databases

iPTMnetiQ6UXZ3.

Polymorphism and mutation databases

BioMutaiCD300LD.
DMDMi74758584.

Proteomic databases

PaxDbiQ6UXZ3.
PeptideAtlasiQ6UXZ3.
PRIDEiQ6UXZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375352; ENSP00000364501; ENSG00000204345.
GeneIDi100131439.
KEGGihsa:100131439.
UCSCiuc002jkz.3. human.

Organism-specific databases

CTDi100131439.
GeneCardsiCD300LD.
HGNCiHGNC:16848. CD300LD.
HPAiHPA027756.
MIMi616301. gene.
neXtProtiNX_Q6UXZ3.
PharmGKBiPA162382124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J31V. Eukaryota.
ENOG410ZH9V. LUCA.
GeneTreeiENSGT00470000042273.
HOGENOMiHOG000231065.
HOVERGENiHBG063279.
InParanoidiQ6UXZ3.
OMAiMENLKRD.
OrthoDBiEOG78PVBM.
PhylomeDBiQ6UXZ3.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GenomeRNAii100131439.
PROiQ6UXZ3.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CD300LD.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of human CD300d, a novel receptor expressed by myeloid cells."
    Martinez-Barriocanal A., Sayos J.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors."
    Comas-Casellas E., Martinez-Barriocanal A., Miro F., Ejarque-Ortiz A., Schwartz S. Jr., Martin M., Sayos J.
    J. Biol. Chem. 287:9682-9693(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY, GLYCOSYLATION, MUTAGENESIS OF ARG-158.
    Tissue: Peripheral blood monocyte.
  4. "Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility."
    Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L., Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.
    Hum. Genet. 112:34-41(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCLM4_HUMAN
AccessioniPrimary (citable) accession number: Q6UXZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.