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Protein

Transmembrane channel-like protein 5

Gene

TMC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 5
Gene namesi
Name:TMC5
ORF Names:UNQ8238/PRO33604
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:22999. TMC5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 458458ExtracellularSequence analysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence analysisAdd
BLAST
Topological domaini480 – 4856CytoplasmicSequence analysis
Transmembranei486 – 50823HelicalSequence analysisAdd
BLAST
Topological domaini509 – 52517ExtracellularSequence analysisAdd
BLAST
Transmembranei526 – 54621HelicalSequence analysisAdd
BLAST
Topological domaini547 – 61973CytoplasmicSequence analysisAdd
BLAST
Transmembranei620 – 64021HelicalSequence analysisAdd
BLAST
Topological domaini641 – 65414ExtracellularSequence analysisAdd
BLAST
Transmembranei655 – 67521HelicalSequence analysisAdd
BLAST
Topological domaini676 – 69823CytoplasmicSequence analysisAdd
BLAST
Transmembranei699 – 71921HelicalSequence analysisAdd
BLAST
Topological domaini720 – 73213ExtracellularSequence analysisAdd
BLAST
Transmembranei733 – 75321HelicalSequence analysisAdd
BLAST
Topological domaini754 – 78633CytoplasmicSequence analysisAdd
BLAST
Transmembranei787 – 80721HelicalSequence analysisAdd
BLAST
Topological domaini808 – 83528ExtracellularSequence analysisAdd
BLAST
Transmembranei836 – 85621HelicalSequence analysisAdd
BLAST
Topological domaini857 – 90044CytoplasmicSequence analysisAdd
BLAST
Transmembranei901 – 92121HelicalSequence analysisAdd
BLAST
Topological domaini922 – 100685ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923498.

Polymorphism and mutation databases

BioMutaiTMC5.
DMDMi313104276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10061006Transmembrane channel-like protein 5PRO_0000289966Add
BLAST

Proteomic databases

EPDiQ6UXY8.
PaxDbiQ6UXY8.
PeptideAtlasiQ6UXY8.
PRIDEiQ6UXY8.

PTM databases

iPTMnetiQ6UXY8.
PhosphoSiteiQ6UXY8.

Expressioni

Gene expression databases

BgeeiQ6UXY8.
CleanExiHS_TMC5.
ExpressionAtlasiQ6UXY8. baseline and differential.
GenevisibleiQ6UXY8. HS.

Organism-specific databases

HPAiHPA040810.
HPA042037.

Interactioni

Protein-protein interaction databases

BioGridi122929. 1 interaction.
IntActiQ6UXY8. 1 interaction.
MINTiMINT-5005276.
STRINGi9606.ENSP00000379531.

Structurei

3D structure databases

ProteinModelPortaliQ6UXY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 1434Poly-Ser

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH09. Eukaryota.
ENOG410XR0Y. LUCA.
GeneTreeiENSGT00760000119171.
HOGENOMiHOG000154633.
HOVERGENiHBG108587.
InParanoidiQ6UXY8.
OMAiDFNITNE.
PhylomeDBiQ6UXY8.
TreeFamiTF313462.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAYYRNNWS EEDPDYPDYS GSQNRTQGYL KTQGYPDVPG PLNNPDYPGT
60 70 80 90 100
RSNPYSVASR TRPDYPGSLA EPNYPRSLSN PDYSGTRSNA YSAASRTSPD
110 120 130 140 150
HPTSLPEPDY SEFQSHPYHR ASSRQPDYPG SQRNPDFAGS SSSGNYAGSR
160 170 180 190 200
THPDHFGSLE PDYPGAQSNS DHPGPRANLN HPGSRKNLEH TSFRINPYAD
210 220 230 240 250
SLGKPDYPGA DIQPNSPPFF GEPDYPSAED NQNLPSTWRE PDYSDAENGH
260 270 280 290 300
DYGSSETPKM TRGVLSRTSS IQPSFRHRSD DPVGSLWGEN DYPEGIEMAS
310 320 330 340 350
MEMANSYGHS LPGAPGSGYV NPAYVGESGP VHAYGNPPLS ECDWHKSPQG
360 370 380 390 400
QKLIASLIPM TSRDRIKAIR NQPRTMEEKR NLRKIVDKEK SKQTHRILQL
410 420 430 440 450
NCCIQCLNSI SRAYRRSKNS LSEILNSISL WQKTLKIIGG KFGTSVLSYF
460 470 480 490 500
NFLRWLLKFN IFSFILNFSF IIIPQFTVAK KNTLQFTGLE FFTGVGYFRD
510 520 530 540 550
TVMYYGFYTN STIQHGNSGA SYNMQLAYIF TIGACLTTCF FSLLFSMAKY
560 570 580 590 600
FRNNFINPHI YSGGITKLIF CWDFTVTHEK AVKLKQKNLS TEIRENLSEL
610 620 630 640 650
RQENSKLTFN QLLTRFSAYM VAWVVSTGVA IACCAAVYYL AEYNLEFLKT
660 670 680 690 700
HSNPGAVLLL PFVVSCINLA VPCIYSMFRL VERYEMPRHE VYVLLIRNIF
710 720 730 740 750
LKISIIGILC YYWLNTVALS GEECWETLIG QDIYRLLLMD FVFSLVNSFL
760 770 780 790 800
GEFLRRIIGM QLITSLGLQE FDIARNVLEL IYAQTLVWIG IFFCPLLPFI
810 820 830 840 850
QMIMLFIMFY SKNISLMMNF QPPSKAWRAS QMMTFFIFLL FFPSFTGVLC
860 870 880 890 900
TLAITIWRLK PSADCGPFRG LPLFIHSIYS WIDTLSTRPG YLWVVWIYRN
910 920 930 940 950
LIGSVHFFFI LTLIVLIITY LYWQITEGRK IMIRLLHEQI INEGKDKMFL
960 970 980 990 1000
IEKLIKLQDM EKKANPSSLV LERREVEQQG FLHLGEHDGS LDLRSRRSVQ

EGNPRA
Length:1,006
Mass (Da):114,797
Last modified:November 30, 2010 - v3
Checksum:i7132E259B2FAF2EC
GO
Isoform 2 (identifier: Q6UXY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     859-916: Missing.

Show »
Length:948
Mass (Da):108,061
Checksum:iE8434EA7798CC590
GO
Isoform 3 (identifier: Q6UXY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.
     247-348: ENGHDYGSSE...LSECDWHKSP → MLSDDHVNEI...DTPGSSHETV

Show »
Length:760
Mass (Da):87,820
Checksum:i1C9E6B58A899F775
GO
Isoform 4 (identifier: Q6UXY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-359: Missing.

Note: No experimental confirmation available.
Show »
Length:647
Mass (Da):75,486
Checksum:iCE0C71C7A117888B
GO

Sequence cautioni

The sequence BAB14629.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti419 – 4191N → D in CAH18212 (PubMed:15489334).Curated
Sequence conflicti547 – 5471M → T in AAH38118 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti328 – 3281S → N.
Corresponds to variant rs16972013 [ dbSNP | Ensembl ].
VAR_057285
Natural varianti355 – 3551A → T.
Corresponds to variant rs36019638 [ dbSNP | Ensembl ].
VAR_061850

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 359359Missing in isoform 4. 1 PublicationVSP_026043Add
BLAST
Alternative sequencei1 – 246246Missing in isoform 3. 3 PublicationsVSP_026044Add
BLAST
Alternative sequencei247 – 348102ENGHD…WHKSP → MLSDDHVNEIIIQVENVSSG VQSHPSSNQIFQEKVLLDSS INMVLSISDIDVIDSQTVSK RNDQKGNQVLRFSTSLNESM SQTLHSLECMGIDTPGSSHE TV in isoform 3. 3 PublicationsVSP_026045Add
BLAST
Alternative sequencei859 – 91658Missing in isoform 2. 1 PublicationVSP_026046Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263164 mRNA. Translation: AAP78779.1.
AY236494 mRNA. Translation: AAP69872.1.
AY358155 mRNA. Translation: AAQ88522.1.
AC130456 Genomic DNA. No translation available.
BC027602 mRNA. Translation: AAH27602.1.
BC038118 mRNA. Translation: AAH38118.1.
CR749359 mRNA. Translation: CAH18212.1.
AK023655 mRNA. Translation: BAB14629.1. Different initiation.
CCDSiCCDS10577.1. [Q6UXY8-3]
CCDS42126.1. [Q6UXY8-2]
CCDS45431.1. [Q6UXY8-1]
RefSeqiNP_001098718.1. NM_001105248.1. [Q6UXY8-1]
NP_001098719.1. NM_001105249.1. [Q6UXY8-2]
NP_001248770.1. NM_001261841.1. [Q6UXY8-1]
NP_001295090.1. NM_001308161.1.
NP_079056.2. NM_024780.4. [Q6UXY8-3]
XP_011544254.1. XM_011545952.1. [Q6UXY8-1]
XP_011544255.1. XM_011545953.1. [Q6UXY8-1]
XP_011544256.1. XM_011545954.1. [Q6UXY8-1]
UniGeneiHs.115838.

Genome annotation databases

EnsembliENST00000219821; ENSP00000219821; ENSG00000103534. [Q6UXY8-3]
ENST00000381414; ENSP00000370822; ENSG00000103534. [Q6UXY8-2]
ENST00000396229; ENSP00000379531; ENSG00000103534. [Q6UXY8-1]
ENST00000542583; ENSP00000446274; ENSG00000103534. [Q6UXY8-1]
ENST00000561503; ENSP00000456148; ENSG00000103534. [Q6UXY8-4]
GeneIDi79838.
KEGGihsa:79838.
UCSCiuc002dgb.5. human. [Q6UXY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263164 mRNA. Translation: AAP78779.1.
AY236494 mRNA. Translation: AAP69872.1.
AY358155 mRNA. Translation: AAQ88522.1.
AC130456 Genomic DNA. No translation available.
BC027602 mRNA. Translation: AAH27602.1.
BC038118 mRNA. Translation: AAH38118.1.
CR749359 mRNA. Translation: CAH18212.1.
AK023655 mRNA. Translation: BAB14629.1. Different initiation.
CCDSiCCDS10577.1. [Q6UXY8-3]
CCDS42126.1. [Q6UXY8-2]
CCDS45431.1. [Q6UXY8-1]
RefSeqiNP_001098718.1. NM_001105248.1. [Q6UXY8-1]
NP_001098719.1. NM_001105249.1. [Q6UXY8-2]
NP_001248770.1. NM_001261841.1. [Q6UXY8-1]
NP_001295090.1. NM_001308161.1.
NP_079056.2. NM_024780.4. [Q6UXY8-3]
XP_011544254.1. XM_011545952.1. [Q6UXY8-1]
XP_011544255.1. XM_011545953.1. [Q6UXY8-1]
XP_011544256.1. XM_011545954.1. [Q6UXY8-1]
UniGeneiHs.115838.

3D structure databases

ProteinModelPortaliQ6UXY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122929. 1 interaction.
IntActiQ6UXY8. 1 interaction.
MINTiMINT-5005276.
STRINGi9606.ENSP00000379531.

PTM databases

iPTMnetiQ6UXY8.
PhosphoSiteiQ6UXY8.

Polymorphism and mutation databases

BioMutaiTMC5.
DMDMi313104276.

Proteomic databases

EPDiQ6UXY8.
PaxDbiQ6UXY8.
PeptideAtlasiQ6UXY8.
PRIDEiQ6UXY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219821; ENSP00000219821; ENSG00000103534. [Q6UXY8-3]
ENST00000381414; ENSP00000370822; ENSG00000103534. [Q6UXY8-2]
ENST00000396229; ENSP00000379531; ENSG00000103534. [Q6UXY8-1]
ENST00000542583; ENSP00000446274; ENSG00000103534. [Q6UXY8-1]
ENST00000561503; ENSP00000456148; ENSG00000103534. [Q6UXY8-4]
GeneIDi79838.
KEGGihsa:79838.
UCSCiuc002dgb.5. human. [Q6UXY8-1]

Organism-specific databases

CTDi79838.
GeneCardsiTMC5.
HGNCiHGNC:22999. TMC5.
HPAiHPA040810.
HPA042037.
neXtProtiNX_Q6UXY8.
PharmGKBiPA134923498.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH09. Eukaryota.
ENOG410XR0Y. LUCA.
GeneTreeiENSGT00760000119171.
HOGENOMiHOG000154633.
HOVERGENiHBG108587.
InParanoidiQ6UXY8.
OMAiDFNITNE.
PhylomeDBiQ6UXY8.
TreeFamiTF313462.

Miscellaneous databases

ChiTaRSiTMC5. human.
GenomeRNAii79838.
PROiQ6UXY8.

Gene expression databases

BgeeiQ6UXY8.
CleanExiHS_TMC5.
ExpressionAtlasiQ6UXY8. baseline and differential.
GenevisibleiQ6UXY8. HS.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins."
    Keresztes G., Mutai H., Heller S.
    BMC Genomics 4:24-24(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis."
    Kurima K., Yang Y., Sorber K., Griffith A.J.
    Genomics 82:300-308(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-1006 (ISOFORM 1).
    Tissue: Rectum tumor.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 667-1006.
    Tissue: Placenta.

Entry informationi

Entry nameiTMC5_HUMAN
AccessioniPrimary (citable) accession number: Q6UXY8
Secondary accession number(s): Q68DK8
, Q8IY20, Q8NHV6, Q9H8I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 30, 2010
Last modified: July 6, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.