Q6UXY8 (TMC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane channel-like protein 5

Gene names

Name:	TMC5
ORF Names:	UNQ8238/PRO33604

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1006 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as ion channels, transporters or modulators of such.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMC family.
Sequence caution	The sequence BAB14629.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UXY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UXY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     859-916: Missing.

Isoform 3 (identifier: Q6UXY8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-246: Missing.
     247-348: ENGHDYGSSE...LSECDWHKSP → MLSDDHVNEI...DTPGSSHETV

Isoform 4 (identifier: Q6UXY8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-359: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1006	1006	Transmembrane channel-like protein 5		PRO_0000289966
Regions
	Topological domain	1 – 458	458	Extracellular Potential
	Transmembrane	459 – 479	21	Helical; Potential
	Topological domain	480 – 485	6	Cytoplasmic Potential
	Transmembrane	486 – 508	23	Helical; Potential
	Topological domain	509 – 525	17	Extracellular Potential
	Transmembrane	526 – 546	21	Helical; Potential
	Topological domain	547 – 619	73	Cytoplasmic Potential
	Transmembrane	620 – 640	21	Helical; Potential
	Topological domain	641 – 654	14	Extracellular Potential
	Transmembrane	655 – 675	21	Helical; Potential
	Topological domain	676 – 698	23	Cytoplasmic Potential
	Transmembrane	699 – 719	21	Helical; Potential
	Topological domain	720 – 732	13	Extracellular Potential
	Transmembrane	733 – 753	21	Helical; Potential
	Topological domain	754 – 786	33	Cytoplasmic Potential
	Transmembrane	787 – 807	21	Helical; Potential
	Topological domain	808 – 835	28	Extracellular Potential
	Transmembrane	836 – 856	21	Helical; Potential
	Topological domain	857 – 900	44	Cytoplasmic Potential
	Transmembrane	901 – 921	21	Helical; Potential
	Topological domain	922 – 1006	85	Extracellular Potential
	Compositional bias	140 – 143	4	Poly-Ser
Natural variations
	Alternative sequence	1 – 359	359	Missing in isoform 4.		VSP_026043
	Alternative sequence	1 – 246	246	Missing in isoform 3.		VSP_026044
	Alternative sequence	247 – 348	102	ENGHD…WHKSP → MLSDDHVNEIIIQVENVSSG VQSHPSSNQIFQEKVLLDSS INMVLSISDIDVIDSQTVSK RNDQKGNQVLRFSTSLNESM SQTLHSLECMGIDTPGSSHE TV in isoform 3.		VSP_026045
	Alternative sequence	859 – 916	58	Missing in isoform 2.		VSP_026046
	Natural variant	328	1	S → N. Corresponds to variant rs16972013 [ dbSNP | Ensembl ].		VAR_057285
	Natural variant	355	1	A → T. Corresponds to variant rs36019638 [ dbSNP | Ensembl ].		VAR_061850
Experimental info
	Sequence conflict	419	1	N → D in CAH18212. Ref.5
	Sequence conflict	547	1	M → T in AAH38118. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 7132E259B2FAF2EC	FASTA	1,006	114,797
	10 20 30 40 50 60 MSAYYRNNWS EEDPDYPDYS GSQNRTQGYL KTQGYPDVPG PLNNPDYPGT RSNPYSVASR 70 80 90 100 110 120 TRPDYPGSLA EPNYPRSLSN PDYSGTRSNA YSAASRTSPD HPTSLPEPDY SEFQSHPYHR 130 140 150 160 170 180 ASSRQPDYPG SQRNPDFAGS SSSGNYAGSR THPDHFGSLE PDYPGAQSNS DHPGPRANLN 190 200 210 220 230 240 HPGSRKNLEH TSFRINPYAD SLGKPDYPGA DIQPNSPPFF GEPDYPSAED NQNLPSTWRE 250 260 270 280 290 300 PDYSDAENGH DYGSSETPKM TRGVLSRTSS IQPSFRHRSD DPVGSLWGEN DYPEGIEMAS 310 320 330 340 350 360 MEMANSYGHS LPGAPGSGYV NPAYVGESGP VHAYGNPPLS ECDWHKSPQG QKLIASLIPM 370 380 390 400 410 420 TSRDRIKAIR NQPRTMEEKR NLRKIVDKEK SKQTHRILQL NCCIQCLNSI SRAYRRSKNS 430 440 450 460 470 480 LSEILNSISL WQKTLKIIGG KFGTSVLSYF NFLRWLLKFN IFSFILNFSF IIIPQFTVAK 490 500 510 520 530 540 KNTLQFTGLE FFTGVGYFRD TVMYYGFYTN STIQHGNSGA SYNMQLAYIF TIGACLTTCF 550 560 570 580 590 600 FSLLFSMAKY FRNNFINPHI YSGGITKLIF CWDFTVTHEK AVKLKQKNLS TEIRENLSEL 610 620 630 640 650 660 RQENSKLTFN QLLTRFSAYM VAWVVSTGVA IACCAAVYYL AEYNLEFLKT HSNPGAVLLL 670 680 690 700 710 720 PFVVSCINLA VPCIYSMFRL VERYEMPRHE VYVLLIRNIF LKISIIGILC YYWLNTVALS 730 740 750 760 770 780 GEECWETLIG QDIYRLLLMD FVFSLVNSFL GEFLRRIIGM QLITSLGLQE FDIARNVLEL 790 800 810 820 830 840 IYAQTLVWIG IFFCPLLPFI QMIMLFIMFY SKNISLMMNF QPPSKAWRAS QMMTFFIFLL 850 860 870 880 890 900 FFPSFTGVLC TLAITIWRLK PSADCGPFRG LPLFIHSIYS WIDTLSTRPG YLWVVWIYRN 910 920 930 940 950 960 LIGSVHFFFI LTLIVLIITY LYWQITEGRK IMIRLLHEQI INEGKDKMFL IEKLIKLQDM 970 980 990 1000 EKKANPSSLV LERREVEQQG FLHLGEHDGS LDLRSRRSVQ EGNPRA
	Isoform 2 [UniParc]. Checksum: E8434EA7798CC590	FASTA	948	108,061
	10 20 30 40 50 60 MSAYYRNNWS EEDPDYPDYS GSQNRTQGYL KTQGYPDVPG PLNNPDYPGT RSNPYSVASR 70 80 90 100 110 120 TRPDYPGSLA EPNYPRSLSN PDYSGTRSNA YSAASRTSPD HPTSLPEPDY SEFQSHPYHR 130 140 150 160 170 180 ASSRQPDYPG SQRNPDFAGS SSSGNYAGSR THPDHFGSLE PDYPGAQSNS DHPGPRANLN 190 200 210 220 230 240 HPGSRKNLEH TSFRINPYAD SLGKPDYPGA DIQPNSPPFF GEPDYPSAED NQNLPSTWRE 250 260 270 280 290 300 PDYSDAENGH DYGSSETPKM TRGVLSRTSS IQPSFRHRSD DPVGSLWGEN DYPEGIEMAS 310 320 330 340 350 360 MEMANSYGHS LPGAPGSGYV NPAYVGESGP VHAYGNPPLS ECDWHKSPQG QKLIASLIPM 370 380 390 400 410 420 TSRDRIKAIR NQPRTMEEKR NLRKIVDKEK SKQTHRILQL NCCIQCLNSI SRAYRRSKNS 430 440 450 460 470 480 LSEILNSISL WQKTLKIIGG KFGTSVLSYF NFLRWLLKFN IFSFILNFSF IIIPQFTVAK 490 500 510 520 530 540 KNTLQFTGLE FFTGVGYFRD TVMYYGFYTN STIQHGNSGA SYNMQLAYIF TIGACLTTCF 550 560 570 580 590 600 FSLLFSMAKY FRNNFINPHI YSGGITKLIF CWDFTVTHEK AVKLKQKNLS TEIRENLSEL 610 620 630 640 650 660 RQENSKLTFN QLLTRFSAYM VAWVVSTGVA IACCAAVYYL AEYNLEFLKT HSNPGAVLLL 670 680 690 700 710 720 PFVVSCINLA VPCIYSMFRL VERYEMPRHE VYVLLIRNIF LKISIIGILC YYWLNTVALS 730 740 750 760 770 780 GEECWETLIG QDIYRLLLMD FVFSLVNSFL GEFLRRIIGM QLITSLGLQE FDIARNVLEL 790 800 810 820 830 840 IYAQTLVWIG IFFCPLLPFI QMIMLFIMFY SKNISLMMNF QPPSKAWRAS QMMTFFIFLL 850 860 870 880 890 900 FFPSFTGVLC TLAITIWRII TYLYWQITEG RKIMIRLLHE QIINEGKDKM FLIEKLIKLQ 910 920 930 940 DMEKKANPSS LVLERREVEQ QGFLHLGEHD GSLDLRSRRS VQEGNPRA
	Isoform 3 [UniParc]. Checksum: 1C9E6B58A899F775	FASTA	760	87,820
	10 20 30 40 50 60 MLSDDHVNEI IIQVENVSSG VQSHPSSNQI FQEKVLLDSS INMVLSISDI DVIDSQTVSK 70 80 90 100 110 120 RNDQKGNQVL RFSTSLNESM SQTLHSLECM GIDTPGSSHE TVQGQKLIAS LIPMTSRDRI 130 140 150 160 170 180 KAIRNQPRTM EEKRNLRKIV DKEKSKQTHR ILQLNCCIQC LNSISRAYRR SKNSLSEILN 190 200 210 220 230 240 SISLWQKTLK IIGGKFGTSV LSYFNFLRWL LKFNIFSFIL NFSFIIIPQF TVAKKNTLQF 250 260 270 280 290 300 TGLEFFTGVG YFRDTVMYYG FYTNSTIQHG NSGASYNMQL AYIFTIGACL TTCFFSLLFS 310 320 330 340 350 360 MAKYFRNNFI NPHIYSGGIT KLIFCWDFTV THEKAVKLKQ KNLSTEIREN LSELRQENSK 370 380 390 400 410 420 LTFNQLLTRF SAYMVAWVVS TGVAIACCAA VYYLAEYNLE FLKTHSNPGA VLLLPFVVSC 430 440 450 460 470 480 INLAVPCIYS MFRLVERYEM PRHEVYVLLI RNIFLKISII GILCYYWLNT VALSGEECWE 490 500 510 520 530 540 TLIGQDIYRL LLMDFVFSLV NSFLGEFLRR IIGMQLITSL GLQEFDIARN VLELIYAQTL 550 560 570 580 590 600 VWIGIFFCPL LPFIQMIMLF IMFYSKNISL MMNFQPPSKA WRASQMMTFF IFLLFFPSFT 610 620 630 640 650 660 GVLCTLAITI WRLKPSADCG PFRGLPLFIH SIYSWIDTLS TRPGYLWVVW IYRNLIGSVH 670 680 690 700 710 720 FFFILTLIVL IITYLYWQIT EGRKIMIRLL HEQIINEGKD KMFLIEKLIK LQDMEKKANP 730 740 750 760 SSLVLERREV EQQGFLHLGE HDGSLDLRSR RSVQEGNPRA
	Isoform 4 [UniParc]. Checksum: CE0C71C7A117888B	FASTA	647	75,486
	10 20 30 40 50 60 MTSRDRIKAI RNQPRTMEEK RNLRKIVDKE KSKQTHRILQ LNCCIQCLNS ISRAYRRSKN 70 80 90 100 110 120 SLSEILNSIS LWQKTLKIIG GKFGTSVLSY FNFLRWLLKF NIFSFILNFS FIIIPQFTVA 130 140 150 160 170 180 KKNTLQFTGL EFFTGVGYFR DTVMYYGFYT NSTIQHGNSG ASYNMQLAYI FTIGACLTTC 190 200 210 220 230 240 FFSLLFSMAK YFRNNFINPH IYSGGITKLI FCWDFTVTHE KAVKLKQKNL STEIRENLSE 250 260 270 280 290 300 LRQENSKLTF NQLLTRFSAY MVAWVVSTGV AIACCAAVYY LAEYNLEFLK THSNPGAVLL 310 320 330 340 350 360 LPFVVSCINL AVPCIYSMFR LVERYEMPRH EVYVLLIRNI FLKISIIGIL CYYWLNTVAL 370 380 390 400 410 420 SGEECWETLI GQDIYRLLLM DFVFSLVNSF LGEFLRRIIG MQLITSLGLQ EFDIARNVLE 430 440 450 460 470 480 LIYAQTLVWI GIFFCPLLPF IQMIMLFIMF YSKNISLMMN FQPPSKAWRA SQMMTFFIFL 490 500 510 520 530 540 LFFPSFTGVL CTLAITIWRL KPSADCGPFR GLPLFIHSIY SWIDTLSTRP GYLWVVWIYR 550 560 570 580 590 600 NLIGSVHFFF ILTLIVLIIT YLYWQITEGR KIMIRLLHEQ IINEGKDKMF LIEKLIKLQD 610 620 630 640 MEKKANPSSL VLERREVEQQ GFLHLGEHDG SLDLRSRRSV QEGNPRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins." Keresztes G., Mutai H., Heller S. BMC Genomics 4:24-24(2003) [PubMed: 12812529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." Kurima K., Yang Y., Sorber K., Griffith A.J. Genomics 82:300-308(2003) [PubMed: 12906855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Testis.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 200-1006 (ISOFORM 1). Tissue: Rectum tumor.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 667-1006. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY263164 mRNA. Translation: AAP78779.1. AY236494 mRNA. Translation: AAP69872.1. AY358155 mRNA. Translation: AAQ88522.1. AC130456 Genomic DNA. No translation available. BC027602 mRNA. Translation: AAH27602.1. BC038118 mRNA. Translation: AAH38118.1. CR749359 mRNA. Translation: CAH18212.1. AK023655 mRNA. Translation: BAB14629.1. Different initiation.
IPI	IPI00220470. IPI00432771. IPI00470897. IPI00644372.
RefSeq	NP_001098718.1. NM_001105248.1. NP_001098719.1. NM_001105249.1. NP_079056.2. NM_024780.4.
UniGene	Hs.115838.
3D structure databases
ProteinModelPortal	Q6UXY8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6UXY8. 1 interaction.
STRING	Q6UXY8.
Polymorphism databases
DMDM	152061114.
Proteomic databases
PRIDE	Q6UXY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396229; ENSP00000379531; ENSG00000103534.
GeneID	79838.
KEGG	hsa:79838.
UCSC	uc002dgb.2. human. uc002dgc.2. human. uc002dgd.1. human. uc002dgf.2. human.
Organism-specific databases
CTD	79838.
GeneCards	GC16P019422.
HGNC	HGNC:22999. TMC5.
HPA	HPA040810. HPA042037.
neXtProt	NX_Q6UXY8.
PharmGKB	PA134923498.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14456.
GeneTree	ENSGT00550000074255.
HOGENOM	HBG505694.
HOVERGEN	HBG108587.
InParanoid	Q6UXY8.
OMA	ELNCCAQ.
PhylomeDB	Q6UXY8.
Gene expression databases
ArrayExpress	Q6UXY8.
Bgee	Q6UXY8.
CleanEx	HS_TMC5.
Genevestigator	Q6UXY8.
Family and domain databases
InterPro	IPR012496. TMC. [Graphical view]
Pfam	PF07810. TMC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	69502.

Entry information

Entry name

TMC5_HUMAN

Accession

Primary (citable) accession number: Q6UXY8
Secondary accession number(s): Q68DK8 , Q8IY20, Q8NHV6, Q9H8I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.