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Q6UXY1 (BI2L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Short name=BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name=Pinkbar
Gene names
Name:BAIAP2L2
ORF Names:UNQ9336/PRO34007
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane. Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts. Ref.4

Tissue specificity

Expressed in the epithelial layer of the intestine (at protein level). Ref.4

Domain

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation By similarity.

Sequence similarities

Contains 1 IMD (IRSp53/MIM homology) domain.

Contains 1 SH3 domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6UXY1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6UXY1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     441-454: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
PRO_0000256130

Regions

Domain1 – 239239IMD
Domain324 – 38764SH3

Natural variations

Alternative sequence441 – 45414Missing in isoform 2.
VSP_021324

Experimental info

Sequence conflict2521C → R in AAH15619. Ref.3
Sequence conflict4111M → MTPM in AAH15619. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A9D16724F6FCE118

FASTA52958,987
        10         20         30         40         50         60 
MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE 

        70         80         90        100        110        120 
RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL LQHMEKNTKL DMQFIKDSRQ 

       130        140        150        160        170        180 
HYELEYRHRA ANLEKCMSEL WRMERKRDKN VREMKESVNR LHAQMQAFVS ESQRAAELEE 

       190        200        210        220        230        240 
KRRYRFLAEK HLLLSNTFLQ FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG 

       250        260        270        280        290        300 
PPYPSGRLTP TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA 

       310        320        330        340        350        360 
SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD VVEVLVPEAQ 

       370        380        390        400        410        420 
NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT SMTSMSPMTP MNPGNELPSR 

       430        440        450        460        470        480 
SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG 

       490        500        510        520 
STAVATDVKK LMSSEQYPPQ ELFPRGTNPF ATVKLRPTIT NDRSAPLIR 

« Hide

Isoform 2 [UniParc].

Checksum: 8B77252604C9AFC3
Show »

FASTA51557,353

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Eye.
[4]"Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures."
Pykalainen A., Boczkowska M., Zhao H., Saarikangas J., Rebowski G., Jansen M., Hakanen J., Koskela E.V., Peranen J., Vihinen H., Jokitalo E., Salminen M., Ikonen E., Dominguez R., Lappalainen P.
Nat. Struct. Mol. Biol. 18:902-907(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358164 mRNA. Translation: AAQ88531.1.
AL022322, AL031587 Genomic DNA. Translation: CAI17932.1.
AL031587, AL022322 Genomic DNA. Translation: CAI18966.1.
AL031587, AL022322 Genomic DNA. Translation: CAQ06637.1.
AL022322, AL031587 Genomic DNA. Translation: CAQ10440.1.
BC015619 mRNA. Translation: AAH15619.1.
RefSeqNP_079321.3. NM_025045.5.
XP_005261808.1. XM_005261751.2.
UniGeneHs.474822.

3D structure databases

ProteinModelPortalQ6UXY1.
SMRQ6UXY1. Positions 2-220, 327-387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123120. 1 interaction.
STRING9606.ENSP00000371085.

PTM databases

PhosphoSiteQ6UXY1.

Polymorphism databases

DMDM74749434.

Proteomic databases

PaxDbQ6UXY1.
PRIDEQ6UXY1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381669; ENSP00000371085; ENSG00000128298. [Q6UXY1-1]
GeneID80115.
KEGGhsa:80115.
UCSCuc003auw.3. human. [Q6UXY1-1]

Organism-specific databases

CTD80115.
GeneCardsGC22M038480.
HGNCHGNC:26203. BAIAP2L2.
HPAHPA003043.
neXtProtNX_Q6UXY1.
PharmGKBPA142672563.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25242.
HOGENOMHOG000038005.
HOVERGENHBG100621.
InParanoidQ6UXY1.
OMARKRDKNV.
PhylomeDBQ6UXY1.
TreeFamTF325648.

Gene expression databases

ArrayExpressQ6UXY1.
BgeeQ6UXY1.
CleanExHS_BAIAP2L2.
GenevestigatorQ6UXY1.

Family and domain databases

InterProIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR14206. PTHR14206. 1 hit.
PfamPF08397. IMD. 1 hit.
[Graphical view]
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80115.
NextBio70342.
PROQ6UXY1.

Entry information

Entry nameBI2L2_HUMAN
AccessionPrimary (citable) accession number: Q6UXY1
Secondary accession number(s): B0QYE2, Q96BG7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM