Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name:
BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name:
Pinkbar
Gene namesi
ORF Names:UNQ9336/PRO34007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:26203. BAIAP2L2.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: GO_Central
  • cell-cell contact zone Source: UniProtKB
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • cytosol Source: GO_Central
  • plasma membrane Source: UniProtKB-SubCell
  • vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128298.
PharmGKBiPA142672563.

Polymorphism and mutation databases

BioMutaiBAIAP2L2.
DMDMi74749434.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002561301 – 529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei481PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6UXY1.
PeptideAtlasiQ6UXY1.
PRIDEiQ6UXY1.

PTM databases

iPTMnetiQ6UXY1.
PhosphoSitePlusiQ6UXY1.

Expressioni

Tissue specificityi

Expressed in the epithelial layer of the intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000128298.
CleanExiHS_BAIAP2L2.
ExpressionAtlasiQ6UXY1. baseline and differential.
GenevisibleiQ6UXY1. HS.

Organism-specific databases

HPAiHPA003043.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6UXY1.
SMRiQ6UXY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 239IMDPROSITE-ProRule annotationAdd BLAST239
Domaini324 – 387SH3PROSITE-ProRule annotationAdd BLAST64

Domaini

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IFGP. Eukaryota.
ENOG4111HBF. LUCA.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG100621.
InParanoidiQ6UXY1.
KOiK20127.
OMAiPSEYWDG.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ6UXY1.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030126. Pinkbar.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 2 hits.
PTHR14206:SF5. PTHR14206:SF5. 2 hits.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV
60 70 80 90 100
YFSAIQKIGE RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL
110 120 130 140 150
LQHMEKNTKL DMQFIKDSRQ HYELEYRHRA ANLEKCMSEL WRMERKRDKN
160 170 180 190 200
VREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ
210 220 230 240 250
FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG PPYPSGRLTP
260 270 280 290 300
TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA
310 320 330 340 350
SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD
360 370 380 390 400
VVEVLVPEAQ NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT
410 420 430 440 450
SMTSMSPMTP MNPGNELPSR SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ
460 470 480 490 500
SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG STAVATDVKK LMSSEQYPPQ
510 520
ELFPRGTNPF ATVKLRPTIT NDRSAPLIR
Length:529
Mass (Da):58,987
Last modified:July 5, 2004 - v1
Checksum:iA9D16724F6FCE118
GO
Isoform 2 (identifier: Q6UXY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-454: Missing.

Show »
Length:515
Mass (Da):57,353
Checksum:i8B77252604C9AFC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252C → R in AAH15619 (PubMed:15489334).Curated1
Sequence conflicti411M → MTPM in AAH15619 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021324441 – 454Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358164 mRNA. Translation: AAQ88531.1.
AL022322, AL031587 Genomic DNA. Translation: CAI17932.1.
AL031587, AL022322 Genomic DNA. Translation: CAI18966.1.
AL031587, AL022322 Genomic DNA. Translation: CAQ06637.1.
AL022322, AL031587 Genomic DNA. Translation: CAQ10440.1.
BC015619 mRNA. Translation: AAH15619.1.
CCDSiCCDS43018.1. [Q6UXY1-1]
RefSeqiNP_079321.3. NM_025045.5. [Q6UXY1-1]
XP_005261808.1. XM_005261751.4. [Q6UXY1-1]
XP_011528681.1. XM_011530379.2. [Q6UXY1-2]
UniGeneiHs.474822.

Genome annotation databases

EnsembliENST00000332536; ENSP00000328876; ENSG00000128298. [Q6UXY1-2]
ENST00000381669; ENSP00000371085; ENSG00000128298. [Q6UXY1-1]
GeneIDi80115.
KEGGihsa:80115.
UCSCiuc003auw.4. human. [Q6UXY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358164 mRNA. Translation: AAQ88531.1.
AL022322, AL031587 Genomic DNA. Translation: CAI17932.1.
AL031587, AL022322 Genomic DNA. Translation: CAI18966.1.
AL031587, AL022322 Genomic DNA. Translation: CAQ06637.1.
AL022322, AL031587 Genomic DNA. Translation: CAQ10440.1.
BC015619 mRNA. Translation: AAH15619.1.
CCDSiCCDS43018.1. [Q6UXY1-1]
RefSeqiNP_079321.3. NM_025045.5. [Q6UXY1-1]
XP_005261808.1. XM_005261751.4. [Q6UXY1-1]
XP_011528681.1. XM_011530379.2. [Q6UXY1-2]
UniGeneiHs.474822.

3D structure databases

ProteinModelPortaliQ6UXY1.
SMRiQ6UXY1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6UXY1.
PhosphoSitePlusiQ6UXY1.

Polymorphism and mutation databases

BioMutaiBAIAP2L2.
DMDMi74749434.

Proteomic databases

PaxDbiQ6UXY1.
PeptideAtlasiQ6UXY1.
PRIDEiQ6UXY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332536; ENSP00000328876; ENSG00000128298. [Q6UXY1-2]
ENST00000381669; ENSP00000371085; ENSG00000128298. [Q6UXY1-1]
GeneIDi80115.
KEGGihsa:80115.
UCSCiuc003auw.4. human. [Q6UXY1-1]

Organism-specific databases

CTDi80115.
GeneCardsiBAIAP2L2.
HGNCiHGNC:26203. BAIAP2L2.
HPAiHPA003043.
neXtProtiNX_Q6UXY1.
OpenTargetsiENSG00000128298.
PharmGKBiPA142672563.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFGP. Eukaryota.
ENOG4111HBF. LUCA.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG100621.
InParanoidiQ6UXY1.
KOiK20127.
OMAiPSEYWDG.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ6UXY1.
TreeFamiTF325648.

Miscellaneous databases

GenomeRNAii80115.
PROiQ6UXY1.

Gene expression databases

BgeeiENSG00000128298.
CleanExiHS_BAIAP2L2.
ExpressionAtlasiQ6UXY1. baseline and differential.
GenevisibleiQ6UXY1. HS.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030126. Pinkbar.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 2 hits.
PTHR14206:SF5. PTHR14206:SF5. 2 hits.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBI2L2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXY1
Secondary accession number(s): B0QYE2, Q96BG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.