Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6UXY1

- BI2L2_HUMAN

UniProt

Q6UXY1 - BI2L2_HUMAN

Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide By similarity.By similarity

    GO - Molecular functioni

    1. phospholipid binding Source: UniProtKB

    GO - Biological processi

    1. filopodium assembly Source: InterPro
    2. membrane organization Source: UniProtKB
    3. regulation of actin cytoskeleton organization Source: InterPro
    4. signal transduction Source: InterPro

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    Short name:
    BAI1-associated protein 2-like protein 2
    Alternative name(s):
    Planar intestinal- and kidney-specific BAR domain protein
    Short name:
    Pinkbar
    Gene namesi
    ORF Names:UNQ9336/PRO34007
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:26203. BAIAP2L2.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junction 1 Publication. Cytoplasmic vesicle membrane 1 Publication
    Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.

    GO - Cellular componenti

    1. cell-cell contact zone Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell
    4. vesicle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672563.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2PRO_0000256130Add
    BLAST

    Proteomic databases

    PaxDbiQ6UXY1.
    PRIDEiQ6UXY1.

    PTM databases

    PhosphoSiteiQ6UXY1.

    Expressioni

    Tissue specificityi

    Expressed in the epithelial layer of the intestine (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ6UXY1.
    BgeeiQ6UXY1.
    CleanExiHS_BAIAP2L2.
    GenevestigatoriQ6UXY1.

    Organism-specific databases

    HPAiHPA003043.

    Interactioni

    Protein-protein interaction databases

    BioGridi123120. 1 interaction.
    STRINGi9606.ENSP00000371085.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6UXY1.
    SMRiQ6UXY1. Positions 2-220, 327-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 239239IMDPROSITE-ProRule annotationAdd
    BLAST
    Domaini324 – 38764SH3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation By similarity.By similarity

    Sequence similaritiesi

    Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG25242.
    HOGENOMiHOG000038005.
    HOVERGENiHBG100621.
    InParanoidiQ6UXY1.
    OMAiRKRDKNV.
    PhylomeDBiQ6UXY1.
    TreeFamiTF325648.

    Family and domain databases

    InterProiIPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR14206. PTHR14206. 1 hit.
    PfamiPF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6UXY1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV    50
    YFSAIQKIGE RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL 100
    LQHMEKNTKL DMQFIKDSRQ HYELEYRHRA ANLEKCMSEL WRMERKRDKN 150
    VREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ 200
    FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG PPYPSGRLTP 250
    TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA 300
    SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD 350
    VVEVLVPEAQ NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT 400
    SMTSMSPMTP MNPGNELPSR SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ 450
    SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG STAVATDVKK LMSSEQYPPQ 500
    ELFPRGTNPF ATVKLRPTIT NDRSAPLIR 529
    Length:529
    Mass (Da):58,987
    Last modified:July 5, 2004 - v1
    Checksum:iA9D16724F6FCE118
    GO
    Isoform 2 (identifier: Q6UXY1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         441-454: Missing.

    Show »
    Length:515
    Mass (Da):57,353
    Checksum:i8B77252604C9AFC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2521C → R in AAH15619. (PubMed:15489334)Curated
    Sequence conflicti411 – 4111M → MTPM in AAH15619. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei441 – 45414Missing in isoform 2. 1 PublicationVSP_021324Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358164 mRNA. Translation: AAQ88531.1.
    AL022322, AL031587 Genomic DNA. Translation: CAI17932.1.
    AL031587, AL022322 Genomic DNA. Translation: CAI18966.1.
    AL031587, AL022322 Genomic DNA. Translation: CAQ06637.1.
    AL022322, AL031587 Genomic DNA. Translation: CAQ10440.1.
    BC015619 mRNA. Translation: AAH15619.1.
    CCDSiCCDS43018.1. [Q6UXY1-1]
    RefSeqiNP_079321.3. NM_025045.5. [Q6UXY1-1]
    XP_005261808.1. XM_005261751.2. [Q6UXY1-1]
    UniGeneiHs.474822.

    Genome annotation databases

    EnsembliENST00000381669; ENSP00000371085; ENSG00000128298. [Q6UXY1-1]
    GeneIDi80115.
    KEGGihsa:80115.
    UCSCiuc003auw.3. human. [Q6UXY1-1]

    Polymorphism databases

    DMDMi74749434.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358164 mRNA. Translation: AAQ88531.1 .
    AL022322 , AL031587 Genomic DNA. Translation: CAI17932.1 .
    AL031587 , AL022322 Genomic DNA. Translation: CAI18966.1 .
    AL031587 , AL022322 Genomic DNA. Translation: CAQ06637.1 .
    AL022322 , AL031587 Genomic DNA. Translation: CAQ10440.1 .
    BC015619 mRNA. Translation: AAH15619.1 .
    CCDSi CCDS43018.1. [Q6UXY1-1 ]
    RefSeqi NP_079321.3. NM_025045.5. [Q6UXY1-1 ]
    XP_005261808.1. XM_005261751.2. [Q6UXY1-1 ]
    UniGenei Hs.474822.

    3D structure databases

    ProteinModelPortali Q6UXY1.
    SMRi Q6UXY1. Positions 2-220, 327-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123120. 1 interaction.
    STRINGi 9606.ENSP00000371085.

    PTM databases

    PhosphoSitei Q6UXY1.

    Polymorphism databases

    DMDMi 74749434.

    Proteomic databases

    PaxDbi Q6UXY1.
    PRIDEi Q6UXY1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381669 ; ENSP00000371085 ; ENSG00000128298 . [Q6UXY1-1 ]
    GeneIDi 80115.
    KEGGi hsa:80115.
    UCSCi uc003auw.3. human. [Q6UXY1-1 ]

    Organism-specific databases

    CTDi 80115.
    GeneCardsi GC22M038480.
    HGNCi HGNC:26203. BAIAP2L2.
    HPAi HPA003043.
    neXtProti NX_Q6UXY1.
    PharmGKBi PA142672563.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25242.
    HOGENOMi HOG000038005.
    HOVERGENi HBG100621.
    InParanoidi Q6UXY1.
    OMAi RKRDKNV.
    PhylomeDBi Q6UXY1.
    TreeFami TF325648.

    Miscellaneous databases

    GenomeRNAii 80115.
    NextBioi 70342.
    PROi Q6UXY1.

    Gene expression databases

    ArrayExpressi Q6UXY1.
    Bgeei Q6UXY1.
    CleanExi HS_BAIAP2L2.
    Genevestigatori Q6UXY1.

    Family and domain databases

    InterProi IPR027681. BAIAP2.
    IPR013606. IRSp53/MIM_homology_IMD.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR14206. PTHR14206. 1 hit.
    Pfami PF08397. IMD. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51338. IMD. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.
    4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiBI2L2_HUMAN
    AccessioniPrimary (citable) accession number: Q6UXY1
    Secondary accession number(s): B0QYE2, Q96BG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3