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Q6UXY1

- BI2L2_HUMAN

UniProt

Q6UXY1 - BI2L2_HUMAN

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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).By similarity

GO - Molecular functioni

  1. phospholipid binding Source: UniProtKB

GO - Biological processi

  1. filopodium assembly Source: InterPro
  2. membrane organization Source: UniProtKB
  3. regulation of actin cytoskeleton organization Source: InterPro
  4. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name:
BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name:
Pinkbar
Gene namesi
ORF Names:UNQ9336/PRO34007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:26203. BAIAP2L2.

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junction 1 Publication. Cytoplasmic vesicle membrane 1 Publication
Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.

GO - Cellular componenti

  1. cell-cell contact zone Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
  4. vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2PRO_0000256130Add
BLAST

Proteomic databases

PaxDbiQ6UXY1.
PRIDEiQ6UXY1.

PTM databases

PhosphoSiteiQ6UXY1.

Expressioni

Tissue specificityi

Expressed in the epithelial layer of the intestine (at protein level).1 Publication

Gene expression databases

BgeeiQ6UXY1.
CleanExiHS_BAIAP2L2.
ExpressionAtlasiQ6UXY1. baseline and differential.
GenevestigatoriQ6UXY1.

Organism-specific databases

HPAiHPA003043.

Interactioni

Protein-protein interaction databases

BioGridi123120. 1 interaction.
STRINGi9606.ENSP00000371085.

Structurei

3D structure databases

ProteinModelPortaliQ6UXY1.
SMRiQ6UXY1. Positions 2-220, 327-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 239239IMDPROSITE-ProRule annotationAdd
BLAST
Domaini324 – 38764SH3PROSITE-ProRule annotationAdd
BLAST

Domaini

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG25242.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG100621.
InParanoidiQ6UXY1.
OMAiRKRDKNV.
PhylomeDBiQ6UXY1.
TreeFamiTF325648.

Family and domain databases

InterProiIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6UXY1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV
60 70 80 90 100
YFSAIQKIGE RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL
110 120 130 140 150
LQHMEKNTKL DMQFIKDSRQ HYELEYRHRA ANLEKCMSEL WRMERKRDKN
160 170 180 190 200
VREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ
210 220 230 240 250
FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG PPYPSGRLTP
260 270 280 290 300
TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA
310 320 330 340 350
SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD
360 370 380 390 400
VVEVLVPEAQ NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT
410 420 430 440 450
SMTSMSPMTP MNPGNELPSR SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ
460 470 480 490 500
SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG STAVATDVKK LMSSEQYPPQ
510 520
ELFPRGTNPF ATVKLRPTIT NDRSAPLIR
Length:529
Mass (Da):58,987
Last modified:July 5, 2004 - v1
Checksum:iA9D16724F6FCE118
GO
Isoform 2 (identifier: Q6UXY1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-454: Missing.

Show »
Length:515
Mass (Da):57,353
Checksum:i8B77252604C9AFC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2521C → R in AAH15619. (PubMed:15489334)Curated
Sequence conflicti411 – 4111M → MTPM in AAH15619. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei441 – 45414Missing in isoform 2. 1 PublicationVSP_021324Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358164 mRNA. Translation: AAQ88531.1.
AL022322, AL031587 Genomic DNA. Translation: CAI17932.1.
AL031587, AL022322 Genomic DNA. Translation: CAI18966.1.
AL031587, AL022322 Genomic DNA. Translation: CAQ06637.1.
AL022322, AL031587 Genomic DNA. Translation: CAQ10440.1.
BC015619 mRNA. Translation: AAH15619.1.
CCDSiCCDS43018.1. [Q6UXY1-1]
RefSeqiNP_079321.3. NM_025045.5. [Q6UXY1-1]
XP_005261808.1. XM_005261751.2. [Q6UXY1-1]
UniGeneiHs.474822.

Genome annotation databases

EnsembliENST00000332536; ENSP00000328876; ENSG00000128298. [Q6UXY1-2]
ENST00000381669; ENSP00000371085; ENSG00000128298. [Q6UXY1-1]
GeneIDi80115.
KEGGihsa:80115.
UCSCiuc003auw.3. human. [Q6UXY1-1]

Polymorphism databases

DMDMi74749434.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358164 mRNA. Translation: AAQ88531.1 .
AL022322 , AL031587 Genomic DNA. Translation: CAI17932.1 .
AL031587 , AL022322 Genomic DNA. Translation: CAI18966.1 .
AL031587 , AL022322 Genomic DNA. Translation: CAQ06637.1 .
AL022322 , AL031587 Genomic DNA. Translation: CAQ10440.1 .
BC015619 mRNA. Translation: AAH15619.1 .
CCDSi CCDS43018.1. [Q6UXY1-1 ]
RefSeqi NP_079321.3. NM_025045.5. [Q6UXY1-1 ]
XP_005261808.1. XM_005261751.2. [Q6UXY1-1 ]
UniGenei Hs.474822.

3D structure databases

ProteinModelPortali Q6UXY1.
SMRi Q6UXY1. Positions 2-220, 327-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123120. 1 interaction.
STRINGi 9606.ENSP00000371085.

PTM databases

PhosphoSitei Q6UXY1.

Polymorphism databases

DMDMi 74749434.

Proteomic databases

PaxDbi Q6UXY1.
PRIDEi Q6UXY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332536 ; ENSP00000328876 ; ENSG00000128298 . [Q6UXY1-2 ]
ENST00000381669 ; ENSP00000371085 ; ENSG00000128298 . [Q6UXY1-1 ]
GeneIDi 80115.
KEGGi hsa:80115.
UCSCi uc003auw.3. human. [Q6UXY1-1 ]

Organism-specific databases

CTDi 80115.
GeneCardsi GC22M038480.
HGNCi HGNC:26203. BAIAP2L2.
HPAi HPA003043.
neXtProti NX_Q6UXY1.
PharmGKBi PA142672563.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25242.
GeneTreei ENSGT00390000005995.
HOGENOMi HOG000038005.
HOVERGENi HBG100621.
InParanoidi Q6UXY1.
OMAi RKRDKNV.
PhylomeDBi Q6UXY1.
TreeFami TF325648.

Miscellaneous databases

GenomeRNAii 80115.
NextBioi 70342.
PROi Q6UXY1.

Gene expression databases

Bgeei Q6UXY1.
CleanExi HS_BAIAP2L2.
ExpressionAtlasi Q6UXY1. baseline and differential.
Genevestigatori Q6UXY1.

Family and domain databases

InterProi IPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR14206. PTHR14206. 1 hit.
Pfami PF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBI2L2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXY1
Secondary accession number(s): B0QYE2, Q96BG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3