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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Gene

BAIAP2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name:
BAI1-associated protein 2-like protein 2
Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name:
Pinkbar
Gene namesi
ORF Names:UNQ9336/PRO34007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128298.16
HGNCiHGNC:26203 BAIAP2L2
MIMi617536 gene
neXtProtiNX_Q6UXY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128298
PharmGKBiPA142672563

Polymorphism and mutation databases

BioMutaiBAIAP2L2
DMDMi74749434

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002561301 – 529Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei481PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6UXY1
PeptideAtlasiQ6UXY1
PRIDEiQ6UXY1

PTM databases

iPTMnetiQ6UXY1
PhosphoSitePlusiQ6UXY1

Expressioni

Tissue specificityi

Expressed in the epithelial layer of the intestine (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000128298
CleanExiHS_BAIAP2L2
ExpressionAtlasiQ6UXY1 baseline and differential
GenevisibleiQ6UXY1 HS

Organism-specific databases

HPAiHPA003043

Structurei

3D structure databases

ProteinModelPortaliQ6UXY1
SMRiQ6UXY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 239IMDPROSITE-ProRule annotationAdd BLAST239
Domaini324 – 387SH3PROSITE-ProRule annotationAdd BLAST64

Domaini

The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).By similarity

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IFGP Eukaryota
ENOG4111HBF LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG100621
InParanoidiQ6UXY1
KOiK20127
OMAiPSEYWDG
OrthoDBiEOG091G05ZV
PhylomeDBiQ6UXY1
TreeFamiTF325648

Family and domain databases

CDDicd11914 SH3_BAIAP2L2, 1 hit
Gene3Di1.20.1270.601 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR027681 IRSp53/IRTKS/Pinkbar
IPR030126 Pinkbar
IPR035593 Pinkbar_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF5 PTHR14206:SF5, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UXY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV
60 70 80 90 100
YFSAIQKIGE RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL
110 120 130 140 150
LQHMEKNTKL DMQFIKDSRQ HYELEYRHRA ANLEKCMSEL WRMERKRDKN
160 170 180 190 200
VREMKESVNR LHAQMQAFVS ESQRAAELEE KRRYRFLAEK HLLLSNTFLQ
210 220 230 240 250
FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG PPYPSGRLTP
260 270 280 290 300
TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA
310 320 330 340 350
SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD
360 370 380 390 400
VVEVLVPEAQ NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT
410 420 430 440 450
SMTSMSPMTP MNPGNELPSR SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ
460 470 480 490 500
SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG STAVATDVKK LMSSEQYPPQ
510 520
ELFPRGTNPF ATVKLRPTIT NDRSAPLIR
Length:529
Mass (Da):58,987
Last modified:July 5, 2004 - v1
Checksum:iA9D16724F6FCE118
GO
Isoform 2 (identifier: Q6UXY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-454: Missing.

Show »
Length:515
Mass (Da):57,353
Checksum:i8B77252604C9AFC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252C → R in AAH15619 (PubMed:15489334).Curated1
Sequence conflicti411M → MTPM in AAH15619 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021324441 – 454Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358164 mRNA Translation: AAQ88531.1
AL022322 Genomic DNA No translation available.
AL031587 Genomic DNA No translation available.
BC015619 mRNA Translation: AAH15619.1
CCDSiCCDS43018.1 [Q6UXY1-1]
RefSeqiNP_079321.3, NM_025045.5 [Q6UXY1-1]
XP_005261808.1, XM_005261751.4 [Q6UXY1-1]
XP_011528681.1, XM_011530379.2 [Q6UXY1-2]
UniGeneiHs.474822

Genome annotation databases

EnsembliENST00000332536; ENSP00000328876; ENSG00000128298 [Q6UXY1-2]
ENST00000381669; ENSP00000371085; ENSG00000128298 [Q6UXY1-1]
GeneIDi80115
KEGGihsa:80115
UCSCiuc003auw.4 human [Q6UXY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBI2L2_HUMAN
AccessioniPrimary (citable) accession number: Q6UXY1
Secondary accession number(s): B0QYE2, Q96BG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome