Q6UXY1 (BI2L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Short name=BAI1-associated protein 2-like protein 2

Alternative name(s):
Planar intestinal- and kidney-specific BAR domain protein
Short name=Pinkbar

Gene names

Name:	BAIAP2L2
ORF Names:	UNQ9336/PRO34007

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane. Note: Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts. Ref.4
Tissue specificity	Expressed in the epithelial layer of the intestine (at protein level). Ref.4
Domain	The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation By similarity.
Sequence similarities	Contains 1 IMD (IRSp53/MIM homology) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
Domain	SH3 domain
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Inferred from sequence or structural similarity. Source: UniProtKB filopodium assembly Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cell-cell contact zone Inferred from direct assay Ref.4. Source: UniProtKB cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell vesicle membrane Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	phospholipid binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6UXY1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6UXY1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     441-454: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2		PRO_0000256130
Regions
	Domain	1 – 239	239	IMD
	Domain	324 – 387	64	SH3
Natural variations
	Alternative sequence	441 – 454	14	Missing in isoform 2.		VSP_021324
Experimental info
	Sequence conflict	252	1	C → R in AAH15619. Ref.3
	Sequence conflict	411	1	M → MTPM in AAH15619. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A9D16724F6FCE118	FASTA	529	58,987
	10 20 30 40 50 60 MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE 70 80 90 100 110 120 RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL LQHMEKNTKL DMQFIKDSRQ 130 140 150 160 170 180 HYELEYRHRA ANLEKCMSEL WRMERKRDKN VREMKESVNR LHAQMQAFVS ESQRAAELEE 190 200 210 220 230 240 KRRYRFLAEK HLLLSNTFLQ FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG 250 260 270 280 290 300 PPYPSGRLTP TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA 310 320 330 340 350 360 SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD VVEVLVPEAQ 370 380 390 400 410 420 NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT SMTSMSPMTP MNPGNELPSR 430 440 450 460 470 480 SYPLRGSHSL DDLLDRPGNS IAPSEYWDGQ SRSRTPSRVP SRAPSPAPPP LPSSRRSSMG 490 500 510 520 STAVATDVKK LMSSEQYPPQ ELFPRGTNPF ATVKLRPTIT NDRSAPLIR
	Isoform 2 [UniParc]. Checksum: 8B77252604C9AFC3	FASTA	515	57,353
	10 20 30 40 50 60 MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE 70 80 90 100 110 120 RALQSPTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGGL LQHMEKNTKL DMQFIKDSRQ 130 140 150 160 170 180 HYELEYRHRA ANLEKCMSEL WRMERKRDKN VREMKESVNR LHAQMQAFVS ESQRAAELEE 190 200 210 220 230 240 KRRYRFLAEK HLLLSNTFLQ FFGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG 250 260 270 280 290 300 PPYPSGRLTP TCLDMPPRPL GEFSSPRSRH GSGSYGTEPD ARPASQLEPD RRSLPRTPSA 310 320 330 340 350 360 SSLYSGSAQS SRSNSFGERP GGGGGARRVR ALVSHSEGAN HTLLRFSAGD VVEVLVPEAQ 370 380 390 400 410 420 NGWLYGKLEG SSASGWFPEA YVKALEEGPV NPMTPVTPMT SMTSMSPMTP MNPGNELPSR 430 440 450 460 470 480 SYPLRGSHSL DDLLDRPGNS TPSRVPSRAP SPAPPPLPSS RRSSMGSTAV ATDVKKLMSS 490 500 510 EQYPPQELFP RGTNPFATVK LRPTITNDRS APLIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[4]	"Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures." Pykalainen A., Boczkowska M., Zhao H., Saarikangas J., Rebowski G., Jansen M., Hakanen J., Koskela E.V., Peranen J., Vihinen H., Jokitalo E., Salminen M., Ikonen E., Dominguez R., Lappalainen P. Nat. Struct. Mol. Biol. 18:902-907(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358164 mRNA. Translation: AAQ88531.1. AL022322, AL031587 Genomic DNA. Translation: CAI17932.1. AL031587, AL022322 Genomic DNA. Translation: CAI18966.1. AL031587, AL022322 Genomic DNA. Translation: CAQ06637.1. AL022322, AL031587 Genomic DNA. Translation: CAQ10440.1. BC015619 mRNA. Translation: AAH15619.1.
IPI	IPI00059940. IPI00746115.
RefSeq	NP_079321.3. NM_025045.4.
UniGene	Hs.474822.
3D structure databases
ProteinModelPortal	Q6UXY1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371085.
PTM databases
PhosphoSite	Q6UXY1.
Polymorphism databases
DMDM	74749434.
Proteomic databases
PaxDb	Q6UXY1.
PRIDE	Q6UXY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381669; ENSP00000371085; ENSG00000128298.
GeneID	80115.
KEGG	hsa:80115.
UCSC	uc003auw.3. human.
Organism-specific databases
CTD	80115.
GeneCards	GC22M038480.
HGNC	HGNC:26203. BAIAP2L2.
HPA	HPA003043.
neXtProt	NX_Q6UXY1.
PharmGKB	PA142672563.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25242.
HOGENOM	HOG000038005.
HOVERGEN	HBG100621.
InParanoid	Q6UXY1.
OMA	TRLDMPP.
OrthoDB	EOG470TH8.
Gene expression databases
ArrayExpress	Q6UXY1.
Bgee	Q6UXY1.
CleanEx	HS_BAIAP2L2.
Genevestigator	Q6UXY1.
GermOnline	ENSG00000128298. Homo sapiens.
Family and domain databases
InterPro	IPR013606. IRSp53/MIM_homology_IMD. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF08397. IMD. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS51338. IMD. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80115.
NextBio	70342.

Entry information

Entry name

BI2L2_HUMAN

Accession

Primary (citable) accession number: Q6UXY1
Secondary accession number(s): B0QYE2, Q96BG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.